高橋 尚人 先生のプロフィール

高橋 尚人 先生

たかはし なおと

高橋 尚人 先生

東京大学医学部附属病院小児・新生児集中治療部教授・部長

専門分野

小児科学、新生児医学

紹介

東京大学医学部附属病院小児・新生児集中治療部教授・部長として、NICU(Neonatal Intensive Care Unit:新生児特定集中治療室)における治療と新生児感染症対策に精力的に取り組む。とりわけ新生児免疫・血液・感染症学を主な研究テーマとし、新しい新生児感染症である新生児TSS様発疹症(NTED)を発見・解明するなどの成果を挙げ、新生児医療の発展に貢献し続けている。

略歴

1985年 東北大学医学部卒業
1985年 東北大学医学部附属病院小児科 研修医
1985年 いわき市立磐城共立病院 医員
1987年 東京女子医大母子総合医療センター 助手
1995年 東京女子医大母子総合医療センター 講師
1995年 Samuel Lunenfeld Research Institute, Research Fellow (Toronto,Canada)
1997年 東京女子医大母子総合医療センター 講師
2000年 東京女子医科大学母子総合医療センター助教授
2001年 自治医大総合周産期母子医療センター 准教授
2012年 東京大学医学部附属病院総合周産期母子医療センター 准教授、副センター長
2013年 東京大学医学部附属病院小児医療センター新生児・小児集中治療部 部長(兼任)
2017年 東京大学医学部附属病院小児・新生児集中治療部教授・部長

所属学会・資格・役職など

医学博士
日本小児科学会指導医・専門医
日本周産期・新生児医学会 専門医
日本周産期・新生児医学会 新生児蘇生法インストラクター
日本周産期・新生児医学会 指導医

日本小児科学会理事
日本周産期・新生児医学会理事・学術委員会委員長
日本新生児成育医学会 理事
周産期精神保健研究会 理事
日本生命倫理学会評議員

小児科診療 編集主幹
周産期医学 編集委員
Neonatology Editor

受賞・著書・論文など

【受賞】
第5回女子医大医師会賞 2000年
平成22年度日本小児科学会学術研究賞 2010年

【著書】
新生児ポケットマニュアル、診断と治療社、2010年
東大病院新生児診療マニュアル。診断と治療社, 東京, 2017

【論文】
Takahashi N, Hoshi J. Nishida H. Water Balance and abnormalities of electrolytes and acid-base balance in extremely Premature Infants in high ambient humidity. Acta Paediatrica Japonica 1994; 36:250-255
Takahashi N, Nishida H, Kuratsuji T. FcRI and FcRIII on polymorphonuclear leukocytes in cord blood. Arch Dis Child 1994; 70:F31-F35
Takahashi N, Nishida H, Hoshi J. Severe B Cell depletion in newborns from renal transplant mothers taking Immunosuppressive Agents.

