前田 隆浩 まえだ たかひろ 先生

来歴等

略歴

1985年 長崎大学医学部原研内科 入局
1996年 長崎大学原研内科 助手
2000年 長崎大学医学部附属病院 総合診療部 講師
2001年 長崎大学医学部附属病院 総合診療部 助教授
2004年 長崎大学大学院医歯薬学総合研究科 離島・へき地医療学講座 教授
2010年 長崎大学保健・医療推進センター 離島・へき地医療教育研究部門 部門長／教授
2012年 長崎大学大学院医歯薬学総合研究科 地域医療学分野 教授
2018年 長崎大学大学院医歯薬学総合研究科 総合診療学分野 教授

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論文

• 1. Possible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population. Environ Health Prev Med. 2021 Jan 29;26(1):17

  Shimizu Y, Arima K, Noguchi Y, Kawashiri SY, Yamanashi H, Tamai M, Nagata Y, MaedaT.

• 2. Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population. Sci Rep. 2020 Aug 25;10(1):14148

  Shimizu Y, Arima K, Noguchi Y, Kawashiri SY, Yamanashi H, Tamai M, Nagata Y, Maeda T.

• 3. Human T-cell lymphotropic virus type-1 infection associated with sarcopenia: community-based cross-sectional study in Goto, Japan. Aging (Albany NY). 2020 Jul 24;12（15）:15504-15513

  Yamanashi H, Nobusue K, Nonaka F, Honda Y, Shimizu Y, Kawashiri SY, Izumida M, Kubo Y, Tamai M, Nagata Y, Yanagihara K, Kulkarni B, Kinra S, Kawakami A, Maeda T.

• 4. Association between human T cell leukemia virus type-1 (HTLV-1) infection and advanced periodontitis in relation to atherosclerosis among elderly Japanese: a cross-sectional study. Environ Health Prev Med. 2019 Dec 28;24(1):81.

  Shimizu Y, Yamanashi H, Kitamura M, Furugen R, Iwasaki T, Fukuda H, Hayashida H, Kawasaki K, Kiyoura K, Kawashiri SY, Saito T, Kawakami A, Maeda T.

• 5. Emigration of regional quota graduates of Japanese medical schools to non-designated prefectures: a prospective nationwide cohort study. BMJ Open. 2019 Jul 31;9(7):e029335.

  Yoshida S, Matsumoto M, Kashima S, Owaki T, Iguchi S, Inoue K, Tazuma S, Maeda T.

• 6. Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study. Environ Health Prev Med. 2019 Jun 10;24(1):42.

  Shimizu Y, Yamanashi H, Kitamura M, Furugen R, Iwasaki T, Fukuda H, Hayashida H, Kawasaki K, Kiyoura K, Kawashiri SY, Saito T, Kawakami A, Maeda T.

• 7. Lineage-specific RUNX2 super-enhancer activates MYC and promotes the development of blastic plasmacytoid dendritic cell neoplasm. Nat Commun. 2019 Apr 10;10(1):1653.

  Kubota S, Tokunaga K, Umezu T, Yokomizo-Nakano T, Sun Y, Oshima M, Tan KT, Yang H, Kanai A, Iwanaga E, Asou N, Maeda T, Nakagata N, Iwama A, Ohyashiki K, Osato M, Sashida G.

• 8. Geographic Distribution of Regional Quota Program Graduates of Japanese Medical Schools: A Nationwide Cohort Study. 2019 Aug;94(8):1244-1252.

  Matsumoto M, Kashima S, Owaki T, Iguchi S, Inoue K, Tazuma S, Maeda T.

• 9. Association between chronic kidney disease and carotid intima-media thickness in relation to circulating CD34-positive cell count among community-dwelling elderly Japanese men. Atherosclerosis. 2019 Apr;283:85-91.

  Shimizu Y, Yamanashi H, Noguchi Y, Koyamatsu J, Nagayoshi M, Kiyoura K, Fukui S, Tamai M, Kawashiri SY, Kondo H, Maeda T.

• 10. Recurrent 8q24 rearrangement in blastic plasmacytoid dendritic cell neoplasm: association with immunoblastoid cytomorphology, MYC expression, and drug response. Leukemia. 2018 Dec;32(12):2590-2603.

  Sakamoto K, Katayama R, Asaka R, Sakata S, Baba S, Nakasone H, Koike S, Tsuyama N, Dobashi A, Sasaki M, Ichinohasama R, Takakuwa E, Yamazaki R, Takizawa J, Maeda T, Narita M, Izutsu K, Kanda Y, Ohshima K, Takeuchi K.

