有賀 正 ありが ただし 先生

来歴等

略歴

1978年　北海道大学医学部卒業
1978年　北海道大学医学部小児科学講座で研修
1979年　札幌市近郊総合病院小児科（天使、市立小樽、幌南）で各1年勤務
1982年　北海道大学医学部付属病院小児科勤務（非常勤医員）
1987年　米国ハーバード大学ボストン小児病院勤務（研究員）
1989年　北海道社会保険中央病院小児科勤務
1990年　北海道大学医学部付属病院小児科勤務（非常勤医員）
1993年　札幌市豊平保健所勤務/北海道大学医学部小児科研究生
1998年　手稲渓仁会病院小児科勤務
1999年　北海道大学医学部遺伝子治療講座（寄附講座）客員助教授
2004年　北海道大学大学院医学研究科小児科学分野教授
2018年　北海道大学名誉教授
2018年　社会医療法人母恋理事長

論文

1. Fujioka H, Ariga T, Horiuchi K, Ishikiriyama S, Oyama K, Otus M, Kawashima K, Yamamoto Y, Sugihara T, Sakiyama Y Detection of a novel silent deletion, a missense mutation and a nonsense mutation in the TCOF1 gene. Pediatr Int 50, 806-809, 2008.
2. Sato D, Kawara H, Shimokawa O, Harada N, Tonoki H, Takahashi N, Imai Y, Kimura H, Matsumoto N, Ariga T, Niikawa N,Yoshiura K. A girl with Down syndrome and partial trisomy for 21pter-q22.13: A clue to narrow the Down syndrome critical region. Am J Med Genet A. 146:124-7, 2008
3. Minegishi Y, Saito M, Tsuchiya S, Tsuge I, Takada H, Hara T, Kawamura N, Ariga T, Pasic S, Stojkovic O, Metin A, Karasuyama H. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature. 448:1058-62, 2007.
4. Endo R, Ebihara T, Ishiguro N, Teramoto S, Ariga T, Sakata C, Hayashi A, Ishiko H, Kikuta H. Detection of four genetic subgroup-specific antibodies to human metapneumovirus attachment (G) protein in human serum. Journal of General Virology 89, 1970-1977. 2008.
5. Suzuki Y, Kobayashi R, Iguchi A, Sato T, Kaneda M, Kobayashi K, Ariga T. The syndrome of inappropriate secretion of antidiuretic hormone associated with SCT: clinical differences following SCT using cord blood and BM/peripheral blood. Bone Marrow Transplantation, 42, 743-748, 2008
6. Kida M, Fujioka H, Kosaka Y, Hayashi K, Sakiyama Y, Ariga T. The first confirmed case with C3 deficiency caused by compound heterozygous mutations in the C3 gene; a new aspect of pathogenesis for C3 deficiency. Blood Cell Mol. Dis. 40. 410-413, 2008
7. Kobayashi R, Kaneda M, Sato T, Ichikawa M, Suzuki D, Ariga T. The clinical feature of invasive fungal infection in pediatric patients with hematologic and malignant diseases: a 10-year analysis at a single institution at Japan. J Pediatr Hematol Oncol. 30, 886-90, 2008.
8. Nakajima M, Yamada M, Yamaguchi K, Sakiyama Y, Oda A, Nelson DL, Yawaka Y, Ariga T. Possible application of flow cytometry for evaluation of the structure and functional status of WASP in peripheral blood mononuclear cells. Eur J Haematol 87, 223-230, 2009
9. Morinishi Y, Imai K, Nakagawa N, Sato H, Horiuchi K, Ohtsuka Y, Kaneda Y, Taga T, Hisakawa H, Miyaji R, Endo M, Oh-ishi T, Kamachi Y, Akahane K, Kobayashi C, Tsuchida M, Morio T, Sasahara Y, Kumaki S, Ishigaki K, Yoshida M, Urabe T, Kobayashi N, Okimoto Y, Reichenbach J, Hashii Y, Tsuji Y, Kogawa K, Yamaguchi Seiji, Kanegane H, Miyawaki T, Yamada M, Ariga T, Nonoyama S. Identification of severe combined immunodeficiency by T-cell receptor excision circles quantification using neonatal Guthrie cards. J Pedatr, 155, 829-833, 2009.
