関 常司 せき じょうじ 先生

来歴等

略歴

1982年　東京大学医学部卒業
1985年　東京大学第一内科　医員
1988年　東京大学第一内科 助手
1988年　ドイツ・ゲーテ大学生理学教室留学
1991年　東京大学第一内科　医員
1994年　東京大学第一内科 助手　
1997年　東京大学　医学博士取得
2004年　東京大学腎臓内分泌内科 講師　

論文

Seki G, Taniguchi S, Uwatoko S, Suzuki K, Kurokawa K. Evidence for conductive Cl- pathway in the basolateral membrane of rabbit renal proximal tubule S3 segment. J Clin Invest 1993; 92:1229-1235.

Seki G, Coppola S, Yoshitomi K, Burckhardt B C, Samarzija I, Muller-Berger S, Frömter E. On the mechanism of bicarbonate exit from renal proximal tubular cells. Kidney Int 1996; 49:1671-1677.

Igarashi T, Inatomi J, Sekine T, Kanai Y, Kunimi K, Tsukamoto K, Satoh H, Schimadzu M, Tozawa F, Mori T, Schiobara M, Seki G, Endou H. Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities. Nat Genet 1999; 23: 264-266.

Kunimi M, Seki G, Hara C, Taniguchi S, Uwatoko S, Goto A, Kimura S, Fujita T. Dopamine inhibits renal Na+:HCO3- cotransporter in rabbits and normotensive rats but not in spontaneously hypertensive rats. Kidney Int 2000; 57: 534-543.

Usui T, Hara M, Satoh H, Moriyama N, Kagaya H, Amano S, Oshika T, Ishii Y, Ibaraki N, Hara C, Kunimi M, Noiri E, Tsukamoto K, Inatomi J, Kawakami H, Endou H, Igarashi T, Goto A, Fujita T, Araie M, Seki G. Molecular basis of ocular abnormalities associated with proximal renal tubular acidosis. J Clin Invest 2001; 108: 107-115.

Horita S, Yamada H, Inatomi J, Moriyama N, Sekine T, Igarashi T, Endo Y, Dasouki M, Ekim M, Al-Gazali L, Shimadzu M, Seki G, Fujita T. Functional analysis of NBC1 mutants associated with proximal renal tubular acidosis and ocular abnormalities. J Am Soc Nephrol 2005; 16: 2270-2278.

Shirakabe K, Priori G, Yamada H, Ando H, Horita H, Fujita T, Fujimoto I, Mizutani A, Seki G, Mikoshiba K. IRBIT, an inositol 1,4,5-trisphosphate receptor-binding protein, specifically binds to and activates pancreas-type Na+/HCO3- cotransporter 1 (pNBC1). Proc Natl Acad Sci USA 2006; 103:9542-9547.

Suzuki M, Paesschen WV, Stalmans I, Horita S, Yamada H, Bergmans BA, Legius E, Riant F, Jonghe PD, Li Y, Sekine T, Igarashi T, Fujimoto I, Mikoshiba K, Shimadzu M, Shiohara M, Braverman N, Al-Gazali L, Fujita Y, Seki G. Defective membrane expression of the Na+-HCO3− cotransporter NBCe1 is associated with familial migraine. Proc Natl Acad Sci U S A 2010; 107: 15963-15968.

Endo Y, Suzuki M, Yamada H, Horita S, Kunimi M, Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Moriyama N, Kudo A, Kawakami H, Yamauchi T, Kubota N, Kadowaki T, Kume H, Enomoto Y, Homma Y, Seki G, Fujita T. Thiazolidinediones enhance sodium-coupled bicarbonate absorption from renal proximal tubules via PPARγ-dependent non-genomic signaling. Cell Metab 2011; 13, 550-561.

Nakamura M, Yamazaki O, Shirai A, Horita S, Satoh N, Suzuki M, Hamasaki Y, Noiri E, Kume H, Enomoto Y, Homma Y, Seki G. Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome. Kidney Int 2015; 87: 535-542.

著書

Na+-HCO3コトランスポーター；Annual Review 腎臓　225-227, 2000. （中外医学社）
近位尿細管機能異常；改訂第7版内科学書 391-393, 2009. (中山書店)
腎尿細管性アシドーシス；改訂第7版内科学書 396-398, 2009. (中山書店)
Pathophysiological roles of mutations in the electrogenic Na+-HCO3- cotransporter NBCe1. In Mutations in Human Genetic Disease, Edited by David N. Cooper and Jian-Min Chen, pp167- pp180,2012. (InTech Publisher)
Molecular mechanism of renal tubular acidosis. In Advances in Medicine and Biology　Vol 77. pp161-pp176, 2014 Edited by Leon V. Berhardt. (Nova Publisher)

その他

• 【受賞】 三共生命科学研究振興財団研究助成賞、1997年

• 【受賞】World Congress of Nephrology　ベストポスター賞、2003年

• 【受賞】第2回トランスポーター研究会　優秀演題賞、2007年