小此木 範之 おこのぎ のりゆき 先生

来歴等

略歴

2008年　群馬大学医学部卒業
2010年　群馬大学医学部附属病院　初期臨床研修修了
2010年　筑波大学附属病院
2011年　群馬大学医学部附属病院
2012年　日高病院
2014年　群馬大学医学部附属病院
2014年　群馬大学大学院博士課程修了
2015年　放射線医学総合研究所・重粒子医科学センター病院（現・QST病院）
2016年　放射線医学総合研究所病院（現・QST病院）婦人腫瘍科科長

論文

1. Oike T, Ohno T, Wakatsuki M, Noda SE, Saitoh J, Mizukami T, Yoshimoto Y, Okonogi N, Katoh H, Shibuya K, Suzuki Y, Ishikawa H, Ebara T, Takahashi T, Nakano T. The benefit of small bowel and pelvic bone sparing in excluding common iliac lymph node region from conventional radiation fields in patients with uterine cervical cancer: a dosimetric study. J Radiat Res. 2010;51(6):715-21
2. Okonogi N, Hashimoto T, Ishida M, Ohno T, Terunuma T, Okumura T, Sakae T, Sakurai H. Designed-seamless irradiation technique for extended whole mediastinal proton-beam irradiation for esophageal cancer. Radiat Oncol. 2012 ;7(1):173.
3. Okonogi N, Takeshi E, Ishikawa H, Yoshida D, Ueno M, Maeno T, Suga T, Nakano T. A Seven-year Disease-Free Survivor of Malignant Pleural Mesothelioma Treated with Hyperthermia and Chemotherapy in a 61-year-old male: a case report. J Med Case Rep. 2012 ;6:427. doi: 10.1186/1752-1947-6-427.
4. Takahashi T, Saitoh J, Okonogi N, Okazaki A. Role of Hyperthermia in the Treatment of Gastrointestinal Cancers. Thermal Med 2013; 29(1): 25-36.
5. Okonogi N, Saitoh J, Suzuki Y, Noda SE, Ohno T, Oike T, Ohkubo Y, Ando K, Sato H, Nakano T. Changes in Bone Mineral Density in Uterine Cervical Cancer Patients After Radiation Therapy. Int J Radiat Oncol Biol Phys. 2013 ;87:968-74.
6. Okonogi N, Oike T, Shirai K, Tamaki T, Noda S, Suzuki Y, NakanoT. Current Advances in Radiotherapy for Newly Diagnosed Glioblastoma Multiforme. J Neurol Neurophysiol. 2014, 5:4
7. Okonogi N, Nakamura K, Suzuki Y, Suto N, Suzue K, Kaminuma T, Nakano T, Hirai H. Cranial irradiation induces bone marrow-derived microglia in adult mouse brain tissue. J Radiat Res. 2014; 55(4):713-719
8. Sato H, Suzuki Y, Ide M, Katoh T, Noda SE, Ando K, Oike T, Yoshimoto Y, Okonogi N, Mimura K, Asao T, Kuwano H, Nakano T. HLA class I expression and its alteration by preoperative hyperthermo-chemoradiotherapy in patients with rectal cancer. PLoS One. 2014 Sep 26;9(9):e108122. doi: 10.1371/journal.pone.0108122. eCollection 2014.
9. Yoshimoto Y, Suzuki Y, Mimura K, Ando K, Oike T, Sato H, Okonogi N, Maruyama T, Izawa S, Noda SE, Fujii H, Kono K, Nakano T. Radiotherapy-induced anti-tumor immunity contributes to the therapeutic efficacy of irradiation and can be augmented by CTLA-4 blockade in a mouse model. PLoS One. 2014;9(3):e92572.
10. Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K. Dose standardization of radiofrequency hyperthermia benefit patients with malignancies? Ann. Cancer Res. Ther. 2014;1(22):28-35
11. Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K. A novel strategy of radiofrequency hyperthermia (neothermia) in combination with preoperative chemoradiotherapy for the treatment of advanced rectal cancer: a pilot study. Cancer Med. 2015 Jun;4(6):834-43.
12. Okonogi N, Shirai K, Oike T, Murata K, Noda S, Suzuki Y, NakanoT. Topics in Chemotherapy, Molecular-targeted Therapy, and Immunotherapy for Newly Diagnosed Glioblastoma Multiforme. Anticancer Res. 2015 35 (3) 1229-1235
13. Yoshimoto Y, Oike T, Okonogi N, Suzuki Y, Ando K, Sato H, Noda SE, Isono M, Mimura K, Kono K, Nakano T. Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation. J Radiat Res. 2015;56(3):509-14
14. Ushijima H, Suzuki Y, Oike T, Komachi M, Yoshimoto Y, Ando K, Okonogi N, Sato H, Noda SE, Saito JI, Nakano T. Radio-sensitization effect of an mTOR inhibitor, temsirolimus, on lung adenocarcinoma A549 cells under normoxic and hypoxic conditions. J Radiat Res. 2015 Jul;56(4):663-8.
