髙橋 和久 たかはし かずひさ 先生

来歴等

略歴

1985年　順天堂大学医学部附属順天堂医院　内科臨床研修医
1987年　順天堂大学医学部呼吸器内科学　専攻生
1994年　米国ハーバード大学医学部附属マサチューセッツ総合病院 腫瘍外科学留学 ポスドク
1997年　順天堂大学医学部呼吸器内科学　助手
1999年　順天堂大学医学部呼吸器内科学　医局長講師
2003年　順天堂大学医学部呼吸器内科学　助教授
2005年　順天堂大学大学院医学研究科呼吸器内科学　教授
　　　　 順天堂大学医学部呼吸器内科学　教授
2014年　順天堂大学医学部附属順天堂医院　副院長
2019年　順天堂大学医学部附属順天堂医院　院長
2020年　北京大学　客員教授

論文

2019年以降英文論文のみ
1.Nanjo Y, Newstead MW, Aoyagi T, Zeng X, Takahashi K, Yu FS, Tateda K, Standiford TJ. Overlapping Roles for Interleukin-36 Cytokines in Protective Host Defense against Murine Legionella pneumophila Pneumonia. Infect Immun. 87(1): e00583-18, 2019 Jan 2.Seyama K, Nukiwa T, Sato T, Suzuki M, Konno S, Takahashi K, Nishimura M, Steinmann K, Sorrells S, Chen J, Hayashi KI. Safety and pharmacokinetics of Alpha-1 MP (Prolastin®-C) in Japanese patients with alpha1-antitrypsin (AAT) deficiency. Respir Investig. 57(1):89-96, 2019 Jan　
3.Kato M, Sasaki S, Kurokawa K, Nakamura T, Yamada T, Sasano H, Arano N, Komura M, Ihara H, Nagashima O, Shiota S, Takahashi F, Takahashi K. Usual interstitial pneumonia pattern in the lower lung lobes as a prognostic factor in idiopathic pleuroparenchymal fibroelastosis. Respiration. 97(4):319-328, 2019 Jan　
4.Tanabe Y, Harada N, Ito J, Matsuno K, Takeshige T, Harada S, Takemasa M, Kotajima M, Ishimori A, Katsura Y, Makino F, Atsuta R, Takahashi K. Difference between two exhaled nitric oxide analyzers, NIOX VERO® electrochemical hand-held analyzer and NOA280i® chemiluminescence stationary analyzer. J Asthma. 56(2):167-172, 2019 Feb
5.Kohsaka S, Tatsuno K, Ueno T, Nagano M, Shinozaki-Ushiku A, Ushiku T, Takai D, Ikegami M, Kobayashi H, Kage H, Ando M, Hata K, Ueda H, Yamamoto S, Kojima S, Oseto K, Akaike K, Suehara Y, Hayashi T, Saito T, Takahashi F, Takahashi K, Takamochi K, Suzuki K, Nagayama S, Oda Y, Mimori K, Ishihara S, Yatomi Y, Nagase T, Nakajima J, Tanaka S, Fukayama M, Oda K, Nangaku M, Miyazono K, Miyagawa K, Aburatani H, Mano H. Comprehensive assay for the molecular profiling of cancer by target enrichment from formalin-fixed paraffin-embedded specimens. Cancer Sci. 110(4):1464-1479, 2019 Apr　
6.Sasaki S, Kato M, Nakamura K, Namba Y, Nagashima O, Takahashi K. Management of skin sarcoidosis with minocycline monotherapy. Respirol Case Rep. 2019 Mar 13;7(4):e00413, 2019 Mar doi: 10.1002/rcr2.413. eCollection 2019 May.　
7.Kuwasaki E, Nagaoka T, Ihara H, Tsutsumi T, Nakamura A, Yoshikawa H, Yoshida T, Watanabe J, Ichikawa M, Koyama R, Shimada N, Takahashi K. Age is an independent predictor in pathological diagnosis of sarcoidosis: a retrospective analysis of diagnosis by endobronchial ultrasound-guided transbronchial needle aspiration. J Thorac Dis. 11(5):2175-2180, 2019 May
8.Kadoya K, Togo S, Tulafu M, Namba Y, Iwai M, Watanabe J, Okabe T, Jin J, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Takeda T, Kondo N, Takahashi K. Specific features of fibrotic lung fibroblasts highly sensitive to fibrotic processes mediated via TGF-β-ERK5 interaction. Cell Physiol Biochem. 52(4):822-837, 2019 Jun　
