石田 万里 いしだ まり 先生

来歴等

略歴

1987年 広島大学医学部医学科 卒業
1987年 静岡県立総合病院 研修医・医員(〜1990年)
1991年 広島大学大学院 修了 医学博士取得(〜1994年)
1994年 ワシントン州立ワシントン大学医学部 上級研究員(〜1998年)
1998年 広島大学医学部附属病院 医員(〜2002年)
2002年 広島大学原爆放射線医科学研究所 ゲノム障害病理教室 助手(〜2006年)
2006年 広島大学大学院 医歯薬学総合研究科 心臓血管生理医学 助教(〜2007年)
2007年 広島大学大学院 医歯薬学総合研究科 心臓血管生理医学 講師(〜2018年)
2018年 広島大学大学院 医系科学研究科 心臓血管生理医学 准教授

論文

• 1.Two-Year Experience in "Tweeting the Meeting" During the Scientific Sessions - Rapid Report From the Japanese Circulation Society ? Circ Rep. 2:691-694, 2020

  Mizuno A, Kishi T, Matsumoto C, Ishida M, Sanada S, Fukuda M, Sahashi Y, Sugimoto T, Hirano M, Yoshikawa Y, Yamamoto E, Kimura T, Node K.

• 2.Collaborators and Advisors of the COVID-19 Task Force Mission Team of the Japanese Circulation Society, and Directors of the Japanese Circulation Societies. Recommendations for Maintaining the Cardiovascular Care System Under the Conditions of the COVID-19 Pandemic- 1st Edition, April 2020. Circ J. 84: 2023-2026, 2020

  Kishi T, Mizuno A, Ishida M, Matsumoto C, Fukuda M, Sanada S, Itoh N, Oka H, Node K, Komuro I

• 3.Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation. PLoS One. 15: e0235553, 2020

  Bumdelger B, Otani M, Karasaki K, Sakai C, Ishida M, Kokubo H, Yoshizumi M.

• 4.Coronavirus Disease 2019 (COVID-19) Information for Cardiologists　- Systematic Literature Review and Additional Analysis. Circ J. 84:1039-1043, 2020

  Sugimoto T, Mizuno A, Kishi T, Ito N, Matsumoto C, Fukuda M, Kagiyama N, Shibata T, Ohmori T, Oishi S, Fuse J, Kida K, Kawai F, Ishida M, Sanada S, Komuro I, Node K.

• 5.Biological Effects of Low-Dose Chest CT on Chromosomal DNA. Radiology. 295:439-445, 2020

  Sakane H, Ishida M, Shi L, Fukumoto W, Sakai C, Miyata Y, Ishida T, Akita T, Okada M, Awai K, Tashiro S.

• 6.Potential Role of Twitter at an Annual Congress in Japan- Narrative Literature Review of “Tweet the Meeting” - Circ Rep. 1:401-404, 2019

  Mizuno A, Kishi T, Matsumoto C, Kawai F, Ishida M, Sanada S, Hokimoto S, Saito Y, Yamauchi-Takihara K, Komuro I, Node K.

• 7.JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension-the JSH Asahikawa declaration. Hypertens Res. 42:1483?1484, 2019

  Nakamura S, Hasebe N, Yatabe M, Kishi T, Ishida M, Ichihara A, Node K, Ishimitsu T, Itoh H, Ito M, Ohishi M, Ohkubo T, Kai H, Kashihara N, Kario K, Saitoh S, Tsuchihashi T, Nishiyama A, Higaki J, Miura K, Rakugi H, Kawano Y, Tamura K, Yatabe T, Ohya Y, Ito S.

• 8.DNA Damage and Senescence-Associated Inflammation in Cardiovascular Disease. Biol Pharm Bull. 42:531-537, 2019.

  Ishida T, Ishida M, Tashiro S, Takeishi Y.

• 9.Elevated Plasma Renin Activity Caused by Accelerated-malignant Hypertension in a Patient with Aldosterone-producing Adenoma Complicated with Renal Insufficiency. Intern Med. 58:3107-3111, 2019

  Maruhashi T, Amioka M, Kishimoto S, Ikenaga H, Oki K, Ishida M, Kihara Y, Higashi Y.

