細矢 匡 ほそや ただし 先生

細矢 匡, 上阪 等. 【自己免疫疾患-新たな発症メカニズムと治療戦略】(第3章)自己免疫抑制のためのテクノロジーと治療戦略 細胞周期制御療法と抗サイトカイン療法の併用による関節炎の新規治療戦略 実験医学. 2015.08; 33 (12): 1992-1998.

Mari Kihara, Takahiko Sugihara, Tadashi Hosoya, Nobuyuki Miyasaka. Clinical significance of complement as a biomarker of disease activity in 4 cases of IgG4-related disease with retroperitoneal fibrosis. Clin. Exp. Rheumatol.. 2013.11; 31 (6): 947-949.

Toshihiro Nanki, Ikumi Onoue, Kenji Nagasaka, Aiko Takayasu, Masashi Ebisawa, Tadashi Hosoya, Toshizumi Shirai, Takahiko Sugihara, Shinya Hirata, Tetsuo Kubota, Masayoshi Harigai, Nobuyuki Miyasaka. Suppression of elevations in serum C reactive protein levels by anti-IL-6 autoantibodies in two patients with severe bacterial infections. Ann. Rheum. Dis.. 2013.06; 72 (6): 1100-1102.

Kayoko Kaneko, Toshihiro Nanki, Tadashi Hosoya, Fumitaka Mizoguchi, Nobuyuki Miyasaka. Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis. Mod Rheumatol. 2010.12; 20 (6): 632-636.

Kaneko Kayoko, Nanki Toshihiro, Hosoya Tadashi, Mizoguchi Fumitaka, Miyasaka Nobuyuki. 関節リウマチ患者2例におけるエタネルセプトで誘発された壊死性半月体形成性糸球体腎炎(Etanercept-induced necrotizing crescentic glomerulonephritis in two patients with rheumatoid arthritis) Modern Rheumatology. 2010.12; 20 (6): 632-636.

保田 晋助, 大庭 聖也, 細矢 匡. COVID-19による血栓症について インフルエンザ. 2021.10; 22 (3): 165-169.

細矢 匡. 【厚生労働省指定難病の診断基準と重症度】多発性筋炎・皮膚筋炎 分子リウマチ治療. 2017.01; 10 (1): 6-9.

高田 秀人, 細矢 匡, 木村 直樹, 川畑 仁人, 上阪 等. 多発性筋炎関連血栓性血小板減少性紫斑病(TTP)にリツキシマブが奏効した症例 関東リウマチ. 2016.03; (49): 62-69.

高田 秀人, 細矢 匡, 木村 直樹, 川畑 仁人, 上阪 等. 多発性筋炎関連血栓性血小板減少性紫斑病(TTP)にリツキシマブが奏効した症例 関東リウマチ. 2016.03; 49 62-69.

細矢 匡. 【全身性自己免疫難病の診断・重症度基準アップデート】多発性筋炎・皮膚筋炎 炎症と免疫. 2015.10; 23 (6): 512-516.

Tadashi Hosoya, Fumitaka Mizoguchi, Hisanori Hasegawa, Keiko Miura, Ryuji Koike, Tetsuo Kubota, Nobuyuki Miyasaka, Hitoshi Kohsaka. A Case Presenting with the Clinical Characteristics of Tumor Necrosis Factor (TNF) Receptor-associated Periodic Syndrome (TRAPS) without TNFRSF1A Mutations Successfully Treated with Tocilizumab. Intern. Med.. 2015; 54 (16): 2069-2072.

細矢 匡. 【キナーゼ阻害によるリウマチ性疾患の治療-現在と未来-】CDK 分子リウマチ治療. 2014.10; 7 (4): 202-206.

Tadashi Hosoya, Nobuyuki Miyasaka. [TNF and TNF receptor signaling pathway]. Nippon Rinsho. 2012.11; 70 Suppl 8 186-191.

細矢 匡, 宮坂 信之. 【分子標的薬-がんから他疾患までの治癒をめざして-】基礎研究 分子標的薬の作用機序・薬理作用 免疫炎症関連標的分子・標的経路 TNFと受容体経路 日本臨床. 2012.11; 70 (増刊8 分子標的薬): 186-191.

細矢 匡, 上阪 等. 【低分子抗炎症薬の進歩】CDK阻害薬の発見から臨床応用の可能性まで 炎症と免疫. 2012.04; 20 (3): 278-283.

