崎谷 康佑 さきたに こうすけ 先生

来歴等

略歴

私立武蔵高校 卒業
東京大学理科III類 入学
東京大学医学部医学科 卒業
東京大学大学院博士課程内科学専攻 修了（医学博士）
米国NYコロンビア大学 留学（日本学術振興会特別研究員PD）
東京大学医学部附属病院
JR東京総合病院
日本赤十字社医療センター 消化器内科
朝日生命成人病研究所附属医院 消化器内科 部長
さきたに内科・内視鏡クリニック 開設
医療法人社団佑光会 理事長
習志野市医師会 理事（成人保健分野）
文京動坂診療所 院長

論文

• 1. Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers.

  Toyoshima O, Yoshida S, Nishizawa T, Toyoshima A, Sakitani K, Matsuno T, Yamada T, Matsuo T, Nakagawa H, Koike K.World J Gastrointest Endosc. 2021 Sep 16;13(9):426-436. doi: 10.4253/wjge.v13.i9.426.PMID: 34630892

• 2. Consistency between the endoscopic Kyoto classification and pathological updated Sydney system for gastritis: A cross-sectional study.

  Toyoshima O, Nishizawa T, Yoshida S, Matsuno T, Odawara N, Toyoshima A, Sakitani K, Watanabe H, Fujishiro M, Suzuki H.J Gastroenterol Hepatol. 2022 Feb;37(2):291-300. doi: 10.1111/jgh.15693. Epub 2021 Oct 6.PMID: 34569096

• 3. Comparison of endoscopic gastritis based on Kyoto classification between diffuse and intestinal gastric cancer.

  Toyoshima O, Nishizawa T, Yoshida S, Aoki T, Nagura F, Sakitani K, Tsuji Y, Nakagawa H, Suzuki H, Koike K.World J Gastrointest Endosc. 2021 May 16;13(5):125-136. doi: 10.4253/wjge.v13.i5.125.PMID: 34046150

• 4. Helicobacter pylori eradication improved the Kyoto classification score on endoscopy.

  Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Kinoshita K, Torii A, Yamada A, Suzuki H, Koike K.JGH Open. 2020 May 29;4(5):909-914. doi: 10.1002/jgh3.12360. eCollection 2020 Oct.PMID: 33102763

• 5. Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication.

  Sakitani K, Nishizawa T, Toyoshima A, Yoshida S, Matsuno T, Yamada T, Irokawa M, Takahashi Y, Nakai Y, Toyoshima O, Koike K.World J Gastrointest Endosc. 2020 Sep 16;12(9):276-284. doi: 10.4253/wjge.v12.i9.276.PMID: 32994858

• 6. Clinical features of cardiac nodularity-like appearance induced by Helicobacter pylori infection.

  Nishizawa T, Sakitani K, Suzuki H, Yoshida S, Kataoka Y, Nakai Y, Ebinuma H, Kanai T, Toyoshima O, Koike K.World J Gastroenterol. 2020 Sep 21;26(35):5354-5361. doi: 10.3748/wjg.v26.i35.5354.PMID: 32994693

• 7. Colonoscopy using back brace support belt: A randomized, prospective trial.

  Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Yoshida S, Fukagawa K, Hata K, Ishihara S, Suzuki H.JGH Open. 2019 Nov 7;4(3):441-445. doi: 10.1002/jgh3.12276. eCollection 2020 Jun.PMID: 32514451

• 8. Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection.

  Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Watanabe H, Yoshida S, Nakai Y, Hata K, Ebinuma H, Suzuki H, Koike K.Endosc Int Open. 2020 Jun;8(6):E770-E774. doi: 10.1055/a-1136-9890. Epub 2020 May 25.PMID: 32490162

• 9. Adverse events associated with bidirectional endoscopy with midazolam and pethidine.

  Nishizawa T, Sakitani K, Suzuki H, Takeuchi M, Takahashi Y, Takeuchi K, Yamakawa T, Yoshida S, Hata K, Ebinuma H, Koike K, Toyoshima O.J Clin Biochem Nutr. 2020 Jan;66(1):78-81. doi: 10.3164/jcbn.19-73. Epub 2019 Oct 30.PMID: 32001961

• 10. Small-caliber endoscopes are more fragile than conventional endoscopes.

  Nishizawa T, Sakitani K, Suzuki H, Yamakawa T, Takahashi Y, Yoshida S, Nakai Y, Hata K, Ebinuma H, Koike K, Toyoshima O.Endosc Int Open. 2019 Dec;7(12):E1729-E1732. doi: 10.1055/a-1036-6186. Epub 2019 Dec 10.PMID: 31828209

• 11. CF290 for pancolonic chromoendoscopy improved sessile serrated polyp detection and procedure time: a propensity score-matching study.

