髙取 宏昌 たかとり ひろあき 先生

来歴等

略歴

1997年 三重大学医学部 卒業
1997年 千葉大学医学部附属病院 第二内科研修医
1998年 国立佐倉病院 内科勤務
2000年 横浜労災病院 内科勤務
2001年 千葉大学大学院 博士課程入学
2005年 同 修了、医学博士 取得
2005年 下都賀総合病院 内科勤務
2006年 米国国立衛生研究所（NIH, NIAMS, Dr. John O’Shea研究室） 研究員
2009年 千葉大学大学院医学研究院 特任助教
2011年 千葉大学医学部附属病院 アレルギー・膠原病内科 助教
2017年 浜松医療センター 膠原病・リウマチ内科 医長
2017年 千葉大学大学院医学研究院 特任講師
2019年 浜松医療センター 膠原病・リウマチ内科 科部長
2020年 千葉大学大学院医学研究院 アレルギー・臨床免疫学 非常勤講師
2022年 豊橋創造大学 保健医療学部 非常勤講師

論文

• 1. Prevalence and risk factors of osteonecrosis of the femoral head in patients with ANCA-associated vasculitis: a multicentre cohort study. RMD Open. 9: e002787, 2023.

  Mimura N, Iwamoto T, Furuta S, Ikeda K, Kobayashi Y, Nakamura T, Saku A, Kagami SI, Matsuki A, Takahashi K, Umibe T, Nakagomi D, Sanayama Y, Sugimoto T, Fukuta M, Hiraguri M, Kawashima H, Hirose K, Takatori H, Suehiro K, Takahashi S, Tamachi T, Kato M, Takizawa F, Kawarai Y, Hagiwara S, Nakamura J, Ohtori S, Nakajima H

• 2. A case of methotrexate-associated Epstein-Barr virus-positive mucocutaneous ulcer. Skin Health Dis. 2: e108, 2022.

  Sakamoto K, Baba T, Takatori H, Nagao K, Misawa J, Honda T

• 3. A20 (Tnfaip3) expressed in CD4+ T cells suppresses Th2 cell-mediated allergic airway inflammation in mice. Biochem Biophys Res Commun. 629: 47-53, 2022.

  Yokoyama Y, Tamachi T, Iwata A, Maezawa Y, Meguro K, Yokota M, Takatori H, Suto A, Suzuki K, Hirose K, Yamaguchi N, Honda H, and Nakajima H

• 4. T-bet and STAT6 Coordinately Suppress the Development of IL-9-Mediated Atopic Dermatitis-Like Skin Inflammation in Mice. J Invest Dermatol. 141: 1274-1285.e5, 2021.

  Makita S, Takatori H, Matsuki A, Kawashima H, Iwata A, Tanaka S, Nakagomi D, Oya Y, Matsumura R, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H

• 5. Post-Transcriptional Regulation of Immune Responses and Inflammatory Diseases by RNA-Binding ZFP36 Family Proteins. Front Immunol. 12: 711633, 2021.

  Makita S, Takatori H, Nakajima H

• 6. RNA-Binding Protein ZFP36L2 Downregulates Helios Expression and Suppresses the Function of Regulatory T Cells. Front Immunol. 11: 1291, 2020.

  Makita S, Takatori H, Iwata A, Tanaka S, Furuta S, Ikeda K, Suto A, Suzuki K, Ramos SBV, Nakajima H

• 7. Experience of musculoskeletal ultrasound scanning improves physicians' physical examination skills in assessment of synovitis. Clin Rheumatol. 39: 1091-1099, 2020.

  Saku A, Furuta S, Kato M, Furuya H, Suzuki K, Fukuta M, Suehiro K, Makita S, Tamachi T, Ikeda K, Takatori H, Maezawa Y, Suto A, Hirose K, Nakajima H

• 8. Methotrexate-associated lymphoproliferative disorder with hypopituitarism and central diabetes insipidus. Endocrinol Diabetes Metab Case Rep. 2019: 19-0082, 2019.

  Aoshima M, Nagayama K, Takeshita K, Ajima H, Orikasa S, Iwazaki A, Takatori H, Oki Y

• 9. Regulatory Mechanisms of IL-33-ST2-Mediated Allergic Inflammation. Front Immunol. 9: 2004, 2018.

  Takatori H, Makita S, Ito T, Matsuki A, Nakajima H

• 10. Sox12 promotes T reg differentiation in the periphery during colitis. J Exp Med. 215: 2509-2519, 2018.

  Tanaka S, Suto A, Iwamoto T, Kageyama T, Tamachi T, Takatori H, Suzuki K, Hirose K, Ohara O, Lefebvre V, Nakajima H

• 11. Dectin-1 Plays an Important Role in House Dust Mite-Induced Allergic Airway Inflammation through the Activation of CD11b+ Dendritic Cells. J Immunol. 198: 61-70, 2017.

  Ito T, Hirose K, Norimoto A, Tamachi T, Yokota M, Saku A, Takatori H, Saijo S, Iwakura Y, Nakajima H

• 12. IL-22 induces Reg3γ and inhibits allergic inflammation in house dust mite-induced asthma models. J Exp Med. 214: 3037-3050, 2017.

  Ito T, Hirose K, Saku A, Kono K, Takatori H, Tamachi T, Goto Y, Renauld JC, Kiyono H, Nakajima H

• 13. T-bet inhibits innate lymphoid cell-mediated eosinophilic airway inflammation by suppressing IL-9 production. J Allergy Clin Immunol. 139: 1355-1367.e6, 2017.

