堀江 義則 先生のプロフィール

堀江 義則 先生

ほりえ よしのり

堀江 義則 先生

国際医療福祉大学 臨床医学研究センター 教授 医療法人財団 順和会 山王メディカルセンター 内科部長 慶應義塾大学医学部消化器内科・客員教授

専門分野

内科・消化器内科、アルコール医学生物学

紹介

慶應義塾大学医学部卒。同大学消化器内科講師・永寿総合病院内科副部長・部長を経て、国際医療福祉大学臨床医学研究センター教授・慶應義塾大学医学部客員教授。日本アルコール・薬物医学会理事や内閣府アルコール健康障害対策関係者会議委員を務めるなど、消化器分野の豊富な知識と経験をもとに、アルコール性の病変に対して幅広く活躍している。

略歴

1988年   慶應義塾大学医学部卒業
1988年   慶應義塾大学医学部 内科学教室入室
1990年   国立療養所 久里浜病院内科へ出向
1992年   慶應義塾大学医学部 消化器内科入室
1994年   Louisiana State University Shreveport校 生理学教室へ留学
1997年   慶應義塾大学医学部 消化器内科帰室
2003年   慶應義塾大学医学部 消化器内科講師
2004年   永寿総合病院 内科副部長 
2004年~
2015年   慶應義塾大学医学部消化器内科・非常勤講師
2004年   永寿総合病院 内科部長 
2010年   国際医療福祉大学 臨床医学研究センター 教授
2010年   医療法人財団 順和会 山王病院 内科部長(消化器)
2015年   国際医療福祉大学 臨床医学研究センター 教授
2015年   医療法人財団 順和会 山王メディカルセンター 内科部長
2015年   慶應義塾大学医学部客員教授

所属学会・資格・役職など

[所属学会]

日本内科学会(認定医、指導医)
日本消化器病学会(専門医、学会評議員、関東支部評議員)
日本肝臓学会(専門医、東部会評議員)
日本消化器内視鏡学会(専門医)
日本消化管学会(暫定認定医)
日本アルコール・薬物医学会(理事、学会評議員、渉外委員長)
日本微小循環学会
アルコール医学生物学研究会(監事、運営委員)
国際アルコール学会
米国アルコール学会
国際中医薬学会 (World Federation of Chinese Medicine Societies)  (理事)

[資格]

日本医師会認定産業医

[役職]
2014年 内閣府 アルコール健康障害対策関係者会議委員

受賞・著書・論文など

[英文原著]

1. Moriya S, Nagata S, Yokoyama H, Kato S, Horie Y, Ito T, Ebihara Y, Ishii H. Expression of gamma-glutamyl transpeptidase mRNA after depletion of glutathione in rat liver. Alcohol Alcohol 1994; 29 Suppl 1: 107-111.

2. Horie Y, Wolf R, Miyasaka M, Anderson DC, Granger DN. Leukocyte adhesion and the hepatic microvascular responses to intestinal ischemia-reperfusion. Gastroenterology 1996; 111: 666-673.

3. Ohki E, Kato S, Horie Y, Mizukami T, Tamai H, Yokoyama H, Ito D, Fukuda M, Suzuki H, Kurose I, Ishii H. Chronic ethanol consumption enhances endotoxin induced hepatic

[英文原著]

1. Moriya S, Nagata S, Yokoyama H, Kato S, Horie Y, Ito T, Ebihara Y, Ishii H. Expression of gamma-glutamyl transpeptidase mRNA after depletion of glutathione in rat liver. Alcohol Alcohol 1994; 29 Suppl 1: 107-111.

2. Horie Y, Wolf R, Miyasaka M, Anderson DC, Granger DN. Leukocyte adhesion and the hepatic microvascular responses to intestinal ischemia-reperfusion. Gastroenterology 1996; 111: 666-673.

3. Ohki E, Kato S, Horie Y, Mizukami T, Tamai H, Yokoyama H, Ito D, Fukuda M, Suzuki H, Kurose I, Ishii H. Chronic ethanol consumption enhances endotoxin induced hepatic sinusoidal leukocyte adhesion. Alcohol. Clin. Exp. Res. 1996; 20: 350A-355A.

