藤田医科大学東京 先端医療研究センター 教授

小沢 洋子 おざわ ようこ 先生

公開日
2026/10/14

日本眼科学会 代議員・眼科専門医 日本網膜硝子体学会 理事 日本糖尿病眼学会 常務理事 日本眼循環学会 理事 日本眼薬理学会 評議員 日本眼炎症学会 会員 日本近視学会 会員 日本抗加齢医学会 副理事長・日本抗加齢医学会指導士 日本炎症・再生医学会 評議員 日本再生医療学会 再生医療認定医 日本微小循環学会 評議員 The Association for Research in Vision and Ophthalmology（ARVO） 会員 American Academy of Ophthalmology（AAO） 会員 The Macula Society 会員 The Retina Society 会員

来歴等

略歴

1992年 慶應義塾大学医学部 卒業
2001年 慶應義塾大学医学部 生理学教室 国内留学
2005年 慶應義塾大学医学部 眼科学教室 助手
2008年 慶應義塾大学医学部 眼科学教室 専任講師
2009年 網膜細胞生物学研究室 チーフ（兼任）
2016年 Schepens Eye Research Institute, Harvard Medical School Visiting Scholar （兼任）
2020年 聖路加国際病院 眼科部長
2020年 慶應義塾大学医学部 眼科学教室 特任准教授（兼任）
2023年 藤田医科大学東京 先端医療研究センター 臨床再生医学講座 羽田クリニック アイセンター 教授

論文

  • 1. Early changes in the central vision and the macula in diabetic retinal disease: associations with serum biomarkers. Frontiers in Endocrinology. 2026 in press.

    Nagai N, Shinoda H, Meguro S, Sonoda S, Sakamto T, Negishi K, Ozawa Y*.

  • 2. Low contrast visual acuity in healthy adults: Impact on non-pathologic myopia. PLoS One. September 21, 2026.

    Narimatsu T, Onozato N, Togawa H, Shimmura S, Ozawa Y*.

  • 3. Associations between Progression of Retinal Pigment Epithelial and Outer Retinal Atrophy and Choroidal Thickness: A 2-Year observation. Ophthalmology Science. 2026;6:100939.

    Nagai N, Shinoda H, Matsubara H, Terasaki H, Hirano T, Kato A, Miki A, Hirai H, Murao F, Imaizumi H, Gomi F, Mitamura Y, Ogata N, Kusuhara S, Yasukawa T, Murata T, Sakamoto T, Kondo M, Ozawa Y*.

  • 4. Associations between retinal thickness and background factors in eyes without retinal diseases. Sci Rep 2025 Jul 1;15(1):21796.

    Ozawa Y¶*, Onozato N, Togwa H, Shimmura S.

  • 5. Extent of complete retinal pigment epithelial and outer retinal atrophy with foveal center involvement is associated with visual acuity. Ophthalmology Science. 2025;5:100612.

    Nagai N, Matsubara H, Terasaki H, Hirano T, Kato A, Miki A, Hirai H, Murao F, Imaizumi H, Gomi F, Mitamura Y, Ogata N, Kusuhara S, Yasukawa T, Murata T, Sakamoto T, Kondo M, Shinoda H, Ozawa Y*.

  • 6. Recent daily life burdens associated with neovascular age-related macular degeneration involve difficulties in use of electronic devices. Sci Rep. 2024 Jun 20;14(1):14181.

    Ozawa Y¶*, Yoshihara K, Mezghani M, Pierzchała P, Nikodem M, Barbier S, Nomoto M, Aitoku Y.

  • 7.Diabetic choriocapillaris flow deficits affect the outer retina and are related to hemoglobin A1c and systolic blood pressure levels. Sci Rep. 2023 Dec 19;13(1):22570.

    Nagai N, Mushiga Y, Ozawa Y*.

  • 8. Evaluating fine changes in visual function of diabetic eyes using spatial-sweep steady-state pattern electroretinography. Sci Rep. 2023 Aug 22;13(1):13686.