9.Jin J, Togo S, Kadoya K, Tulafu M, Namba Y, Iwai M, Watanabe J, Nagahama K, Okabe T, Hidayat M, Kodama Y, Kitamura H, Ogura T, Kitamura N, Ikeo K, Sasaki S, Tominaga S, Takahashi K. Pirfenidone attenuates lung fibrotic fibroblast responses to transforming growth factor-β1. Respir Res. 20(1):119, 2019 Jun 11
10.Zuoyou L, Shiota S, Morio Y, Sugiyama A, Sekiya M, Iwakami SI, Ienaga H, Fukuchi Y, Takahashi K. Borderline pulmonary hypertension associated with chronic hypercapnia in chronic pulmonary disease. Respir Physiol Neurobiol. 262:20-25, 2019 Apr
11.Kurokawa K, Asao T, Ko R, Nagaoka T, Suzuki K, Takahashi K. Severe mediastinitis over a month after endobronchial ultrasound-guided transbronchial needle aspiration. Respirol Case Rep. 2019 Apr 9;7(5):e00426. doi: 10.1002/rcr2.426. eCollection 2019 Jul
12.Tsutsumi T, Nagaoka T, Yoshida T, Wang L, Kuriyama S, Suzuki Y, Nagata Y, Harada N, Kodama Y, Takahashi F, Morio Y, Takahashi K. Nintedanib ameliorates experimental pulmonary arterial hypertension via inhibition of endothelial mesenchymal transition and smooth muscle cell proliferation. PLoS One. 14(7):e0214697, 2019 Jul 24
13.Kato M, Sasaki S, Nakamura T, Kurokawa K, Yamada T, Ochi Y, Ihara H, Takahashi F, Takahashi K. Gastrointestinal adverse effects of nintedanib and the associated risk factors in patients with idiopathic pulmonary fibrosis. Sci Rep. 9(1):12062, 2019 Aug 19
14.Karasutani K, Baskoro H, Sato T, Arano N, Suzuki Y, Mitsui A, Shimada N, Kodama Y, Seyama K, Fukuchi Y, Takahashi K. Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice. J Vis Exp. 151, 2019 Sep 26
15.Ihara H, Kikuchi K, Taniguchi H, Fujita S, Tsuruta Y, Kato M, Mitsuishi Y, Tajima K, Kodama Y, Takahashi F, Takahashi K, Azuma N. 23-valent pneumococcal polysaccharide vaccine improves survival in dialysis patients by preventing cardiac events. Vaccine. 37(43):6447-6453, 2019 Oct 8
16.Hidayat M, Mitsuishi Y, Takahashi F, Tajima K, Yae T, Miyahara K, Hayakawa D, Winardi W, Ihara H, Koinuma Y, Wirawan A, Nurwidya F, Kato M, Kobayashi I, Sasaki S, Takamochi K, Hayashi T, Suehara Y, Moriyama M, Moriyama H, Habu S, Takahashi K. Role of FBXW7 in the quiescence of gefitinib-resistant lung cancer stem cells in EGFR-mutant non-small cell lung cancer. Bosn J Basic Med Sci. 19(4); 335-367, 2019 Nov 8
17.Kurokawa K, Hara H, Iwakami S, Genda T, Iwakami N, Miyashita Y, Fujioka M, Sasaki S, Takahashi K. Cholestatic Liver Injury Induced by Pembrolizumab in a Patient with Lung Adenocarcinoma. Intern Med. 58(22):3283-3287, 2019 Nov 15
18.Kato M, Yamada T, Kataoka S, Arai Y, Miura K, Ochi Y, Ihara H, Koyama R, Sasaki S, Takahashi K. Prognostic differences among patients with idiopathic interstitial pneumonias with acute exacerbation of varying pathogenesis: a retrospective study. Respir Res. 20(1):287, 2019 Dec 18