10. Minegishi Y, Saito M, Nagasawa M, Takada H, Hara T, Tsuchiya S, Agematsu K, Yamada N, Kawamura N, Ariga T, Tsuge I, Karasuyama H. Molecular explanation for the contradiction between systemic Th17 defect and localized bacterial infection in hyper-IgE syndrome. J Exp Med 206, 1291-1301, 2009
11. Oshima J, Haruta M, Arai Y, Ksai F, Fujiwara Y, Ariga T, Okita H, Fukuzawa M, Hta J-I, Horie H, Kaneko Y. Two candidate tumor suppressor genes, MEOX2 and SOSTDCI, indentified in a 7p21 homozygous deletion region in a Wilms tumor. Genes Chromosomes Cancer 48, 1037-1050, 2009
12. Toita N, Kawamura N, Hatano N, Takezaki S, Ohkura Y, Yamada M, Okano M, Okada T, Sasaki F, Kubota KC, Itoh T, Ariga T. A five-year old boy with unicentric Castleman’s disease affecting the mesentery: Utility of serum IL-6 level and 18F-FDG PET for diagnosis. J Pediatr Hematol Oncol i31, 693-695, 2009.
13. Kida M, Tsutsumi T, Shindoh M, Ikeda H, Ariga T. De novo mutation in the DSPP gene associated with Dentinogenesis Imperfecta type II in a Japanese Family. Eur J Oral Sci, 117, 691-694, 2009.
14. Shirkoohi R, Endo R, Ishiguro N, Teramoto S, Kikuta H, Ariga T. Antibodies against structural and nonstructural proteins of human bocavirus in human sera. Clin Vaccine Immunol. 17 :190-193, 2010.
15. Roos D, Kuhns DB, Maddalena A, Roesler J, Lopez JA, Ariga T, Avcin T, de Boer M, Bustamante J, Condino-Neto A, Di Matteo G, He J, Hill RH, Holland SM, Kannengiesser C, Köker MY, Kondratenko I, van Leeuwen K, Malech HL, Marodi L, Nunoi H, Stasia M-J, Witwer CT, Wolach B and Gallin J. Hematologically important mutations: X-linked chronic granulomatous disease (third update) Blood Cell Mol Dis, 45: 246-265, 2010
16. Maekawa K, Yamada M, Okura, Sato Y, Nobuaki Kawamura N, Ariga T. X-linked agammaglobulinemia in a 10-year-old boy with a novel non-invariant splice-site mutation in Btk gene. Blood Cell Mol. Dis.44, 300-304, 2010.
17. Yamada M, Arai T, Oishi T, Hatano N, Kobayashi I, Kubota M, Suzuki N, Yoda M, Kawamura N, Ariga T. Determination of the deletion breakpoints in two patients with contiguous gene syndrome encompassing CYBB gene. Eur J Med Genet, 53 383-388, 2010
18. Lee S-K, Lee K-E, Kang H-Y, Hwang Y-H, Kida M, Tsutsumi T, Ariga T, Park J-C, Kim J-W. A Mutation in the DSPP Gene Affects Enamel Formation. Oral Dis. 17, 314-319, 2011
19. Kobayashi I, Okura Y, Yamazaki Y, Takezaki S, Yamada M, Kawamura N, Kuwana M, Ariga T. Anti-CADM-140/MDA5 antibody in juvenile dermatomyositis complicated with interstitial lung disease. J Pediatr. 158:675-7, 2011
20. Iguchi A, Kawamura N, Kobayashi R, Takezaki S, Ohkura Y, Inamoto J, Ohshima J, Ichikawa M, Sato T, Kaneda M, Cho Y, Yamada M, Kobayashi I, Ariga T. Successful reduced-intensity stem cell transplantation from unrelated cord blood in three patients with X-linked severe combined immunodeficiency. Bone Marrow Transplant. 46: 1526-31, 2011