細矢 匡, 横山 和佳, 神田 直, 増田 義重, 杉原 毅彦. 中枢神経ループス、ループス肺臓炎、血球貪食症候群で発症した高齢発症SLEの一例 関東リウマチ. 2011.03; 44 107-115.

木原 まり, 木村 直樹, 細矢 匡, 杉原 毅彦, 増田 義重, 稲松 孝思. 低補体血症が疾患活動性の指標となりシクロホスファミドが有効であったIgG4関連自己免疫性膵炎と後腹膜線維症の一例 関東リウマチ. 2010.03; 43 173-181.

細矢 匡, 南木 敏宏, 尾上 育美, 長坂 憲治, 窪田 哲朗, 針谷 正祥, 赤星 透, 宮坂 信之. 黄色ブドウ球菌による全身性多発膿瘍を認めたが、CRP陰性で抗IL-6抗体が同定された悪性関節リウマチの一例 関東リウマチ. 2010.03; 43 17-24.

青島 正大, 青柳 佳樹, 細矢 匡. 【高齢者呼吸器疾患の病態と治療・管理】高齢者市中肺炎の診断と治療 呼吸器科. 2007.12; 12 (6): 491-498.

Fumi Sato-Kaneko, Xiaodong Wang, Shiyin Yao, Tadashi Hosoya, Fitzgerald S. Lao, Karen Messer, Minya Pu, Nikunj M. Shukla, Howard B. Cottam, Michael Chan, Dennis A. Carson, Maripat Corr, and Tomoko Hayashi. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy BioMed Research International. 2018.09;

Tomoko Niwano, Tadashi Hosoya, Saori Kadowaki, Etsushi Toyofuku, Takuya Naruto, Masaki Shimizu, Hidenori Ohnishi, Ryuji Koike, Tomohiro Morio, Kohsuke Imai, Masayuki Yoshida, Shinsuke Yasuda. An adult case of suspected A20 haploinsufficiency mimicking polyarteritis nodosa. Rheumatology (Oxford). 2022.05;

Fumiaki Kondo, Takahiko Sugihara, Natsuka Umezawa, Hisanori Hasegawa, Tadashi Hosoya, Naoki Kimura, Masaaki Mori, Shinsuke Yasuda. Associated factors with poor treatment response to initial glucocorticoid therapy in patients with adult-onset Still's disease. Arthritis Res Ther. 2022.04; 24 (1): 92.

Seiji Noda, Tadashi Hosoya, Yoji Komiya, Yasuhiro Tagawa, Kentaro Endo, Keiichiro Komori, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Tetsuya Saito, Fumitaka Mizoguchi, Shinsuke Yasuda. synovial fibroblast subset in arthritic joints has high osteoblastic and chondrogenic potentials in vitro. Arthritis Res Ther. 2022.02; 24 (1): 45.

Tetsuya Saito, Nikunj M Shukla, Fumi Sato-Kaneko, Yukiya Sako, Tadashi Hosoya, Shiyin Yao, Fitzgerald S Lao, Karen Messer, Minya Pu, Michael Chan, Paul J Chu, Howard B Cottam, Tomoko Hayashi, Dennis A Carson, Maripat Corr. Small Molecule Calcium Channel Activator Potentiates Adjuvant Activity. ACS Chem Biol. 2022.01; 17 (1): 217-229.

Yamamoto A, Saito T, Hosoya T, Kawahata K, Asano Y, Sato S, Mizoguchi F, Yasuda S, Kohsaka H. Therapeutic effect of cyclin-dependent kinase 4/6 inhibitor on dermal fibrosis in murine models of systemic sclerosis. Arthritis & rheumatology (Hoboken, N.J.). 2021.12;

Hosoya T, Oda G, Nakagawa T, Onishi I, Hosoya T, Ishiguro M, Ishikawa T, Uetake H. Plasma Levels of Decorin Increased in Patients during the Progression of Breast Cancer. Journal of clinical medicine. 2021.11; 10 (23):

Seiya Oba, Tadashi Hosoya, Miki Amamiya, Takahiro Mitsumura, Daisuke Kawata, Hirokazu Sasaki, Mari Kamiya, Akio Yamamoto, Takahiro Ando, Sho Shimada, Tsuyoshi Shirai, Tsukasa Okamoto, Tomoya Tateishi, Akira Endo, Junichi Aiboshi, Nobuyuki Nosaka, Hideo Yamanouchi, Toyomu Ugawa, Eiki Nagaoka, Keiji Oi, Susumu Tao, Yasuhiro Maejima, Yukie Tanaka, Kousuke Tanimoto, Hiroaki Takeuchi, Shuji Tohda, Akihiro Hirakawa, Tetsuo Sasano, Hirokuni Arai, Yasuhiro Otomo, Yasunari Miyazaki, Shinsuke Yasuda. Arterial and Venous Thrombosis Complicated in COVID-19: A Retrospective Single Center Analysis in Japan. Front Cardiovasc Med. 2021.11; 8 767074.