• 10.Genetic Prediction of Atherosclerosis - Significance of Polymorphisms in Bone Morphogenetic Protein Signaling Molecule Genes. Circ J. 83:709-710, 2019

  Ishida M.

• 11.Chromosomal Abnormalities in Human Lymphocytes after Computed Tomography Scan Procedure. Radiat Res. 190:424-432, 2018

  Shi L, Fujioka K, Sakurai-Ozato N, Fukumoto W, Satoh K, Sun J, Awazu A, Tanaka K, Ishida M, Ishida T, Nakano Y, Kihara Y, Hayes CN, Aikata H, Chayama K, Ito T, Awai K, Tashiro S.

• 12.XRCC3 polymorphism is associated with hypertension-induced left ventricular hypertrophy. Hypertens Res. 41:426-434, 2018 (*equally contributed, MI; corresponding author)

  Ariyandy A*, Sakai C*, Ishida M*, Mizuta R, Miyagawa K, Tashiro S, Kinomura A, Hiraaki K, Ueda K, Yoshizumi M, Ishida T.

• 13.Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells. PLoS One. 12:e0187934, 2017

  Sakai C, Ishida M, Ohba H, Yamashita H, Uchida H, Yoshizumi M, Ishida T.

• 14.DNA damage in lymphocytes induced by cardiac CT and comparison with physical exposure parameters. Eur Radiol. 27:1660-1666, 2017

  Fukumoto W, Ishida M, Sakai C, Tashiro S, Ishida T, Nakano Y, Tatsugami F, Awai K.

• 15.EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4. PLoS One. 11:e0165132, 2016

  Kamata R, Bumdelger B, Kokubo H, Fujii M, Yoshimura K, Ishida T, Ishida M, Yoshizumi M.

• 16.Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms. PLoS One. 11:e0147088, 2016

  Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M.

• 17.Smoking Cessation Reverses DNA Double-strand Breaks in Human Mononuclear Cells. PLoS One. 9:e103993, 2014

  Ishida M, Ishida T, Tashiro S, Uchida H, Sakai C, Hironobe N, Miura K, Hashimoto Y, Arihiro K, Chayama K, Kihara Y, Yoshizumi M.

• 18.Role of DNA damage in cardiovascular disease. Circ J. 78:42-50, 2014

  Ishida T, Ishida M, Tashiro S, Yoshizumi M, Kihara Y.

• 19.Induction of Timp1 in Smooth Muscle Cells during Development of Abdominal Aortic Aneurysms. Hiroshima Journal of Medical Sciences 62:63-67, 2013

  Bumdelger B, Kokubo H, Kamata R, Fujii M, Ishida M, Ishida T, Yoshizumi M.

• 20.The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction. Nucleic Acids Res. 37:3959-68. 2009

  Katsura M, Tsuruga T, Date O, Yoshihara T, Ishida M, Tomoda Y, Okajima M, Takaku M, Kurumizaka H, Kinomura A, Mishima HK, Miyagawa K .

• 21.Nifedipine interferes with migration of vascular smooth muscle cells via inhibition of Pyk2-Src axis. J Atheroscler Thromb. 16:230-238, 2009

  Soe NN, Ishida T, Ishida M, Sawano M, Abe K, Miho N, Chayama K, Kihara Y, Yoshizumi M.

• 22.Angiotensin II-induced Osteopontin Expression in Vascular Smooth Muscle Cells Involves Gq/11, Ras, ERK, Src and Ets-1. Hypertens. Res., 31:987-998, 2008

  Shimote-Abe K, Nakashima H, Sawano M, Ishida M, Soe NN, Yoshizumi M, Ishida T.

• 23.Haploinsufficiency of Rad51B Causes Centrosome Fragmentation and Aneuploidy in Human Cells. Cancer Res., 66: 6018-24, 2006.

  Date O, Katsura M, Ishida M, Yoshihara T, Kinomura A, Sueda T, Miyagawa K.

• 24.Haploinsufficiency of the Mus81-Eme1 endonuclease activates the intra-S-phase and G2/M checkpoints and promotes rereplication in human cells. Nucleic Acids Res. , 34: 880-92, 2006.

  Hiyama T, Katsura M, Yoshihara T, Ishida M, Kinomura A, Tonda T, Asahara T, Miyagawa K.

