室田 浩之 むろた ひろゆき 先生

来歴等

略歴

1995年 長崎大学医学部皮膚科 入局
2003年 長崎大学医学部皮膚科 助手
2004年 大阪大学医学部皮膚科 助手
2012年 大阪大学医学部皮膚科 講師
2014年 大阪大学医学部皮膚科 准教授
2018年 長崎大学大学院 医歯薬学総合研究科 皮膚病態学分野 教授
2021年 長崎大学大学院 先導医療研究コア ライフサイエンス・イノベーション研究 ユニットリーダー兼任

論文

• 1:Sweat in the pathogenesis of atopic dermatitis. Allergol Int. 2018 Oct;67(4):455-459. doi: 10.1016/j.alit.2018.06.003. Epub 2018 Aug 3. PMID: 30082151.

  Murota H, Yamaga K, Ono E, Katayama I.

• 2: Exacerbating factors of itch in atopic dermatitis. Allergol Int. 2017 Jan;66(1):8-13. doi: 10.1016/j.alit.2016.10.005. Epub 2016 Nov 15. PMID: 27863904.

  Murota H, Katayama I.

• 3:Periostin in the pathogenesis of skin diseases. Cell Mol Life Sci. 2017 Dec;74(23):4321-4328. doi: 10.1007/s00018-017-2647-1. Epub 2017 Sep 15. PMID: 28916993.

  Murota H, Lingli Y, Katayama I.

• 4:Why does sweat lead to the development of itch in atopic dermatitis? Exp Dermatol. 2019 Dec;28(12):1416-1421. doi: 10.1111/exd.13981. Epub 2019 Jul 3. PMID: 31152459.

  Murota H, Yamaga K, Ono E, Murayama N, Yokozeki H, Katayama I.

• 5:Claudin-3 Loss Causes Leakage of Sweat from the Sweat Gland to Contribute to the Pathogenesis of Atopic Dermatitis. J Invest Dermatol. 2018 Jun;138(6):1279-1287. doi: 10.1016/j.jid.2017.11.040. Epub 2017 Dec 23. PMID: 29277540.

  Yamaga K, Murota H, Tamura A, Miyata H, Ohmi M, Kikuta J, Ishii M, Tsukita S, Katayama I.

• 6:Evolving understanding on the aetiology of thermally provoked itch. Eur J Pain. 2016 Jan;20(1):47-50. doi: 10.1002/ejp.777. Epub 2015 Sep 28. PMID: 26415614; PMCID: PMC5055078.

  Murota H, Katayama I.

• 7:Attenuated Activation of Homeostatic Glucocorticoid in Keratinocytes Induces Alloknesis via Aberrant Artemin Production. J Invest Dermatol. 2018 Jul;138(7):1491-1500. doi: 10.1016/j.jid.2018.02.010. Epub 2018 Feb 21. PMID: 29474943.

  Matsumoto A, Murota H, Terao M, Katayama I.

• 8:Sweat glucose and GLUT2 expression in atopic dermatitis: Implication for clinical manifestation and treatment. PLoS One. 2018 Apr 20;13(4):e0195960. doi: 10.1371/journal.pone.0195960. PMID: 29677207; PMCID: PMC5909908.

  Ono E, Murota H, Mori Y, Yoshioka Y, Nomura Y, Munetsugu T, Yokozeki H, Katayama I.

• 9:Assessment of antihistamines in the treatment of skin allergies. Curr Opin Allergy Clin Immunol. 2011 Oct;11(5):428-37. doi: 10.1097/ACI.0b013e32834a96e9. PMID: 21841471.

  Murota H, Katayama I.

• 10:Sweat, the driving force behind normal skin: an emerging perspective on functional biology and regulatory mechanisms. J Dermatol Sci. 2015 Jan;77(1):3-10. doi: 10.1016/j.jdermsci.2014.08.011. Epub 2014 Sep 6. PMID: 25266651.

  Murota H, Matsui S, Ono E, Kijima A, Kikuta J, Ishii M, Katayama I.

• 11:Increased serum CXCR2 ligand levels in livedo vasculopathy with winter ulcerations: Possible contribution of neutrophil recruitment to lesional skin. J Dermatol Sci. 2016 Apr;82(1):57-9. doi: 10.1016/j.jdermsci.2016.01.004. Epub 2016 Jan 8. PMID: 26827264.

  Yang L, Murota H, Shindo S, Yang F, Serada S, Fujimoto M, Naka T, Katayama I.

• 12:Topical cholesterol treatment ameliorates hapten-evoked cutaneous hypersensitivity by sustaining expression of 11β-HSD1 in epidermis. Exp Dermatol. 2014 Jan;23(1):68-70. doi: 10.1111/exd.12284. PMID: 24224519.

  Murota H, Itoi S, Terao M, Matsui S, Kawai H, Satou Y, Suda K, Katayama I.

• 13:Dynamic analysis of histamine-mediated attenuation of acetylcholine-induced sweating via GSK3β activation. J Invest Dermatol. 2014 Feb;134(2):326-334. doi: 10.1038/jid.2013.323. Epub 2013 Jul 30. PMID: 23900020.

  Matsui S, Murota H, Takahashi A, Yang L, Lee JB, Omiya K, Ohmi M, Kikuta J, Ishii M, Katayama I.

• 14:Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis. J Allergy Clin Immunol. 2012 Sep;130(3):671-682.e4. doi: 10.1016/j.jaci.2012.05.027. Epub 2012 Jul 4. PMID: 22770266.

  Murota H, Izumi M, Abd El-Latif MI, Nishioka M, Terao M, Tani M, Matsui S, Sano S, Katayama I.

• 15:Impact of sedative and non-sedative antihistamines on the impaired productivity and quality of life in patients with pruritic skin diseases. Allergol Int. 2010 Dec;59(4):345-54. doi: 10.2332/allergolint.10-OA-0182. Epub 2010 Aug 25. PMID: 20864795.

  Murota H, Kitaba S, Tani M, Wataya-Kaneda M, Azukizawa H, Tanemura A, Umegaki N, Terao M, Kotobuki Y, Katayama I.

• 16:Heat- inductible turbidity precipitates in plasma samples of livedo reticularis with summer ulceration: hypothesis for abnormal coagulation in summer. Thromb Haemost. 2005 Jul;94(1):222-3. PMID: 16116688.

  Murota H, Muroi E, Hamasaki Y, Shimizu K, Masuzawa M, Katayama I.

• 17:Disruption of tumor necrosis factor receptor p55 impairs collagen turnover in experimentally induced sclerodermic skin fibroblasts. Arthritis Rheum. 2003 Apr;48(4):1117-25. doi: 10.1002/art.10896. PMID: 12687556.

  Murota H, Hamasaki Y, Nakashima T, Yamamoto K, Katayama I, Matsuyama T.

著書

• 1.Evolution of Atopic Dermatitis in the 21st Century／Springer Singapore／2018

• 2.Perspiration Research (Current Problems in Dermatology) ／S Karger Ag／2016

受賞

• 第14回ガルデルマ賞

• 第１回高木賞

• 大阪大学皮膚科同窓会賞

• ISAD 11th Rajka Symposium Best Oral Presentation Award

その他

• 【テレビ出演】『美と若さの新常識～カラダのヒミツ～』　「汗の老化が美をむしばむ！」

• 【テレビ出演】「ザ！世界仰天ニュース」 2018年5月29日

SNS・ブログ等

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