19.Yamaguchi Y, Shiota S, Kusunoki Y, Hamaya H, Ishii M, Kodama Y, Akishita M, Kida K, Takahashi K, Nagase T, Fukuchi Y. Polysomnographic features of low arousal threshold in overlap syndrome involving obstructive sleep apnea and chronic obstructive pulmonary disease. Sleep Breath. 23(4):1095-1100, 2019 Dec
20.Hayakawa D, Takahashi F, Mitsuishi Y, Tajima K, Hidayat M, Winardi W, Ihara H, Kanamori K, Matsumoto N, Asao T, Ko R, Shukuya T, Takamochi K, Hayashi T, Suehara Y, Takeda Nakamura I, Ueno T, Kohsaka S, Mano H, Takahashi K. Activation of insulin-like growth factor-1 receptor confers acquired resistance to osimertinib in non-small cell lung cancer with EGFR T790M mutation. Thorac Cancer. 11(1):140-149, 2020 Jan
21.Hosomi Y, Morita S, Sugawara S, Kato T, Fukuhara T, Gemma A, Takahashi K, Fujita Y, Harada T, Minato K, Takamura K, Hagiwara K, Kobayashi K, Nukiwa T, Inoue A; North-East Japan Study Group. Gefitinib Alone Versus Gefitinib Plus Chemotherapy for Non-Small-Cell Lung Cancer With Mutated Epidermal Growth Factor Receptor: NEJ009 Study. J Clin Oncol. 38(2):115-123, 2020 Jan
22.Ko Y, Asakawa K, Tobino K, Oguma T, Hirai T, Takada T, Takahashi K, Seyama K; Multicenter Lymphangioleiomyomatosis Sirolimus Trial for Safety Study Group. Quantitative analysis of computed tomography of the lungs in patients with lymphangioleiomyomatosis treated with sirolimus. Heliyon 6(2):e03345. doi: 10.1016/j.heliyon, 2020 Feb 6
23.Tateishi K, Ko R, Shukuya T, Okuma Y, Watanabe S, Kuyama S, Murase K, Tsukita Y, Ashinuma H, Nakagawa T, Uematsu K, Nakao M, Mori Y, Kaira K, Mouri A, Miyabayashi T, Sakashita H, Matsumoto Y, Tanigawa T, Koizumi T, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group. Clinical Outcomes of Second-Line Chemotherapy in Patients with Previously Treated Advanced Thymic Carcinoma: A Retrospective Analysis of 191 Patients from the NEJ023 Study. Oncologist 25(4): e668-e674. doi: 10.1634/theoncologist.2019-0593, 2020 Apr
24.Sekine I, Shintani Y, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Dosaka-Akita H, Takiguchi Y, Miyaoka E, Okumura M, Yoshino I. A Japanese lung cancer registry study on demographics and treatment modalities in medically treated patients. Cancer Sci. 111(5):1685-1691, 2020 May
25.Wang K, Verbakel JY, Oke J, Fleming-Nouri A, Brewin J, Roberts N, Harada N, Atsuta R, Takahashi K, Mori K, Fujisawa T, Shirai T, Kawayama T, Inoue H, Lazarus S, Szefler S, Martinez F, Shaw D, Pavord ID, Thomas M. Using fractional exhaled nitric oxide to guide step-down treatment decisions in patients with asthma: a systematic review and individual patient data meta-analysis. Eur Respir J. 55(5):1902150, 2020 May
26.Okamoto S, Suzuki K, Hayashi T, Muraki K, Nagaoka T, Nishino K, Sekimoto Y, Sasaki S, Takahashi K, Seyama K. Transbronchial lung biopsy for the diagnosis of lymphangioleiomyomatosis: the severity of cystic lung destruction assessed by the modified Goddard scoring system as a predictor for establishing the diagnosis. Orphanet J Rare Dis 15(1):125, 2020 May
