平田 一人 ひらた かずと 先生

来歴等

略歴

1978年 大阪市立大学医学部 卒業
1983年 大阪市立大学医学部附属病院医学研究科 修了
1987年 カナダシャーブルック大学医学部薬理学教室、Postdoctoral research fellow（文部省在外研究員）
2006年 大阪市立大学大学院医学研究科呼吸器内科学 教授
2012年 大阪市立大学医学部附属病院 副院長
2018年 公立大学法人大阪市立大学 理事、大阪市立大学医学部附属病院 病院長、大阪市立大学 名誉教授
2019年 公立大学法人大阪理事、大阪市立大学医学部附属病院 病院長
2022年 医療法人藤井会 石切生喜病院 病院長

論文

• 1. Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung.

  Suzuki S, Asai K, Gi M, Kojima K, Kakehashi A, Oishi Y, Matsue T, Yukimatsu N, Hirata K, Kawaguchi T, Wanibuchi H.J Toxicol Pathol. 2022 Jul;35(3):247-254. doi: 10.1293/tox.2021-0077. Epub 2022 May 21.PMID: 35832896 Free PMC article.

• 2. Possible role of insulin resistance in activation of plasma xanthine oxidoreductase in health check-up examinees.

  Kurajoh M, Fukumoto S, Akari S, Murase T, Nakamura T, Takahashi K, Yoshida H, Nakatani S, Tsuda A, Morioka T, Mori K, Imanishi Y, Hirata K, Emoto M.Sci Rep. 2022 Jun 18;12(1):10281. doi: 10.1038/s41598-022-11094-y.PMID: 35717455 Free PMC article.

• 3. Phase II Study of the Modified Weekly Nab-paclitaxel Regimen in Previously Treated Patients With Advanced Non-Small Cell Lung Cancer.

  Yoshimura N, Sawa K, Nakai T, Matsumoto Y, Mitsuoka S, Kimura T, Asai K, Yana T, Kawaguchi T, Hirata K.Am J Clin Oncol. 2021 Dec 1;44(12):613-618. doi: 10.1097/COC.0000000000000876.PMID: 34753884 Clinical Trial.

• 4. Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry.

  Kurajoh M, Fukumoto S, Yoshida S, Akari S, Murase T, Nakamura T, Ishii H, Yoshida H, Nagata Y, Morioka T, Mori K, Imanishi Y, Hirata K, Emoto M.Sci Rep. 2021 Apr 1;11(1):7378. doi: 10.1038/s41598-021-86962-0.PMID: 33795813 Free PMC article.

• 5. Plasma xanthine oxidoreductase activity change over 12 months independently associated with change in serum uric acid level: MedCity21 health examination registry.

  Kurajoh M, Fukumoto S, Murase T, Nakamura T, Nagata Y, Nakatani S, Tsuda A, Yamada S, Morioka T, Mori K, Imanishi Y, Kawada N, Hirata K, Emoto M.Clin Chem Lab Med. 2020 Aug 1;59(4):e137-e140. doi: 10.1515/cclm-2020-0563. Print 2021 Mar 26.PMID: 32735550 No abstract available.

• 6. Association of plasma xanthine oxidoreductase activity with blood pressure affected by oxidative stress level: MedCity21 health examination registry.

  Yoshida S, Kurajoh M, Fukumoto S, Murase T, Nakamura T, Yoshida H, Hirata K, Inaba M, Emoto M.Sci Rep. 2020 Mar 10;10(1):4437. doi: 10.1038/s41598-020-61463-8.PMID: 32157204 Free PMC article.

• 7. Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis.

  Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T.Int J Chron Obstruct Pulmon Dis. 2019 Nov 14;14:2507-2516. doi: 10.2147/COPD.S226623. eCollection 2019.PMID: 31814716 Free PMC article.

• 8. Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice.

  Kubo H, Asai K, Kojima K, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T.Mar Drugs. 2019 Nov 28;17(12):673. doi: 10.3390/md17120673.PMID: 31795292 Free PMC article.

• 9. Predictive impact of low-frequency pretreatment T790M mutation in patients with EGFR-mutated non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors.

  Matsumoto Y, Sawa K, Fukui M, Oyanagi J, Yoshimoto N, Suzumura T, Watanabe T, Kaneda H, Mitsuoka S, Asai K, Kimura T, Yamamoto N, Hirata K, Koh Y, Kawaguchi T.Lung Cancer. 2020 Jan;139:80-88. doi: 10.1016/j.lungcan.2019.10.029. Epub 2019 Nov 2.PMID: 31751804

• 10. Effect of tiotropium/olodaterol on sedentary and active time in patients with COPD: post hoc analysis of the VESUTO® study.

  Minakata Y, Motegi T, Ueki J, Gon Y, Nakamura S, Anzai T, Hirata K, Ichinose M.Int J Chron Obstruct Pulmon Dis. 2019 Aug 7;14:1789-1801. doi: 10.2147/COPD.S208081. eCollection 2019.PMID: 31496678 Free PMC article. Clinical Trial.