4. Kurose I, Higuchi H, Kato S, Miura S, Watanabe N, Kamegaya Y, Tomita K, Takaishi M, Horie Y, Fukuda M, Mizukami K, Ishii H. Oxidative stress on mitochondria and cell membrane of cultured rat hepatocytes and perfused liver exposed to ethanol. Gastroenterology 1997; 112:1331-1343.

5. Horie Y, Wolf R, Anderson DC, Granger DN. Hepatic leukostasis and hypoxic stress in adhesion molecule-deficient mice after gut ischemia-reperfusion. J. Clin. Invest. 1997; 99: 781-788.

6. Horie Y, Chervenak RP, Wolf R, Gerritsen ME, Anderson DC, Komatsu S, Granger DN. Lymphocytes mediate TNF-α induced endothelial cell adhesion molecule expression: Studies on severe combined immunodeficient and RAG-1 mutant mice. J. Immunol. 1997; 159:5053-5062.

7. Horie Y, Wolf R, Granger DN. Role of nitric oxide in gut ischemia-reperfusion-induced hepatic microvascular dysfunction. Am. J. Physiol. 1997; 273; G1007-G1013.

8. Horie Y, Wolf R, Russell J, Shanley TP, Granger DN. Role of Kupffer cells in gut ischemia-reperfusion-induced hepatic microvascular dysfunction in mice. Hepatology. 1997; 26: 1499-1505.

9. Horie Y, Kato S, Ohki E, Hamamatsu S, Fukumura D, Kurose I, Suzuki H, Suematsu M, Miura S, Ishii H. Effect of lipopolysaccharides on erythrocyte velocity in rat liver. J. Gastroenterol. 1997; 32: 783-790.

10. Horie Y, Wolf R, Anderson DC, Granger DN. Nitric oxide modulates gut ischemia/reperfusion-induced P-selectin expression in murine liver. Am. J. Physiol. 1998; 275: H520-H526.

11. Horie Y, Wolf R, Flores SC, McCord JM, Epstein CJ, Granger DN. Transgenic mice with increased Copper/Zinc-superoxide dismutase activity are resistant to hepatic leukostasis and capillary No-reflow after gut Ischemia/Reperfusion. Circ. Res. 1998; 83: 691-696.

12. Mori N, Horie Y, Gerritsen ME, Anderson DC, Granger DN. Anti-inflammatory drugs and endothelial cell adhesion molecule expression in murine vascular beds. Gut 1999; 44: 186-195.

13. Mori N, Horie Y, Gerritsen ME, Granger DN. Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. Am. J. Physiol. 1999; 276:H1647-1654.

14. Horie Y, Wolf R, Chervenak RP, Jennings SR, Granger DN. T-lymphocytes contribute to hepatic leukostasis and hypoxic stress induced by gut ischemia reperfusion. Microcirculation 1999; 6: 267-280.

15. Nakamura Y, Yokoyama H, Okamura Y, Ohgo H, Fukuda M, Horie Y, Kato S, Ishii H. Evidence for ethanol oxidation by Kupffer cells. Alcohol Clin Exp Res 1999; 23(4 Suppl): 92S-95S.

16. Tamai H, Kato S, Horie Y, Ohki E, Yokoyama H, Ishii H. Effect of acute ethanol administration on the intestinal absorption of endotoxin in rats. Alcohol Clin Exp Res 2000; 24: 390-394.

17. Horie Y, Kato S, Ohki E, Tamai H, Yamagishi Y, Ishii H . Hepatic microvascular dysfunction in endotoxemic rats after acute ethanol administration. Alcohol Clin Exp Res 2000; 24: 691-698.

18. Horie Y, Kimura H, Kato S, Ohki E, Tamai H, Yamagishi Y, Ishii H. Role of nitric oxide in endotoxin-induced hepatic microvascular dysfunction in rats chronically fed ethanol. Alcohol Clin Exp Res 2000; 24: 845-851.

19. Horie Y, Kato S, Ohki E, Tamai H, Ishii H. Role of Endothelin in Endotoxin induced Hepatic Microvascular Dysfunction in Rats Fed Ethanol Chronically. J. Gastroenterol. Hepatol. 2001; 16: 916-922.

20. Mori N, Horie Y, Nimura Y, Wolf R, Granger DN. Hepatic microvascular responses to ischemia-reperfusion in low-density lipoprotein receptor knockout mice. Am J Physiol 2000; 279: G1257-1264.