27.Sugiyama AI, Shiota S, Yamada T, Ito J, Suzuki K, Takahashi K. Sleep-related breathing disorders associated with the characteristics of underlying congenital rare diseases of Moebius syndrome and Poland syndrome. Respirol Case Rep 8(5): e00579, 2020 May
28.Kohsaka S, Hayashi T, Nagano M, Ueno T, Kojima S, Kawazu M, Shiraishi Y, Kishikawa S, Suehara Y, Takahashi F, Takahashi K, Suzuki K, Takamochi K, Mano H. Identification of Novel CD74-NRG2αFusion From Comprehensive Profiling of Lung Adenocarcinoma in Japanese Never or Light Smokers. J Thorac Oncol 15(6):948-961, 2020 Jun
29.Kozuki T, Nogami N, Hataji O, Tsunezuka Y, Seki N, Harada T, Fujimoto N, Bessho A, Takamura K, Takahashi K, Satouchi M, Kato T, Shukuya T, Yamashita N, Okamoto H, Shinkai T, Thoracic Oncology Research Group. Open-label, multicenter, randomized phase II study on docetaxel plus bevacizumab or pemetrexed plus bevacizumab for treatment of elderly (aged ≥75 years) patients with previously untreated advanced non-squamous non-small cell lung cancer: TORG1323. Transl Lung Cancer Res 9(3): 459-470, 2020 Jun
30.Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Terao C, Amariuta T, Gazal S, Kochi Y, Horikoshi M, Suzuki K, Ito K, Koyama S, Ozaki K, Niida S, Sakata Y, Sakata Y, Kohno T, Shiraishi K, Momozawa Y, Hirata M, Matsuda K, Ikeda M, Iwata N, Ikegawa S, Kou I, Tanaka T, Nakagawa H, Suzuki A, Hirota T, Tamari M, Chayama K, Miki D, Mori M, Nagayama S, Daigo Y, Miki Y, Katagiri T, Ogawa O, Obara W, Ito H, Yoshida T, Imoto I, Takahashi T, Tanikawa C, Suzuki T, Sinozaki N, Minami S, Yamaguchi H, Asai S, Takahashi Y, Yamaji K, Takahashi K, Fujioka T, Takata R, Yanai H, Masumoto A, Koretsune Y, Kutsumi H, Higashiyama M, Murayama S, Minegishi N, Suzuki K, Tanno K, Shimizu A, Yamaji T, Iwasaki M, Sawada N, Uemura H, Tanaka K, Naito M, Sasaki M, Wakai K, Tsugane S, Yamamoto M, Yamamoto K, Murakami Y, Nakamura Y, Raychaudhuri S, Inazawa J, Yamauchi T, Kadowaki T, Kubo M, Kamatani Y. Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases. Nat Genet. 52(7):669-679, 2020 Jun
31.Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K. Nintedanib Inhibits Epithelial-Mesenchymal Transition in A549 Alveolar Epithelial Cells Through Regulation of the TGF-β/Smad Pathway. Respir Investig 58(4): 275-284, 2020 Jul
32.Jingo K, Harada N, Nishioki T,Torasawa M,Yamada T, Asao T, Takagi T,Takeshige T, Ito J,Takahashi K. Anaphylaxis to three humanized antibodies for severe asthma: A case study. Allergy Asthma Clin Immunol. 10;16:46. doi: 10.1186/s13223-020-00446-w. eCollection 2020 Jun
33.Kobayashi K, Soejima K, Fukunaga K, Shintani Y, Sekine I, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Yamamoto N, Takiguchi Y, Miyaoka E, Okumura M, Yoshino I, and on behalf of the Group on behalf of the Japanese Joint Committee of Lung Cancer Registry. Key prognostic factors for EGFR-mutated non-adenocarcinoma lung cancer patients in the Japanese Joint Committee of Lung Cancer Registry Database. Lung Cancer 146: 236-243, 2020 Aug