• 11. Isoflavone Aglycones Attenuate Cigarette Smoke-Induced Emphysema via Suppression of Neutrophilic Inflammation in a COPD Murine Model.

  Kojima K, Asai K, Kubo H, Sugitani A, Kyomoto Y, Okamoto A, Yamada K, Ijiri N, Watanabe T, Hirata K, Kawaguchi T.Nutrients. 2019 Aug 29;11(9):2023. doi: 10.3390/nu11092023.PMID: 31470503 Free PMC article.

• 12. Handgrip strength measurement in patients with chronic obstructive pulmonary disease: Possible predictor of exercise capacity.

  Kyomoto Y, Asai K, Yamada K, Okamoto A, Watanabe T, Hirata K, Kawaguchi T.Respir Investig. 2019 Sep;57(5):499-505. doi: 10.1016/j.resinv.2019.03.014. Epub 2019 May 10.PMID: 31085119

• 13. Efficacy and safety of ultrasound (US) guided percutaneous needle biopsy for peripheral lung or pleural lesion: comparison with computed tomography (CT) guided needle biopsy.

  Yamamoto N, Watanabe T, Yamada K, Nakai T, Suzumura T, Sakagami K, Yoshimoto N, Sato K, Tanaka H, Mitsuoka S, Asai K, Kimura T, Kanazawa H, Hirata K, Kawaguchi T.J Thorac Dis. 2019 Mar;11(3):936-943. doi: 10.21037/jtd.2019.01.88.PMID: 31019783 Free PMC article.

• 14. Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults.

  Tanaka F, Fukumoto S, Morisaki T, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Nakano A, Kimura T, Yamagami H, Tanigawa T, Morikawa H, Watanabe T, Kawada N, Hirata K, Fujiwara Y.Esophagus. 2019 Jul;16(3):309-315. doi: 10.1007/s10388-019-00662-3. Epub 2019 Mar 29.PMID: 30927164

• 15. COPD uncovered: a cross-sectional study to assess the socioeconomic burden of COPD in Japan.

  Igarashi A, Fukuchi Y, Hirata K, Ichinose M, Nagai A, Nishimura M, Yoshisue H, Ohara K, Gruenberger JB.Int J Chron Obstruct Pulmon Dis. 2018 Aug 28;13:2629-2641. doi: 10.2147/COPD.S167476. eCollection 2018.PMID: 30214181 Free PMC article.

• 16. Association between Functional Dyspepsia and Gastric Depressive Erosions in Japanese Subjects.

  Tanaka F, Tominaga K, Fujikawa Y, Morisaki T, Otani K, Hosomi S, Nagami Y, Kamata N, Taira K, Nakano A, Kimura T, Yamagami H, Tanigawa T, Morikawa H, Fukumoto S, Watanabe T, Kawada N, Hirata K, Fujiwara Y.Intern Med. 2019 Feb 1;58(3):321-328. doi: 10.2169/internalmedicine.1325-18. Epub 2018 Sep 12.PMID: 30210122 Free PMC article.

• 17. Efficacy of tiotropium/olodaterol on lung volume, exercise capacity, and physical activity.

  Ichinose M, Minakata Y, Motegi T, Ueki J, Gon Y, Seki T, Anzai T, Nakamura S, Hirata K.Int J Chron Obstruct Pulmon Dis. 2018 May 1;13:1407-1419. doi: 10.2147/COPD.S166023. eCollection 2018.PMID: 29750027 Free PMC article. Clinical Trial.

• 18. Correlation between disease activity and serum ferritin in clinically amyopathic dermatomyositis with rapidly-progressive interstitial lung disease: a case report.

  Yamada K, Asai K, Okamoto A, Watanabe T, Kanazawa H, Ohata M, Ohsawa M, Hirata K.BMC Res Notes. 2018 Jan 16;11(1):34. doi: 10.1186/s13104-018-3146-7.PMID: 29338781 Free PMC article.

• 19. Current usage and effectiveness of influenza medications and factors regarding the time taken to alleviate fever based on postcard questionnaire survey.

  Tochino Y, Fujioka M, Sakazaki H, Ikuno Y, Tochino R, Yoshii N, Shintaku H, Hirata K.J Gen Fam Med. 2017 Jun 21;18(6):386-392. doi: 10.1002/jgf2.109. eCollection 2017 Dec.PMID: 29264069 Free PMC article.

• 20. Asthma-COPD overlap syndrome-Coexistence of chronic obstructive pulmonary disease and asthma in elderly patients and parameters for their differentiation.

  Tochino Y, Asai K, Shuto T, Hirata K.J Gen Fam Med. 2017 Mar 24;18(1):5-11. doi: 10.1002/jgf2.2. eCollection 2017 Mar.PMID: 29263981 Free PMC article. Review.

• 21. PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort.