21. Horie Y, Kajihara M, Yamagishi Y, Kimura H, Tamai H Kato S, Ishii H.  A Japanese herbal medicine, Sho-Saiko-To, prevents ischemia/reperfusion-induced hepatic microvascular dysfunction in rats. J Gastroenterol Hepatol 2001; 16: 1260-1266.

22. Yamagishi Y, Horie Y, Kato S, Kajihara M, Tamai H, Granger DN, Ishii H. Ethanol modulates gut ischemia/reperfusion-induced liver injury in rats. Am J Physiol  2002; 282: G640-G646.

23. Zeki S, Miura S, Suzuki H, Watanabe N, Adachi M, Yokoyama H, Horie Y, Saito H, Kato S, Ishii H. Xanthine oxidase-derived oxygen radicals play significant roles in the development of chronic pancreatitis in WBN/Kob rats. J Gastroenterol Hepatol 2002; 17: 606-616.

24. Horie Y, Yamagishi Y, Kato S, Kajihara M, Tamai H, Granger DN, Ishii H. Role of ICAM-1 in chronic ethanol consumption-enhanced liver injury after gut ischemia-reperfusion in rats. Am J Physiol Gastrointest Liver Physiol 2002; 283: G537-543.

25. Tamai H, Horie Y, Kato S, Yokoyama H, Ishii H. Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats. Alcohol Clin Exp Res 2002; 26: 75S-80S.

26. Horie Y, Ishii H. National survey of alcoholic liver diseases in Japan. Proceeding in Asian Pacific Association for the Study of the Liver Meeting 2002. 2002; 109-112..

27. Horie Y, Yamagishi Y, Kato S, Kajihara M, Kimura H, Ishii H. Low-dose ethanol attenuates gut ischemia/reperfusion-induced liver injury in rats via nitric oxide production. J Gastroenterol Hepatol 2003; 18: 211-217.

28. Horie Y, Han JY, Kajihara M, Tamai H, Shinzo Kato S, and Ishii H. A herbal medicine, Cardiotonic Pills, prevents gut ischemia-reperfusion-induced hepatic microvascular dysfunction in rats. Microcirculation Ann 2003; 19: 31-32.

29. Adachi M, Saito H, Kobayashi H, Horie Y, Kato S, Yoshioka M, Ishii H.  Hepatic injury in 12 patients taking the herbal weight loss AIDS Chaso or Onshido.  Ann Intern Med. 2003; 139: 488-492.

30. Horie Y, Yamagishi Y, Kajihara M, Kato S, Ishii H. National Survey of Hepatocellular Carcinoma in Heavy Drinkers in Japan. Alcohol Clin Exp Res 2003; 27 (Suppl): 32S-36S.

31. Yamagishi Y, Horie Y,, Kajihara M, Konishi M, Ebinuma H, Saito H, Kato S, Yokoyama A, Maruyama K, Ishii H. Hepatocellular carcinoma in heavy drinkers with negative markers for viral hepatitis. Hepatol Res. 2004; 28: 177-183.

32. Horie Y, Kajihara M, Mori S, Yamagishi Y, Kimura H, Tamai H, Kato S, Ishii H.  A Japanese herbal medicine, “Saiko-Keishi-To”, prevents ischemia/reperfusion-induced hepatic microvascular dysfunction in rats. World J Gastroenterol 2004; 10; 2241-2244.

33. Fukuda M, Yokoyama H, Mizukami T, Ohgo H, Okamura Y, Kamegaya Y, Horie Y, Kato S and Ishii H. Kupffer cell depletion attenuates superoxide anion release into the hepatic sinusoids after lipopolysaccharide treatment. J Gastroenterol Hepatol 2004; 19:1155-1162, 2004.

34. Han JY, Akiba Y, Miura S, Horie Y, Suzuki H, Kato S, Nagata H, Oda M, Ishii H, andHibi T. Cardiotonic Pills, improves tha aggregation of the mesenteric microvasculatory disturbances following reperfusion in chronically ethanol-fed rats. Microcirculation Ann 2004; 20: 23-24.

35. Horie Y, Han JY, and Ishii H. Herbal Cardiotonic Pills prevent gut ischemia-reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically. Microcirculation Ann 2004; 20: 31-32.