【受賞】
第5回女子医大医師会賞 2000年
平成22年度日本小児科学会学術研究賞 2010年

【著書】
新生児ポケットマニュアル、診断と治療社、2010年
東大病院新生児診療マニュアル。診断と治療社, 東京, 2017

【論文】
Takahashi N, Hoshi J. Nishida H. Water Balance and abnormalities of electrolytes and acid-base balance in extremely Premature Infants in high ambient humidity. Acta Paediatrica Japonica 1994; 36:250-255
Takahashi N, Nishida H, Kuratsuji T. FcRI and FcRIII on polymorphonuclear leukocytes in cord blood. Arch Dis Child 1994; 70:F31-F35
Takahashi N, Nishida H, Hoshi J. Severe B Cell depletion in newborns from renal transplant mothers taking Immunosuppressive Agents. Transplantation 1994; 57:1617-1621
Takahashi N, Nishida H, Arai T, Kaneda Y. Abnormal cardiac histology in severe intrauterine growth retardation infants with heart failure. Acta Paediatrica Japonica 1995;37:341-346
Takahashi N, Imanishi K, Nishida H, Uchiyama T. Evidence for immunologic immaturity of cord blood T cells. Cord blood T cells are susceptible to tolerance induction to in vitro stimulation with a superantigen. J Immunol 1995, 155:5213-19
Takahashi N, Nishida H, Kato H, Imanishi K, Sakata Y, Uchiyama. Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period. Lancet 1998; 351: 1614-19
Takahashi N, Kato H, Imanishi K, Miwa K, Yamanami S, Nishida H, Uchiyama T. Immunopathophysiological aspects of an emerging neonatal infectious disease induced by a bacterial superantigen. J Clin Invest 2000; 106:1409-1415
Maruyama K, Ikebe H, Koizumi T, Tsuchida Y, Tanimura M, Nishida H, Takahashi N, Fujimura M, Tokunaga Y. Case-control study of perinatal factors and hepatoblastoma in children with an extremely low birthweight. Pediatr Int 2000; 42: 492-8.
Kato H, Takahashi N, Arimura Y, Imanishi K, Nishida H, Uchiyama T. The percentage of superantigen-reactive T cells in peripheral blood significantly decreases before massively increasing in patients with neonatal TSS-like exanthematous disease in the early acute phase. J Infect Chemother 2002 8:111-114.
Sato T, Takahashi N, Komatsu Y, Wada M, Matsunaga M, Ito K, Uchiyama M, Nishida H. Urinary acidification in extremely low birth weight infants. Early Hum Dev 2002; 70: 15-24
Kikuchi K, Takahashi N, Piao C, Totsuka K, Nishida H, Uchiyama T. Molecular epidemiology of methicillin-resistant Staphylococcus aureus strains causing neonatal toxic shock syndrome-like exanthematous disease in neonatal and perinatal wards. J Clin Microbiol 2003, 41: 3001-3006.
Ichihashi K, Takahashi N, Honma Y, Momoi M. Cerebral ventricular volume assessment by three-dimensional ultrasonography. J Perinat Med 2005; 33: 332-335.
Ichihashi K, Yada Y, Takahashi N, Honma Y, Momoi MY. Utility of a Doppler-derived index combining systolic and diastolic performance (Tei index) for detecting hypoxic cardicac damage in newborns. J Perinat Med 2005; 33: 549-552.
Takahashi N, Hattori M, Miwa K, Nishida H. Antibodies against superantigenic exotoxins produced by Staphylococcus aureus in sera from mothers and their infants’ cord blood. Am J Perinatol 2006; 23: 413-420
Honma Y, Yada Y, Takahashi N, Momoi MY, Nakamura Y. Certain type of chronic lung disease of newborns is associated with Ureaplasma urealyticum infection in utero. Pediatr Int. 2007; 49:479-84
Ichihashi K, Yada Y, Takahashi N, Honma Y, Momoi MY. Integrated backscatter of the brain of preterm infants. J Perinat Med 2008;36:253-55.
Wada M, Kusuda S, Takahashi N, Nishida H. Fluid and electrolyte balance in extremely premature infants<24 weeks of gestation in the first week of life. Pediatr Int 2008; 50: 331-6.
