伊藤 光泰 いとう みつやす 先生

来歴等

略歴

1974年 名古屋大学医学部 卒業
1978年 アメリカ合衆国 Mayo Clinic 内分泌研究部 研究員
1991年 浜松医科大学第三内科 講師
1994年 藤田保健衛生大学（現・藤田医科大学）医学部内科学内分泌代謝科 助教授
2001年 藤田保健衛生大学（現・藤田医科大学）医学部内分泌・代謝内科学講座 教授（〜2015年）
2015年 藤田医科大学 名誉教授
2015年 医療法人誠厚会 名駅前診療所保健医療 センター長

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論文

• 1. Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial. Lancet Diabetes Endocrinol. 2017 Dec;5(12):951-964. PMID: 29079252

  Ueki K, Sasako T, Okazaki Y, Kato M, Okahata S, Katsuyama H, Haraguchi M, Morita A, Ohashi K, Hara K, Morise A, Izumi K, Ishizuka N, Ohashi Y, Noda M, Kadowaki T; J-DOIT3 Study Group.

• 2. Pharmacological topics of bone metabolism: recent advances in pharmacological management of osteoporosis. J Pharmacol Sci. 2008 Apr;106(4):530-5. PMID: 18431035

  Suzuki A, Sekiguchi S, Asano S, Itoh M.

• 3. Circulating microRNAs in autoimmune thyroid diseases. Clin Endocrinol (Oxf). 2014 Aug;81(2):276-81. PMID: 24533739

  Yamada H, Itoh M, Hiratsuka I, Hashimoto S.

• 4. Circulating MicroRNAs in Graves' Disease in Relation to Clinical Activity. Thyroid. 2016 Oct;26(10):1431-1440. PMID: 27610819

  Hiratsuka I, Yamada H, Munetsuna E, Hashimoto S, Itoh M.

• 5. The soliloquy of a clinical endocrinologist who spent half a century as an academic member. Endocr J. 2024;71(4):313-315. PMID: 38684420

  Itoh M.

• 6. Changes in Serum Immunoglobulin G4 Levels in Patients with Newly Diagnosed Graves' Disease. Exp Clin Endocrinol Diabetes. 2020 Feb;128(2):119-124. PMID: 30235492

  Hiratsuka I, Yamada H, Itoh M, Shibata M, Takayanagi T, Makino M, Sugimura Y, Hayakawa N, Hashimoto S, Suzuki A.

• 7. Expression of erbB receptors mRNA in thyroid tissues. Biochim Biophys Acta. 2004 Aug 4;1673(3):194-200. PMID: 15279891

  Kato S, Kobayashi T, Yamada K, Nishii K, Sawada H, Ishiguro H, Itoh M, Funahashi H, Nagasaka A.

• 8. Seasonal changes of serum 25-hydroxyvitamin D and intact parathyroid hormone levels in a normal Japanese population. J Bone Miner Metab. 2005;23(2):147-51. PMID: 15750693

  Ono Y, Suzuki A, Kotake M, Zhang X, Nishiwaki-Yasuda K, Ishiwata Y, Imamura S, Nagata M, Takamoto S, Itoh M.

• 9. cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells. Life Sci. 2002 Mar 22;70(18):2187-98. PMID: 12002810

  Ohtsuki M, Shiraishi H, Kato T, Kuroda R, Tazawa M, Sumi-Ichinose C, Tada S, Udagawa Y, Itoh M, Hishida H, Ichinose H, Nagatsu T, Hagino Y, Nomura T.

• 10. Hypovitaminosis D in type 2 diabetes mellitus: Association with microvascular complications and type of treatment. Endocr J. 2006 Aug;53(4):503-10. PMID: 16829706.

  Suzuki A, Kotake M, Ono Y, Kato T, Oda N, Hayakawa N, Hashimoto S, Itoh M.

• 11. Comparative study of the usefulness of a novel insulin therapy in Japanese patients with Type 2 diabetes for concomitant use of an oral antidiabetic agent with twice-daily dosing either of insulin aspart, biphasic insulin aspart-30, or insulin detemir: Two times Insulin injection Combined with oral therapy Efficacy Study (TWICE study). Fujita Med J. 2021;7(1):1-7. PMID: 35111536

  Itoh M, Suzuki A, Katoh T, Sawai Y, Asano S, Imamura S, Hayashi Y, Goto S, Takahashi N, Kawabe T.