  Toyoshima O, Yoshida S, Nishizawa T, Yamakawa T, Sakitani K, Hata K, Takahashi Y, Fujishiro M, Watanabe H, Koike K.Endosc Int Open. 2019 Aug;7(8):E987-E993. doi: 10.1055/a-0953-1909. Epub 2019 Jul 24.PMID: 31367679

• 12. A combination of serum anti-Helicobacter pylori antibody titer and Kyoto classification score could provide a more accurate diagnosis of H pylori.

  Nishizawa T, Sakitani K, Suzuki H, Yamakawa T, Takahashi Y, Yamamichi N, Watanabe H, Seto Y, Koike K, Toyoshima O.United European Gastroenterol J. 2019 Apr;7(3):343-348. doi:10.1177/2050640619825947. Epub 2019 Jan 15.PMID: 31019702

• 13. Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity, atrophy, and age: A cross-sectional study.

  Toyoshima O, Nishizawa T, Sakitani K, Yamakawa T, Takahashi Y, Yamamichi N, Hata K, Seto Y, Koike K, Watanabe H, Suzuki H.World J Gastroenterol. 2018 Sep 21;24(35):4061-4068. doi: 10.3748/wjg.v24.i35.4061.PMID: 30254410

• 14. Early detection of gastric cancer after Helicobacter pylori eradication due to endoscopic surveillance.

  Sakitani K, Nishizawa T, Arita M, Yoshida S, Kataoka Y, Ohki D, Yamashita H, Isomura Y, Toyoshima A, Watanabe H, Iizuka T, Saito Y, Fujisaki J, Yahagi N, Koike K, Toyoshima O.Helicobacter. 2018 Aug;23(4):e12503. doi: 10.1111/hel.12503. Epub 2018 Jun 20.PMID: 29924436

• 15. Adhesive Interactions between Mononuclear Phagocytes and Intestinal Epithelium Perturb Normal Epithelial Differentiation and Serve as a Therapeutic Target in Inflammatory Bowel Disease.

  Ihara S, Hirata Y, Hikiba Y, Yamashita A, Tsuboi M, Hata M, Konishi M, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K.J Crohns Colitis. 2018 Nov 9;12(10):1219-1231. doi: 10.1093/ecco-jcc/jjy088.PMID: 29917067

• 16. Overexpression of HER2 in the pancreas promotes development of intraductal papillary mucinous neoplasms in mice.

  Shibata W, Kinoshita H, Hikiba Y, Sato T, Ishii Y, Sue S, Sugimori M, Suzuki N, Sakitani K, Ijichi H, Mori R, Endo I, Maeda S.Sci Rep. 2018 Apr 18;8(1):6150. doi: 10.1038/s41598-018-24375-2.PMID: 29670173

• 17. Helicobacter pylori infection in subjects negative for high titer serum antibody.

  Toyoshima O, Nishizawa T, Arita M, Kataoka Y, Sakitani K, Yoshida S, Yamashita H, Hata K, Watanabe H, Suzuki H.World J Gastroenterol. 2018 Apr 7;24(13):1419-1428. doi: 10.3748/wjg.v24.i13.1419.PMID: 29632423

• 18. Decline in perception of acid regurgitation symptoms from gastroesophageal reflux disease in diabetes mellitus patients.

  Sakitani K, Suzuki N, Ihara S, Hirata Y, Kawazu S, Iwamoto Y, Koike K.PLoS One. 2018 Mar 15;13(3):e0194466. doi: 10.1371/journal.pone.0194466. eCollection 2018.PMID: 29543865

• 19. Decrease in PSCA expression caused by Helicobacter pylori infection may promote progression to severe gastritis.

  Toyoshima O, Tanikawa C, Yamamoto R, Watanabe H, Yamashita H, Sakitani K, Yoshida S, Kubo M, Matsuo K, Ito H, Koike K, Seto Y, Matsuda K.Oncotarget. 2017 Dec 14;9(3):3936-3945. doi: 10.18632/oncotarget.23278. eCollection 2018 Jan 9.PMID: 29423095

• 20. CXCR4-expressing Mist1+ progenitors in the gastric antrum contribute to gastric cancer development.

  Sakitani K, Hayakawa Y, Deng H, Ariyama H, Kinoshita H, Konishi M, Ono S, Suzuki N, Ihara S, Niu Z, Kim W, Tanaka T, Liu H, Chen X, Tailor Y, Fox JG, Konieczny SF, Onodera H, Sepulveda AR, Asfaha S, Hirata Y, Worthley DL, Koike K, Wang TC.Oncotarget. 2017 Nov 10;8(67):111012-111025. doi: 10.18632/oncotarget.22451. eCollection 2017 Dec 19.PMID: 29340033

• 21. Clinical characteristics of patients with diabetes mellitus and fatty liver diagnosed by liver/spleen Hounsfield units on CT scan.

