仲野 和彦 なかの かずひこ 先生

来歴等

略歴

1996年 大阪大学歯学部 卒業
1996年 大阪大学歯学部附属病院 小児歯科 研修医
1997年 大阪大学歯学部附属病院 小児歯科 医員
2002年 博士（歯学）（大阪大学） 取得
2003年 大阪大学歯学部附属病院 小児歯科 助手
2007年 大阪大学歯学部附属病院 小児歯科 講師
2011年 大阪大学大学院歯学研究科小児歯科学教室 准教授
2014年 大阪大学大学院歯学研究科小児歯科学教室 教授（〜現在）
2014年 大阪大学歯学部附属病院 小児歯科 科長（〜現在）
2018年 大阪大学大学院歯学研究科 副研究科長（〜現在）
2018年 大阪大学歯学部 副学部長（〜現在）

論文

• 1. (2011) Common knowledge regarding prevention of infective endocarditis among general dentists in Japan. J Cardiol. 57:123-130.

  Nakano K, Ooshima T.

• 2. (2011) The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke. Nat Commun. 2:485.

  Nakano K, Hokamura K, Taniguchi N, Wada K, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K, Ooshima T.

• 3. (2012) Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis. Sci Rep. 2:332.

  Kojima A, Nakano K, Wada K, Takahashi H, Katayama K, Yoneda M, Higurashi T, Nomura R, Hokamura K, Muranaka Y, Matsuhashi N, Umemura K, Kamisaki Y, Nakajima A, Ooshima T.

• 4. (2012) Amoxicillin-resistant oral streptococci identified in dental plaque specimens from healthy Japanese adults. J Cardiol. 59:285-290.

  Masuda K, Nemoto H, Nakano K, Naka S, Nomura R, Ooshima T.

• 5. (2013) Distribution of amoxicillin-resistant oral streptococci in dental plaque specimens obtained from Japanese children and adolescents at risk for infective endocarditis. J Cardiol. 62:296-300.

  Nemoto H, Nomura R, Ooshima T, Nakano K.

• 6. (2015) Distribution of Streptococcus mutans with collagen-binding proteins in the oral cavity of IgA nephropathy patients. Clin Exp Nephrol. 19:844-850.

  Misaki T, Naka S, Kuroda K, Nomura R, Shiooka T, Naito Y, Suzuki Y, Yasuda H, Isozaki T, Nakano K.

• 7. (2016) Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study. Sci. Rep. 6: 20074.

  Tonomura S, Ihara M, Kawano T, Tanaka T, Okuno Y, Saito S, Friedland RP, Kuriyama N, Nomura R, Watanabe Y, Nakano K, Toyoda K, Nagatsuka K.

• 8. (2016) Presence of Streptococcus mutans harboring the cnm gene correlates with dental caries status and IgA nephropathy conditions. Sci Rep. 6: 36455.

  Misaki T, Naka S, Hatakeyama R, Fukunaga A, Nomura R, Isozaki T, Nakano K.

• 9. (2016) Contributions of Streptococcus mutans Cnm and PA antigens to aggravation of non-alcoholic steatohepatitis in mice. Sci Rep. 6: 36886.

  Naka S, Hatakeyama R, Takashima Y, Matsumoto-Nakano M, Nomura R, Nakano K.

• 10. (2016) Oral Cnm-positive Streptococcus mutans expressing collagen binding activity is a risk factor for cerebral microbleeds and cognitive impairment. Sci Rep. 6: 38561.

  Watanabe I, Kuriyama N, Miyatani F, Nomura R, Naka S, Nakano K, Ihara M, Iwai K, Matsui D, Ozaki E, Koyama T, Nishigaki M, Yamamoto T, Tamura A, Mizuno T, Akazawa K, Takada A, Takeda A, Takeda K, Yamada K, Nakagawa M, Tanaka T, Kanamura N, Friedland RP, Watanabe Y.