34.Igawa S, Naoki K, Shintani Y, Sekine I, Shukuya T, Takayama K, Inoue A, Okamoto I, Kiura K, Takahashi K, Yamamoto N, Takiguchi Y, Miyaoka E, Okumura M, Yoshino I. Survival and Prognostic Factors in Elderly Patients Receiving Second-line Chemotherapy for Relapsed Small-Cell Lung Cancer: Results from the Japanese Joint Committee of Lung Cancer Registry. Lung Cancer. 146: 160-164, 2020 Aug
35.Harada N, Harada S, Ito J, Atsuta R, Hori S, Takahashi K. Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study. J Med Internet Res. 22(8):e19006, 2020 Aug 14
36.Miyawaki T, Kenmotsu H, Mori K, Miyawaki E, Mamesaya N, Kawamura T, Kobayashi H, Omori S, Wakuda K, Ono A, Naito T, Murakami H, Harada H, Endo M, Ohde Y, Takahashi K, Takahashi T. Association Between Clinical Tumor Burden and Efficacy of Immune Checkpoint Inhibitor Monotherapy for Advanced Non-Small-Cell Lung Cancer. Clin Lung Cancer. 21(5): e405-e414, 2020 Sep
37.Hayashi T, Kohsaka S, Takamochi K, Hara K, Kishikawa S, Sano K, Takahashi F, Suehara Y, Saito T, Takahashi K, Suzuki K, Yao T. Clinicopathological characteristics of lung adenocarcinoma with compound EGFR mutations. Hum Pathol. 103:42-51, 2020 Sep
38.Kato Y, Kato M, Ihara H, Hayakawa E, Shibayama K, Miura K, Yamada T, Mitsuishi Y, Shukuya T, Ito J, Matsunaga T, Sato T, Suzuki K, Takahashi K. Hermansky-Pudlak syndrome-associated pneumothorax with rapid progression of respiratory failure: a case report. BMC Pulm Med. 20(1):259, 2020 Oct
39.Takei S, Ihara H, Togo S, Nakamura A, Fujimoto Y, Watanabe J, Kurokawa K, Shibayama K, Sumiyoshi I, Ochi Y, Iwai M, Okabe T, Chonan M, Misawa S, Ohsaka A, Takahashi K. The synergetic effect of Imipenem-clarithromycin combination in the Mycobacteroides abscessus complex. BMC Microbiol. 20(1):316, 2020 Oct 19
40.Okuma Y, Ko R, Shukuya T, Tateishi K, Imai H, Iwasawa S, Miyauchi E, Kojima T, Fujita Y, Hino T, Yamanda S, Suzuki T, Fukuizumi A, Sakakibara T, Harada T, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group. Prognostic factors for patients with metastatic or recurrent thymic carcinoma receiving palliative-intent chemotherapy. Lung Cancer. 148:122-128, 2020 Oct
41.Kato M, Takahashi F, Sato T, Mitsuishi Y, Tajima K, Ihara H, Nurwidya F, Baskoro H, Murakami A, Kobayashi I, Hidayat M, Shimada N, Sasaki S, Mineki R, Fujimura T, Kumasaka T, Niwa S, Takahashi K. Tranilast Inhibits Pulmonary Fibrosis by Suppressing TGFβ/SMAD2 Pathway. 14: 4593-4603, 2020 Oct 29

著書

世界で一番やさしい　肺がん（知ってなおすシリーズ）　高橋和久著　発行／エクスナレッジ
呼吸器内科　診療マニュアル　高橋和久、熱田了　編集　日本医学館
講義録　腫瘍学　高橋和久編集　メデャカルビュー社
EBMを活かす呼吸診療　高橋和久、児玉裕三編集　メディカルビュー社
がんサポート　肺がん特集＆リハビリテーション2015年9月号　エビデンス社
など多数

その他

• 【受賞学術賞】 1992年　RMCB研究奨励賞

• 【受賞学術賞】2002年　順天堂大学医学部同窓会　学術奨励賞

• 【受賞学術賞】2014年　APSR Harasawa Research Award

• 【受賞学術賞】2017年　東京都医師会功労賞（学術委員会）