尾﨑 由基男 おざき ゆきお 先生

来歴等

略歴

1977年　東京大学医学部卒業
1987年　東京大学　 医学博士取得
1987年　山梨医科大学　臨床検査医学講師
1991年　山梨医科大学　臨床検査医学　助教授　
1997年　山梨大学医学部　臨床検査医学　教授
2015年　笛吹中央病院　院長

論文

1. Ozaki, Y., Satoh, K., Qi, R., Yatomi, Y., Yanagi, S., Sada, K., Yamamura, H., Yanabu, M., Nomura, S. and Kume, S.: Anti-CD9 monoclonal antibody activates p72syk in human platelets. Journal of Biological Chemistry 270:15119-15124,1995　
2. Hisano, N., Yatomi, Y., Satoh, K., Akimoto, S., Mitsumata, M., Fujino, M., and Ozaki, Y.　Induction and suppression of endothelial cell apoptosis by sphingolipids: relevance to platelet-endothelial cell interaction. Blood 93, 4293-4299, 1999　　
3. Yatomi, Y., Ohmori, T., Ge, R., Kazama, F., Okamoto, H., Sano, T., Satoh, K., Igarashi, Tigyi, G., Y., Kume, S., and Ozaki, Y. Sphingosine 1-phosphate as a major bioactive lysophospholipid released from platelets and interacting with endothelial cells. Blood 　96, 3431-3438, 2000　
4. Wu, Y., Ozaki, Y., Yatomi, Y., et al. Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling. Blood 　97, 3836-3845, 2001
5. Suzuki-Inoue, K., Ozaki, Y., Yatomi, Y., Ohmori, T., and Satoh, K. Rac, a small GTP-binding protein, and p21-activated kinase are activated during platelet spreading on collagen-coated surfaces: roles of integrin alpha2 beta1. Blood 98, 3708-3716, 2001
6. Wu, Y., Asazuma, N., Yatomi, Y., Takafuta, T., Berndt, M., and Ozaki, Y. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase. Blood 　101, 3469-3476, 2003
7. Suzuki-Inoue, K., Fuller, GLJ., García, A., Eble, JA., Pöhlmann, S., Inoue, O., Gartner, T., Hughan. SC., Pearce. AC, Laing, GD, David, R., Theakston, G., Schweighoffer, E., Zitzmann, N., Morita, T., Tybulewicz, VLJ, Ozaki, Y., and Watson, SP. A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107, 542-549, 2006　
8. Suzuki-Inoue K, Kato Y, Inoue O, Kaneko MK, MIshima K, Yatomi Y, Yamazaki Y, Narimatsu H, and Ozaki Y. Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells. Journal of Biological Chemistry 282:25993-26001, 2007
9. Suzuki-Inoue K, Inoue O, Ding G, Nishimura S, Hokamura K, Eto K, Kashiwagi H, Tomiyama Y, Yatomi Y, Umemura K, Shin Y, Hirashima M, Ozaki Y. Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethalilty of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. Journal of Biological Chemsitry. 285:24494-507, 2010
10. 　Osada M, Inoue O, Ding G, Shirai T, Ichise H, Hirayama K, Takano K, Yatomi Y, Hirashima M, Fujii H, Suzuki-Inoue K, and Ozaki Y. Platelet activation receptor CLEC-2 regulates blood/lymphatic vessel separation by inhibiting proliferation, migration, and tube-formation of lymphatic endothelial cells. Journal of Biological Chemistry 287, 22241-22252, 2012
11. Tamura S, Suzuki-Inoue K, Tsukiji N, Shirai T, Sasaki T, Osada M, Satoh K, Ozaki Y.　Podoplanin-positive periarteriolar stromal cells promote megakaryocyte growth and proplatelet formation in mice by CLEC-2.　Blood. 127,1701-1710,2016

著書

血液内科ケーススタディ、　新興医学出版社、2006

その他

• 【受賞】 1990年　第一回日本臨床病理学会　学会賞

• 【受賞】1995年　臨床病理学研究振興会　小酒井賞

• 【受賞】2012年　オーストラリア血栓止血学会　Barry Firkin賞