  Sawa K, Koh Y, Kawaguchi T, Kambayashi S, Asai K, Mitsuoka S, Kimura T, Yoshimura N, Yoshimoto N, Kubo A, Saka H, Matsumura A, Wanibuchi H, Yamamoto N, Nishiyama N, Hirata K.Lung Cancer. 2017 Oct;112:96-101. doi: 10.1016/j.lungcan.2017.07.039. Epub 2017 Aug 7.PMID: 29191607

• 22. Dose Escalation Study of Concurrent Chemoradiotherapy With the Use of Involved-field Conformal Radiotherapy and Accelerated Hyperfractionation in Combination With Cisplatin and Vinorelbine Chemotherapy for Stage III Non-small Cell Lung Cancer: The Final Report.

  Yoshimura N, Tada T, Matsumoto Y, Sawa K, Yoshimoto N, Suzumura T, Tanaka H, Mitsuoka S, Kimura T, Tamiya T, Hirashima T, Kawaguchi T, Kudoh S, Hosono M, Hirata K.Am J Clin Oncol. 2018 Oct;41(10):967-971. doi: 10.1097/COC.0000000000000412.PMID: 29045265 Clinical Trial.

• 23. Interstitial Lung Disease Induced by Osimertinib for Epidermal Growth Factor Receptor (EGFR) T790M-positive Non-small Cell Lung Cancer.

  Matsumoto Y, Kawaguchi T, Yamamoto N, Sawa K, Yoshimoto N, Suzumura T, Watanabe T, Mitsuoka S, Asai K, Kimura T, Yoshimura N, Kuwae Y, Hirata K.Intern Med. 2017 Sep 1;56(17):2325-2328. doi: 10.2169/internalmedicine.8467-16. Epub 2017 Aug 10.PMID: 28794368 Free PMC article.

• 24. Study Design of VESUTO®: Efficacy of Tiotropium/Olodaterol on Lung Hyperinflation, Exercise Capacity, and Physical Activity in Japanese Patients with Chronic Obstructive Pulmonary Disease.

  Ichinose M, Minakata Y, Motegi T, Ueki J, Seki T, Anzai T, Takizawa A, Grönke L, Hirata K.Adv Ther. 2017 Jul;34(7):1622-1635. doi: 10.1007/s12325-017-0554-3. Epub 2017 May 23.PMID: 28537001 Free PMC article.

• 25. Decreased levels of irisin, a skeletal muscle cell-derived myokine, are related to emphysema associated with chronic obstructive pulmonary disease.

  Sugiyama Y, Asai K, Yamada K, Kureya Y, Ijiri N, Watanabe T, Kanazawa H, Hirata K.Int J Chron Obstruct Pulmon Dis. 2017 Mar 2;12:765-772. doi: 10.2147/COPD.S126233. eCollection 2017.PMID: 28424548 Free PMC article.

• 26. Identification of a Novel Rhizopus-specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis.

  Sato K, Oinuma KI, Niki M, Yamagoe S, Miyazaki Y, Asai K, Yamada K, Hirata K, Kaneko Y, Kakeya H.Med Mycol. 2017 Oct 1;55(7):713-719. doi: 10.1093/mmy/myw146.PMID: 28199672

• 27. Alectinib-Induced Erythema Multiforme and Successful Rechallenge with Alectinib in a Patient with Anaplastic Lymphoma Kinase-Rearranged Lung Cancer.

  Kimura T, Sowa-Osako J, Nakai T, Ohyama A, Kawaguchi T, Tsuruta D, Ohsawa M, Hirata K.Case Rep Oncol. 2016 Dec 8;9(3):826-832. doi: 10.1159/000453314. eCollection 2016 Sep-Dec.PMID: 28101031 Free PMC article.

• 28. Atrial natriuretic peptide protects against bleomycin-induced pulmonary fibrosis via vascular endothelial cells in mice : ANP for pulmonary fibrosis.

  Okamoto A, Nojiri T, Konishi K, Tokudome T, Miura K, Hosoda H, Hino J, Miyazato M, Kyomoto Y, Asai K, Hirata K, Kangawa K.Respir Res. 2017 Jan 3;18(1):1. doi: 10.1186/s12931-016-0492-7.PMID: 28049526 Free PMC article.

• 29. Efficacy and safety of indacaterol/glycopyrronium in Japanese patients with COPD: Pooled analysis of SHINE and ARISE.

  Asai K, Hirata K, Hashimoto S, Fukuchi Y, Kitawaki T, Ikeda K, Fogel R, Banerji D.Respir Investig. 2016 Nov;54(6):428-435. doi: 10.1016/j.resinv.2016.06.006. Epub 2016 Aug 24.PMID: 27886854

• 30. Impaired nuclear factor erythroid 2-related factor 2 expression increases apoptosis of airway epithelial cells in patients with chronic obstructive pulmonary disease due to cigarette smoking.

  Yamada K, Asai K, Nagayasu F, Sato K, Ijiri N, Yoshii N, Imahashi Y, Watanabe T, Tochino Y, Kanazawa H, Hirata K.BMC Pulm Med. 2016 Feb 9;16:27. doi: 10.1186/s12890-016-0189-1.PMID: 26861788 Free PMC article.