下村 健寿 しもむら けんじゅ 先生

来歴等

略歴

1997年 福島県立医科大学医学部 卒業
1997年 群馬大学医学部附属病院 旧第一内科入局
2004年 群馬大学医学部内科学大学院 卒業 医学博士取得
2004年 英国オックスフォード大学生理学講座（OCGF） 専任研究員
2012年 自治医科大学生理学講座 講師
2014年 福島県立医科大学 腫瘍生体エレクトロニクス講座 特任教授
2015年 福島県立医科大学 医療エレクトロニクス研究講座 主任教授（兼任）
2017年 福島県立医科大学 病態制御薬理医学講座（旧・薬理学講座） 主任教授

論文

• The hypothalamus to brainstem circuit suppresses late-onset body weight gain. Sci Rep 9, 18360, 2019.

  Maejima Y, Kato S, Horita S, Ueta Y, Takenoshita S, Kobayashi K, Shimomura K

• TAK-242, a specific inhibitor of Toll-like receptor 4 signalling, prevents endotoxemia-induced skeletal muscle wasting in mice. Sci Rep 10, 694, 2020.

  Ono Y, Maejima Y, Saito M, Sakamoto K, Horita S, Shimomura K, Inoue S, Kotani J

• The undeveloped properties of GABA neurons in the ventral tegmental area promote energy intake for growth in juvenile rats. Sci Rep 9, 11848, 2019

  Maejima Y, Yokota S, Horita S, Shimomura K

• Excitability of oxytocin neurons in paraventricular nucleus is regulated by voltage-gated potassium channels Kv4.2 and Kv4.3. Biosci Biotechnol Biochem 83, 202-211, 2019

  Imai R, Yokota S, Horita S, Ueta Y, Maejima Y, Shimomura K

• Similar effect of quercetin on CYP2E1 and CYP2C9 activates in humans? Eur J Clin Pharmacol (ahead of print) 2018

  Misaka S, Shimomura K

• The effect of avertin anesthesia and mixture of three types of anesthetic agents on food intake and body weight in high fat-induced obese male and female mice. Exp Anim 68, 57-69, 2019

  Maejima Y, Yokota S, O’Hashi R, Aoyama M, Shimomura K

• The anorexigenic neural pathways of oxytocin and its clinical implication. Neuroendocrinology 107, 91-104, 2018

  Maejima Y, Yokota S, Nishimori K Shimomura K

• Impact of sex, fat distribution and initial bod weight on oxytocin’s body weight regulation. Scientific Reports 7, 8599 2017

  Maejima Y, Aoyama M, Sakamoto K, Jojima T, Aso Y, Takasu K, Takenoshita S, Shimomura K

• Nesfatin-1 inhibits voltage gated K+ channels in pancreatic beta cells. Peptides 95, 10-15, 2017

  Maejima Y, Horita S, Kobayashi D, Aoki M, O’hashi R, Imai R, Sakamoto K, Mori M, Takasu K, Ogawa K, Takenoshita S, Zhao S, Hazama A, Shimomura K

• Orexin action on oxytocin neurons in the paraventricular nucleus of the hypothalamus. NeuroReport 28, 360-366, 2017

  Maejima Y, Takahashi S, Takasu K, Takenoshita S, Ueta Y, Shimomura K

• Mutation in KATP channel and neonatal diabetes. Intern Med 56, 2387-2393, 2017

  Shimomura K. Maejima Y

• Non-alcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men and women. Intern Med 56,763-771, 2017

  Tokita Y, Maejima Y, Shimomura K, Takenoshita S, Ishiyama N, Akuzawa M, Shimomura Y, Nakajima K

• Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells Nature Communications 7, 13496 2016

  Brereton M, Rohm M, Shimomura K, Holland C, Tornovsky-Babeay S, Dadon D, Iberl M, Chibalina M, Lee S, Glaser B, Dor Y, Rorsman P, Clark A, Ashcroft F

• Islet insulin secretion measurements in mouse. Curr Protoc Mouse Biol 6, 256-271, 2016

  Hugill A, Shimomura K, Cox RD

• Projection from a single NUCB2/nesfatin-1 neuron in the paraventricular nucleus to different brain regions involved in feeding. Brain Struct Funct 221, 4723-4731, 2016.

