長谷部 直幸 はせべ なおゆき 先生

来歴等

略歴

1984年 旭川医科大学大学院卒業
（砂川市立、名寄市立、道北病院、逓信病院、旭川刑務所医務課長）
1990～1993年 米国ハーバード大学研究員
2000年 旭川医科大学 第一内科助教授
2007年 旭川医科大学 循環呼吸神経病態内科学 教授

論文

(主な論文)

Aonuma T, Hasebe N et al. Apoptosis-Resistant Cardiac Progenitor Cells Modified With Apurinic/Apyrimidinic Endonuclease/Redox Factor 1 Gene Overexpression Regulate Cardiac Repair After Myocardial Infarction. Stem Cells Transl Med. 2016, 5: 1067-78.

Fujino T, Hasebe N. Alteration of histone H3K4 methylation in glomerular podocytes associated with proteinuria in patients with membranous nephropathy. BMC Nephrol. 2016; 17(1):179.

Mogi M, Hasebe N et al. The results of a survey of physicians about the Japanese Society of Hypertension Guidelines for the Management of Hypertension 2014 and its clinical use. Hypertens Res. 2016; 39: 660-3.

Maruyama K, Hasebe N et al. Malnutrition, renal dysfunction and left ventricular hypertrophy synergistically increase the long-term incidence of cardiovascular events. Hypertens Res. 2016 ; 39:633-9.

Talib AK, Hasebe N et al. Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up. Heart Vessels. 2016; 31:　2035-2044.

Zen K, Hasebe N et al, Cardiac event risk stratification in patients with end-stage renal disease: Sub-analysis of the B-SAFE study. Int J Cardiol. 2016; 202: 694-700.

Sakamoto N, Hasebe N et al. Late Gadolinium Enhancement on Cardiac MRI Correlates with QT Dynamicity Represented by QT/RR Relationship in Patients with Ventricular Arrhythmias. Ann Noninvasive Electrocardiol. 2016; 21: 126-35.

Matsuki M, Hasebe N et al. Ninjurin1 is a novel factor to regulate angiogenesis through the function of pericytes. Circ J. 2015; 79: 1363-71

Sakamoto N, Hasebe N et al. Late gadolinium enhancement of cardiac magnetic resonance imaging indicates abnormalities of time-domain T-wave alternans in hypertrophic cardiomyopathy with ventricular tachycardia. Heart Rhythm. 2015; 12: 1747-55.

Izawa K, Hasebe N　et al. Impaired Glutathione Redox System Paradoxically Suppresses Angiotensin II-Induced Vascular Remodeling. PLoS One. 2014 Oct 24;9:e108115

Kabara M, Hasebe N et al. Immortalized multipotent pericytes derived from the vasa vasorum in the injured vasculature. A cellular tool for studies of vascular remodeling and regeneration. Lab Invest. 2014; 94: 1340-54.

Saito T, Hasebe N et al. Cerebral Microbleeds and Asymptomatic Cerebral Infarctions in Patients with Atrial Fibrillation. J Stroke Cerebrovasc Dis. 2014 ; 23: 1616-22.

Shimamoto K, Hasebe N et al. Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014). Hypertens Res. 2014; 37: 253-387

Fujino T, Hasebe N et al. Silencing of p53 RNA through transarterial delivery ameliorates renal tubular injury and downregulates GSK-3β expression after ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2013; 305: F1617-27.

Yamauchi A, Hasebe N et al. Apurinic/apyrimidinic endonucelase 1 maintains adhesion of endothelial progenitor cells and reduces neointima formation. Am J Physiol Heart Circ Physiol. 2013; 305: H1158-67.

Sato N, Hasebe N et al. CAMUI investigators. Combination of antihypertensive therapy in the elderly, multicenter investigation (CAMUI) trial: results after 1 year. J Hypertens. 2013; 31: 1245-55.

Aburakawa Y, Hasebe N et al. Prostacyclin stimulated integrin-dependent angiogenic effects of endothelial progenitor cells and mediated potent circulation recovery in ischemic hind limb model. Circ J. 2013; 77: 1053-62.

Moroi M, Hasebe N et al. Association between abnormal myocardial fatty acid metabolism and cardiac-derived death among patients undergoing hemodialysis: results from a cohort study in Japan. Am J Kidney Dis. 2013; 61: 466-75.

