木村 健二郎 きむら けんじろう 先生

来歴等

略歴

1974年9月　東京大学医学部卒業、東京大学医学部附属病院研修医
1977年4月　独協医科大学循環器内科助手
1978年2月　東京大学医学部第二内科医員
1981年8月　デンマーク・コペンハーゲン大学医学部病理学研究所留学
1985年4月　東京大学医学部附属病院第二内科助手
1994年8月　東京大学医学部附属病院第二内科講師
1997年4月　東京大学大学院医学系研究科・腎臓内科学講師
1998年8月　東京大学医学部附属病院治験管理センター副センター長
2001年4月　聖マリアンナ医科大学教授、腎臓・高血圧内科部長
2003年8月　聖マリアンナ医科大学病院腎臓病センター長
2014年9月　独立行政法人　地域医療機能推進機構東京高輪病院　院長

論文

Kamijo A, Kimura K, Sugaya S, Yamanouchi M, Hase H, Kaneko T, Hirata Y, Goto A, Fujita T, Omata M : Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage. Kidney Int 2002; 62: 1628-1637
Kamijo A, Kimura K, Sugaya T, Yamanouchi M, Hikawa A, Hirano N, Hirata Y, Goto A, Omata M: Urinary fatty acid-binding protein as a new clinical marker of the progression of chronic renal disease. J Lab Clin Med 2004; 143: 23-30
Miyashita K, Tojo A, Kimura K, Goto A, Omata M, Nishiyama K, Fujita T: Blood Pressure Response to Erythropoetin Injection in Hemodialysis and Predialysis Patients. Hypertens Res 2004; 27: 80-84
Kamijo A, Sugaya T, Hikawa A, Okada M, Okumura F, Yamanouchi M, Honda A, Okabe M, Fujino T, Hirata Y, Omata M, Kaneko R, Fujii H, Fukamizu A, Kimura K: Urinary excretion of fatty acid-binding protein reflects stress overload on the proximal tubules. Am J Pathol 2004; 165: 1243-125
Tojo A, Onozato ML, Fukuda S, Asaba K, Kimura K, Fujita T: Nitric oxide generated by nNOS in the macula densa regulates the afferent arteriolar diameter in rat kidney. Med Electron Microsc 2004; 37: 236-241
Kusaba T, Konnno Y, Hatta S, Fujino T, Yasuda T, Miura H, Sasaki H, Okabayashi J, Murao M, Sakurada T, Imai G, Shirai S, Kuboshima S, Shima Y, Ogimoto G, Sato T, Masuhara K, Kimura K: More stable and reliable pharmacokinetics with preprandial administration of cyclosporine compared with postprandial administration in patients with refractory nephrotic syndrome. Pharmacotherapy 2005; 25: 52-58
Kamijo A, Sugaya T, Hikawa A, Yamanouchi M, Hirata Y, Ishimitsu T, Numabe A, Takagi M, Hayakawa H, Tabei F, Sugimoto T, Mise N, Kimura K: Clinical evaluation of urinary excretion of liver-type fatty acid-binding protein as a marker for the monitoring of chronic kidney disease: A multicenter trial. J Lab Clin Med 2005; 145: 125-133
Kamijo A, Sugaya T, Hikawa A, Yamanouchi M, Hirata Y, Ishimitsu T, Numabe A, Takagi M, Hayakawa H, Tabei F, Sugimoto T, Mise N, Omata M, Kimura K : Urinary liver-type fatty acid binding protein as a useful biomarker in chronic kidney disease. Mol Cell Biochem 2006; 284:175-182
Kamijo-Ikemori A, Sugaya T, Obama A, Hiroi J, Miura H, Ohtani-Kaneko R, Hirata K, Kimura K: Liver-Type Fatty Acid-Binding Protein Attenuates Renal Injury Induced by Unilateral Ureteral Obstruction. Am J Pathol 2006; 169: 1107-1117
Kamijo-Ikemori, A., T. Sugaya, Kimura, K.:Urinary fatty acid binding protein in renal disease. Clin Chim Acta 2006; 374: 1-7
Kusaba T, Hatta T, Sonomura K, Mori Y, Tokoro T, Nagata T Umeda Y, Nagata K, Yasuda T, Sato T, Kimura K, Matsubara H: Idiopathic nodular glomerulosclerosis: three Japanese cases and review of the literature. Clin Nephrol 2007; 67: 32-37