  Maejima Y, Kumamoto K, Takenoshita S, Shimomura K

• Water intake disorder in DEND syndrome afflicted patient with R50P mutation. Endocr J. 62. 387-392, 2015

  Maejima Y, Hasegawa S, Horita S, Kumamoto K, Galbanovskis J, Takenoshita S, Shimomura K

• Nasal oxytocin administration reduces food intake without affecting locomotor activity and glycemia with c-Fos induction in limited brain areas. Neuroendocrinology 101, 35-44, 2015

  Maejima Y, Rita RS, Santoso P, Aoyama M, Hiraoka Y, Nishimori K, Gantula D, Shimomura K, Yada T

• (2014) Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett 588, 4404-4412, 2014

  Maejima Y, Sakuma S, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T

• Reversible changes in pancreatic islet structure and function produced by elevated glucose. Nature Communications 5, 4639 2014

  Brereton M, Iberl M, Shimomura K, Zhang Q, Adriaenssens A, Proks P, Spiliotis I, Dace W, Mattis K, Ramracheya R, Gribble F, Reiman F, Clark A, Rorsman P, Ashcroft F

• A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1. Diabetes 62. 3797-3806, 2013

  Shimomura K, Tusa M, Iberl M, Brenton MF, Kaizik S, Proks P, Lahmann C, Yaluri N, Modi S, Huopio H, Ustinov J, Otonkoski T, Laakso M, Ashcroft FM

• Paraventricular nucleus nesfatin-1 neurons are regulated by pituitary adenylate cyclase-activating polypeptide (PACAP). Neurosci Lett 551. 39-42, 2013

  Maejima Y, Shimomura K, Sakuma K, Yang Y, Arai T, Mori M, Yada T

• A universally conserved residue in SUR1 subunit of the KATP channel is essential for translating nucleotide binding at SUR1 into channel opening. J Physiol 590. 5025-5036, 2012

  de Wet H, Shimomura K（共同筆頭筆者）, Aittoniemi J, Ahmad N, Lafond M, Sansom MS, Ashcroft FM

• A mutation in KCNJ11 causing human hyperinsulinism (Y12K) results in a glucose-intolerant phenotype in the mouse. Diabetologia 53. 2352-2356, 2010

  Hugill A, Shimomura K, Ashcroft FM, Cox RD

• The first clinical case of mutation at K185 of Kir6.2 (KCNJ11): a major ATP-binding residue. Diabet Med 27. 225-229, 2010

  Shimomura K, de Nancleas GP, Fontinou C, Caiman M, Castano L, Ashcrfot FM

• Adjacent mutations in gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism. EMBO Mol Med 1. 166-177, 2009

  Shimomura K, Flanagan SE, Zadek B, Lethby M, Zubcevic L, Girard CAJ, Petz O, Kapoor RR, Hussain K, Skae M, Clayton P, Hattersley A, Ellard S, Ashcroft FM

• Insulin secretion from beta-cells is affected by deletion of nicotinamide transhydrogenase. Methods Enzymol 457. 451-480, 2009

  Shimomura K, Galvanovskis J, Goldworthy M, Hugill A, Kaizik S, Lee A, Meadows N, Quwailid MM, Rydstrom J, Teboul L, Ashcroft F, Cox RD

• An in-flame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. J Clin Endocrinol Metab 94. 2551-2557, 2009

  Craig TJ, Shimomura K, Holl RW, Flanagan SE, Ellard S, Ashcroft FM

• Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapituates neonatal diabetes. J Clin Invest 119. 80-90, 2009

