肱岡 泰三 ひじおか たいぞう 先生

来歴等

略歴

1982年 大阪大学医学部 卒業
1986年 国立大阪南病院消化器科 医員
1989年 米国ﾉｰｽｶﾛﾗｲﾅ大学ﾁｬｯﾍﾟﾙﾋﾙ校医学部薬理学 研究員
1992年 大阪大学医学部第１内科 医員
1993年 大阪大学大学院 修了 医学博士取得
1999年 国立大阪南病院消化器科 医長
2005年 独立行政法人国立病院機構大阪南医療センター　がん疾患センター 部長
2009年 独立行政法人国立病院機構大阪南医療センター 統括診療部長
2016年 独立行政法人国立病院機構大阪南医療センター 副院長
2020年 独立行政法人国立病院機構大阪南医療センター 院長

論文

• Ethanol-induced disturbance of hepatic microcirculation and hepatic hypoxia.Biochemical Pharmacology 41;1551-1557,1991.

  Hijioka T, Sato N, Matsumura T, et al.

• Wy-14643 but not 2-ethylhexanol increases intracellular free calcium in cultured Kupffer cells.Toxicology Letters 59;239-244,1991.

  Hijioka T, Keller BJ, Thurman RG.

• Evidence that adenosine is a key component in Carolina rinse responsible for reducing graft failure after orthotopic liver transplantation in the rat.Transplantation 52;992-998,1991.

  Gao W, Hijioka T, Lemasters JJ, Thurman RG, et al.

• Ethanol induced focal cell necrosis via microcirculatory disturbance in the perfused rat liver. Alcohol & Alcoholism, supplement 1, 317-320,1991.

  Oshita M, Sato N, Hijioka T, Kamada T, et al.

• Hormones increase oxygen uptake in periportal and pericentral regions of the liver lobule. Am J Physiology 25(4); G645-650,1992.

  Matsumura T, Yoshihara H, Hijioka T, Thurman RG, et al.

• Kupffer cells contain voltage-dependent calcium channels. Molecular Pharmacology 41;435-440,1992.

  Hijioka T, Rosenberg RL, Lemasters JJ, Thurman RG.

• Effect of short-term ethanol treatment on voltage-dependent calcium channels in Kupffer cells. Hepatology 18(2);400-405,1993.

  Hijioka T, Goto M, Lemasters JJ, Thurman RG.

• Roles of endothelin-1 and nitric oxide in the mechanism for ethanol-induced vasoconstriction in rat liver. Jornal of Clinical Investigation 91;1337-1342,1993.

  Oshita M, Takei Y, Hijioka T, Kamada T, et al.

• Role of Kupffer cells in storage and metabolism of benzo(a)-pyrene in the liver. Drug Metab Dispos 22:680-687,1994.

  Zhong Z, Hijioka T, Kauffman FC, Thurman RG, et al.

• Role of Fas ligand in apoptosis induced by hepatitis C virus infection. Biochem. Biophys. Res. Commun. 204:468-474,1994.

  Mita E, Hayashi N, Hijioka T, Kamada T, et al.

• Endogenous nitric oxide attenuates ethanol-induced perturbation of hepatic circulation in the isolated perfused rat liver. Hepatology 20(4):961-965,1994.

  Oshita M, Takei Y, Hijioka T, Kamada T, et al.

• Binding cells of 125I-iodoamphetamine in rat liver Ann Nucl Med 11:27-32,1997.

  Hijioka T, Kashiwagi T, Kamada T, et al.

• Circulating matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 as serum markers of fibrosis in patients with chronic hepatitis C. Relationship to interferon response. J Hepatol 26:574-583,1997.

  Kasahara A, Hayashi N, Hijioka T, Kamada T, et al.

• A novel strategy for cancer therapy by mutated mammalian degenerin gene transfer Cancer Gene Therapy 7:1341-1347,2000.

  Horimoto M, Sasaki Y, Hijioka T, Hayashi N, et al.

• The significance of interferon and ribavirin combination therapy followed by interferon monotherapy for patients with chronic hepatitis C in Japan. Hepatol Res. 29:142-147, 2004.

  Hiramatsu N, Kasahara A, Hijioka T, Hayashi N, et al.