Saito T, Sako Y, Sato-Kaneko F, Hosoya T, Yao S, Lao FS, Shpigelman J, Messer K, Pu M, Shukla NM, Chan M, Chu PJ, Cottam HB, Hayashi T, Carson DA, Corr M. Small Molecule Potentiator of Adjuvant Activity Enhancing Survival to Influenza Viral Challenge. Frontiers in immunology. 2021.09; 12 701445.

Tadashi Hosoya, Dunai Cordelia, Benedict D Michael, Chie Miyabe, Jun Nagai, Thomas T Murooka, Yoshishige Miyabe. Editorial: Targeting the Chemoattractant System in Inflammation. Front Pharmacol. 2021.08; 12 744290.

Tadashi Hosoya, Takahiko Sugihara, Nobuyuki Miyasaka, Shinsuke Yasuda. Novel treatment strategy of polymyalgia rheumatica targeting drug-free remission. Clin Exp Rheumatol. 2021.05; 39 (3): 701-702.

Sugihara T, Ishizaki T, Onoguchi W, Baba H, Matsumoto T, Iga S, Kubo K, Kamiya M, Hirano F, Hosoya T, Miyasaka N, Harigai M. Effectiveness and safety of treat-to-target strategy in elderly-onset rheumatoid arthritis: a 3-year prospective observational study. Rheumatology (Oxford, England). 2021.01; 60 (9): 4252-4261.

Hosoya T, Shukla NM, Fujita Y, Yao S, Lao FS, Baba H, Yasuda S, Cottam HB, Carson DA, Hayashi T, Corr M. Identification of Compounds With Glucocorticoid Sparing Effects on Suppression of Chemokine and Cytokine Production by Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Frontiers in pharmacology. 2020.11; 11 607713.

Tadashi Hosoya, Tetsuya Saito, Hiroyuki Baba, Nao Tanaka, Seiji Noda, Youji Komiya, Yasuhiro Tagawa, Akio Yamamoto, Fumitaka Mizoguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka, Shinsuke Yasuda. Chondroprotective effects of CDK4/6 inhibition via enhanced ubiquitin-dependent degradation of JUN in synovial fibroblasts. Rheumatology (Oxford). 2022.08; 61 (8): 3427-3438.

Kenji Oku, Tatsuya Atsumi, Yuji Akiyama, Hirofumi Amano, Naoto Azuma, Toshiyuki Bohgaki, Yu Funakubo Asanuma, Tetsuya Horita, Tadashi Hosoya, Kunihiro Ichinose, Masaru Kato, Yasuhiro Katsumata, Yasushi Kawaguchi, Atsushi Kawakami, Tomohiro Koga, Hitoshi Kohsaka, Yuya Kondo, Kanae Kubo, Masataka Kuwana, Akio Mimori, Tsuneyo Mimori, Toshihide Mimura, Kosaku Murakami, Kazuhisa Nakano, Shingo Nakayamada, Hiroshi Ogishima, Kazumasa Ohmura, Kazuyoshi Saito, Hajime Sano, Mihoko Shibuya, Yuko Takahashi, Yoshinari Takasaki, Tsutomu Takeuchi, Naoto Tamura, Yoshiya Tanaka, Hiroto Tsuboi, Shinichiro Tsunoda, Naoichiro Yukawa, Noriyuki Yamakawa, Kazuhiko Yamamoto, Takayuki Sumida. Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics (SLICC). Mod Rheumatol. 2018.07; 28 (4): 642-648.

Tadashi Hosoya, Fumi Sato-Kaneko, Alast Ahmadi, Shiyin Yao, Fitzgerald Lao, Kazutaka Kitaura, Takaji Matsutani, Dennis A Carson, Tomoko Hayashi. Induction of oligoclonal CD8 T cell responses against pulmonary metastatic cancer by a phospholipid-conjugated TLR7 agonist. Proc. Natl. Acad. Sci. U.S.A.. 2018.07; 115 (29): E6836-E6844.