• 11. Human T-cell Leukemia Virus-1 Infection is Associated with Atherosclerosis as Measured by Carotid Intima-Media Thickness in Japanese Community-Dwelling Older People. Clin Infect Dis. 2018 Jul 2;67(2):291-294.

  Yamanashi H, Koyamatsu J, Nagayoshi M, Shimizu Y, Kawashiri SY, Kondo H, Fukui S, Tamai M, Sato S, Yanagihara K, Kawakami A, Maeda T.

• 12. Results of physician licence examination and scholarship contract compliance by the graduates of regional quotas in Japanese medical schools: a nationwide cross-sectional survey. BMJ Open. 2017 Dec 22;7(12):e019418.

  Matsumoto M, Takeuchi K, Owaki T, Iguchi S, Inoue K, Kashima S, Tazuma S, Maeda T.

• 13. Platelets and circulating CD34-positive cells as an indicator of the activity of the vicious cycle between hypertension and endothelial dysfunction in elderly Japanese men. Atherosclerosis. 2017 Apr;259:26-31.

  Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Kawashiri S, Inoue K, Nagata Y, Maeda T.

• 14. Haploinsufficiency for NR3C1, the gene encoding the glucocorticoid receptor, in blastic plasmacytoid dendritic cell neoplasms. Blood. 2016 Jun 16;127(24):3040-53.

  Emadali A, Hoghoughi N, Duley S, Hajmirza A, Verhoeyen E, Cosset FL, Bertrand P, Roumier C, Roggy A, Suchaud-Martin C, Chauvet M, Bertrand S, Hamaidia S, Rousseaux S, Josserand V, Charles J, Templier I, Maeda T, Bruder-Costa J, Chaperot L, Plumas J, Jacob MC, Bonnefoix T, Park S, Gressin R, Tensen CP, Mecucci C, Macintyre E, Leroux D, Brambilla E, Nguyen-Khac F, Luquet I, Penther D, Bastard C, Jardin F, Lefebvre C, Garnache F, and Callanan MB.

• 15. Follow-up study of the regional quota system of Japanese medical schools and prefecture scholarship programmes: a study protocol. BMJ Open. 2016 Apr 15;6(4):e011165.

  Matsumoto M, Takeuchi K, Tanaka J, Tazuma S, Inoue K, Owaki T, Iguchi S, and Maeda T.

• 16. Circulating CD34-positive cells, glomerular filtration rate and triglycerides in relation to hypertension. Atherosclerosis. 2015 Nov;243(1):71-6.

  Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Nagayoshi M, Kadota K, Maeda T.

• 17. Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: the Nagasaki Islands Study. Atherosclerosis. 2014 Apr;233(2):525-529.

  Shimizu Y, Sato S, Koyamatsu J, Yamanashi H, Tamai M, Kadota K, Arima K, Yamasaki H, Takamura N, Aoyagi K, Maeda T.

• 18. Association of arterial stiffness and diabetes with triglycerides-to-HDL cholesterol ratio for Japanese men: The Nagasaki Islands Study. Atherosclerosis 2013 Jun;228(2):491-5.

  Shimizu Y, Nakazato M, Sekita T, Kadota K, Yamasaki H, Takamura N, Aoyagi K, Maeda T.

• 19. The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the anti-apoptotic gene BCL2-A1. Blood. 2012 May 31;119(22):5191-200.

  Karrich JJ, Balzarolo M, Schmidlin H, Libouban M, Nagasawa M, Gentek R, Kamihira S, Maeda T, Amsen D, Wolkers MC, Blom B.

• 20. Bortezomib suppresses function and survival of plasmacytoid dendritic cells by targeting intracellular trafficking of Toll-like receptors and endoplasmic reticulum homeostasis. Blood 2011 Jan 13;117(2):500-9.

  Hirai M, Kadowaki N, Kitawaki T, Fujita H, Mkaori-Kondo A, Fukui R, Miyake K, Maeda T, Kamkihira S, Miyachi Y, and Uchiyama T.

• 21. Risk of coronary heart disease and mortality for adults with subclinical hypothyroidism. JAMA. 2010 Dec 8;304(22):2481-2; author reply 2482.

  Takamura N, Hayashida N, and Maeda T.

• 22. Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development. Cell. 2008 Oct 3;135(1):37-48.

  Babacar Cisse, Michele L. Caton, Manfred Lehner, Takahiro Maeda, Stefanie Scheu, Richard Locksley, Dan Holmberg, Christiane Zweier, Nicolette S. den Hollander, Sairna G. Kant, Wolfgang Holter, Anita Rauch, Yuan Zhuang, and Boris Reizis.

• 23. A novel plasmacytoid dendritic cell line, CAL-1, established from a patient with blastic natural killer cell lymphoma. Int J Hematol. 2005 Feb;81(2):148-54.

