島田 朗 しまだ あきら 先生

来歴等

略歴

1986年 慶應義塾大学医学部卒業
1986年- 慶應義塾大学病院内科 研修医
1988年- 立川共済病院内科 専修医
1990年- 慶應義塾大学医学部内科（腎内分泌代謝）専修医
1993年- アメリカStanford大学内科postdoctoral fellow
1996年- 東京都済生会中央病院内科 医員
1999年- 慶應義塾大学医学部内科（腎内分泌代謝）講師
2010年- 東京都済生会中央病院内科 部長
2012年- 慶應義塾大学薬学部 客員教授（非常勤）
2015年- 埼玉医科大学 内分泌・糖尿病内科 教授

論文

1. Shimada A, Rohane P, Fathman CG, Charlton B : Pathogenic and protective roles of CD45RB(low) CD4+ cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. Diabetes.45:71-78, 1996
2. Shimada A, Charlton B, Taylor EC, Fathman CG. : Beta-cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice. Diabetes 45:1063-1067, 1996
3. Shimada A, Morimoto J, Kodama K, Suzuki R, Oikawa Y, Funae O, Kasuga A, Saruta T, Narumi S : Elevated serum IP-10 level observed in type 1 diabetes. Diabetes Care 24: 510-515, 2001
4. Oikawa Y, Shimada A, Kasuga A, Morimoto J, Osaki T, Tahara H, Miyazaki T, Tashiro F, Yamato E, Miyazaki J, Saruta T : Systemic administration of IL-18 promotes diabetes development in young nonobese diabetic mice. J. Immunol. 171:5865-5875, 2003
5. Irie J, Shimada A, Oikawa Y, Shigihara T, Saruta T : N-acetyl-cysteine accelerates transfer of diabetes into non-obese diabetic-scid mice. Diabetologia 47:1803-1809, 2004
6. Morimoto J, Yoneyama Y, Shimada A, Shigihara T, Yamada S, Oikawa Y, Matsushima K, Saruta T, Narumi S : CXCL10 neutralization suppresses the occurrence of diabetes in non-obese diabetic mice through enhanced b-cell proliferation resulting in increased b-cell mass without affecting insulitis. J. Immunol. 173:7017-7024, 2004
7. Shigihara T, Shimada A, Oikawa Y, Yoneyama H, Kanazawa Y, Okubo Y, Matsushima K, Yamato E, Miyazaki J, Kasuga A, Saruta T, Narumi S : CXCL10 DNA Vaccination Prevents Spontaneous Diabetes through Enhanced {beta} Cell Proliferation in NOD Mice. J. Immunol. 175:8401-8408, 2005
8. Kanazawa Y, Shimada A, Oikawa Y, Okubo Y, Tada A, Imai T, Miyazaki J, Itoh H : Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes. J. Autoimm. 32:104-109, 2009
9. Tada A, Shimada A, Yamada T, Oikawa Y, Yamada Y, Okubo Y, Irie J, Bluestone JA, Itoh H : A mimic of viral double-stranded RNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse. J. Immunol. 187:4947-4953, 2011
10. Yamada Y, Okubo Y, Shimada A, Oikawa Y, Yamada S, Narumi S, Matsushima K, Itoh H : Acceleration of diabetes development in CXC chemokine receptor 3 (CXCR3)-deficient NOD mice. Diabetologia 55:2238-2245, 2012
11.Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Mori K, Yoneya S, Kohda M, Okazaki Y, Maruyama T, Shimada A, Yasuda K, Nishida N, Tokunaga K, Koike A. A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA. PLoS One. 2014 Nov 3;9(11):e111715.
12.Kawasaki E, Maruyama T, Imagawa A, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Hanafusa T. Diagnostic criteria for acute-onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus. J Diabetes Investig. 2014 Feb 12;5(1):115-8.
13.Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T. Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG) protein in fulminant type 1 diabetes. PLoS One. 2014 Apr 23;9(4):e95110.
14.Oikawa Y, Tanaka H, Uchida J, Atsumi Y, Osawa M, Katsuki T, Kawai T, Shimada A. Slowly progressive insulin-dependent (type 1) diabetes positive for anti-GAD antibody ELISA test may be strongly associated with a future insulin-dependent state. Endocr J. 2016 Oct 18. [Epub ahead of print]
15.Yajima K, Oikawa Y, Ogata K, Hashiguchi A, Shimada A. CD4+ T cell-dominant insulitis in acute-onset Type 1 diabetes mellitus associated with intraductal papillary mucinous adenoma. Endocr J. 2016 Sep 30;63(9):841-847.
16.Teramoto Y, Nakamura Y, Asami Y, Imamura T, Takahira S, Nemoto M, Sakai G, Shimada A, Noda M, Yamamoto A. Case of type 1 diabetes associated with less-dose nivolumab therapy in a melanoma patient. J Dermatol. 2016 Jun 23. [Epub ahead of print]
17.Yasui J, Kawasaki E, Tanaka S, Awata T, Ikegami H, Imagawa A, Uchigata Y, Osawa H, Kajio H, Kawabata Y, Shimada A, Takahashi K, Yasuda K, Yasuda H, Hanafusa T, Kobayashi T; JapanDiabetes Society Committee on Type 1 Diabetes Mellitus Research. Clinical and Genetic Characteristics of Non-Insulin-Requiring Glutamic Acid Decarboxylase (GAD) Autoantibody-Positive Diabetes: A Nationwide Survey in Japan. PLoS One. 2016 May 13;11(5):e0155643.
18.Kobayashi T, Aida K, Fukui T, Jimbo E, Shimada A, Mori Y, Fujii T, Yagihashi S. Pancreatic ductal hyperplasia/dysplasia with obstructive chronic pancreatitis: an association with reduced pancreatic weight in type 1 diabetes. Diabetologia. 2016 Apr;59(4):865-7.

著書

Prediction, prevention and genetic counseling in IDDM. Lessons from animal models NOD mouse, John Wiley & Sons Ltd., 1996
内科実地診療必携　生活習慣病 糖尿病、朝倉書店、1999
症例から学ぶEBM時代の糖尿病診療 緩徐進行型１型糖尿病の治療方針、医学書院、2004
糖尿病の症状と最新治療がわかる本、成美堂出版、2004
糖尿病 インスリン療法．MR教育研修テキスト、エルゼビアジャパン、2004
からだの科学（増刊）糖尿病2005 １型糖尿病の発症予防、日本評論社、2005
2012 今日の治療指針　１型糖尿病、医学書院、2012
やさしい臨床医学テキスト 第三版　代謝疾患、薬事日報社、2014
いまさら聞けない糖尿病診療　１型糖尿病と膵島関連自己抗体、南山堂、2014
2015 今日の治療指針　糖尿病ケトアシドーシス、医学書院、2015

その他

• 【受賞】1997年 東京都医師会医学研究費 奨励賞

• 【受賞】1998年 難病医学研究財団　医学研究振興賞