Oku Kenji, Atsumi Tatsuya, Akiyama Yuji, Amano Hirofumi, Azuma Naoto, Bohgaki Toshiyuki, Funakubo Asanuma Yu, Horita Tetsuya, Hosoya Tadashi, Ichinose Kunihiro, Kato Masaru, Katsumata Yasuhiro, Kawaguchi Yasushi, Kawakami Atsushi, Koga Tomohiro, Kohsaka Hitoshi, Kondo Yuya, Kubo Kanae, Kuwana Masataka, Mimori Akio, Mimori Tsuneyo, Mimura Toshihide, Murakami Kosaku, Nakano Kazuhisa, Nakayamada Shingo, Ogishima Hiroshi, Ohmura Kazumasa, Saito Kazuyoshi, Sano Hajime, Shibuya Mihoko, Takahashi Yuko, Takasaki Yoshinari, Takeuchi Tsutomu, Tamura Naoto, Tanaka Yoshiya, Tsuboi Hiroto, Tsunoda Shinichiro, Yukawa Naoichiro, Yamakawa Noriyuki, Yamamoto Kazuhiko, Sumida Takayuki. Systemic Lupus International Collaborating Clinics(SLICC)によって確立された全身性エリテマトーデスの代替分類基準の評価(Evaluation of the alternative classification criteria of systemic lupus erythematosus established by Systemic Lupus International Collaborating Clinics(SLICC)) Modern Rheumatology. 2018.07; 28 (4): 642-648.

Nikunj M Shukla, Kei-Ichiro Arimoto, Shiyin Yao, Jun-Bao Fan, Yue Zhang, Fumi Sato-Kaneko, Fitzgerald S Lao, Tadashi Hosoya, Karen Messer, Minya Pu, Howard B Cottam, Dennis A Carson, Tomoko Hayashi, Dong-Er Zhang, Maripat Corr. Identification of Compounds That Prolong Type I Interferon Signaling as Potential Vaccine Adjuvants. SLAS Discov. 2018.05; 2472555218774308.

Fumi Sato-Kaneko, Xiaodong Wang, Shiyin Yao, Tadashi Hosoya, Fitzgerald S Lao, Karen Messer, Minya Pu, Nikunj M Shukla, Howard B Cottam, Michael Chan, Dennis A Carson, Maripat Corr, Tomoko Hayashi. Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy. BioMed research international. 2018; 2018 8091283.

Fumi Sato-Kaneko, Shiyin Yao, Alast Ahmadi, Shannon S Zhang, Tadashi Hosoya, Megan M Kaneda, Judith A Varner, Minya Pu, Karen S Messer, Cristiana Guiducci, Robert L Coffman, Kazutaka Kitaura, Takaji Matsutani, Ryuji Suzuki, Dennis A Carson, Tomoko Hayashi, Ezra Ew Cohen. Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight. 2017.09; 2 (18):

H Takada, T Hosoya, N Kimura, K Kawahata, H Kohsaka. Successful use of rituximab in a patient with refractory thrombotic thrombocytopaenic purpura complicated by polymyositis. Scand. J. Rheumatol.. 2017.03; 46 (2): 163-165.

Tadashi Hosoya, Hideyuki Iwai, Yu Yamaguchi, Kimito Kawahata, Nobuyuki Miyasaka, Hitoshi Kohsaka. Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppression. Ann. Rheum. Dis.. 2016.01; 75 (1): 253-259.

Takeshi Kusuda, Tadashi Hosoya, Takayasu Mori, Katsuhito Ihara, Hidenori Nishida, Motoko Chiga, Eisei Sohara, Tatemitsu Rai, Ryuji Koike, Shinichi Uchida, Hitoshi Kohsaka. Acquired Gitelman Syndrome in an Anti-SSA Antibody-positive Patient with a SLC12A3 Heterozygous Mutation. Intern. Med.. 2016.01; 55 (21): 3201-3204.

Takahiko Sugihara, Tatsuro Ishizaki, Tadashi Hosoya, Shoko Iga, Waka Yokoyama, Fumio Hirano, Nobuyuki Miyasaka, Masayoshi Harigai. Structural and functional outcomes of a therapeutic strategy targeting low disease activity in patients with elderly-onset rheumatoid arthritis: a prospective cohort study (CRANE). Rheumatology (Oxford). 2015.05; 54 (5): 798-807.