Miyamoto M, Yoshida Y, Taguchi I, Nagasaka Y, Tasaki M, Zhang Y, Xu B, Nameta M, Sezaki H, Cuellar L. M. Osawa T, Morishita H, Sekiyama S, Yaoita E, Kimura K, Yamamoto T: In-Depth Proteomic Profiling of the Normal Human Kidney Glomerulus Using Two-Dimensional Protein Prefractionation in Combination with Liquid Chromatography-Tandem Mass Spectrometry. J Proteome Res 2007; 6: 3680-3690
Kawakami T, Kawanabe T, Saito C, Kannari M, Mizoguchi M, Nagafuchi H, Okazaki T, Ozaki S, Kimura K, Soma Y: Clinical and histopathologic features of 8 patients with microscopic polyangiitis including two with a slowly progressive clinical course. J Am Acad Dermatol 2007; 5: 840-848
Sasaki H, Chikaraishi T, Furuhata H, Tsutsumi S, Miyano S, Nakano T, Sato Y, Kimura K, Takahashi T: Anaphylactic Reaction After Initial Exposure of Basiliximab: Case Reports. Transplantation Proceedings 2007; 39: 3457-3459
Nishimatsu H, Suzuki E, Takeda R, Takahashi M, Oba S, Kimura K, Nagano T, Hirata Y: Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese zucker rats. Hypertension Res 2008; 31: 737-743
Takeda R, Suzuki E, Takahashi M, Oba S, Nishimatsu H, Kimura K, Nagano T, Nagai R, Hirata Y: Calcineurin is critical for sodium-induced neointimal formation in normotensive and hypertensive rats. Am J Physiol Heart Circ Physiol 2008; 294: H2871-H2878
Takahashi M, Suzuki E, Takeda R, Oba S, Nishimatsu H, Kimura K, Nagano T, Nagai R, Hirata Y: Angiotensin II and tumor necrosis factor-α synergistically promote monocyte chemoattractant protein-1 expression: roles of NF-кB, p38, and reactive oxygen species. Am J Physiol Heart Circ Physiol 2008; 294: H2879-H2888
Sasaki H, Chikaraishi T, Furuhata S, Tsutsumi H, Miyano S, Nakazawa R, Nakano T, Kudo H, Kitajima K, Takahashi T, Satoh Y, Kimura K: Autologous blood transfusion for kidney transplant recipients. Transplantation Proceedings 2008; 40: 1371-1372
Kawakami T, Fujita A, Shirai S, Kimura K, Soma Y: Therapeutic effect of Mizoribine on bullous pemphigoid associated with membranous nephropathy. J Am Acad Dermatol 2009; 60: 523-524
Kamijo-Ikemori A, Sugaya T, Sekizuka A, Hirata K, Kimura K: Amelioration of diabetic tubulointerstitical damage in liver-type fatty acid-binding protein transgenic mice. Nephrol Dial Transplant 2009; 24:788-800
Shirai S, Yasuda T, Tsuchida H, Kuboshima S, Konno Y, Shima Y, Sato T, *Hatta S, Masuhara K, Kimura K: Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephritic syndrome. Clin Exp Nephrol 2009; 13: 123-129
Yokoyama T, Kamijo-Ikemori A, Sugaya T, Hoshino S, Yasuda T, Kimura K: Urinary excretion of liver type fatty acid binding protein accurately reflects the degree of tubulointerstitical damage. Am J Pathol 2009; 174: 2096-2106
Kawakami T, Shirai S, Kimura K, Soma Y: Successful Use of Mizoribine to Treat Recurrent Corticosteroid-Resistant Palpable Purpura in a Patient With Henoch-Schӧnlein Purpura Nephritis. Arch Dermatol 2010; 146: 212-213
