中野 武 なかの たけし 先生

来歴等

略歴

1955年 長野県出身
1979年 信州大学医学部医学科 卒業
1979年 信州大学医学部　第三内科 勤務
1986年 医学博士
1986年 米国留学 North Carolina大学Chapel Hill 神経分子遺伝部門研究員
1991年 安曇野赤十字病院 入職
2004年 安曇野赤十字病院 副院長
2015年 安曇野赤十字病院 病院長

論文

• Adult GM1-gangliosidosis : Clinical patterns and rectal biopsy.Neurology 35:834-840,1985.

  Nakano T, Ikeda S, Kondo K, Yanagisawa N, Tsuji S

• A point mutation in the coding sequence of the beta－hexosaminidase alpha gene results in defective processing of the enzyme protein in an unusual GM2－gangliosidosis variant. J Neurochem 51: 984-987,1988.

  Nakano T, Muscillo M, Ohno K, Hoffman AJ, Suzuki K

• Structure of full-length cDNA coding for sulfatide activator, a co-beta-glucosidase and two other homologous proteins : two alternate forms of the sulfatide activator. J Biochem 195: 152-154,1989.

  Nakano T, Sandhoff K, Stumper J, Chistomanou H, Suzuki K

• Genetic cause of a juvenile form of Sandhoff disease : abnormal splicing of beta-hexosaminidase beta chain gene transcript due to a point mutation within intron 12. J Biol Chem 264: 5155-5158,1989.

  Nakano T, Suzuki K

• Point mutation within Exon 5 of beta-Hexosaminidase alpha Gene in a Japanese Infant with Tay-Sachs Disease. Ann Neurol 27:465-473,1990.

  Nakano T, Nanba E, Tanaka A, Ohno K, Suzuki Y, Suzuki K

• Ultrastructual findings of rectal and skin biopsies in adult GM1-gangliosidosis. Acta Pathol Jpn 36: 1823-1831,1986.

  Ikeda S, Ushiyama M, Nakano T, Kikkawa T, Kondo K, Yanagisawa N

• Blood-brain barrier permeability to horseradish peroxidase in twicher and cuprizone-intoxicated mice. Brain Research　425:186-190,1987.

  Kondo A, Nakano T, Suzuki K

• Infantile and fetal globoid cell leukodystrophy : analysis of galactosylceramide and galactosylsphingosine. Ann Neurol 24:517－522,1988.

  Kobayashi T, Goto I, Yamanaka T, Suzuki Y, Nakano T, Suzuki K

• Molecular genetics of beta-N-acetylhexosaminidase alpha subunit mutations. Salvayre R, Douste-Blazy L, Gatt S eds : Lipid storage disorders. pp215-223. Plenum Publishing Corporation, New York,1988.

  Ohno K, Muscillo M, Nakano T, Suzuki K

• Isolation of a cDNA coding the human GM2 activator protein. FEBS LETTER 251:197-200,1989.

  Scroder M, Klima H, Nakano T, Kwon H, Quintern LE､ Gartner S, Suzuki K, Sandhoff K

• Juvenile Sandhoff disease : a Japanese patient carrying a mutation identical to that found earlier in Canadian patient. J Neurol Sci 98: 277-286,1990.

  Mitsuo K, Nakano T, Kobayashi T, Goto I, Taniike M, Suzuki K

• Sulfatide Activator Protein alternative splicing that generates three mRNA and a newly found mutation responsible for a clinical disease. J Biol Chem 266:7556-7560,1991.

  Holtschmidt H, Sandhoff K, Kwon HY, Harzer K, Nakano T, Suzuki K

• Accumulation of Lysosphingolipids in Tissues from Patients with GM1 and GM2 Gangliosidoses. J Neurochem 59:1452-1458,1992.

  Kobayashi T, Goto I, Okada S, Orii T, Ohno K, Nakano T

• GM1 Gangliosidosis in Adults ： Clinical and Molecular Analysis of 16 Japanese Patients. Ann Neurol l31:328-332,1992.

  Yoshida K, Oshima A, Sakuraba H, Nakano T, Yanagisawa N, Inui K, Okada S, Uyama E, Namba R, Kondo K, Iwasaki S, Takamiya K, Suzuki Y

• Altered sensitivities to potentials inhibitors of cholesterol biosynthesis in Niemann-Pick TypeC fibroblasts. Cell Structure and Function 18:231-240,1993.

  Ohno K, Nanba E, Nakano T, Inui K, Okada S, Takeshita K

• Detection of immune complexes in experimental allergic neuritis. J Nurol Sci 63: 229-239,1984.

  Koh CS, Nakano T, Tsukada N, Yanagisawa N, Okano T, Taketomi T

• Asymptomatic Homozygous Gene Carrier in a Family with Type1 Familial Amyloid Polyneuropathy. Eur Neurol l32: 308-313,1992.

  Ikeda S, Nakano T, Yanagisawa N, Nakazato M, Tsukagoshi H

• Three Patients with Isolated Adrenocorticotropin Deficiency Presenting with Neuroleptic Malignant Syndrome-like Symptoms. Internal Medicine 40: 510-514,2001.

  Sekijima Y, Hoshi K, Kasai H, Okada M, Namiki S, Ohta K, Nakano T, Hirayama J, Ikeda S

• Validity of a newly developed Japanese SS-QOL (Stroke-Specific Quality of Life) measure. Quality of life research 30: 285,2001.

  Origasa H, Nakano T, Morioka T, Owa M

• Hypersomnia and Low CSF Hypocretin-1 (Orexin-A ) Concentration in a Patient with Multiple Sclerosis Showing Bilateral Hypothalamic Lesions. Internal medicine 42:743-745 2003.

  Kato T, Kanbayashi T, Yamamoto K, Nakano T, Shimizu T, Hashimoto T, Ikeda S