小池 健一 こいけ けんいち 先生

来歴等

略歴

1975年 信州大学医学部医学科 卒業
1984年 医学博士 取得
2004年 信州大学医学部小児医学講座 教授
2005年 信州大学医学部附属病院 病院長補佐
2008年 信州大学医学部附属病院 病院長
2011年 信州大学 副学長
2016年 厚生連篠ノ井総合病院 院長
2016年 信州大学 名誉教授
2017年 厚生連南長野医療センター篠ノ井総合病院 統括院長

論文

• Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia. Br J Haematol. 2019 187(2):163-173.

  Shigemura T, Matsuda K, Kurata T, Sakashita K, Okuno Y, Muramatsu H, Yue F, Ebihara Y, Tsuji K, Sasaki K, Nakahata T, Nakazawa Y, Koike K.

• Panobinostat inhibits the proliferation of CD34+CD38−cells under stimulation of hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia. Pediatric Blood & Cancer 2018 377(14):1319-1330.

  Kurata, T, Matsuda K, Hirabayashi K, Shigemura T, Sakashita K, Nakahata T, Koike K.

• Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia. J Hematol Oncol. 2016 9(1):27. doi: 10.1186/s13045-016-0256-3.

  Nakazawa Y, Matsuda K, Kurata T, Sueki A, Tanaka M, Sakashita K, Imai C, Wilson MH, Koike K.

• Analysis of KRAS and NRAS gene mutations in Arab Asian children with acute leukemia: High frequency of RAS mutations in acute lymphoblastic leukemia. Pediatr Blood Cancer. 2015 62:2157-61.

  Al-Kzayer LF, Sakashita K, Al-Jadiry MF, Al-Hadad SA, Ghali HH, Uyen LT, Liu T, Matsuda K, Abdulkadhim JM, Al-Shujairi TA, Matti ZI, Sughayer MA, Rihani R, Madanat FF, Inoshita T, Kamata M, Koike K.

• In vitro expansion of CD34+CD38- cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia. Leukemia. 2014 29:606-14.

  Sakashita K, Kato I, Daifu T, Saida S, Hiramatsu H, Nishinaka Y, Ebihara Y, Ma F, Matsuda K, Saito S, Hirabayashi K, Kurata T, Uyen LT, Nakazawa Y, Tsuji K, Heike T, Nakahata T, Koike K.

• Myeloid progenitors with PTPN11 and non-RAS pathway gene mutations are refractory to treatment with 6-mercaptopurine in juvenile myelomonocytic leukemia. Leukemia. 2014 28:1545-8.

  Matsuda K, Nakazawa Y, Iwashita C, Kurata T, Hirabayashi K, Saito S, Tanaka M, Yoshikawa K, Yanagisawa R, Sakashita K, Sasaki S, Honda T, Koike K.

• Analysis of Class I and II Aberrations in Iraqi Childhood Acute Myeloid Leukemia Using Filter Paper Cards. Ann Hematol. 2014 93:949-55.

  Al-Kzayer LF, Uyen LT, Al-Jadiry MF, Al-Hadad SA, Al-Badri SA, Ghali HH, Ameen NA, Liu T, Matsuda K, Abdulkadhim JM, Al-Shujairi TA, Matti ZI, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Khalil HM, Inoshita T, Kamata M, Koike K, Sakashita K.

• Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards. Pediatr Blood Cancer. 2012 59:461-7.

  Al-Kzayer LF, Sakashita K, Matsuda K, Al-Hadad SA, Al-Jadiry MF, Abed WM, Abdulkadhim JM, Al-Shujairi TA, Hasan JG, Al-Abdullah HM, Al-Ani MH, Saber PA, Inoshita T, Kamata M, Koike K.

• Long-term haematological improvement after non-intensive or no chemotherapy in juvenile myelomonocytic leukaemia and poor correlation with adult myelodysplasia spliceosome-related mutations. Br J Haematol. 2012 157:647-50.

  Matsuda K, Yoshida N, Miura S, Nakazawa Y, Sakashita K, Hyakuna N, Saito M, Kato F, Ogawa A, Watanabe A, Sotomatsu M, Kobayashi C, Ito T, Ishida F, Manabe A, Kojima S, Koike K.

• Long-term survival after non-intensive chemotherapy in some juvenile myelomonocytic leukemia patients with CBL mutations, and the possible presence of normal individuals with the mutations. Blood. 2010 115:5429-31.

  Matsuda K, Taira C, Sakashita K, Saito S, Tanaka-Yanagisawa M, Yanagisawa R, Nakazawa Y, Shiohara M, Fukushima K, Oda M, Honda T, Nakahata T, Koike K.

• Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia. Br J Haematol. 2009 141: 567-75.

  Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa D, Kawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K.

• Recent advances in the pathogenesis and management of juvenile myelomonocytic leukemia. Br J Haematol, 141:567-75, 2008.

  Koike K, Matsuda K.

• Acquirement of loss of the wild-type NRAS locus with aggressive disease progression in a patient with juvenile myelomonocytic leukemia and a heterozygous NRAS mutation. Haematologica, 2007;92 1576-1578.

  Matsuda K, Nakazawa Y, Sakashita K, Shiohara M, Yamauchi K, Koike K.

• Spontaneous improvement of hematologic abnormalities in patients having juvenile myelomonocytic leukemia with specific RAS mutations. Blood, 109:5477-80, 2007.

  Matsuda K, Shimada A, Yoshida N, Ogawa A, Watanabe A, Yajima S, Iizuka S, Koike K, Yanai F, Kawasaki K, Yanagimachi M, Kikuchi A, Ohtsuka Y, Hidaka E, Yamauchi K, Tanaka M, Yanagisawa R, Nakazawa Y, Shiohara M, Manabe A, Kojima S, Koike K.

• Chromosomal change during 6-mercaptopurine (6-MP) therapy in juvenile myelomonocytic leukemia: the growth of a 6-MP-refractory clone that already exists at onset. Leukemia, 20: 485-490, 2006.

  Matsuda K, Matsuzaki S, Miki J, Hidaka E, Yanagisawa R, Nakazawa Y, Sakashita K, Kamijo T, Asami K, Sano K, Koike K.

• Dynamic DNA methylation change in CpG island region of p15 gene during human myeloid development. J Clin Invest, 2001, 108:1195-204.

  Sakashita K, Koike K, Kinoshita T, Shiohara M, Kamijo T, Taniguchi S, Kubota T

著書

• 【共著】小池健一.小児の貧血.医学書院医学書籍編集部. 『今日の診断指針』第7 版.

• 【共著】小池健一.小児のHIV感染症『今日の治療指針』2014年度版.

• 【共著】小池健一.ネルソン小児科学第19版.日本語版小児の組織球増殖疾患.

• 【共著】小池健一.放射線の子どもへの健康影響.チャイルドヘルス.15：626-629, 2012 診断と治療社.

• 【共著】小池健一.薬剤や放射線障害による貧血.進歩する子どもの貧血の診断と治療.チャイルドヘルス.15：432-425, 2012 診断と治療社

• 【共著】小池健一.チェルノブイリ原発事故と福島第一原発事故.-人体への影響-.日本小児血液がん学会雑誌.49：323-327, 2012

その他

• 【受賞】2006年2月 第６回インターネット活用教育実践コンクール　内閣総理大臣賞

• 【受賞】2006年 10月　第13回読売国際協力賞　受賞