    Nagai N, Mushiga Y, Ozawa Y*.

  • 9. Long-term surveillance provides real-world evidences of safety and effectiveness in intravitreal aflibercept treatment for age-related macular degeneration. Sci Rep. 2023 Jun 30;13(1):10597.

    Ozawa Y¶*, Ohgami K, Sasaki K, Hirano K, Sunaya T.

  • 10. Retinal Pigment Epithelial Abnormality and Choroidal Large Vascular Flow Imbalance Are Associated with Choriocapillaris Flow Deficits in Age-Related Macular Degeneration in Fellow Eyes. J Clin Med. 2023 Feb 8;12(4):1360.

    Nagai N, Mushiga Y, Ozawa Y*.

  • 11. Impact of treating age-related macular degeneration before visual function is impaired. J Clin Med. 2022, 11(19), 5726.

    Aichi R, Nagai N, Ohkoshi K, Ozawa Y*.

  • 12. Retinal circulation time/arm-to-retina time ratio in the fluorescein angiography to evaluate retina-specific hemodynamics. Sci Rep. 2022, Oct 19;12(1):17457.

    Mushiga Y, Nagai N, Ohkoshi K, Ozawa Y*.

  • 13. Choriocapillaris Flow Imbalance in Fellow Eyes in Age-related Macular Degeneration. Invest Ophthalmol Vis Sci. 2022 Aug 2;63(9):13.

    Harada N, Nagai N, Mushiga Y, Ozawa Y*.

  • 14. Effects of Epigenetic Modification of PGC-1α by a Chemical Chaperon on Mitochondria Biogenesis and Visual Function in Retinitis Pigmentosa Cells 2022, 11, 1497.

    Ozawa Y¶*, Toda E, Homma K, Osada H, Nagai N, Tsubota K, Okano H.

  • 15. Arm-to-retina time predicts visual outcome of anti-vascular endothelial growth factor treatment for macular edema due to central retinal vein occlusion. Sci Rep. 2022 Feb 9;12(1):2194.

    Takei T, Nagai N, Ohkoshi K, Ozawa Y*.

  • 16. Shorter axial length is a risk factor for proliferative vitreoretinopathy grade C in eyes unmodified by surgical invasion. J Clin Med. 2021, 10(17), 3944.

    Minami S, Uchida A, Nagai N, Shinoda H, Kurihara T, Ban N, Terasaki H, Takagi H, Tsubota K, Sakamoto T, Ozawa Y*.

  • 17. Neuroprotective effect of 4-phenylbutyric acid against photo-stress in the retina. Antioxidants. 2021 Jul 10(7), 1147.

    Guzman NA, Homma K, Osada H, Toda E, Ban N, Nagai N, Negishi K, Tsubota K, Ozawa Y*.

  • 18. ADIPOR1 deficiency-induced suppression of retinal ELOVL2 and docosahexaenoic acid levels during photoreceptor degeneration and visual loss. Cell Death Dis. 2021 May 7;12(5):458.

    Osada H, Toda E, Homma K, Guzman NA, Nagai N, Ogawa M, Negishi K, Arita M, Tsubota K, Ozawa Y*.

  • 19. Myopia, Corneal Endothelial Cell Density and Morphology in a Japanese Population-Based Cross-Sectional Study: The JPHC-NEXT Eye Study. Sci Rep. 2021 Mar 18;11(1):6366.

    Aketa N, Uchino M, Kawashima M, Uchino Y, Yuki K, Ozawa Y, Sasaki M, Yamagishi K, Sawada N, Tsugane S, Tsubota K, Iso H.

  • 20. Taurine rescues mitochondria-related metabolic impairments in the patient-derived induced pluripotent stem cells and epithelial-mesenchymal transition in the retinal pigment epithelium. Redox Biol. 2021. Feb 28; 41:101921.

    Homma K, Toda E, Osada H, Nagai N, Era T, Tsubota K, Okano H, Ozawa Y*.

  • 21. Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models. Commun Biol. 2020 Dec 9;3(1):767.