15. Okonogi N, Katoh H, Kawamura H, Tamaki T, Kaminuma T, Murata K, Ohkubo Y, Takakusagi Y, Onishi M, Sekihara T, Okazaki A, Nakano T. Clinical outcomes of helical tomotherapy for super-elderly patients with localized and locally advanced prostate cancer: comparison with patients under 80 years of age. J Radiat Res. 2015 Nov;56(6):889-96.
16. Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K. Output-limiting symptoms induced by radiofrequency hyperthermia. Are they predictable? Int J Hyperthermia. 2016 Mar;32(2):199-203.
17. Oike T, Niimi A, Okonogi N, Murata K, Matsumura A, Noda SE, Kobayashi D, Iwanaga M, Tsuchida K, Kanai T, Ohno T, Shibata A, Nakano T. Visualization of complex DNA double-strand breaks in a tumor treated with carbon ion radiotherapy. Sci Rep. 2016 Mar 1;6:22275. doi: 10.1038/srep22275.
18. Shoji H, Motegi M, Osawa K, Okonogi N, Okazaki A, Andou Y, Asao T, Kuwano H, Takahashi T, Ogoshi K. Radiofrequency thermal treatment with chemoradiotherapy for advanced rectal cancer. Oncol Rep. 2016 May;35(5):2569-75.
19. Shiba S, Wakatsuki M, Kato S, Ohno T, Okonogi N, Karasawa K, Kiyohara H, Tsujii H, Nakano T, Kamada T, Shozu M; Working Group of the Gynecological Tumor. Carbon-ion radiotherapy for locally advanced cervical cancer with bladder invasion. J Radiat Res. 2016 Nov;57(6):684-690
20. Ohno T, Noda SE, Okonogi N, Murata K, Shibuya K, Kiyohara H, Tamaki T, Ando K, Oike T, Ohkubo Y, Wakatsuki M, Saitoh JI, Nakano T. In-room computed tomography-based brachytherapy for uterine cervical cancer: results of a 5-year retrospective study. J Radiat Res. 2017 Jul 1;58(4):543-551. doi: 10.1093/jrr/rrw121.
21. Kawashima M, Kawamura H, Onishi M, Takakusagi Y, Okonogi N, Okazaki A, Sekihara T, Ando Y, Nakano T. The Impact of the Grid Size on TomoTherapy for Prostate Cancer. J Med Phys. 2017 Jul-Sep;42(3):144-150. doi: 10.4103/jmp.JMP_123_16.
22. Shiba S, Okonogi N, Kato S, Wakatsuki M, Kobayashi D, Kiyohara H, Ohno T, Karasawa K, Nakano T, Kamada T. Clinical Impact of Re-irradiation with Carbon-ion Radiotherapy for Lymph Node Recurrence of Gynecological Cancers. Anticancer Res. 2017 Oct;37(10):5577-5583.
23. Okonogi N, Kobayashi D, Suga T, Imai T, Wakatsuki M, Ohno T, Kato S, Nakano T, Kamada T. Human papillomavirus genotype affects metastatic rate following radiotherapy in patients with uterine cervical cancer. Oncol Lett. 2018 Jan;15(1):459-466. doi: 10.3892/ol.2017.7327
24. Okonogi N, Wakatsuki M, Kato S, Shiba S, Kobayashi D, Kiyohara H, Karasawa k, Ohno T, Nakano T, Kamada T, Shozu M; ; WORKING GROUP OF GYNECOLOGICAL TUMORS. Long-term Outcomes of Carbon-ion Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Uterine Cervix. Anticancer research. Anticancer Res. 2018 Jan;38(1):457-463.
25. Okonogi N, Wakatsuki M, Kato S, Karasawa K, Kiyohara H, Shiba S, Kobayashi D, Nakano T, Kamada T, Shozu M; Working Group of Gynecological Tumors. Clinical outcomes of carbon ion radiotherapy with concurrent chemotherapy for locally advanced uterine cervical adenocarcinoma in a phase 1/2 clinical trial (Protocol 1001). Cancer Med. 2018 Jan 17. doi: 10.1002/cam4.1305.
26. Irie D, Okonogi N, Wakatsuki M, Kato S, Ohno T, Karasawa K, Kiyohara H, Kobayashi D, Tsuji H, Nakano T, Kamada T, Shozu M; and The Working Group of the Gynecological Tumor. Carbon-ion radiotherapy for inoperable endometrial carcinoma. J Radiat Res. 2018 May 1;59(3):309-315. doi: 10.1093/jrr/rry003.
27. Okonogi N, Suzuki Y, Sato H, Oike T, Yoshimoto Y, Mimura K, Noda SE, Okamoto M, Tamaki T, Morokoshi Y, Hasegawa S, Ohgaki H, Yokoo H, Nakano T. Combination therapy of intravenously injected microglia and radiotherapy prolongs survival in a rat model of spontaneous malignant glioma. Int J Radiat Oncol Biol Phys. 2018 Nov 1;102(3):601-608. doi: 10.1016/j.ijrobp.2018.06.018.
28. Okonogi N, Fukahori M, Wakatsuki M, Ohkubo Y, Kato S, Miyasaka Y, Tsuji H, Nakano T, Kamada T. Dose constraints in the rectum and bladder following carbon-ion radiotherapy for uterus carcinoma: a retrospective pooled analysis. Radiat Oncol. 2018 Jun 25;13(1):119. doi: 10.1186/s13014-018-1061-7.