• 12. Phosphate overload induces podocyte injury via type III Na-dependent phosphate transporter. Am J Physiol Renal Physiol. 2011 Apr;300(4):F848-56. PMID: 21307129

  Sekiguchi S, Suzuki A, Asano S, Nishiwaki-Yasuda K, Shibata M, Nagao S, Yamamoto N, Matsuyama M, Sato Y, Yan K, Yaoita E, Itoh M.

• 13. The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism. 2008 Feb;57(2):268-73. PMID: 18191059

  Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, Kakizawa H, Hayakawa N, Suzuki A, Takeda J, Horikawa Y, Itoh M.

• 14. Lung cancer associated with hypercalcemia induced by concurrently elevated parathyroid hormone and parathyroid hormone-related protein levels. Metabolism. 2002 Jul;51(7):871-5. PMID: 12077733

  Uchimura K, Mokuno T, Nagasaka A, Hayakawa N, Kato T, Yamazaki N, Kobayashi T, Nagata M, Kotake M, Itoh M, Tsujimura T, Iwase K.

• 15. The relationship between glycemic control and plasma vascular endothelial growth factor and endothelin-1 concentration in diabetic patients. Metabolism. 2004 May;53(5):550-5. PMID: 15131756

  Kakizawa H, Itoh M, Itoh Y, Imamura S, Ishiwata Y, Matsumoto T, Yamamoto K, Kato T, Ono Y, Nagata M, Hayakawa N, Suzuki A, Goto Y, Oda N.

• 16. Effects of transgenic Pit-1 overexpression on calcium phosphate and bone metabolism. J Bone Miner Metab. 2010 Mar;28(2):139-48. PMID: 19795094

  Suzuki A, Ammann P, Nishiwaki-Yasuda K, Sekiguchi S, Asano S, Nagao S, Kaneko R, Hirabayashi M, Oiso Y, Itoh M, Caverzasio J.

• 17. Oral alendronate can suppress bone turnover but not fracture in kidney transplantation recipients with hyperparathyroidism and chronic kidney disease. J Bone Miner Metab. 2013 Jan;31(1):116-22. PMID: 23076292

  Yamamoto S, Suzuki A, Sasaki H, Sekiguchi-Ueda S, Asano S, Shibata M, Hayakawa N, Hashimoto S, Hoshinaga K, Itoh M.

• 18. Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide. Biochim Biophys Acta. 2004 Feb 24;1670(3):181-98. PMID: 14980445

  Fujiwara K, Mori K, Kaneko YS, Nakashima A, Nagasaka A, Itoh M, Ota A.

• 19. cGMP inhibits GTP cyclohydrolase I activity and biosynthesis of tetrahydrobiopterin in human umbilical vein endothelial cells. J Pharmacol Sci. 2003 Nov;93(3):265-71. PMID: 14646243

  Shiraishi H, Kato T, Atsuta K, Sumi-Ichinose C, Ohtsuki M, Itoh M, Hishida H, Tada S, Udagawa Y, Nagatsu T, Hagino Y, Ichinose H, Nomura T.

• 20. High prevalence of hypovitaminosis D in pregnant Japanese women with threatened premature delivery. J Bone Miner Metab. 2011 Sep;29(5):615-20. PMID: 21384110

  Shibata M, Suzuki A, Sekiya T, Sekiguchi S, Asano S, Udagawa Y, Itoh M.

• 21. Simultaneous measurement of serum chemokines in autoimmune thyroid diseases: possible role of IP-10 in the inflammatory response. Endocr J. 2015;62(12):1059-66. PMID: 26400025

  Hiratsuka I, Itoh M, Yamada H, Yamamoto K, Tomatsu E, Makino M, Hashimoto S, Suzuki A.

• 22. Genetic variations in calpain-10 gene are not a major factor in the occurrence of type 2 diabetes in Japanese. J Clin Endocrinol Metab. 2003 Jan;88(1):244-7. PMID: 12519860

  Horikawa Y, Oda N, Yu L, Imamura S, Fujiwara K, Makino M, Seino Y, Itoh M, Takeda J.

• 23. Level of urinary liver-type fatty acid-binding protein is associated with cardiac markers and electrocardiographic abnormalities in type-2 diabetes with chronic kidney disease stage G1 and G2. Heart Vessels. 2015 May;30(3):362-8. PMID: 24626813

  Maeda Y, Suzuki A, Ishii J, Sekiguchi-Ueda S, Shibata M, Yoshino Y, Asano S, Hayakawa N, Nakamura K, Akiyama Y, Kitagawa F, Sakuishi T, Fujita T, Hashimoto S, Ozaki Y, Itoh M.

