柿崎 秀宏 かきざき ひでひろ 先生

来歴等

略歴

1983年 北海道大学医学部泌尿器科 医員
1992年 北海道大学医学部泌尿器科 助手
1994年 米国ペンシルヴェニア州ピッツバーグ大学医学部 留学
1996年 北海道大学医学部泌尿器科 助手
1998年 北海道大学医学部泌尿器科 講師
2003年 北海道大学医学部腎泌尿器外科 助教授
2005年 旭川医科大学医学部泌尿器科 教授

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論文

• 1.One-stage repair of perineal hypospadias and scrotal transposition. Eur. Urol., 10: 364-367

  Koyanagi T., Nonomura K., Gotoh T., Nakanishi S. and Kakizaki H. (1984)

• 2.Sympathetic innervation of the male feline urethral rhabdosphincter. Neuroscience Letters, 129: 165-167.

  Kakizaki H., Koyanagi T. and Kato M. (1991)

• 3.Relevance of detrusor hyperreflexia, vesical compliance and urethral pressure to occurrence of vesicoureteral　reflux in myelodysplastic patients. J. Urol., 147(2):413-415.

  Kobayashi S., Shinno Y., Kakizaki H. and Koyanagi T. (1992)

• 4.Experience with one-stage repair of severe proximal hypospadias: Operative technique and results.　　　　　　Eur. Urol., 24:106-110.

  Koyanagi T., Nonomura K., Kakizaki H., Takeuchi I. and Yamashita T. (1993)

• 5.An electromyographic study on the urethral rhabdosphincter in normal and chronically rhizotomized cats: 　　　analysis of electrical potentials evoked by sympathetic nerve stimulation. J. Urol., 151: 238-243.

  Kakizaki H., Koyanagi T., Shinno Y., Kobayashi S., Matsumura K. and Kato M. (1994)

• 6.Preexisting neurogenic voiding dysfunction in children with imperforate anus: problems in management.　　　　J. Urol., 151: 1041-1044.

  Kakizaki H., Nonomura K., Asano Y., Shinno Y., Ameda K. and Koyanagi T. (1994)

• 7.One-stage repair of hypospadias: is there no simple method universally applicable to all types of hypospadias? 　J. Urol., 152: 1232-1237.

  Koyanagi T., Nonomura K., Yamashita T., Kanagawa K. and Kakizaki H. (1994)

• 8.Fascial sling for the management of urinary incontinence due to sphincter incompetence. J. Urol., 153: 644-647.

  Kakizaki H., Shibata T., Shinno Y., Kobayashi S., Matsumura K. and Koyanagi T. (1995)

• 9.Continence mechanism of the orthotopic neobladder: Urodynamic analysis of ileocolic neobladder and external　urethral sphincter function. Int. J. Urol., 2: 267-272.

  Kakizaki H., Shibata K., Ameda K., Shinno Y., Nonomura K. and Koyanagi T. (1995)

• 10.Role of spinal nitric oxide in the facilitation of the micturition reflex by bladder irritation. J. Urol., 155: 355-360.

  Kakizaki H. and de Groat W.C. (1996)

• 11.Role of NMDA and AMPA glutamatergic transmission in spinal c-fos expression after urinary tract irritation. 　Am. J. Physiol. 270 (Regulatory Integrative Comp. Physiol. 39): R990-996.

  Kakizaki H., Yoshiyama M. and de Groat W.C. (1996)

• 12.Reflex pathways controlling urethral striated and smooth muscle function in the male rat. Am. J. Physiol.272 　(Regulatory Integrative Com. Physiol. 41) : R1647-1656.

  Kakizaki H., Fraser M.O. and de Groat W.C. (1997)

• 13.Reorganization of somato-urethral reflexes following spinal cord injury in the rat. J. Urol., 158:1562-1567.

  Kakizaki H. and de Groat, W.C. (1997)

• 14.Role of glutamatergic transmission in the ascending limb of the micturition reflex pathway in the rat.　　　　　J. Pharmacol. Exp. Ther. 285: 22-27

  Kakizaki H., Yoshiyama M., Roppolo J.R., Booth A.M. and de Groat W.C. (1998)

• 15.Clinical features of vesicoureteral reflux in infants and outcome of conservative therapeutic approach.　　　　Eur. Urol., 34: 221-225

  Kakizaki H., Nonomura K., Yamashita T., Shibata T., Koyama T. and Koyanagi T. (1998)

• 16.Current view and status of the treatment of lower urinary tract symptoms and neurogenic lower urinary tract 　dysfunction. Brit. J. Urol., 85 (Suppl. 2): 25-30

  Kakizaki H. and Koyanagi T. (2000)

• 17.Effects of WAY100635, a selective 5-HT1A-receptor antagonist on the micturition-reflex pathway in the rat. 　　Am. J. Physiol., Regulatory Integrative Comp. Physiol., 280: R1407-R1413

  Kakizaki H., Yoshiyama M., Koyanagi T., de Groat W.C. (2001)