• 11. (2017) Gene therapy improves dental manifestations in hypophosphatasia model mice. J Periodontal Res. 52, 471-478.

  Okawa R, Iijima O, Kishino M, Okawa H, Toyosawa S, Sugano-Tajima H, Shimada T, Okada T, Ozono K, Ooshima T, Nakano K.

• 12. (2017) Oral manifestations of Japanese patients with osteogenesis imperfecta. Ped Dent J. 27, 73-78.

  Okawa R, Kubota T, Kitaoka T, Kokomoto K, Ozono K, Nakano K.

• 13. (2018) Current knowledge among Japanese experienced general dentists regarding prevention of infective endocarditis. Odontology. 106: 297-305.

  Nomura R, Kokomoto K, Ohara T, Nakatani S, Ooshima T, Nakano K.

• 14. (2018) Current knowledge among pediatric dentistry specialists in Japan regarding prevention of infective endocarditis. Ped Dent J. 28:110-117.

  Kokomoto K, Nomura R, Ohara T, Nakatani S, Ooshima T, Nakano K.

• 15. (2018) A potential new risk factor for stroke: Streptococcus mutans with collagen-binding protein. World Neurosurgery. 113: e77-e81.

  Inenaga C, Hokamura K, Nakano K, Nomura R, Naka S, Ohashi T, Ooshima T, Kuriyama N, Hamasaki T, Wada K, Umemura K, Tanaka T.

• 16. (2019) Relationship between Streptococcus mutans expressing Cnm in the oral cavity and non-alcoholic steatohepatitis: A pilot study. BMJ Open Gastroenterol. 6: e000329.

  Tonomura S, Naka S, Tabata K, Hara T, Mori K, Tanaka S, Sumida Y, Kanemasa K, Nomura R, Matsumoto-Nakano M, Ihara M, Takahashi N, Nakano K.

• 17. (2019) JCS 2017 guideline on prevention and treatment of infective endocarditis. Circ J. 83:1767-1809.

  Nakatani S, Ohara T, Ashihara K, Izumi C, Iwanaga S, Eishi K, Okita Y, Daimon M, Kimura T, Toyoda K, Nakase H, Nakano K, Higashi M, Mitsutake K, Murakami T, Yasukochi S, Okazaki S, Sakamoto H, Tanaka H, Nakagawa I, Nomura R, Fujiu K, Miura T, Morizane T; Japanese Circulation Society Joint Working Group.

• 18. (2019) Japanese nationwide survey of hypophosphatasia reveals prominent differences in genetic and dental findings between odonto and non-odonto types. PLoS ONE. 14: e0222931.

  Okawa R, Kokomoto K, Kitaoka T, Kubota T, Watanabe A, Taketani T, Michigami T, Ozono K, Nakano K.

• 19. (2019) Possible link between dental diseases and arteriosclerosis in patients on hemodialysis. PLoS ONE. 14: e0225038.

  Misaki T, Fukunaga A, Shimizu Y, Ishikawa A, Nakano K.

• 20. (2019) Presence of specific strains of Streptococcus mutans, a pathogen of dental caries, in the tonsils is associated with IgA nephropathy. Sci Rep. 9: 20130.

  Ito S, Misaki T, Naka S, Wato K, Nagasawa Y, Nomura R, Otsugu M, Matsumoto-Nakano M, Nakano K, Kumagai H, Oshima N.

• 21. (2020) Contribution of severe dental caries induced by Streptococcus mutans to the pathogenicity of infective endocarditis. Infect Immun. 88: e00897-19.

  Nomura R, Matayoshi A, Otsugu M, Kitamura T, Teramoto N, Nakano K.

• 22. (2020) Oral carriage of Streptococcus mutans harboring the cnm gene relates to an increased incidence of cerebral microbleeds. Stroke 51: 3632-3639.

  Hosoki S, Saito S, Tonomura S, Ishiyama H, Yoshimoto T, Ikeda S, Ikenouchi H, Yamamoto Y, Hattori Y, Miwa K, Friedland R, Carare R, Nakahara J, Suzuki N, Koga M, Toyoda K, Nomura R, Nakano K, Takegami M, Ihara M.