    Nagai N, Kawashima H, Toda E, Homma K, Osada H, Guzman N, Shibata S, Uchiyama Y, Okano H, Tsubota K, Ozawa Y*.

  • 22. Oxidative stress in the light-exposed retina and its implication in age-related macular degeneration. Redox Biol. 2020 Nov 2;101779.

    Ozawa Y¶*.

  • 23. Association between axial length and choroidal thickness in early age-related macular degeneration. PLoS One. 2020 Oct 9;15(10): e0240357.

    Sato M, Minami S, Nagai N, Suzuki M, Kurihara T, Shinojima A, Sonobe H, Akino K, Ban N, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y*.

  • 24. Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane. Br J Ophthalmol. 2020 Oct 5; bjophthalmol-2020-317478.

    Akino K, Nagai N, Watanabe K, Ban N, Kurihara T, Uchida A, Shinoda H, Tsubota K, Ozawa Y*.

  • 25. Ocular and Systemic Effects of Antioxidative Supplement Use in Young and Healthy Adults: Real-World Cross-Sectional Data. Antioxidants (Basel). 2020 Jun 3;9(6): E487.

    Minami S, Nagai N, Suzuki M, Uchida A, Shinoda H, Tsubota K, Ozawa Y*.

  • 26. The area and number of intraretinal cystoid spaces predict the visual outcome after ranibizumab monotherapy in diabetic macular edema. J Clin Med. 2020 May 8;9(5): E1391.

    Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y*.

  • 27. Correlation between macular pigment optical density and neural thickness and volume of the retina. Nutrients. 2020 Mar 25;12(4).

    Nagai N, Asato T, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y*.

  • 28. Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator. FASEB J. 2020 Apr;34(4):5016-5026.

    Kawashima H, Ozawa Y*, Toda E, Homma K, Osada H, Narimatsu T, Nagai N, Tsubota K.

  • 29. Angiopoietin-like protein 2 is a multistep regulator of inflammatory neovascularization in a murine model of age-related macular degeneration. J Biol Chem. 2016 Apr; 291(14)7373-85.

    Hirasawa M, Takubo K, Osada H, Miyake S, Toda E, Endo M, Umezawa K, Tsubota K, Oike Y, Ozawa Y*.

  • 30. Association of Macular Pigment Optical Density (MPOD) with serum concentration of oxidized low-density lipoprotein (oxidized LDL) in Healthy Adults. Retina. 2015 Apr; 35(4):820-6.

    Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y*.

著書

  • 1. Ozawa Y¶*. Oxidative Stress in the RPE and Its Contribution to AMD Pathogenesis: Implication of Light Exposure. Springer Japan. Neuroprtection and Neuroreguration for Retinal Diseases. 2014 239-253

  • 2. Ozawa Y¶*, Sasaki M. Lutein and Oxidative Stress-Mediated Retinal Neurodegeneration in Diabetes. PREEDY Diabetes. 2013, 223-228.

  • 3. Ozawa Y¶*, Tsubota K, Okano H. Angiogenesis in Response to Hypoxia. Encyclopedia of the Eye (4-volume Set) VISI: 00122.2010/06.

  • 4. 小沢洋子.　慢性炎症による眼疾患～加齢黄斑変性の病態メカニズム　基盤病態としての慢性炎症　別冊・医学のあゆみ　2023

  • 5. 小沢洋子. 最新の糖尿病網膜症治療―新たな分子標的薬の開発を含めて. 糖尿病網膜症診療Update―最新の知見からチーム医療の現状までー 2021

  • 6. 小沢洋子. 眼疾患とビタミン. ビタミンバイオファクタ―総合辞典. 朝倉書店 2021

  • 7. 小沢洋子. 後部ぶどう膜腫・裂孔原性網膜剥離・網膜中心静脈閉塞症・網膜静脈分枝閉塞症・網膜動脈閉塞症・眼虚血症候群・硝子体出血. 『今日の疾患辞典』デジタル版（商品名：Current Decision Support（CDS）2020.

