松井 真 まつい まこと 先生

来歴等

略歴

1981年 京都大学医学部医学科 卒業
1987年 京都大学大学院医学研究科内科系 修了 医学博士取得
1987年 京都大学医学部附属病院神経内科 文部教官助手
1989年 米国ハーバード大学 留学（research fellow）
1991年 佐賀医科大学医学部内科学 文部教官助手
1993年 佐賀医科大学医学部附属病院内科 講師
1997年 国立療養所宇多野病院神経内科 医長
2005年 金沢医科大学医学部神経内科学 主任教授
2021年 芳珠記念病院 脳神経内科 顧問

論文

• A double-label flow cytometric analysis of the simultaneous expression of OKT4 and Leu2a antigens on circulating T lymphocytes in myasthenia gravis. J Neuroimmunol 1986; 11: 311-319.

  Matsui, M. and Kameyama, M.

• The imbalance in CSF T cell subsets in active multiple sclerosis. Acta Neurol Scand 1988;77: 202-209.

  Matsui, M., Mori, K.J., Saida, T., Akiguchi, I., and Kameyama, M.

• Circulating CD4+CD8+ cells in myasthenia gravis: supplementary immunological parameter for long-term prognosis. J Neurol 1989; 236: 329-335.

  Matsui, M., Fukuyama, H., Akiguchi, I., and Kameyama, M.

• Cellular immunoregulatory mechanisms in the central nervous system: characterization of noninflammatory and inflammatory cerebrospinal fluid lymphocytes. Ann Neurol 1990; 27: 647-651.

  Matsui, M., Mori, K.J., and Saida, T.

• T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature 1990; 346: 183-187.

  Ota, K., Matsui, M., Milford, E.L., Mackin, G.A., Weiner, H.L., and Hafler, D.A.

• Double-blind pilot trial of oral tolerization with myelin antigens in early relapsing-remitting multiple sclerosis. Science 1993; 259: 1321-1324.

  Weiner, H.L., Mackin, G.A., Matsui, M., Orav, E.J., Khoury, S., Dawson, D.M., and Hafler, D.A.

• Potential role of thymoma and other mediatinal tumors in the pathogenesis of myasthenia gravis. J Neuroimmunol 1993; 44: 171-176.

  Matsui, M., Wada, H., Ohta, M., and Kuroda, Y.

• Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J Immunol 1994; 152: 5581-5592.

  Wucherpfennig, K.W., Zhang, J., Witek, C., Matsui, M., Modabber, Y., Ota, K., and Hafler, D.A.

• Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J Exp Med 1994; 179: 279-290.

  Wucherpfennig, K.W., Sette, A., Southwood, S., Oseroff, C., Matsui, M., Strominger, J.L., and Hafler, D.A.

• Characterization of humoral and cellular immunity in the central nervous system of HAM/TSP. J Neurol Sci 1995; 130: 183-189.

  Matsui, M., Nagumo, F., Tadano, J., and Kuroda, Y.

• Aberrant immunity in the central nervous system in relation to disease progression in HAM/TSP. Clin Immunol Immunopath 1997; 82: 203-206.

  Matsui, M., and Kuroda, Y.

• Homozygosity for an allele carrying intermediate CAG repeats in the dentatorubral-pallidoluysian atrophy (DRPLA) gene results in spastic paraplegia. Neurology 1997; 48: 1087-1090.

  Kurohara, K., Kuroda, Y., Maruyama, H., Kawakami, H., Yukitake, M., Matsui, M., and Nakamura, S.

• Immunological disturbances in the central nervous system linked to MRI findings in multiple sclerosis. J Neuroimmunol 2002; 125: 149-154.

  Wang, H.-Y., Matsui, M., and Saida, T.

• Chemokine receptors associated with immunity within and outside the central nervous system in early relapsing-remitting multiple sclerosis. J Neuroimmunol 2002; 133: 184-192.

  Wang, H.-Y., Matsui, M., Araya, S., Onai, N., Matsushima, K., and Saida, T.

• Circulating lymphocyte subsets linked to intracellular cytokine profiles in normal humans. Clin Exp Immunol 2003; 134: 225-231.