Yamagata K, Makino H, Akizawa T, Iseki K, Itoh S, Kimura K, Koya D, Narita I, Mitarai T, Miyazaki M, Tsubakihara Y, Watanabe T, Wada T, Sakai O, Advisory Committee for FROM-J: Design and methods of a strategic outcome study for chronic kidney disease: Frontier of Renal Outcome Modification in Japan. Clin Exp Nephrol 2010;14：144-151
Matsui K, Shibagaki Y, Sasaki H, Chikaraishi T, Yasuda T, Kimura K: Mycophenolate mofetil-induced agranulocytosis in a renal transplant recipient. Clin Exp Nephrol 2010; 14: 637-640
Kamijo-Ikemori A, Sugaya T, Yasuda T, Kawata T, Ota A, Tatsunami S, Kaise R, Ishimitsu T, Tanaka Y, Kimura K: Clinical significance of urinary liver-type fatty acid-binding protein in diabetic nephropathy of type 2 diabetic patients. Diabetes Care 2011; 34: 691-696
Matsui K, Kamijo-Ikemori A, Sugaya T, Yasuda T, Kimura K: Renal liver-type fatty acid binding protein (L-FABP) attenuates acute kidney injury in aristolochic acid nephrotoxicity. Am J Pathol 2011; 178: 1021-1032
Matsui K, Kamijo-Ikemori A, Hara M, Sugaya T, Kodama T, Fujitani S, Taira Y, Yasuda T, Kimura K: Clinical significance of tubular and podocyte biomarkers in acute kidney injury. Clin Exp Nephrol 2011; 15: 220-225
Kamijo-Ikemori A, Sugaya T, Matsui K, Yokoyama T, Kimura K: Roles of human liver type fatty acid binding protein in kidney disease clarified using hL-FABP chromosomal transgenic mice. Nephrology 2011; 16: 539-544
Yazawa M, Kido R, Shibagaki Y, Yasuda T, Nakazawa R, Sasaki H, Sato Y, Chikaraishi T, Kimura K: Kidney function, albuminuria and cardiovascular risk factors in post-operative living kidney donors: a single-center, cross-sectional study. Clin Exp Nephrol 2011; 15: 514-521
Sakurada T, Kojima S, Oishi D, Koitabashi K, Miyamoto M, Shirai S, Shibagaki Y, Sato T, Kimura K: Prothrombin Fragment 1+2(F1-2) in effluent is a useful marker for peritoneal permeability in peritoneal dialysis patients using neutral dialysate. Advances in Peritoneal Dialysis 2011; 27: 2-5
Hiraki K, Kamijo-Ikemori A, Yasuda T, Hotta C, Izawa K P.,Watanabe S, Sugaya T, Kimura K: Moderate-intensity single exercise session does not induce renal damage. J Clin Lab Anal 2013; 27: 177-80
Kamijo-Ikemori A, Sugaya T, Ichikawa D, Hoshino S, Matsui K, Yokoyama T, Yasuda T, Hirata K, Kimura K: Urinary liver type fatty acid binding protein in diabetic nephropathy. Clin Chim Acta 2013; 424: 104-8
Yasuda T, Endoh M, Suzuki D, Yoshimura A, Ideura T, Tamura K, Kamata K, Toya Y, Umemura S, Kimura K: Effects of valsartan on progression of kidney disease in Japanese hypertensive patients with advanced, predialysis, chronic kidney disease: Kanagawa Valsartan Trial (KVT). Hypertension Research 2013; 36: 240-246
Miyamoto M, Sakurada T, Oishi D,Koitabashi K, Hanada K, Takemura H, Shibagaki Y, Yasuda T, Kimura K: The first case report of peritoneal dialysis related peritonitis caused by Microbacterium paraoxydans. Clin Nephrol 2013; 79: 402-406
Kawamura T, Joh K, Okonogi H, Koike K, Utsunomiya Y, Miyazaki Y, Matsushima M, Yoshimura M, Horikoshi S, Suzuki Y, Furusu A, Yasuda T, Shirai S, Shibata T, Endou M, Hattori M, Akioka Y, Katafuchi R, Hashiguchi A, Kimura K , Matsuo S, Tomino Y: A histologic classification of IgA nephropathy for predicting long-term prognosis:emphasis on end-stage renal disease. J Nephrol 2013; 26: 350-357