• Early decline of hemoglobin correlates with progression of ribavirin-induced hemolytic anemia during interferon plus ribavirin combination therapy in patients with chronic hepatitis C. J Gatroenterol 41:862-872, 2006

  Oze T, Hiramatsu N, Hijioka T, Hayashi N, et al.

• Type B fulminant hepatitis is closely associated with a highly mutated hepatitis B virus strain. Intervirology. 50(6):394-401. 2007.

  Kanada A, Takehara T, Hijioka T, Hayashi N,et al.

• Declining　 incidence　of　hepatocellular　carcinoma in Osaka, Japan, from 1990 to 2003. Ann Intern Med.　 3;148(11):820-6. 2008 Jun.

  Tanaka H, I, Hijioka T, Hayashi N, Tsukuma H, et al.

• Site-specific analysis of N-glycans on haptoglobin in sera of patients with pancreatic cancer: a novel approach for the development of tumor markers. Int J Cancer. 122(10):2301-9. 2008.

  Nakano M, Hijioka T, Taniguchi N, Miyoshi E, et al.

• Dynamic epidemiology of acute viral hepatitis in Japan.Intervirology 53(1):70-75, 2010.

  YanoK, Hijioka T, Tatsuhashi H, et al.

• Evaluation of risk factors for the development of cirrhosis in autoimmune hepatitis: Japanese NHO-AIH prospective study. J Gastroenterol. Jan; 46 Suppl 1:56-62, 2011.

  Migita K, Hijioka T, Yatsuhashi H, Ishibashi H, et al.

• Changing of genotypes and molecular epidemiology of spreading subgenotype Ae of hepatitis B virus among patients with acute hepatitis B in Japan. J. Hepatol. Apr;54(Suppl.1): S157-S158,2011.

  Tamada Y, Yatsuhashi H, Hijioka T, Ishibashi H, et al.

• Long-term outcomes of add-on adefovir dipivoxil therapy to ongoing lamivudine in patients with lamivudine-resistant chronic hepatitis B. Hepatol Res Dec; 42(12):1168-74, 2012.

  Toyama T, Ishida H, Hijioka T, Mita E, et al.

• Reducing Peg-IFN doses causes later virologic response or no response in HCV genotype 1 patients treated with Peg-IFN alfa-2b plus ribavirin. J Gastroenterol. Mar;47(3):334-42, 2012.

  Oze T, Hiramatsu N, Hijioka T, Takehara T, et al.

• Hepatitis B virus strains of subgenotype A2 with an identical sequence spreading rapidly from the capital region to all over Japan in patients with acute hepatitis B. Gut 61(5):765-73、2012.

  Tamada Y, Hijioka T, Yatsuhashi H, et al.

• Hepatocellular carcinoma and survival in patients with autoimmune hepatitis (Japanese National Hospital Organization-autoimmune hepatitis prospective study). Liver Int, 31(5): 837-44, 2012

  Migita K, Hijioka T, Yatsuhashi H, et al.

• Impact of alpha-fetoprotein on hepatocellular carcinoma development during entecavir treatment of chronic hepatitis B virus infection.J Gastroenterol. Jul;50(7):785-94, 2015.

  Yamada R, Hiramatsu N, Hijioka T, Takehara T; Osaka Liver Forum.

• Impact of branched-chain amino acid supplementation on the survival in patients with advanced hepatocellular carcinoma treated with sorafenib; a multicenter retrospective cohort study. Hepatol Res. Sep;46(10):1002-10, 2016.

  Imanaka K, Hijioka T, Takehara T, Osaka Liver Forum.

• Liver fibrosis is associated with corrected QT prolongation during Ledipasvir/Sofosbuvir treatment for patients with chronic hepatitis C. Hepatol Commun. Aug 6;2(8):884-892, 2018

  Tahata Y, Sakamori R, Hijioka T, Takehara T, et al.

• Incidence and risk factors of hepatocellular carcinoma change over time in patients with hepatitis C virus infection who achieved sustained virologic response. Hepatol Res. May;49(5):570-578, 2019.

  Yamada R, Hiramatsu N, Hijioka T, Takehara T, et al.

その他

• 【学術発表】平成６年　大阪対ガン協会ガン研究助成 細胞内情報伝達機構の制御によるヒト肝癌遺伝子治療の基礎的検討