三宅幸子みやけさちこ先生

東京都

公開日: 2021/06/17

基本情報
来歴等

基本情報

診療科・主な得意領域

【得意な領域】免疫学

資格・学会・役職

順天堂大学医学部免疫学講座教授

来歴等

略歴

1987年順天堂大学付属順天堂医院内科研修医
1994年順天堂大学医学部膠原病内科学教室助手
1995年米国Harvard大学リウマチ免疫アレルギー科博士研究員
1997年米国Harvard大学リウマチ免疫アレルギー科指導研究員
1999年国立精神・神経センター神経研究所免疫研究部室長
2013年順天堂大学医学部免疫学講座（～現在）教授

論文

1. Alterations of the gut ecological and functional microenvironment in different stages of multiple sclerosis. Proc Natl Acad Sci USA 117(36)22402-22412, 2020

Takewaki D, Suda W, Sato W, Takayasu L, Kumar N, Kimura K, Kaga N, Mizuno T, Miyake S, Hattori M, Yamamura T.
2. Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients. Rheumatology (Oxford). 59(10):2992-3002, 2020

Murayama G, Chiba A, Kuga T, Makiyama A, Yamaji K, Tamura N, Miyake S.
3. A Critical Role for Mucosal-Associated Invariant T Cells as Regulators and Therapeutic Targets in Systemic Lupus Erythematosus. Front Immunol 10:2681, 2019

Murayama G, Chiba A, Suzuki H, Nomura A, Mizuno T, Kuga T, Nakamura S, Amano H, Hirose S, Yamaji K, Suzuki Y, Tamura N, Miyake S.
4. Dysbiosis in the gut microbiota of patients with multiple sclerosis, with a striking depletion of species belonging to Clostridai XIVa and IV clutsers. PLos One 10(9):e0137429, 2015

Miyake S, Kim S, Suda W, Oshima K, Nakamura M, Matsuoka T, Chihara N, Tomita A, Sato W, Kim S-W, Morita H, Hattori M, Yamamura T.
5. Mucosal-associated invariant T cells promote inflammation and exacerbate disease in murine models of arthritis. Arthritis Rhem 64:153-61, 2012

Chiba A, Tajima R, Tomi C, Miyazaki Y, Yamamura T, Miyake S.
6. Interleukin 6 signaling promotes anti—aquaporin 4 autoantibody production from plasmablasts in neuromyelitis optica. Proc Natl Acad Sci USA 108:3701-3706, 2011

Chihara N, Aranami T, Sato W, Miyazaki Y, Miyake S, Okamoto T, Ogawa M, Toda T, Yamamura T.
7. Invariant Vα19i T cells regulate autoimmune inflammation. Nat Immunol 7:987-994, 2006

Croxford JL, Miyake S, Huang Y-Y, Shimamura M, Yamamura T.
8. The involvement of Vα14 NKT cells in the pathogenesis of murine models of arthritis. Arthritis Rheum 52:1941-1948, 2005

Chiba A, Kaieda S, Oki S, Yamamura T, Miyake S.
9. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing Th2 of natural killer T cells. Nature 413: 531-534, 2001 *Eaqual contribution.

Miyake S*, Miyamoto K*, Yamamura T.
10. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet derived growth factor receptor α. Proc Natl Acad Sci USA 95:7927-7932, 1998

Miyake S, Lupher ML, Druker B, Band H