  Maeda T, Murata K, Fukushima T, Sugahara K, Tsuruda K, Anami M, Onimaru Y, Tsukasaki K, Tomonaga M, Moriuchi R, Hasegawa H, Yamada Y, and Kamihira S.

• 24. Aberrant processing of Fas transcripts in adult T-cell leukemia: a possible role in tumor cell survival. Cancer Letters. 2003 Apr 25;193(2):235-42.

  Tawara M, Maeda T, Yamada Y, Harasawa H, Tsuruda K, Sugahara K, Moriuchi R, Tomonaga M, and Kamihira S.

• 25. The conformational alteration of the mutated extracellular domain of Fas in an adult T cell leukemia cell line. Biochem Bioph Res Commun. 2002 Sep 6;296(5):1251-6.

  Maeda T, Nakayama S, Yamada Y, Sugahara K, Isomoto H, Tawara M, Yamasaki R, Onimaru Y, Matsushita T, Ohzono Y, and Kamihira S.

• 26. Successful treatment with a chimeric anti-CD20 monoclomnal antibody (IDEC-C2B8, Rituximab) for a patient with relapsed mantle cell lymphoma who developed a human anti-chimeric antibody. Int J Hematol. 2001 Jul;74(1):70-5.

  Maeda T, Yamada Y, Tawara M, Yamasaki R, Yakata Y, Tsutsumi C, Onimaru Y, Kamihira S, and Tomonaga M.

• 27. Fas gene mutation in the progression of adult T cell leukemia. J Exp Med. 1999 Apr 5;189(7):1063-71.

  Maeda T, Yamada Y, Moriuchi R, Sugahara K, Tsuruda K, Joh T, Atogami S, Tsukasaki K, Tomonaga M, and Kamihira S.

• 28. Poor outcome of autologous stem cell transplantation for adult T cell leukemia/limphoma: a case report and review of the literature. Bone Marrow Transplantat 1999 Jan;23(1):87-9.

  Tsukasaki K, Maeda T, Arimura K, Taguchi J, Fukushima T, Miyazaki Y, Moriuchi Y, Kuriyama K, Yamada Y, and Tomonaga M.

• 29. Interleukin-15 (IL-15) can replace the signal in IL-2-dependent adult T-cell leukemia (ATL) cell Lines: expression of IL-15 receptor alpha on ATL cells. Blood 1998 Jun 1;91(11):4265-72.

  Yamada Y, Sugahara K, Hata T, Tsuruda K, Moriuchi R, Maeda T, Atogami S, Murata K, Fujimoto K, Kohno T, Tsukasaki K, Tomonaga M, Hirakata Y, and Kamihira S.

• 30. Integration patterns of HTLV-I provirus in relation to the clinical course of ATL: frequent clonal change at crisis from indolent disease. Blood. 1997 Feb 1;89(3):948-56.

  Tsukasaki K, Tsushihma H, Yamamura M, Hata T, Murata K, Maeda T, Atogami S, Sohda H, Momita S, Ikeda S, Katamine S, Yamada Y, Kamihira S, and Tomonaga M.

• 31. Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia. J Clin Oncol. 1997 May;15(5):1778-85.

  Yamada Y, Hatta Y, Murata K, Sugahara K, Ikeda S, Mine M, Maeda T, Hirakata Y, Kamihira S, Tsukasaki K, Ogawa S, Hirai H, Koeffler HP, and Tomonaga M.

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著書

• 1. 「Vol. 14 公共哲学としての地域医療」、医学のあゆみ（連載「地域医療の将来展望」）272巻3号、p249-254、医歯薬出版、2020年1月

• 2. 国試・改訂コアカリ対応「地域医療学入門」、日本医学教育学会地域医療教育委員会・全国地域医療教育協議会合同編集委員会監修、診断と治療社、2019年8月

• 3. 「遺伝子とがん」人間科学の百科事典、日本生理人類学会編、丸善出版、2015年1月25日、p43-44

• 4. 「飲酒と喫煙」人間科学の百科事典、日本生理人類学会編、丸善出版、2015年1月25日、p456-458

• 5. 前田隆浩：「タバコをやめれば長生きできる？」カラダの百科事典、日本生理人類学会編, 丸善株式会社発行, 646-650, 2009

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特許

• 1. 新規ヒト形質細胞様樹状細胞株（前田隆浩／2005年8月1日／特願2005-234389）

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受賞

• 1. 2014年6月22日　日本生理人類学会優秀論文賞“Association between alkaline phosphatase and hypertension in a rural Japanese population: The Nagasaki Islands study” Journal of Physiological Anthropology 32:10(2013)