• 25.Role of the JNK pathway in thrombin-induced ICAM-1 expression in endothelial cells. Cardiovasc. Res., 68: 289-298, 2005.

  Miho N, Ishida T, Kuwaba N, Ishida M, Shimote-Abe K, Tabuchi K, Oshima T, Yoshizumi M, Chayama K.

• 26.Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension. Hypertens. Res. , 28: 889-94, 2005.

  Oshima T, Ozono R, Yano Y, Higashi Y, Teragawa H, Miho N, Ishida T, Ishida M, Yoshizimi M, Kambe M.

• 27.XRCC3 deficiency results in a defect in recombination and increased endoreduplication in human cells. EMBO J. , 23:670-80, 2004.

  Yoshihara T, Ishida M, Kinomura A, Katsura M, Tsuruga T, Tashiro S, Asahara T, Miyagawa K.

• 28.Matrix metalloproteinase-9 contributes to human atrial remodeling during atrial fibrillation. J. Am. Coll. Cardiol. , 43:818-25, 2004

  Nakano Y, Niida S, Dote K, Takenaka S, Hirao H, Miura F, Ishida M, Shingu T, Sueda T, Yoshizumi M, Chayama K.

• 29.Mnk1 is required for angiotensin II-induced protein synthesis in vascular smooth muscle cells. Circ. Res. , 93:1218-24, 2003.

  Ishida M, Ishida T, Nakashima H, Miho N, Miyagawa K, Chayama K, Oshima T, Kambe M, Yoshizumi M.

• 30.Effect of amlodipine and cilazapril treatment on platelet Ca2+ handling in spontaneously hypertensive rats. Hypertens Res. , 26:901-6, 2003.

  Oshima T, Ono N, Ozono R, Higashi Y, Ishida M, Ishida T,Miho N, Nakashima H, Yano Y, Kambe M.

• 31.Apoptosis is not increased in myocardium overexpressing type 2 angiotensin II receptor in transgenic mice. Hypertension, 37:6, 1394-8, 2001.

  Sugino H, Ozono R, Kurisu S, Matsuura H, Ishida M, Oshima T, Kambe M, Teranishi Y, Masaki H, Matsubara H.

• 32.The third cytoplasmic loop of the angiotensin II type 1 receptor exerts differential effects on extracellular signal-regulated kinase (ERK1/ERK2) and apoptosis via Ras- and Rap1-dependent pathways. Circ. Res. , 86:7, 729-36, 2000.

  Haendeler J, Ishida M, Hunyady L, Berk BC.

• 33.Angiotensin II induces transactivation of two different populations of the platelet-derived growth factor beta receptor. Key role for the p66 adaptor protein Shc. J. Biol. Chem., 275:21, 15926-32, 2000.

  Heeneman S, Haendeler J, Saito Y, Ishida M, Berk BC.

• 34.[Evaluation of vascular endothelial function] Rinsho Byori, 48:860-6, 2000.

  Oshima T, Higashi Y, Ozono R, Nakano Y, Ishida M, Kambe M, Matsuura H, Kajiyama G.

• 35.Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src. J. Clin. Invest. , 103:6, 789-97, 1999

  Ishida T, Ishida M, Suero J, Takahashi M, Berk BC.

• 36.Shear stress-mediated extracellular signal-regulated kinase activation is regulated by sodium in endothelial cells. Potential role for a voltage-dependent sodium channel. J. Biol. Chem., 274:29, 20144-50, 1999

  Traub O, Ishida T, Ishida M, Tupper JC, Berk BC.

• 37.Activation of extracellular signal-regulated kinases (ERK1/2) by angiotensin II is dependent on c-Src in vascular smooth muscle cells. Circ. Res., 82:1, 7-12, 1998

  Ishida M, Ishida T, Thomas SM, Berk BC.

• 38.Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK. Circ. Res., 82:12, 1272-8, 1998

  Schmitz U, Ishida T, Ishida M, Surapisitchat J, Hasham MI, Pelech S, Berk BC.