• 24. Subclinical hypothyroidism is related to lower heel QUS in postmenopausal women. Endocr J. 2007 Aug;54(4):625-30. PMID: 17641439

  Nagata M, Suzuki A, Sekiguchi S, Ono Y, Nishiwaki-Yasuda K, Itoi T, Yamamoto S, Imamura S, Katoh T, Hayakawa N, Oda N, Hashimoto S, Itoh M.

• 25. Relative levels of the inflammatory cytokine TNFα and the soluble CD40 ligand profile in serum correlate with the thyrotoxic activity of Graves' disease. Thyroid. 2012 May;22(5):516-21. PMID: 22512415

  Yamamoto K, Itoh M, Okamura T, Kimura M, Yokoyama A, Yoshino Y, Makino M, Hayakawa N, Suzuki A.

• 26. Enhanced expression of the inorganic phosphate transporter Pit-1 is involved in BMP-2-induced matrix mineralization in osteoblast-like cells. J Bone Miner Res. 2006 May;21(5):674-83. PMID: 16734382 Free article.

  Suzuki A, Ghayor C, Guicheux J, Magne D, Quillard S, Kakita A, Ono Y, Miura Y, Oiso Y, Itoh M, Caverzasio J.

• 27. Distinctive response of thyroid-infiltrating mononuclear cells to B cell activation through CD40 and interleukin-4 in Graves' patients. Cytokine. 2002 Aug 7;19(3):107-14. PMID: 12242076

  Itoh M, Uchimura K, Yamamoto K, Makino M, Imamura S, Kobayashi T, Fujiwara K, Kato T, Hayakawa N, Sawai Y, Nagasaka A, Iwase K, Nomura T, Hagino Y.

• 28. The C-terminal domain of the adenomatous polyposis coli (Apc) protein is involved in thyroid morphogenesis and function. Med Mol Morphol. 2011 Dec;44(4):207-12. PMID: 22179183

  Yokoyama A, Nomura R, Kurosumi M, Shimomura A, Onouchi T, Iizuka-Kogo A, Smits R, Oda N, Fodde R, Itoh M, Senda T.

• 29. Urinary sorbitol measurement and the effect of an aldose reductase inhibitor on its concentration in the diabetic state. J Diabetes Complications. 2003 Nov-Dec;17(6):337-42. PMID: 14583178

  Nakano I, Tsugawa T, Shinohara R, Watanabe F, Fujita T, Nagata M, Kato T, Himeno Y, Kobayashi T, Fujiwara K, Nagata M, Itoh M, Nagasaka A.

• 30. Insulinoma cell calcium-sensing receptor influences insulin secretion in a case with concurrent familial hypocalciuric hypercalcemia and malignant metastatic insulinoma. Eur J Endocrinol. 2008 Jul;159(1):81-6. PMID: 18430790

  Ono Y, Oda N, Ishihara S, Shimomura A, Hayakawa N, Suzuki A, Horiguchi A, Senda T, Miyakawa S, Itoh M.

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著書

• 1. かかりつけ医のための甲状腺疾患治療ガイド 診断と治療社 2023年

• 2. 日本甲状腺学会甲状腺専門医ガイドブック改訂第2版 診断と治療社 2016年

• 3. よくわかる甲状腺疾患のすべて改訂第2版 永井書店 2009年

• 4. 内分泌・糖尿病内科学 シュプリンガー・ジャパン 2011年

• 5. Principles and Practice 内分泌・代謝 文光堂 2011年

• 6. 内分泌代謝専門医ガイドブック改訂第4版 診断と治療社 2016年

• 7. 日本内分泌学会内分泌代謝科専門医研修ガイドブック 診断と治療社 2018年

• 8. 甲状腺疾患診療マニュアル改訂第3版 診断と治療社 2020年

• 9. 内分泌代謝疾患クリニカルクエスチョン改訂第2版 診断と治療社 2023年

• 10. 臨床病態学改訂 第4版 南江堂 2011年

• 11. 臨床検査ガイド2020年改訂版 文光堂 2020年

• 12. 今日の診断指針改訂第6版 医学書院 2011年

• 13. 今日の診断指針改訂第8版 医学書院 2020年

• 14. 今日の治療指針 医学書院 2014年

• 15. 今日の治療指針 医学書院 2016年

• 16. ガイトン生理学 第11版（訳）エルゼビア・ジャパン 2010年

• 17. 南山堂医学大辞典 第20版 南山堂 2015年

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受賞

• 1. 2011年 日本甲状腺学会 三宅賞