Takahashi N, Hasegawa H, Komiyama M, Ohki T, Yada Y, Koike Y, Kawamata R, Honma Y, Momoi M. Selective excretion of anti-inflammatory cytokine Interleukin-10 in a superantigen-inducing neonatal infectious disease. Cytokine 2009; 45: 39-43
Komiyama M, Takahashi N, Yada Y, Koike Y, Honma Y, Aihara T, Momoi M. Hypothyroxinemia and effectiveness of thyroxin supplementation in very low birth weight infants with abdominal distension and poor weight gain. Early Hum Dev 2009; 85: 267-270
Takahashi N, Kato H, Imanishi K, Ohki T, Uehara R, Momoi MY, Nishida H, Uchiyama T. Change of specific T cells in an emerging neonatal infectious disease induced by a bacterial superantigen. Microbiol Immunol 2009; 53: 524-530.
Takahashi N, Uehara R, Nishida H, Sakuma I, Yamasaki C, Takahashi K, Honma Y, Momoi MY, Uchiyama T. Clinical features of neonatal toxic shock syndrome-like exanthematous disease emerging in Japan. J Infect 2009; 59: 194-200.
Takahashi N, Uehara R, Kobayashi M, Yada Y, Koike Y, Kawamata R, Odaka J, Honma Y, Momoi MY. Cytokine profiles of seventeen cytokines, growth factors and chemokines in cord blood and its relation to perinatal clinical findings. Cytokine 2010;49:331-337.
Yada Y, Honma Y, Koike Y, Takahashi N, Momoi MY. The association of chronic lung disease with Ureaplasma colonization and Interleukin-8 of cord blood. Pediatr Int 2011; 53: (2010 Feb 3[Epub ahead of print]).
Yokoyama K, Takahashi N, Yada Y, Koike Y, Kawamata R, Uehara R, Kono Y, Honma Y, Momoi MY. Prolonged maternak magnesium administration and bone metabolism in neonates. Early Hum Dev 2010; 86: 187-191.
Kusuda S, Takahashi N, Saitoh T, Terai M, Kaneda H, Kato Y, et al. A survey of pediatric ward hospitalization due to respiratory syncytial virus infection after the introduction of palivizumab to high risk infants in Japan. Pediatr Int 2011; 53(3):368-73.
Yada Y, Takahashi N, Uehara R, Honma Y, Koike Y, Momoi MY: Trends and   Clinical Features of Neonates Conceived via Infertility Treatment: 11-year Study in the Perinatal Center at Jichi Medical University Hospital. Jichi Med Univ J 2012, 35: 7-11.
Yanagisawa S, Maeda K, Tazuke Y, Kubota I, Koike Y, Yada Y, Kono Y, Takahashi N, Matsubara S. Do neonates conceived after assisted reproductive technology require neonatal surgery more frequently? A 5-year-long single-center experience. J Obstet Gynecol Res 2013; 39(5):974-8.
Imai M, Watanabe H, Yasui K, Kimura Y, Shitara Y, Tsuchida S, Takahashi N, Taga G. Functional connectivity of the cortex of term and preterm infants and infants with Down’s syndrome. NeuroImage 2014; 85; 272-278.
Takahashi N, Imanishi K, Uchiyama T. Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcu aureus. Microbiol Immunol 2013;57: 737-745.
Kawamata R, Suzuki Y, Yada Y, Koike Y, Kono Y, Yada T, Takahashi N. Gut hormone profiles in preterm and term infants during the first 2 months of life. Journal of Pediatric Endocrinology and Metabolism 2014 Jul;27 (7-8):717-23.
Kawamata R, Suzuki Y, Yada Y, Koike Y, Kono Y, Takahashi N. Gut hormones of preterm infants with abdominal symptoms and hypothyroxinemia. Pediatr Int 2014 (in press)
Takahashi N, Takahashi K, Kobayashi M, Yada Y, Koike Y, Kono Y. Constitutively high-level expression of TGFbeta isoforms in cord blood and its relationship to perinatal findings. Cytokine 2015;73:101-107.
Isojima T, Kushima R, Goishi K, Tsucida S, Watanabe T, Takahashi N, Kitanaka S. Pediatr Int 2015 (in press).