29. Onishi M, Okonogi N, Oike T, Yoshimoto Y, Sato H, Suzuki Y, Kamada T, Nakano T. High linear energy transfer carbon-ion irradiation increases the release of the immune mediator high mobility group box 1 from human cancer cells. 2018 Sep 1;59(5):541-546.
30. Nuryadi E, Sasaki Y, Hagiwara Y, Permata TBM, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda SE, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, Nakano T. Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy. Oncotarget. 2018 Aug 24;9(66):32642-32652. doi: 10.18632/oncotarget.25982. eCollection 2018 Aug 24.
31. Ando K, Suzuki Y, Kaminuma T, Yoshimoto Y, Oike T, Okonogi N, Sato H, Tamaki T, Noda SE, Mimura K, Nakano T. Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia. Int J Hyperthermia. 2018 Sep 17:1-6. doi: 10.1080/02656736.2018.1492027.
32. Ohno T, Noda SE, Murata K, Yoshimoto Y, Okonogi N, Ando K, Tamaki T, Kato S, Hirakawa T, Kanuma T, Minegishi T, Nakano T; Working Group for Gynecologic Cancer. Phase I Study of Carbon Ion Radiotherapy and Image-Guided Brachytherapy for Locally Advanced Cervical Cancer. Cancers (Basel). 2018 Sep 18;10(9). pii: E338. doi: 10.3390/cancers10090338.
33. Murata H, Okamoto M, Takahashi T, Motegi M, Ogoshi K, Shoji H, Onishi M, Takakusagi Y, Okonogi N, Kawamura H, Okazaki A, Asao T, Kuwano H, Nakano T. SUVmax-based Parameters of FDG-PET/CT Reliably Predict Pathologic Complete Response After Preoperative Hyperthermo-chemoradiotherapy in Rectal Cancer. Anticancer Res. 2018 Oct;38(10):5909-5916. doi: 10.21873/anticanres.12935.
34. Okonogi N, Wakatsuki M, Kato S, Karasawa K, Miyasaka Y, Murata H, Nakano T, Kamada T, Shozu M; Working Group of Gynecological Tumors. A Phase 1/2 Study of Carbon Ion Radiotherapy with Concurrent Chemotherapy for Locally Advanced Uterine Cervical Squamous Cell Carcinoma (Protocol 1302). Int J Radiat Oncol Biol Phys. 2019 Jul 1;104(3):631-639. doi: 10.1016/j.ijrobp.2019.02.042
35. Kubota Y, Ohno T, Kawashima M, Murata K, Okonogi N, Noda SE, Tsuda K, Sakai M, Tashiro M, Nakano T. Development of a Vaginal Immobilization Device: A Treatment-planning Study of Carbon-ion Radiotherapy and Intensity-modulated Radiation Therapy for Uterine Cervical Cancer. Anticancer Res. 2019 Apr;39(4):1915-1921. doi: 10.21873/anticanres.13300.
36. Okonogi N, Suzuki Y, Sato H, Oike T, Yoshimoto Y, Mimura K, Noda SE, Okamoto M, Tamaki T, Morokoshi Y, Hasegawa S, Ohgaki H, Yokoo H, Nakano T. In Reply to Minhas and Tran. Int J Radiat Oncol Biol Phys. 2019 May 1;104(1):223-224. doi: 10.1016/j.ijrobp.2019.01.086.
37. Okonogi N, Kaminuma T, Okimoto T, Shinoto M, Yamamoto N, Yamada S, Murata K, Ohno T, Shioyama Y, Tsuji H, Nakano T, Kamada T. Carbon-ion radiotherapy for lymph node oligo-recurrence: a multi-institutional study by the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS). Int J Clin Oncol. 2019 Apr 9. doi: 10.1007/s10147-019-01440-y.
38. Murata H, Okonogi N, Wakatsuki M, Kato S, Kiyohara H, Karasawa K, Ohno T, Nakano T, Kamada T, Shozu M. Long-Term Outcomes of Carbon-Ion Radiotherapy for Malignant Gynecological Melanoma. Cancers (Basel). 2019 Apr 4;11(4). pii: E482. doi: 10.3390/cancers11040482.
39. Wakatsuki M, Kato S, Ohno T, Banu PA, Hoang NC, Yadamsuren E, Supriana N, Cao J, Devi CRB, Calaguas MJ, Chansilpa Y, Cho CK, Adylkhanov T, Okonogi N, Nakano T, Tsujii H. Multi-institutional observational study of prophylactic extended-field concurrent chemoradiotherapy using weekly cisplatin for patients with pelvic node-positive cervical cancer in East and Southeast Asia. Int J Radiat Oncol Biol Phys. 2019 May 21. pii: S0360-3016(19)30737-0. doi: 10.1016/j.ijrobp.2019.04.039. [Epub ahead of print]
40. Sato H, Okonogi N, Yoshimoto Y, Tamaki T, Suzuki Y. [Radiotherapy and PD-L1 Expression]. Gan To Kagaku Ryoho. 2019 May;46(5):845-849.