Hiraki K, Yasuda T, Hotta C, Izawa KP., Morio Y, Watanabe S, Sakurada T, Kimura K: Decreased physical function in pre-dialysis patients with chronic kidney disease. Clin Exp Nephrol 2013; 17: 225-231
Kojima S, Koitabashi K, Iizuka N, Okamoto K, Arito M, Sato T, Kurokawa, M, Suematsu N, Shibagaki Y, Yasuda T, Kimura K, Kato T: Proteomic analysis of whole glomeruli in patients with IgA nephropathy using microsieving. Am J Nephrol 2014; 39: 36-45
Kondo M, Yamagata K, Hoshi S, Saito C, Asahi K, Moriyama T, Tsuruya K, Konta T, Fijimoto S, Narita I, Kimura K, Iseki K, Watanabe T: Budget impact analysis of chronic kidney disease mass screening test in Japan. Clin Exp Nephrol 2014; 18: 885-891
Hanada K, Shirai S, Ito T, Tanabe K, Kimura K: Three cases of nerhrotic syndrome associated with hematological malignancies characterized by glomerular endocapillary proliferation and massive inflammatory cell infiltration. Clin Nephrol 2014; 81: 277-282
Kawakami T, Yamaguchi N, Soma Y, Yokoyama K, Shirai S, Kimura K: Immunoglobulin G4-related Disease Associated with Cutaneous Vasculitis. Acta Derm Venereol 2014; 94: 327-328
Ichikawa D, Kamijo-Ikemori A, Sugaya T, Shibagaki Y, Yasuda T, Katayama K, Hoshino S, Igarashi-Migitaka J, Hirata K, Kimura K:Renoprotective effect of renal liver-type fatty acid binding protein and angiotensin II type 1a receptor loss in renal injury caused by RAS activation. Am J Physiol Renal Physiol 2014; 306: F655-663
Yokota K, Fukuda M, Migita K, Tanaka E, Okamoto T, Kimura K: Three patients with familial Mediterranean fever:A possible underdiagnosed entity in Japan. Intern Med 2014; 53: 2013-2016
Hotta C, Hiraki K, Watanabe S, Izawa K P., Yasuda T, Osaka N, Omiya K, Kimura K: Knee extensor muscle strength and index of renal function associated with an exercise capacity of 5 metabolic equivalents in male chronic heart failure patients with chronic kidney disease. Clin Exp Nephrol 2014; 18: 313-319
Sakurada T, Okamoto T, Oishi D, Koitabashi K, Sueki S, Kaneshiro N, Matsui K, Nakazawa R, Yoshioka M, Konno Y, Sato Y, Shibagaki Y, Chikaraishi T, Kimura K:Subcutaneous pathway diversion for peritoneal dialysis catheter salvage. Advances in Peritoneal Dialysis 2014; 30: 11-14
Kondo M, Yamagata K, Hoshi S-L, Saito C, Asahi K, Moriyama T, Tsuruya K, Konta T, Fujimoto S, Narita I, Kimura K, Iseki K, Watanabe T:Budget impact analysis of chronic kidney disease mass screening test in Japan. Clin Exp Nephrol 2014; 18: 885-891
Haneda M, Utsunomiya K, Koya D, Babazono T, Moriya T, Makino H, Kimura K, Suzuki Y, Wada T, Ogawa S, Inada M, Kanno Y, Shigematsu T, Tsuchiya K, Honda K, Ichikawa K, Shide K:A new classification of Diabetic Nephropathy 2014:a report from Joint Committee on Diabetic Nephropayhy. Clin Exp Nephrol 2015;19:1-5