  Matsui, M., Araya, S., Wang, H.-Y., Onai, N., Matsushima, K., and Saida, T.

• Immunomonitoring measures in relapsing-remitting multiple sclerosis. J Neuroimmunol 2004; 148: 192-199.

  Matsui, M., Araya, S-i., Wang, H.-Y., Matsushima, K., and Saida, T.

• Differences in systemic and central nervous system cellular immunity relevant to relapsing-remitting multiple sclerosis. J Neurol 2005; 252: 908-915.

  Matsui, M., Araya, S-i., Wang, H.-Y., Matsushima, K., and Saida, T.

• Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia. Intern Med 2006; 45: 135-140.

  Ihara, M., Makino, F., Sawada, H., Mezaki, T., Mizutani, K., Nakase, H., Matsui, M., Tomimoto, H., Shimohama, S.

• Nationwide survey of acute juvenile female non-herpetic encephalitis in Japan: relationship to anti-N-Methyl-D-Aspartate receptor encephalitis. Intern Med 2009; 48: 673-679.

  Kamei, S., Kuzuhara, S., Ishikawa, M., Morita, A., Taira, N., Togo, M., Matsui, M., Ogawa, M., Hisanaga, K., Mizutani, T., Kuno, S.

• CD8+CD11ahigh cells decreased in multiple sclerosis but not in neuromyelitis optica. Eur Neurol 2010; 63: 159-163.

  Matsui, M., Tahara, M., Tanaka, M., Tanaka, K., Matsui, M., Konishi, T.

• Phenytoin at optimum doses ameliorates experimental autoimmune encephalomyelitis via modulation of immunoregulatory cells. J Neuroimmunol 2011, 233; 112-119.

  Hashiba, N., Nagayama, S., Araya, S-i., Inada, H., Sonobe, Y., Suzumura, A., Matsui, M.

• Novel FUS mutation in patients with sporadic amyotrophic lateral sclerosis and cortical basal degeneration. J Clin Neurosci 2012; 19: 1738-1739.

  Nagayama, S., Minato-Hashiba, N., Nakata, M., Kaito, M., Nakanishi, M., Tanaka, K., Arai, M., Akiyama, H., Matsui, M.

• Relevance of distinct monocyte subsets to clinical course of ischemic stroke patients. PLOS one 2013; 8: e69409.

  Kaito, M., Araya, S-i., Gondo, Y., Fujita, M., Minato, N., Nakanishi, M., Matsui, M.

• Intractable cough as characteristic symptom of neuromyelitis optica and neuromyelitis optica spectrum disorder. Mult Scler J 2016; 22: 576-577.

  Fujita-Nakata, M., Tomioka, R., Tanaka, K., Nakanishi, M., Nagayama, S., Takahashi, R., Machiya, T., Hamada, T., Matsui, M.

• Relationship of systemic inflammation and cellular immunity with advancement of cognitive decline in patients with Alzheimer’s disease. Clin Exp Neurimmunol 2018; 9: 182-188.

  Kawai, U., Uchida, N., Oono, M., Fujita-Nakata, M., Nakanishi, M., Sanada, M., Nagayama, S., Matsui, M.

著書

• 【共著】Matsui, M., Hafler, DA., Weiner, HL. Neurologic aspects of autoimmunity. In: Molecular autoimmunity (Talal, N., ed.) , pp359-383, 1991, Academic Press, London.

• 【共著】Matsui, M. Multiple sclerosis: Diagnosis and treatment, In: Neuroimmunological Diseases (Kusunoki, S., ed.), pp105-122, 2016, Springer Japan, Tokyo.

• 【編集】多発性硬化症・視神経脊髄炎診療ガイドライン2017（「多発性硬化症・視神経脊髄炎診療ガイドライン」作成委員会（委員長　松井　真）編集）、2017年、医学書院、東京

• 【編集】多発性硬化症診療最前線。Pharma Medica 36巻3号、2018年（メディカルレビュー社、東京）

その他

• 【受賞】2019年 12th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS), MSJ-PACTRIMS Investigator Award