• 39.p38 Kinase is a negative regulator of angiotensin II signal transduction in vascular smooth muscle cells: effects on Na+/H+ exchange and ERK1/2. Circ. Res., 83:8, 824-31, 1998

  Kusuhara M, Takahashi E, Peterson TE, Abe J, Ishida M, Han J; Ulevitch R; Berk BC.

• 40.Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma-associated proteins. Characterization of a c-Src-dependent 97-kD protein in vascular smooth muscle cells. Circ. Res., 81:4, 550-7, 1997

  Schmitz U, Ishida M, Berk BC.

• 41.c-Src is required for oxidative stress-mediated activation of big mitogen-activated protein kinase 1. J. Biol. Chem., 272:33, 20389-94, 1997

  Abe J, Takahashi M, Ishida M, Lee JD, Berk BC.

• 42.Angiotensin II signal transduction in vascular smooth muscle cells: role of tyrosine kinases. Keio J Med, 46(2):61-8, 1997

  Ishida M, Berk BC.

• 43.Angiotensin II activates pp60c-src in vascular smooth muscle cells. Circ. Res., 77:1053-9, 1995.

  Ishida M, Marrero MB, Schieffer B, Ishida T, Bernstein KE, Berk BC.

• 44.Angiotensin I-converting enzyme gene polymorphism and salt sensitivity in essential hypertension. Hypertension, 27: 569-72, 1996

  Hiraga H, Oshima T, Watanabe M, Ishida M, Ishida T, Shingu T, Kambe M, Matsuura H, Kajiyama G.

• 45.Effects of insulin on calcium metabolism and platelet aggregation. Hypertension, 28:209-12, 1996

  Ishida M, Ishida T, Ono N, Matsuura H, Watanabe M, Kajiyama G, Kambe M, Oshima T.

• 46.Platelet Ca2+ is not increased in stroke-prone spontaneously hypertensive rats: comparative study with spontaneously hypertensive rats. Hypertension, 27:1312-7, 1996

  Ono N, Oshima T, Ishida M, Ishida T, Matsuura H, Kambe M, Kajiyama G.

• 47.Modulation of target tissue response to angiotensin II and sodium sensitivity in Japanese patients with essential hypertension. Hypertens. Res., 19:141-5, 1996

  Ozono R, Matsuura H, Oshima T, Ishibashi K, Ishida M, Ishida T, Watanabe M, Kajiyama G, Kambe M.

• 48.Dietary salt decreases cytosolic calcium in platelets from Dahl salt-sensitive rats. Am. J. Physiol., 269:R1225-9, 1995

  Ishida T, Ishida M, Matsuura H, Ozono R, Kajiyama G, Oshima T.

• 49.Effects of age and sex on sodium chloride sensitivity: association with plasma renin activity. Clin. Nephrol., 42:376-80, 1994

  Ishibashi K, Oshima T, Matsuura H, Watanabe M, Ishida M, Ishida T, Ozono R, Kajiyama G, Kanbe M.

• 50.Lack of increase in platelet Ca2+ and Na+ in deoxycorticosterone acetate-salt hypertensive rats. Am. J. Physiol., 267:R1288-93, 1994

  Ishida M, Ishida T, Matsuura H, Ozono R, Kajiyama G, Oshima T.

著書

• 1.石田万里，石田隆史，松浦秀夫，梶山梧朗：AII受容体拮抗薬のすべて　第二版，AII受容体拮抗薬の大規模臨床試験に学ぶもの，p.322-326， 先端医学社，2000

• 2.石田万里，木原康樹： がん患者の心臓を守る！腫瘍循環器学Q&A，放射線治療による心血管合併症について教えてください，p. 10-11, 文光堂，2018

• 3.福本航，石田万里，田代聡：最新 Body CT 診断，CTにおける被ばくの生物学的影響，p.84-89，メディカル・サイエンス・インターナショナル，2018

• 4.石田万里：高血圧学（上），血圧調節系と高血圧成因論に関する現状と展望：心血管系による血圧調節，p.190-194, 日本臨床社，2020

その他

• 【受賞】1991年 ヨーロッパ高血圧学会 Travel Awards for Young Investigators

• 【受賞】2003年 高血圧と動脈硬化研究会部会優秀賞

• 【受賞】2005年 武田科学振興財団報彰基金研究奨励賞

• 【受賞】2007年 広島大学女性研究者奨励賞