長谷部 直幸 はせべ なおゆき 先生

来歴等

略歴

1984年 旭川医科大学大学院 卒業
（砂川市立、名寄市立、道北病院、逓信病院、旭川刑務所医務課長）
1990～1993年 米国ハーバード大学研究員
2000年 旭川医科大学 第一内科 助教授
2007年 旭川医科大学 循環呼吸神経病態内科学 教授
2008年9月 旭川医科大学 心血管再生・先端医療開発講座 兼任教授
2010年4月 旭川医科大学 循環・呼吸医療再生フロンティア講座 兼任教授（2016年4月〜地域医療再生フロンティア研究室に改組）
2021年3月 旭川医科大学 内科学講座 循環・呼吸・神経病態内科学分野 教授 定年退職
2021年4月 旭川医科大学 名誉教授、心血管再生・先端医療開発講座 特任教授
2022年3月 旭川医科大学 心血管再生・先端医療開発講座 特任教授 退職
2022年4月 江別市立病院 病院事業管理者

論文

(主な論文)

Aonuma T, Hasebe N et al. Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction. Stem Cells Transl Med. 2016, 5: 1067-78.

Fujino T, Hasebe N. Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy. BMC Nephrol. 2016; 17(1):179.

Mogi M, Hasebe N et al. The results of a survey of physicians about the Japanese Society of Hypertension Guidelines for the Management of Hypertension 2014 and its clinical use. Hypertens Res. 2016; 39: 660-3.

Maruyama K, Hasebe N et al. Malnutrition, renal dysfunction and left ventricular hypertrophy synergistically increase the long-term incidence of cardiovascular events. Hypertens Res. 2016 ; 39:633-9.

Talib AK, Hasebe N et al. Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up. Heart Vessels. 2016; 31:　2035-2044.

Zen K, Hasebe N et al, Cardiac event risk stratification in patients with end-stage renal disease: Sub-analysis of the B-SAFE study. Int J Cardiol. 2016; 202: 694-700.

Sakamoto N, Hasebe N et al. Late Gadolinium Enhancement on Cardiac MRI Correlates with QT Dynamicity Represented by QT/RR Relationship in Patients with Ventricular Arrhythmias. Ann Noninvasive Electrocardiol. 2016; 21: 126-35.

Matsuki M, Hasebe N et al. Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes. Circ J. 2015; 79: 1363-71

Sakamoto N, Hasebe N et al. Late gadolinium enhancement of cardiac magnetic resonance imaging indicates abnormalities of time-domain T-wave alternans in hypertrophic cardiomyopathy with ventricular tachycardia. Heart Rhythm. 2015; 12: 1747-55.

Izawa K, Hasebe N　et al. Impaired Glutathione Redox System Paradoxically Suppresses Angiotensin II-Induced Vascular Remodeling. PLoS One. 2014 Oct 24;9:e108115

Kabara M, Hasebe N et al. Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration. Lab Invest. 2014; 94: 1340-54.

Saito T, Hasebe N et al. Cerebral Microbleeds and Asymptomatic Cerebral Infarctions in Patients with Atrial Fibrillation. J Stroke Cerebrovasc Dis. 2014 ; 23: 1616-22.

Shimamoto K, Hasebe N et al. Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res. 2014; 37: 253-387

Fujino T, Hasebe N et al. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and downregulates GSK-3β expression after ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2013; 305: F1617-27.

Yamauchi A, Hasebe N et al. Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation. Am J Physiol Heart Circ Physiol. 2013; 305: H1158-67.

Sato N, Hasebe N et al. CAMUI investigators. Combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial: results after 1 year. J Hypertens. 2013; 31: 1245-55.

Aburakawa Y, Hasebe N et al. Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model. Circ J. 2013; 77: 1053-62.

Moroi M, Hasebe N et al. Association between abnormal myocardial fatty acid metabolism and cardiac-derived death among patients undergoing hemodialysis: results from a cohort study in Japan. Am J Kidney Dis. 2013; 61: 466-75.

Imai Y, Hasebe N et al. Japanese Society of Hypertension Committee for Guidelines for Self-monitoring of Blood Pressure at Home. The Japanese Society of Hypertension Guidelines for Self-monitoring of Blood Pressure at Home (Second Edition). Hypertens Res. 2012; 35: 777-95.

Nakagawa N, Hasebe N et al. The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney Int. 2012; 82: 158-71

Talib A, Hasebe N et al. The balance of fetuin-A and osteoprotegerin is independently associated with diastolic dysfunction in hemodialysis patients. Hypertens Res. 2012; 35: 426-33.

Takeuchi T, Hasebe N et al. Ischemic preconditioning effect of prodromal angina is attenuated in acute myocardial infarction patients with hypertensive left ventricular hypertrophy. Circ J. 2011; 75: 1192-9.

Nakagawa N, Hasebe N et al. NICE-Combi Study Group. Angiotensin II receptor blocker and long-acting calcium channel blocker combination therapy decreases urinary albumin excretion while maintaining glomerular filtration rate. Hypertens Res. 2011; 34: 1121-6.

Koyama S, Hasebe N et al. The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment. Biochim Biophys Acta. 2011; 1810: 836-42.

Kawabe J, Hasebe N et al.Prostacyclin in vascular diseases. - Recent insights and future perspectives -.Circ J. 74: 836-43, 2010

Aizawa H, Hasebe N et al. TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. Acta Neuropathol. 120: 75-84, 2010

Kawabe J, Hasebe N et al. Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Arterioscler Thromb Vasc Biol. 30: 464-70, 2010

Hasebe N Kikuchi K; NICE Combi Study Group. Controlled-release nifedipine and candesartan low-dose combination therapy in patients with essential hypertension: the NICE Combi (Nifedipine and Candesartan Combination) Study. J Hypertens. 2005; 23: 445-53.

Fujino T, Hasebe N et al. Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. J Clin Invest. 2004; 114: 805-12.

Okada M, Hasebe N et al.Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. Circulation. 2004; 109: 1763-8.

Matsusaka T, Hasebe N et al. Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits. Cardiovasc Res. 2002; 54: 568-75.

Hasebe N et al. Angiographical Study in Angina with Hypertension Induced Insults (ASAHI) Investigators. Reverse J-curve relation between diastolic blood pressure and severity of coronary artery lesion in hypertensive patients with angina pectoris. Hypertens Res. 2002; 25: 381-7.

Aizawa Y, Hasebe N et al. Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Circulation. 2001; 104: 455-60.

Ido A, Hasebe N et al. Coronary sinus occlusion enhances coronary collateral flow and reduces subendocardial ischemia. Am J Physiol Heart Circ Physiol. 2001; 280: H1361-7.

Fujino T, Hasebe N et al. Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats. Cardiovasc Res. 1998; 38: 365-74.

Hasebe N et al. Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs. Am J Physiol. 1995; 268 (2 Pt 2): H781-7.

Hasebe N et al. Enhanced postischemic dysfunction selective to subendocardium in conscious dogs with LV hypertrophy. Am J Physiol. 1994; 266 (2 Pt 2): H702-13.

Hasebe N et al. Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs. Circulation. 1993; 88: 2862-71

著書

内科学（朝倉書店）、循環器疾患最新の治療（南江堂）、専門医のための循環器病学（医学書院）、今日の治療指針（医学書院）、今日の診断指針（医学書院）、高血圧治療ガイドライン2014、エビデンスに基づくCKD診療ガイドライン2013