  Girard C, Wunderlich TW, Shimomura K（共同第二筆者）, Collins S, Kaizik S, Proks P, Abdulkader F, Clark A, Ball V, Zubcevic L, Bentley L, Hugill A, Galvanovskis J, Cox R, Rorsman P, Bruning JC, Ashcroft FM

• The role of the transcription factor Sox4 in insulin secretion and impaired glucose tolerance. Diabetes 57. 2234-2244, 2008

  Goldsworthy M, Hugill A, Freeman H, Horner E, Shimomura K, Bogani D, Pieles G, Mijat V, Arkell R, Bhattacharya S, Ashcroft FM, Cox RD

• A novel mutation causing DEND syndrome. Neurology 69. 1342-1349, 2007

  Shimomura K, Horster F, Wet HD, Flanagan SE, Ellard S, Hattersley AT, Wolf NI, Ashcroft F, Ebinger F

• Increased ATPase activity produced by mutations at arginine-1380 in nucleotide-binding domain 2 of ABCC8 causes neonatal diabetes. Proc Natl Acad Sci USA 104. 18988-18992, 2007

  de Wet H, Rees MG, Shimomura K, Aittoniemi J, Patch AM, Flanagan SE, Ellard S, Hattersley AT, Samson MS, Ashcroft FM

• Mechanism of action of sulphonylurea receptor SUR1 mutation (F132L) that cause DEND syndrome. Hum Mol Genet 16. 2011-2019, 2007

  Proks P, Shimomura K（共同筆頭筆者）, Craig TJ, Girard CA, Ashcroft FM

• Long-term exposure to glucose and lipids inhibits glucose-induced insulin secretion downstream of granule fusion with plasma membrane. Diabetes 56. 1888-1897, 2007

  Olofsson CS, Collins S, Benqtsson M, Ekiasson L, Salehi A, Shimomura K, Tarasov A, Holm C, Ashcroft F, Rorsman P

• Mutations at the same residue (R50) of Kir6.2 (KCNJ11) that cause neonatal diabetes produce different functional effects. Diabetes. 55. 1705-1712, 2006

  Shimomura K, Girard CA, Proks P, Nazim J, Lippiat JD, Cerutti F, Lorini R, Ellard S, Hattersely AT, Barbetti F, Ashcroft FM

• Effect of peroxisome proliferators-activated receptor (PPAR) ligand fenofibrate on Kv channel in the insulin secreting cell line HIT-15. Gen Physiol Biophys 25. 455-460, 2006

  Shimomura K, Ikeda M, Ariyama Y, Proks P, Shimomura Y, Mori M, Matsumoto S

• 3-D structural and functional characterization of the purified KATP channel complex Kir6.2-SUR1. EMBO J 24. 4166-4175, 2005

  Mikhailov MV, Campbell JD, de Wet H, Shimomura K, Zadek B, Collins RF, Sansom MS, Ford RC, Ashcroft FM

• A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice. Diabetologia 48. 675-686, 2005

  Toye AA, Lippiat JD, Proks P, Shimomura K, Bentley L, Hugill A, Mijat V, Goldworthy M, Moir L, Haynes A, Quarterman J, Freeman HC, Ashcroft FM, Cox RD

特許

• 【国際特許】Methods and compositions for the diagnosis of treatment of type 2 diabetes Application Number: 11/523,479 Date: Sept 27,2007 Applicant: The Chancellr, Masters and Scholars of the University of Oxford Inventors: Roger Cox, Frances Ashcroft, Helen Freeman, Kenju Shimomura

その他

• 【受賞】オックスフォード大学メリット賞（2006年）

• 【受賞】オックスフォード大学メリット賞（2010年）

• 【テレビ出演】　NHK-BS「美と若さの新常識」

SNS・ブログ等

• その他メディア
  • 福島県立医科大学 病態制御薬理医学講座