  Sakitani K, Enooku K, Kubo H, Tanaka A, Arai H, Kawazu S, Koike K.J Int Med Res. 2017 Jun;45(3):1208-1220. doi: 10.1177/0300060517707672. Epub 2017 May 28.PMID: 28553763

• 22. Family history is an independent risk factor for the progression of gastric atrophy among patients with Helicobacter pylori infection.

  Nishizawa T, Suzuki H, Sakitani K, Yamashita H, Yoshida S, Hata K, Kanazawa T, Fujiwara N, Kanai T, Yahagi N, Toyoshima O.United European Gastroenterol J. 2017 Feb;5(1):32-36. doi: 10.1177/2050640616642341. Epub 2016 Jun 22.PMID: 28405319

• 23. The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis.

  Jin G, Sakitani K, Wang H, Jin Y, Dubeykovskiy A, Worthley DL, Tailor Y, Wang TC.Oncotarget. 2017 Jun 20;8(25):40606-40619. doi: 10.18632/oncotarget.16506.PMID: 28380450

• 24. Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling.

  Hayakawa Y 1, Sakitani K 1, Konishi M, Asfaha S, Niikura R, Tomita H, Renz BW, Tailor Y, Macchini M, Middelhoff M, Jiang Z, Tanaka T, Dubeykovskaya ZA, Kim W, Chen X, Urbanska AM, Nagar K, Westphalen CB, Quante M, Lin CS, Gershon MD, Hara A, Zhao CM, Chen D, Worthley DL, Koike K, Wang TC.Cancer Cell. 2017 Jan 9;31(1):21-34. doi: 10.1016/j.ccell.2016.11.005. Epub 2016 Dec 15.PMID: 27989802. 1: co-first author

• 25. Efficacy of triple therapy with esomeprazole, amoxicillin, and sitafloxacin as a third-line Helicobacter pylori eradication regimen.

  Hirata Y, Serizawa T, Shichijo S, Suzuki N, Sakitani K, Hayakawa Y, Yamada A, Koike K.Int J Infect Dis. 2016 Oct;51:66-69. doi: 10.1016/j.ijid.2016.08.019. Epub 2016 Aug 30.PMID: 27590563

• 26. TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota.

  Ihara S, Hirata Y, Serizawa T, Suzuki N, Sakitani K, Kinoshita H, Hayakawa Y, Nakagawa H, Ijichi H, Tateishi K, Koike K.J Immunol. 2016 Jun 1;196(11):4603-13. doi: 10.4049/jimmunol.1502548. Epub 2016 Apr 22.PMID: 27183608

• 27. Inhibition of autophagy exerts anti-colon cancer effects via apoptosis induced by p53 activation and ER stress.

  Sakitani K, Hirata Y, Hikiba Y, Hayakawa Y, Ihara S, Suzuki H, Suzuki N, Serizawa T, Kinoshita H, Sakamoto K, Nakagawa H, Tateishi K, Maeda S, Ikenoue T, Kawazu S, Koike K.BMC Cancer. 2015 Oct 24;15:795. doi: 10.1186/s12885-015-1789-5.PMID: 26496833

• 28. Gastric cancer diagnosed after Helicobacter pylori eradication in diabetes mellitus patients.

  Sakitani K, Hirata Y, Suzuki N, Shichijo S, Yanai A, Serizawa T, Sakamoto K, Akanuma M, Maeda S, Yamaji Y, Iwamoto Y, Kawazu S, Koike K.BMC Gastroenterol. 2015 Oct 21;15:143. doi: 10.1186/s12876-015-0377-0.PMID: 26486595

• 29. Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation.

  Sakitani K, Hirata Y, Hayakawa Y, Serizawa T, Nakata W, Takahashi R, Kinoshita H, Sakamoto K, Nakagawa H, Akanuma M, Yoshida H, Maeda S, Koike K.Infect Immun. 2012 Nov;80(11):3795-803. doi: 10.1128/IAI.00637-12. Epub 2012 Aug 13.PMID: 22890997

• 30. Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration.

  Sakitani K, Hirata Y, Watabe H, Yamada A, Sugimoto T, Yamaji Y, Yoshida H, Maeda S, Omata M, Koike K.J Gastroenterol Hepatol. 2011 Oct;26(10):1570-5. doi: 10.1111/j.1440-1746.2011.06767.x.PMID: 21575058

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