36. Horie Y, Han JY, Kajihara M, Mori S, Konishi M, Kajihara M, Kaneko T, Yamagishi Y, Shinzo Kato S, and Ishii H. Herbal Cardiotonic Pills prevents gut ischemia-reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically. World J Gastroenterol 2005; 11(4):511-515.

37. Tomita K, Tamiya G, Ando S, Ohsumi K, Chiyo T, Mizutani A, Kitamura N, Toda K, Kaneko T, Horie Y, Han JY, Kato S, Shimoda M, Oike Y, Tomizawa M, Makino S, Ohkura T, Saito H, Kumagai N, Nagata H, Ishii H, Hibi T. Tumor necrosis factor-{alpha} signalling through activation of Kupffer cells plays an essential role in liver fibrosis of nonalcoholic steatohepatitis in mice. Gut 2006; 55: 415-424.

38. Horie Y, Ishii H, Hibi T. Severe alcoholic hepatitis in Japan: prognosis and therapy.
Alcohol Clin Exp Res. 2005; 29(12 Suppl):251S-258S.

39. Tomita K, Tamiya G, Ando S, Kitamura N, Koizumi H, Kato S, Horie Y, Kaneko T, Azuma T, Nagata H, Ishii H, Hibi T.  AICAR, an AMPK activator, has protective effects on alcohol-induced fatty liver in rats. Alcohol Clin Exp Res. 2005; 29(12 Suppl):240S-245S.

40. Yamagishi Y, Saito H, Tada S, Horie Y, Kato S, Ishii H, Shimojima N, Haga J, Shimazu M, Kitajima M, Hibi T. Value of computed tomography-derived estimated liver volume/standard liver volume ratio for predicting the prognosis of adult fulminant hepatic failure in Japan. J Gastroenterol Hepatol. 2005; 20:1843-1849.

41. Horie Y, Ishii H, Hibi T. Oxidative stress and liver disease. Nippon Shokakibyo Gakkai Zasshi. 2006; 103:789-96.

42. Han JY, Horie Y, Li D, Akiba Y, Nagata H, Miura S, Oda M, Ishii H, Hibi T. Attenuating effect of Myakuryu on mesenteric microcirculatory disorders induced by ischemia and reperfusion. Clin Hemorheol Microcirc. 2006; 34:145-50.

43. Sun K, Wang CS, Guo J, Horie Y, Fang SP, Wang F, Liu YY, Liu LY, Yang JY, Fan JY, Han JY.Protective effects of ginsenoside Rb1, ginsenoside Rg1, and notoginsenoside R1 on lipopolysaccharide-induced microcirculatory disturbance in rat mesentery.
Life Sci. 2007; 81:509-18.

44. Guo J, Sun K, Wang CS, Fang SP, Horie Y, Yang JY, Liu YY, Wang F, Liu LY, Fan JY, Hibi T, Han JY.  Protective effects of dihydroxylphenyl lactic acid and salvianolic acid B on LPS-induced mesenteric microcirculatory disturbance in rats. Shock. 2008; 29: 205-211

45. Han JY, Horie Y, Miura S, Akiba Y, Guo J, Li D, Fan JY, Liu YY, Hu BH, An LH, Chang X, Xu M, Guo DA, Sun K, Yang JY, Fang SP, Xian MJ, Kizaki M, Nagata H, Hibi T.  Compound Danshen injection improves endotoxin-induced microcirculatory disturbance in rat mesentery. World J Gastroenterol. 2007; 13: 3581-3591.

46. Ishii H, Horie Y, Yamagishi Y: Alcoholic liver disease with particular emphasis on alcoholic hepatitis: A clinical perspective. Gut and Liver 2007; 1(Suppl. 2):37-41.

47. Kajihara M, Horie Y, Ishii H. Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) in Asian-Psific region. Gut and Liver 2007; 1(Suppl. 2): 119-124.