  • 8. 小沢洋子. 第10回 眼底検査② 判読の極意. 臨床検査63(3):308-321,2019.

  • 9. 小沢洋子. 第9回眼底検査① 判読手順と異常のメカニズム. 臨床検査63(2):209-212,2019.

  • 10. 小沢洋子. 加齢黄斑変性とルテイン. 食と医療9:58-63, 2019.

  • 11. 小沢洋子. CRMとしての作用とメカニズム. レスベラトロールの基礎と応用 第2版:76-83, 2019.

  • 12. 小沢洋子. 医師が知っておきたいサプリメント・眼科領域．　機能性表示食品DATA BOOK第2版. メディカルビュー社 230-232: 2016.

  • 13. 小沢洋子. ドクターが教える　あなたのカラダとサプリメント. 日本抗加齢協会　監修 メディカルビュー社 30-36: 2016.

  • 14. 小沢洋子. 第一章 眼科研修へのアドバイス　7 MR（医療従事者）との関係. 眼科研修ノート改訂版第2版: 76-77, 2015

  • 15. 小沢洋子, 坪田一男. 先端医療NAVIGATOR　第3章再生医療6 iPS細胞を用いた網膜の再生医療. 105-107, 2013

受賞

  • 1. 2007年 慶應義塾大学医学部三四会奨励賞

  • 2. 2016年 The Global Ophthalmology Awards Program (Research Award)

学会発表

  • 1. Ozawa Y. Structure-function correlation of the retinal pigment epithelial and outer retinal atrophy with foveal center involvement. Asia Pacific Retinal Imaging Society 2026. 13th International Symposium. Korea 2026.

  • 2. Ozawa Y. Structure-function correlation of the retinal pigment epithelial and outer retinal atrophy with foveal center involvement. FujiRetina 2025 Tokyo, Japan.

  • 3. Ozawa Y. Choriocapillaris Flow Imbalance and Asymmetrically Dilated Choroidal Vasculature in Fellow Eyes in Age-related Macular Degeneration。FujiRetina 2024, Tokyo, Japan.

  • 4. Ozawa Y. To explore very early changes of age-related macular degeneration.The 4th Asia Retina Congress 2024, Seoul, Korea. 2024.

  • 5. Ozawa Y. Anti-VEGF therapy for Diabetic Macular Edema (DME)。Novartis Expert Engagement| Novartis India. WEB 2023.

  • 6. Ozawa Y. Impact of intraretinal fluid control on outer retinal structure and visual function in diabetic macular edema (DME). International Ocular Inflammation Society. Berlin, Germany, 2023.

  • 7. Ozawa Y. Diabetic macular edema with proliferative diabetic retinopathy. Asia Retinal Congress, Alcon Luncheon Seminar. Yokohama, Japan, November 26, 2023.

  • 8. Ozawa Y. Impact of lipid metabolism in age-related macular degeneration. FujiRetina 2022. Tokyo, Japan.

  • 9. Ozawa Y. Choriocapillaris Flow Imbalance in Fellow Eyes in Age-related Macular Degeneration. Asia Pacific Retinal Imaging Society 2022. 9th International Symposium. Korea (Web) 2022.

  • 10. Ozawa Y. Cell biology for transplantation. Symposium: Japanese Retina Vitreo Society – Advances in Cells, Gene and Transplant Therapy. Euretina 2022. Hamburg, Germany 2022.

  • 11. Ozawa Y. Neuroprotective approaches for retinal diseases. The 15th Joint Meeting of Chinese-Japanese-Korean Ophthalmologists, Beijing, China (Web), 2022.

その他

  • 1. 【雑誌取材】2024年 月刊文藝春秋 「目耳口のアンチエイジング」

  • 2. 【ラジオ出演】2023年 ラジオ日本放送 坂本梨紗のヘルシー・メルシー!「加齢黄斑変性」

  • 3.【新聞取材】2022年 毎日新聞「今日のセカンドオピニオン」

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