著書

1.小此木　範之. Rad Fan, Vol. 15 No.4 (2017) 特集1: 画像医学は今—2017年のトレンド　放射線治療のイノベーション
2.小此木　範之. ライフライン21　がんの先進医療, Vol. 25 (2017) 特集: がんの先進医療—乳癌・婦人科系のがん　子宮体癌の重粒子線治療
3.小此木　範之、村田　裕人、鎌田　正. 臨床放射線, 63巻8号 (2018) 特集: 子宮頸部腺癌に対する放射線治療　子宮頸部腺癌に対する重粒子線治療
4.小此木　範之、佐藤　浩央、吉本　由哉、田巻　倫明、鈴木　義行.　Rad Fan, Vol. 16 No.12 (2018) 特集1: 放射線療法最前線　免疫チェックポイント阻害薬と放射線療法の併用　放射線治療の理論的背景と現状・今後の可能性
5.小此木 範之、村田　裕人、田巻　倫明、鈴木　義行. Skin Cancer, 33巻2号 (2018) シンポジウム2: 放射線による抗腫瘍免疫の活性化と免疫放射線療法（Immuno-Radiotherapy）の可能性
6.佐藤　浩央、小此木　範之、田巻　倫明、吉本　由哉、竹原　由佳、鈴木　義行. Innervision, 1号 (2019) がん医療における放射線治療最前線　免疫放射線治療の理論的背景と現状・今後の可能性
7.佐藤　浩央、小此木　範之、吉本　由哉、田巻　倫明、鈴木　義行. がんと化学療法, 46巻5号 (2019) がんにおけるPD-L1分子の発現調節　放射線治療とPD-L1発現
8.唐澤久美子、河野佐和、小此木範之、尾松徳彦. 臨床放射線, 64巻4号(2019)　乳癌に対する粒子線治療

その他

• Gunma University Graduate School of Medicine, Dean Award (首席総代) (2014)

• 第59回日本婦人科腫瘍学会学術講演会　優秀ポスター賞（2017）

• International Training Course on Carbon-ion Radiotherapy, Lecture Award, Sliver prize （2017）

• 第56回日本癌治療学会学術集会　優秀演題賞（2018）

• 日本放射線腫瘍学会第32回学術大会　梅垣賞（2019）