植木 伸也 うえき しんや 先生

来歴等

略歴

1998年 北海道大学医学部 卒業
1998年 北海道大学医学部 第一外科
1999年 札幌幌南病院 外科
2000年 岩見沢市立病院 外科
2001年 北海道大学病院 外科
2003年 北海道大学医学部 第一外科 研究
2006年 札幌厚生病院 外科
2007年 アメリカピッツバーグ大学 留学
2010年 市立稚内病院 外科
2013年 札幌厚生病院 外科
2015年 市立函館病院 外科
2020年 独立行政法人地域医療機能推進機構北海道病院 外科 医長

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論文

• 1. Control of allograft rejection by applying a novel nuclear factor-kappaB inhibitor, dehydroxymethylepoxyquinomicin. Transplantation. Dec 27;82(12):1720-7. 2006

  Ueki S, Yamashita K, Aoyagi T, Haga S, Suzuki T, Itoh T, Taniguchi M, Shimamura T, Furukawa H, Ozaki M, Umezawa K, Todo S.

• 2. Critical role of interferon regulatory factor-1 in murine liver transplant ischemia reperfusion injury. Hepatology. May;51(5):1692-701. 2010

  Ueki S, Dhupar R, Cardinal J, Tsung A, Yoshida J, Ozaki KS, Klune JR, Murase N, Geller DA.

• 3. Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation. Hepatology. Jul;54(1):216-28.2011 S.U. and A.C. contributed equally to the work

  Ueki S, Castellaneta A, Yoshida O, Ozaki K, Zhang M, Kimura S, Isse K, Ross M, Shao L, Stolz DB, Thomson AW, Demetris AJ, Geller DA, Murase N.

• 4. Thomson Orthotopic mouse liver transplantation to study liver biology and allograft tolerance. Nature Protocols. 2016 Jul;11(7):1163-74., S.Y. and S.U. contributed equally to the work

  Shinichiro Yokota , Shinya Ueki , Yoshihiro Ono , Shoko Kimura , Osamu Yoshida, Noriko Murase, David A Geller & Angus W

• 5. A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys.　Transplantation. 2007 Oct 27;84(8):1020-8.

  Imai A, Suzuki T, Sugitani A, Itoh T, Ueki S, Aoyagi T, Yamashita K, Taniguchi M, Takahashi N, Miura T, Shimamura T, Furukawa H, Todo S.

• 6. Protection of transplant-induced hepatic ischemia/reperfusion injury with carbon monoxide via MEK/ERK1/2 pathway downregulation.　Am J Physiol Gastrointest Liver Physiol. Jan;294(1):G236-44, 2008

  Kaizu T, Ikeda A, Nakao A, Tsung A, Toyokawa H, Ueki S, Geller DA, Murase N.

• 7. The novel NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin, prevents local and remote organ injury following intestinal ischemia/reperfusion in rats. J Surg Res. Sep;149(1):69-75, 2008

  Suzuki T, Yamashita K, Jomen W, Ueki S, Aoyagi T, Fukai M, Furukawa H, Umezawa K, Ozaki M, Todo S

• 8. Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats. Hepatology. Nov;48(5):1608-20, 2008

  Tomiyama K, Ikeda A, Ueki S, Nakao A, Stolz DB, Koike Y, Afrazi A, Gandhi C, Tokita D, Geller DA, Murase N.

• 9. Donor graft interferon regulatory factor-1 gene transfer worsens liver transplant ischemia/reperfusion injury. Surgery. Aug;146(2):181-9, 2009

  Kim KH, Dhupar R, Ueki S, Cardinal J, Pan P, Cao Z, Cho SW, Murase N, Tsung A, Geller DA.

• 10. Liver graft exposure to carbon monoxide during cold storage protects sinusoidal endothelial cells and ameliorates reperfusion injury in rats. Liver Transpl. Nov;15(11):1458-68, 2009

  Ikeda A, Ueki S, Nakao A, Tomiyama K, Ross MA, Stolz DB, Geller DA, Murase N.

• 11. Carbon monoxide inhibits apoptosis during cold storage and protects kidney grafts donated after cardiac death. Transpl Int. Jan;25(1):107-17, 2012

  Ozaki KS, Yoshida J, Ueki S, Pettigrew GL, Ghonem N, Sico RM, Lee LY, Shapiro R, Lakkis FG, Pacheco-Silva A, Murase N

• 12. The loss of renal dendritic cells and activation of host adaptive immunity are long-term effects of ischemia/reperfusion injury following syngeneic kidney transplantation. Kidney Int. May;81(10):1015-25, 2012

  Ozaki KS, Kimura S, Nalesnik MA, Sico RM, Zhang M, Ueki S, Ross MA, Stolz DB, Murase N.

• 13. Immunomodulatory effect of nuclear factor-κB inhibition by dehydroxymethylepoxyquinomicin in combination with donor-specific blood transfusion. Transplantation. Apr 27;93(8):777-86. 2012

  Goto R, Yamashita K, Aoyagi T, Ueki S, Uno M, Oura T, Kobayashi N, Igarashi R, Shibasaki S, Wakayama K, Hirokata G, Shibata T, Zaitsu M, Umezawa K, Ozaki M, Todo S.

• 14. Interferon regulatory factor-2 is protective against hepatic ischemia-reperfusion injury. Am J Physiol Gastrointest Liver Physiol. Sep 1;303(5) , 2012

  Klune JR, Dhupar R, Kimura S, Ueki S, Cardinal J, Nakao A, Nace G, Evankovich J, Murase N, Tsung A, Geller DA.

• 15. Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury. Hepatology. Apr;57(4):1585-96. 2013

  Zhang M, Ueki S, Kimura S, Yoshida O, Castellaneta A, Ozaki KS, Demetris AJ, Ross M, Vodovotz Y, Thomson AW, B Stolz D, Geller DA, Murase N.

• 16. Contribution of alloantigens to hepatic ischemia/reperfusion injury: Roles of NK cells and innate immune recognition of non-self. Liver Transpl. 2016 Jan;22(1):80-90

  Kimura S, Ozaki KS, Ueki S, Zhang M, Yokota S, Stolz DB, Geller DA, Murase N.

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受賞

• 1. 2009年 アメリカ移植学会 Young Investigator Award