letter
Takahashi N, Nishida H. New exanthematous disease with thrombocytopenia in neonates. Arch Dis Child 1997; 77(1): F79.
Takahashi N, Imanishi K, Kato H, Nishida H, Uchiyama T. A new exanthematous disease induced by toxic shock syndrome toxin-1 in the early neonatal period. Jpn J Infect Dis 1998; 52:25
Takahashi N, Kitajima H, Kusuda S, Morioka I, Itabashi K. Pandemic (H1N1) 2009 in neonates, Japan. Emerg Inf Dis 2011; 17 (9): 1763-65.
van der Mee-Marquet N, Lina G, Quentin R, Yaouanc-Lapalle H, Fie`vre C, Takahashi N, Etienne J. Staphylococcal Exanthematous Disease in a Newborn Due to a Virulent Methicillin-Resistant Staphylococcus aureus Strain Containing the TSST-1 Gene in Europe: an Alert for Neonatologists. J Clin Microbiol 2003; 41: 4883-4884
Miki M, Uchiyama T, Kato H, Nishida H, Takahashi N. A severe case of neonatal-toxic shock syndrome-like exanthematous disease with superantigen-induced high T cell response. Pediatr Inf Dis J 2006; 25: 950-952
Dateki S, Kumamoto T, Takayanagi T, Ohki T, Takahashi N, Moriuchi H. Differential T-cell response in a young child and neonates with toxic shock syndrome. Pediatr Int 2009; 51: 155-156.
Hayase T, Shimizu J, Goto T, Nozaki Y, Mori M, Takahashi N, Namba E, Yamagata T, Momoi MY. Unilaterally and rapidly progressing white matter lesion and elevated cytokines in a patient with Tay-Sachs disease. Brain Dev 2009; 32: 244-7
Ohkuchi A, Matsubara S, Takahashi K, Inoue S, Saito T, Mitsuhashi T, Yamagata T, Takahashi N, Watanabe A, Shimada T, Suzuki M. Ehlers-Danlos type IV in pregnancy with a history of myocardial infarction. J Obstet Gynaecol Res 2009; 35: 797-800.
Saito M, Takahashi N, Ueda S, Kuwabara Y, Komiyama M, Koike Y, Yada, Y, Honma Y, Momoi MY. Cytokine profile in a premature infant with systemic Bacillus cereus infection. Pediatr Int 2010; 52: e34-e36.
Ichikawa M, Takahashi N, Yada Y, Koike Y, Kawamata R, Kono Y, Honma Y,Yotsumoto S, Momoi MY. Selectively high levels of serum interleukin-17 in a newborn infant with progressive severe cholestasis. Pediatrics 2010; 126: 247-250.
Kawamata R, Takahashi N, Yada Y, Koike Y, Kono Y, Momoi MY. Cytokine profile of a premature infant with early-onset listeriosis. Pediatr Int 2011;53: 386-8. Doi:10.1111/j.1442-200X.2011.03375.x.
Koike Y, Takahashi N, Yada Y, Kawamata R, Sato Y, Momoi MY. Selectively high level of serum interleukin 5 in a newborn infant with cow’s milk allergy. Pediatrics 2011; 127: 231-234.
Maruyama A, Takahashi N, MD, Gunji Y, Morimoto A, Yada Y, Koike Y, Momoi MY. Congenital hemophagocytic lymphohistiocytosis in a preterm infant: Cytokine profile and a review of the disease. J Pediatr Hematol Oncol 2011;33:e209-e212
Kojima K, Takahashi N, Yada Y, Koike Y, Matano M, Kono Y, Momoi MY. White matter damage in a neonate of disseminated herpes simplex virus infection. Pediatr Int 2011; 54(3):409-12.
Suzuki Y, Takahashi N, Yada Y, Koike Y, Matano M, Kono Y. Hemophagocytic lymphohistiocytosis in a newborn infant born to a mother with Sjogren syndrome antibodies. J Perinatol 2013; 33:569-571.
Hangai M, Kimura Y, Yasui K, Tsuchida S, Takahashi N. Computed tomography findings of an ongoing subgaleal hemorrhage. Pediatr Int 2014; 56: 623-6.
Fujishiro J, Sugiyama M, Ishimaru T, Uotani C, Tsuchida S, Takahashi N, Shiozawa R, Takita J, Iwanaka T. Cyclic fluctuation of blood pressure in neonatal neuroblastoma. Pediatr Int 2014; 56 (6):934-7.
Morioka I, Takahashi N, Kitajima H. Prevalence of MRSA-colonization patients in Japanese neonatal care units in 2011. Pediatr Int 2014; 56: 211-214.
Kawamata R, Suzuki Y, Yada Y, Koike Y, Kono Y, Yada T, Takahashi N. Gut hormone profiles in preterm and term infants during the first 2 months of life. Journal of Pediatric Endocrinology and Metabolism 2014 Jul;27 (7-8):717-23.
Kawamata R, Suzuki Y, Yada Y, Koike Y, Kono Y, Takahashi N. Gut hormones of preterm infants with abdominal symptoms and hypothyroxinemia. Pediatr Int 2015; 57: 614-9
Nakano Y, Monden Y, Mizuguci M, Naashima M, Koike Y, Gunji Y, Takahashi N, Sugie H, Momoi M, Yamagata T. Acute encephalopathy with callosal, subcortical and thalamic lesions. Neurology Asia 2015; 20(1): 85-89.
Takahashi N, Takahashi K, Kobayashi M, Yada Y, Koike Y, Kono Y. Constitutively high-level expression of TGFbeta isoforms in cord blood and its relationship to perinatal findings. Cytokine 2015;73(1):101-107.
Isojima T, Kushima R, Goishi K, Tsucida S, Watanabe T, Takahashi N, Kitanaka S. Mineral status of premature infants in early life and linear growth at age 3. Pediatr Int 57(5); 864-9, 2015.
Shimozawa H, KonoY, Matano M, Suzuki Y, Koike Y, Yada Y, Yamagata T, Takahashi N. Cytokine profile in two siblings with neonatal lupus erythematousu. Pediatr Int 2015 Dec;57(6):1211-4 .doi:10.1111/ped.12723.
Watanabe H, Shitara Y, Aoki Y, Inoue T, Tsuchida S, Takahasi N, Taga G. Hemoglobin phase of oxygenation and deoxygenation in early brain development measured using fNIRS. Proc Natl Acad USA 2017; 114(9): E1737-1744. doi: 10.1073/pnas.1616866114. Epub 2017 Feb 14.
Shitara Y, Takahashi N, Aoki Y, Kato M, Nishimura R, Tsuchida S, Oka A. Cytokine profiles in pericardial effusion in a Down syndrome infant with transient abnormal myelopoiesis. Tohoku J Exp Med 2017; 241 (2): 149-153.
Nakamura T, Nakamura M, Takahashi N. Neonatal high-permeability pulmonary edema based on serial cytokine profiles and KL-6 in serum: case report. Fukushima J Med Sci. 2017; 63: 1-6.
Nakamura T, Hatanaka D, Kusakari M, Kashima K, Takizawa Y, Takahashi H, Yoshika T, Takahashi N, Kamohara T. Neonatal leukemoid reaction with fetal inflammatory response syndrome is associated with elevated serum granulocyte colony stimulating factor and interleukin-6. Tohoku JEM 2018, 244:145-149.

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高橋 尚人 先生 の記事