Yamauchi J, Ariella Coler-Reilly, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y: Mogamulizumab, an Anti-CCR4 antibody,targets human t-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy. The Journal of Infectious Diseases 2015; 211: 238-248
Wakamiya A, Hiraki K, Hotta C, Izawa K P, Watanabe S, Oishi D, Kaneshiro N, Konno Y, Sakurada T, Shibagaki Y, Kimura K:Poor nutritional status is associated with low physical activity in patients undergoing peritoneal dialysis.Int Journal of Cardiology 2015; 187: 648-650
Hotta C, Hiraki K, Wakamiya A, Otobe Y, Watanabe S, Izawa K P., Kaneshiro N, Konno Y, Sakurada T, Shibagaki Y, Kimura K:Relation of physical function and physical activity to sarcopenia in hemodialysis patients:A preliminary study. Int Journal of Cardiology 2015; 191: 198-200
Yano Y, Fujimoto S, Kramer H, Sato Y, Konta T, Iseki K, Iseki C, Moriyama T, Yamagata K, Tsuruya K, Narita I, Kondo M, Kimura K, Asahi K, Kurahashi I, Ohashi Y, Watanabe T: Long-term blood pressure variability,new-onset diabetes mellitus,and new-onset chronic kidney disease in the Japanese general population. Hypertension 2015; 66: 30-36
Hisamichi M, Yokoyama T, Yazawa M, Kaneshiro N, Sakurada T, Kondo Y, Shibagaki Y, Yasuda T, Kimura K: A rare case of peritoneal dialysis-related peritonitis caused by goldfish water tankderiverd Aeromonas hydrophila. Clin Nephrol 2015; 84: 50-54
Matsui K, Kamijo-Ikemori A, Imai N, Sugaya T, Yasuda T, Tatsunami S, Toyama T, Shimizu M, Furuichi K, Wada T, Shibagaki Y, Kimura K:Clinical significance of urinary liver-type fatty acid-binding protein as a predictor of ESRD and CVD in patients with CKD. Clin Exp Nephrol　2016; 20: 195-203
Kamijo-Ikemori A, Hashimoto N, Sugaya T, Matsui K, Hisamichi M, Shibagaki Y, Miyake F, Kimura K:Elevation of urinary liver-type fatty acid binding protein after cardiac catheterization related to cardiovascular events. Int J Nephrol Renovasc Dis 2015; 8: 91-99
Yamagata K, Makino H, Iseki K, Ito S, Kimura K, Kusano E, Shibata T, Tomita K, Narita I, Nishino T, Fujigaki Y, Mitarai T, Watanabe T, Wada T, Nakamura T, Matsuo S, Study Group for Frontier of Renal Outcome Modifications in Japan (FROM-J): Effect of behavior modification on outcome in early-to moderate-stage chronic kidney disease:a cluster-randomized trial. Plos One 2016; 11: 1-21
Hasegawa K, Tsukamoto K, kunimi M, Asahi K, Iseki K, Moriyama T, Yamagata K, Tsuruya K, Fujimoto S, Narita I, Konta T, Kondo M, Kimura K, Ohashi Y , Watanabe T:Control status of atherosclerotic cardiovascular risk factors among Japanese high-risk subjects:Analyses of a Japanese health check database from 2008 to 2011. J Atheroscler Thromb 2016; 23: 991-1003

著書

・腎生検から学ぶ腎臓病学.診断と治療社、２００２年（編著）
・腎疾患の早期発見とその対策－腎不全への進行を阻止するための総合的アプローチ－
メジカルビュー社、２００４年（編集）
・講義録 腎臓学．（株）メジカルビュー社、２００４年（編集）
・ワシントンマニュアル腎臓内科コンサルト．㈱メディカル・サイエンス・インターナショナル、２００６年（監訳）
・ガイドライン／ガイダンス　CKD．日本医事新報社、２０１１年（編者）
・PDハンドブック．東京医学社、東京、２０１２年（監訳）
・血液浄化療法に強くなる、羊土社、２０１３年（監修）
・臨床医のための腎移植ポケットマニュアル2014:1-461、東京医学社、２０１４年（監修）
・専門医が教える 慢性腎臓病でも長生きする方法、幻冬舎、２０１６年（監修・著）
・献立らくらく無理なく続ける腎臓病の食事、NHK出版、２０１６年（監修）

その他

• 【受賞】 ２０１４年　日本腎臓財団学術賞　「CKDおよびAKIのバイオマーカーとしての尿中L-FABPの臨床的および基礎的研究」