48. Han JY, Horie Y, Fan JY, Sun K, Guo J, Miura S, Hibi T.. Potential of 3, 4-Dihydroxy-phenyl Lactic Acid for Ameliorating Ischemia-Reperfusion-Induced Microvascular Disturbance in Rat Mesentery.  Am J Physiol Gastrointest Liver Physiol 2009; 296: G36-44

49.Han J-Y, Fan J-Y, Horie Y, Miura S, Cui D-H, Ishii H, Hibi T, Tsuneke H, Kimura I. Ameliorating effects of compounds derived from salvia miltiorrhiza root extract on microcirculatiory disturbance and target-organ injury by ischemia-reperfusion. Pharmacology and Therapeutics 2008; 117: 280-295.

50. Yamagishi Y, Saito H, Ebinuma H, Kikuchi M, Ojiro K, Kanamori H, Tada S, Horie Y, Kato S, Hibi T.  A new prognostic formula for adult acute liver failure using computer tomography-derived hepatic volumetric analysis.  J Gastroenterol. 2009; 44: 615-623.

51. Horie Y, Kikuchi M, Yamagishi Y, Rumiko R, Ebinuma H, Saito H, Kato S, Ishii H, Hibi T, and Han JY. Effect of a herbal medicine on fatty liver in rats fed ethanol chronically. Jpn. J. Alcohol & Drug Dependence 2009; 44: 636-648.

52. Tokushige K, Hashimoto E, Horie Y, Taniai M, Higuchi S. Hepatocellular carcinoma in Japanese patients with nonalcoholic fatty liver disease, alcoholic liver disease, and chronic liver disease of unknown etiology: report of the nationwide survey. J Gastroenterol. 2011; 46:1230-1237

53. Horie Y, Yamagishi Y, Ebinuma H, Hibi T. Therapeutic strategies for severe alcoholic hepatitis. Clin Res Hepatol Gastroenterol. 2011; 35, 738-744.

54. Ebinuma H, Saito H, Tada S, Nakamoto N, Ohishi T, Tsunematsu S, Kumagai N, Tsuchimoto K, Tsukada N, Inagaki Y, Horie Y, Takahashi M, Atsukawa K, Okamura Y, Kanai T, Hibi T.
Disadvantages of peginterferon and ribavirin treatment in older patients with chronic hepatitis C: an analysis using the propensity score. Hepatol Int. 2011 Sep 10. [Epub ahead of print] PMID: 22020828

55. Horie Y. Granulocytapheresis and plasma exchange for severe alcoholic hepatitis. J Gastroenterol Hepatol. 2012; 27 Suppl 2:99-103.

56. Horie Y, Yamagishi Y, Ebinuma H, Hibi T. Obesity, Type 2 Diabetes, Age and Female Gender Are Significant Risk Factors in the Development of Alcoholic Liver Cirrhosis. Hepatol Int. 2013; 7: 280-285.

57. Tokushige K, Hashimoto E, Horie Y, Taniai M, Higuchi S. Hepatocellular carcinoma based on cryptogenic liver disease: The most common non-viral hepatocellular carcinoma in patients aged over 80 years. Hepatol Res. 2015; 45: 441-447. doi: 10.1111/hepr.12372. [Epub ahead of print]

58. Kagawa T, HiroseS, Arase Y, Oka A , Anzai K, Tsuruya K, Shiraishi K, Orii R, Ieda S, Nakazawa T, Tomita K, Hokari R, Miura S, Ebinuma H, Saito H, Kitamura T, Horie Y, Okuse C, Wasada M, Inoko H, Tohkin M, Saito Y, Maekawa K, Takikawa H, and Tetsuya Mine T. No Contribution of the ABCB11 p.444A Polymorphism in Japanese Patients with Drug-induced Cholestasis Drug Metab Dispos 2015; 43: 691-697. doi:10.1124/dmd.114.061325

59. Kikuchi M, Horie Y, Ebinuma H,Taniki N, Nakamoto N,Kanai T.Alcoholic liver cirrhosis and significant risk factors for the development of alcohol-related hepatocellular carcinoma—Japan, 2012. Nihon Arukoru YakubutsuI gakkaiZasshi, 2015; In press.

[英文総説]

Horie Y, Ishii H. Liver dysfunction elicited by gut ischemia-reperfusion. Pathophysiology 2001; 8: 11-20.

Horie Y, Ishii H. (Editorial) What factors play a crucial role in the pathogenesis of alcohol related chronic pancreatitis and liver cirrhosis? J Gastroenterol 2004; 39, 915-917.

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