Imai Y, Hasebe N et al. Japanese Society of Hypertension Committee for Guidelines for Self-monitoring of Blood Pressure at Home. The Japanese Society of Hypertension Guidelines for Self-monitoring of Blood Pressure at Home (Second Edition). Hypertens Res. 2012; 35: 777-95.

Nakagawa N, Hasebe N et al. The intrinsic prostaglandin E2-EP4 system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice. Kidney Int. 2012; 82: 158-71

Talib A, Hasebe N et al. The balance of fetuin-A and osteoprotegerin is independently associated with diastolic dysfunction in hemodialysis patients. Hypertens Res. 2012; 35: 426-33.

Takeuchi T, Hasebe N et al. Ischemic preconditioning effect of prodromal angina is attenuated in acute myocardial infarction patients with hypertensive left ventricular hypertrophy. Circ J. 2011; 75: 1192-9.

Nakagawa N, Hasebe N et al. NICE-Combi Study Group. Angiotensin II receptor blocker and long-acting calcium channel blocker combination therapy decreases urinary albumin excretion while maintaining glomerular filtration rate. Hypertens Res. 2011; 34: 1121-6.

Koyama S, Hasebe N et al. The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment. Biochim Biophys Acta. 2011; 1810: 836-42.

Kawabe J, Hasebe N et al.Prostacyclin in vascular diseases. - Recent insights and future perspectives -.Circ J. 74: 836-43, 2010

Aizawa H, Hasebe N et al. TDP-43 pathology in sporadic ALS occurs in motor neurons lacking the RNA editing enzyme ADAR2. Acta Neuropathol. 120: 75-84, 2010

Kawabe J, Hasebe N et al. Prostaglandin I2 promotes recruitment of endothelial progenitor cells and limits vascular remodeling. Arterioscler Thromb Vasc Biol. 30: 464-70, 2010

Hasebe N Kikuchi K; NICE Combi Study Group. Controlled-release nifedipine and candesartan low-dose combination therapy in patients with essential hypertension: the NICE Combi (Nifedipine and Candesartan Combination) Study. J Hypertens. 2005; 23: 445-53.

Fujino T, Hasebe N et al. Decreased susceptibility to renovascular hypertension in mice lacking the prostaglandin I2 receptor IP. J Clin Invest. 2004; 114: 805-12.

Okada M, Hasebe N et al.Thermal treatment attenuates neointimal thickening with enhanced expression of heat-shock protein 72 and suppression of oxidative stress. Circulation. 2004; 109: 1763-8.

Matsusaka T, Hasebe N et al. Magnesium reduces myocardial infarct size via enhancement of adenosine mechanism in rabbits. Cardiovasc Res. 2002; 54: 568-75.

Hasebe N et al. Angiographical Study in Angina with Hypertension Induced Insults (ASAHI) Investigators. Reverse J-curve relation between diastolic blood pressure and severity of coronary artery lesion in hypertensive patients with angina pectoris. Hypertens Res. 2002; 25: 381-7.

Aizawa Y, Hasebe N et al. Pioglitazone enhances cytokine-induced apoptosis in vascular smooth muscle cells and reduces intimal hyperplasia. Circulation. 2001; 104: 455-60.

Ido A, Hasebe N et al. Coronary sinus occlusion enhances coronary collateral flow and reduces subendocardial ischemia. Am J Physiol Heart Circ Physiol. 2001; 280: H1361-7.

Fujino T, Hasebe N et al. Enhanced expression of heparin-binding EGF-like growth factor and its receptor in hypertrophied left ventricle of spontaneously hypertensive rats. Cardiovasc Res. 1998; 38: 365-74.

Hasebe N et al. Effects of hypertrophy on left atrial and ventricular compliance and plasma ANF levels in conscious dogs. Am J Physiol. 1995; 268 (2 Pt 2): H781-7.

Hasebe N et al. Enhanced postischemic dysfunction selective to subendocardium in conscious dogs with LV hypertrophy. Am J Physiol. 1994; 266 (2 Pt 2): H702-13.

Hasebe N et al. Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs. Circulation. 1993; 88: 2862-71

著書

内科学（朝倉書店）、循環器疾患最新の治療（南江堂）、専門医のための循環器病学（医学書院）、今日の治療指針（医学書院）、今日の診断指針（医学書院）、高血圧治療ガイドライン2014、エビデンスに基づくCKD診療ガイドライン2013