• 23. (2021) Dental caries status is associated with arteriosclerosis inpatients on hemodialysis. Clin Exp Nephrol. 25: 87-93.

  Misaki T, Fukunaga A, Nakano K.

• 24. (2021) Cnm-positive Streptococcus mutans and diffusion-weighted imaging hyperintensities in acute intracerebral haemorrhage. Eur J Neurol. 28: 1581-1589.

  Shiga Y, Aoki S, Hosomi N, Nomura R, Nakamori M, Nezu T, Tachiyama K, Kamimura T, Kinoshita N, Shimomura R, Hayashi Y, Imamura E, Ueno H, Wakabayashi S, Nakano K, Kohriyama T, Maruyama H.

• 25. (2021) Streptococcus mutans induces IgA nephropathy-like glomerulonephritis in rats with severe dental caries. Sci Rep. 11: 5784.

  Naka S, Wato K, Misaki T, Ito S, Matsuoka D, Nagasawa Y, Nomura R, Matsumoto-Nakano M, Nakano K.

• 26. (2022) Evaluation of alveolar bone hypomineralization in pediatric hypophosphatasia using orthopantomography. Sci Rep. 12: 1211.

  Okawa R, Nakamoto T, Matayoshi S, Nakano K, Kakimoto N.

• 27. (2022) Risk assessment of Cnm-positive Streptococcus mutans in stroke survivors (RAMESSES): Protocol for a multicenter prospective cohort study. Front Neurol. 13: 816147.

  Hosoki S, Hattori Y, Saito S, Takegami M, Tonomura S, Yamamoto Y, Ikeda S, Hosomi N, Oishi N, Morita Y, Miyamoto Y, Nomura R, Nakano K, Ihara M*.

• 28. (2022) IgA nephropathy and oral bacterial species related to dental caries and periodontitis. Int J Mol Sci. 23:725.

  Nagasawa Y, Misaki T, Ito S, Naka S, Wato K, Nomura R, Matsumoto-Nakano M, Nakano K.

• 29. (2022) Dental manifestation and management of hypophosphatasia. Jpn Dent Sci Rev. 58:208-216.

  Okawa R, Nakano K.

• 30. (2022) Dental manifestations and oral management of X-linked hypophosphatemia. Endocrines. 3: 654-664.

  Okawa R, Nakano K.

• 31. (2023) Simultaneous presence of Campylobacter rectus and cnm-positive Streptococcus mutans in the oral cavity is associated with renal dysfunction in IgA nephropathy patients: 5-year follow-up analysis. Nephron. (in press)

  Misaki T, Naka S, Nagasawa Y, Matsuoka D, Ito S, Nomura R, Matsumoto-Nakano M, Nakano K.

• 32. (2023) Effect of conventional treatment on dental complications and ectopic ossifications among 30 adults with XLH. J Clin Endocrinol Metab. (in press)

  Kato H, Okawa R, Ogasawara T, Hoshino Y, Hidaka N, Koga M, Kinoshita Y, Kobayashi H, Taniguchi Y, Fukumoto S, Nangaku M, Makita N, Hoshi K, Nakano K, Ito N.

• 33. (2023) Harboring Cnm-expressing Streptococcus mutans in the oral cavity relates to both deep and lobar cerebral microbleeds. Eur J Neurol. (in press)

  Ikeda S, Saito S, Hosoki S, Tonomura S, Yamamoto Y, Ikenouchi, H, Ishiyama H, Tanaka T, Hattori Y, Friedland RP, Carare RO, Kuriyama N, Yakushiji Y, Hara H, Koga M, Toyoda K, Nomura R, Takegami Misa, Nakano K, Ihara M.

受賞

• 1. 2003年　日本小児歯科学会 奨励賞

• 2. 2007年　日本小児歯科学会 学術賞“LION AWARD”