  Matsuki A, Takatori H, Makita S, Yokota M, Tamachi T, Suto A, Suzuki K, Hirose K, Nakajima H

• 14. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy. 72: 1043-1053, 2017.

  Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H

• 15. Role of Bcl-3 in the development of follicular helper T cells and in the pathogenesis of rheumatoid arthritis. Arthritis Rheumatol. 67: 2651-2660, 2015.

  Meguro K, Suzuki K, Hosokawa J, Sanayama Y, Tanaka S, Furuta S, Ikeda K, Takatori H, Suto A, Sakamoto A, Ohara O, Nakajima H

• 16. Matrix metalloproteinase 12 is produced by M2 macrophages and plays important roles in the development of contact hypersensitivity. J Allergy Clin Immunol. 135: 1397-1400, 2015.

  Nakagomi D, Suzuki K, Meguro K, Hosokawa J, Tamachi T, Takatori H, Suto A, Matsue H, Ohara O, Nakayama T, Shimada S, Nakajima H

• 17. Helios Enhances Treg Cell Function in Cooperation With FoxP3. Arthritis Rheumatol. 67: 1491-1502, 2015.

  Takatori H, Kawashima H, Matsuki A, Meguro K, Tanaka S, Iwamoto T, Sanayama Y, Nishikawa N, Tamachi T, Ikeda K, Suto A, Suzuki K, Kagami S, Hirose K, Kubo M, Hori S, Nakajima H

• 18. Interleukin-21-producing c-Maf-expressing CD4+ T cells induce effector CD8+ T cells and enhance autoimmune inflammation in scurfy mice. Arthritis Rheumatol. 66: 2079-2090, 2014.

  Iwamoto T, Suto A, Tanaka S, Takatori H, Suzuki K, Iwamoto I, Nakajima H

• 19. Sox5 and c-Maf cooperatively induce Th17 cell differentiation via RORγt induction as downstream targets of Stat3. J Exp Med. 211: 1857-1874, 2014.

  Tanaka S, Suto A, Iwamoto T, Kashiwakuma D, Kagami S, Suzuki K, Takatori H, Tamachi T, Hirose K, Onodera A, Suzuki J, Ohara O, Yamashita M, Nakayama T, Nakajima H

• 20. Tumor suppressor p53 inhibits systemic autoimmune diseases by inducing regulatory T cells. J Immunol. 191: 3614-23, 2013.

  Kawashima H, Takatori H, Suzuki K, Iwata A, Yokota M, Suto A, Minamino T, Hirose K, Nakajima H

• 21. Ultrasound can improve the accuracy of the 2010 American College of Rheumatology/European League against rheumatism classification criteria for rheumatoid arthritis to predict the requirement for methotrexate treatment. Arthritis Rheum. 65: 890-898, 2013.

  Nakagomi D, Ikeda K, Okubo A, Iwamoto T, Sanayama Y, Takahashi K, Yamagata M, Takatori H, Suzuki K, Takabayashi K, Nakajima H

• 22. Therapeutic potential of B and T lymphocyte attenuator expressed on CD8+ T cells for contact hypersensitivity. J Invest Dermatol. 133: 702-711, 2013.

  Nakagomi D, Suzuki K, Hosokawa J, Kobayashi Y, Suto A, Takatori H, Watanabe N, Matsue H, Murphy TL, Murphy KM, Shimada S, Nakajima H

• 23. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity. 32: 840-851, 2010.

  Wei L, Vahedi G, Sun HW, Watford WT, Takatori H, Ramos HL, Takahashi H, Liang J, Gutierrez-Cruz G, Zang C, Peng W, O'Shea JJ, Kanno Y

• 24. Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5. Sci Signal. 2: ra5, 2009.

  Kino T, Takatori H, Manoli I, Wang Y, Tiulpakov A, Blackman MR, Su YA, Chrousos GP, DeCherney AH, Segars JH

• 25. Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22. J Exp Med. 206: 35-41, 2009.

  Takatori H, Kanno Y, Watford WT, Tato CM, Weiss G, Ivanov II, Littman DR, O'Shea JJ

• 26. New complexities in helper T cell fate determination and the implications for autoimmune diseases. Mod Rheumatol. 18: 533-541, 2008.

  Takatori H, Kanno Y, Chen Z, O'Shea JJ

• 27. T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways. J Allergy Clin Immunol. 119: 662-670, 2007.

  Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H

• 28. Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation. J Immunol. 174: 3734-3740, 2005.

  Takatori H, Nakajima H, Hirose K, Kagami S, Tamachi T, Suto A, Suzuki K, Saito Y, Iwamoto I

• 29. Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression. J Immunol. 174: 4105-4112, 2005.

  Takatori H, Nakajima H, Kagami S, Hirose K, Suto A, Suzuki K, Kubo M, Yoshimura A, Saito Y, Iwamoto I

• 30. IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells. J Exp Med. 198: 1717-1727, 2003.

  Suzuki K, Nakajima H, Ikeda K, Maezawa Y, Suto A, Takatori H, Saito Y, Iwamoto I

• 31. 浜松医療センター 総合診療内科に入院した成人発熱患者の臨床像の検討. 浜松医療センター学術誌. 16:14-19, 2022.

  髙取宏昌、米澤春花、田原大悟

受賞

• 1. 2021年度 浜松医療センター ベスト指導医賞受賞