• 18.Clinical experience in lower urinary tract symptoms. Brit. J. Urol., 88 (Suppl. 2): 23-26

  Kakizaki H. Machino R. and Koyanagi T. (2001)

• 19.Questionnaire analysis on sex difference in lower urinary tract symptoms. Urology, 59: 58-62

  Kakizaki H., Matsuura S., Mitsui T., Ameda K., Tanaka H. and Koyanagi T. (2002)

• 20.Human brain region response to distension or cold stimulation of the bladder: 　　　　　　　　　　　　　　　A positron emission tomography study. J. Urol., 168: 2035-2039

  Matsuura S., Kakizaki H., Mitsui T., Shiga T., Tamaki N. and Koyanagi T. (2002)

• 21.NK1 receptor and its interaction with NMDA receptor in spinal c-fos expression after lower urinary tract 　　　irritation. Am. J. Physiol., Regul. Integr. Comp. Physiol., 283: R576-R582

  Mitsui T., Kakizaki H., Matsuura S., Tanaka H., Ameda K., Yoshioka M. and Koyanagi T. (2002)

• 22.Urodynamic effects of α1-blocker tamsulosin on voiding dysfunction in patients with neurogenic bladder. Int. 　J. Urol., 10: 576-581.

  Kakizaki H., Ameda K., Kobayashi S., Tanaka H., Shibata T. and Koyanagi T. (2003)

• 23.Brain activation during detrusor overactivity in patients with Parkinson’s disease: A positron emission 　　　　tomography study. J. Urol., 175: 994-998.

  Kitta T, Kakizaki H, Furuno T, Moriya K, Tanaka H, Shiga T, Tamaki N, Yabe I, Sasaki H, Nonomura K. (2006)

• 24.Solifenacin as add-on therapy for overactive bladder symptoms in men treated for lower urinary tract　　　　　symptoms －ASSIST, randomized controlled study. Urology, 78: 126-133.

  Yamaguchi O, Kakizaki H, Homma Y, Takeda M, Nishizawa O, Gotoh M, Yokoyama O, Seki N, Yoshida M, 　　　　on behalf of the ASSIST Study group. (2011)

• 25.Models for sensory neurons of dorsal root ganglia and stress urinary incontinence. Neurourol. Urodyn., 　　　　30: 653-657.

  Kakizaki H, Kita M, Wada N. (2011)

• 26.A phase III, randomized, double-blind, placebo-controlled study of the β3-adrenoceptor agonist, mirabegron 　50 mg once-daily, in Japanese patients with overactive bladder. BJU Int, 113: 951-960.

  Yamaguchi O, Marui E, Kakizaki H, Homma Y, Igawa Y, Takeda M, Nishizawa O, Gotoh M, Yoshida M, Yokoyama O, Seki N, Ikeda Y, Ohkawa S. (2014)

• 27.Safety and efficacy of mirabegron as add-on therapy in patients with overactive bladder treated with　　　　　solifenacin: a postmarketing, open-label study in Japan (MILAI study). BJU Int., 116: 612-622.

  Yamaguchi O, Kakizaki H, Homma Y, Igawa Y, Takeda M, Nishizawa O, Gotoh M, Yoshida M, Yokoyama O, Seki N, Okitsu A, Hamada T, Kobayashi A, Kuroishi K.. (2015)

• 28.Pathophysiological and therapeutic considerations for non-neurogenic lower urinary tract dysfunction in　　　children. LUTS, 8: 75-85.

  Kakizaki H, Kita M, Watanabe M, Wada N. (2016)

• 29.Mirabegron add-on therapy to tamsulosin for the treatment of overactive bladder in men with lower urinary 　　tract symptoms: A randomized, placebo-controlled study (MATCH). European Urology Focus, doi.org/10.1016/　j.euf.2019.10.019

  Kakizaki H, Lee K-S, Yamamoto O, Jong JJ, Katou D, Sumarsono B, Uno S, Yamaguchi O. (2019)

• 30.Managing sphincter deficiency stress urinary incontinence in the neurogenic patients: Diagnosis and 　　　　　management strategies. Curr Bladder Dusfunct Rep, 24, October,1-6, 2020. DOI: 10.1007/s11884-020-00604-1

  Kakizaki H, Wada N, Watanabe M, Kita M, Hori J, Tamaki G.（2020）

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著書

• 1.よくわかって役に立つ排尿障害のすべて/永井書店/　　2007

• 2.よくわかって役に立つ前立腺肥大症のすべて/永井書店/2009

• 3.過活動膀胱診療ガイドライン第2版/リッチヒルメディカル/2015

• 4.男性下部尿路症状・前立腺肥大症診療ガイドライン/リッチヒルメディカル/2017

• 5.Neurourology –Theory and Practice/Springer Nature B.V./2019

• 6.夜間頻尿診療ガイドライン第2版/リッチヒルメディカル/2020

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その他

• 【受賞】1993年 第52回日本泌尿器科学会坂口賞

• 【受賞】1998年 第５回日本神経因性膀胱学会 学会賞

• 【受賞】2016年 北海道医師会賞・北海道知事賞