白馬 伸洋 はくば のぶひろ 先生

来歴等

略歴

1991年 愛媛大学医学部 卒業
1991年 神戸中央市民病院
1998年 愛媛大学大学院 卒業
1998年 愛媛大学 耳鼻咽喉科 助手
2005年 大阪赤十字病院 耳鼻咽喉科 副部長
2009年 愛媛大学 耳鼻咽喉科 講師
2014年 愛媛大学 耳鼻咽喉科 准教授
2015年 帝京大学医学部附属溝口病院 耳鼻咽喉科 教授
2015年 帝京大学医学部附属溝口病院 耳鼻咽喉科 科長

論文

1. Hakuba N, Gyo K, Yanagihara N / Efflux of glutamate into the perilymph of the cochlea following transient ischemia in the gerbil. Proc. Sendai Ear Symposium. 7:33-34, 1997.
2. Hakuba N, Gyo K, Yanagihara N, Mitani A, Kataoka K. / Efflux of glutamate into the perilymph of the cochlea following transient ischemia in the gerbil. Neurosci Lett. 230(1):69-71, 1997.
3. Hakuba N, Koga K, Gyo K, Usami SI, Tanaka K. / Exacerbation of noise-induced hearing loss in mice lacking the glutamate transporter GLAST. J Neurosci. 20(23):8750-8753, 2000.
4. Hakuba N, Koga K, Shudou M, Watanabe F, Mitani A, Gyo K. / Hearing loss and glutamate efflux in the perilymph following transient hindbrain ischemia in gerbils. J Comp Neurol. 418(2):217-226, 2000.
5. Watanabe F, Koga K, Hakuba N, Gyo K. /Hypothermia prevents hearing loss and progressive hair cell loss after transient cochlear ischemia in gerbils.　Neuroscience. 102(3):639-645, 2001.
6. Hyodo J, Hakuba N, Koga K, Watanabe F, Shudou M, Taniguchi M, Gyo K. / Hypothermia reduces glutamate efflux in perilymph following transient cochlear ischemia. Neuroreport. 12(9):1983-1987, 2001.
7. Taniguchi M, Hakuba N, Koga K, Watanabe F, Hyodo J, Gyo K. / Apoptotic hair cell death after transient cochlear ischemia in gerbils. Neuroreport. 13(18):2459-2462, 2002.
8. Hakuba N, Hato N, Shinomori Y, Sato H, Gyo K. / Labyrinthine fistula as a late complication of middle ear surgery using the canal wall down technique. Otol Neurotol. 23(6):832-835, 2002.
9. Hakuba N, Taniguchi M, Shimizu Y, Sugimoto A, Shinomori Y, Gyo K. / A new method for closing tympanic membrane perforations using basic fibroblast growth factor. Laryngoscope. 113(8):1352-1355, 2003.
10. Hakuba N, Hyodo M. / Synchronous bilateral mucoepidermoid carcinoma of the parotid gland. J Laryngol Otol. 117(5):419-421, 2003.
11. Hakuba N, Matsubara A, Hyodo J, Taniguchi M, Maetani T, Shimizu Y, Tsujiuchi Y,Shudou M, Gyo K. /　AMPA/kainate-type glutamate receptor antagonist reduces progressive inner hair cell loss after transient cochlear ischemia. Brain Res. 979(1-2):194-202, 2003.
12. Hakuba N, Watabe K, Hyodo J, Ohashi T, Eto Y, Taniguchi M, Yang L, Tanaka J, Hata R, Gyo K. / Adenovirus-mediated overexpression of a gene prevents hearing loss and progressive inner hair cell loss after transient cochlear ischemia in gerbils. 1/10 Gene Ther. 10(5):426-433, 2003.
13. Koga K, Hakuba N, Watanabe F, Shudou M, Nakagawa T, Gyo K. / Transient cochlear ischemia causes delayed cell death in the organ of Corti: an experimental study in gerbils. J Comp Neurol. 456(2):105-111, 2003.
14. Gyo K, Hato N, Shinomori Y, Hakuba N. / Lateralization of the tympanic membrane as a complication of canal wall down tympanoplasty: a report of four cases. 2/4 Otol Neurotol. 24(2):145-148, 2003.
15. Maetani T, Hakuba N, Taniguchi M, Hyodo J, Shimizu Y, Gyo K. / Free radical scavenger protects against inner hair cell loss after cochlear ischemia. Neuroreport. 14(14):1881-1884, 2003.
16. Sugimoto A, Hakuba N, Gyo K. /　Reconstruction of mastoid cortex defect using bone morphogenetic protein: an experimental study in the guinea pig. Acta Otolaryngol. 124(3):253-257, 2004.
17. Hakuba N, Hata R, Morizane I, Feng G, Shimizu Y, Fujita K, Yoshida T, Sakanaka M, Gyo K. / Neural stem cells suppress the hearing threshold shift caused by cochlear ischemia. Neuroreport.　16(14):1545-1549, 2005.
18. Morizane I, Hakuba N, Hyodo J, Shimizu Y, Fujita K, Yoshida T, Gyo K. / Ischemic damage increases nitric oxide production via inducible nitric oxide synthase in the cochlea. Neurosci Lett. 391(1-2):62-67, 2005.
19. Morizane I, Hakuba N, Shimizu Y, Shinomori Y, Fujita K, Yoshida T, Shudou M, Gyo K. / Transient cochlear ischemia and its effects on the stria vascularis. Neuroreport. 16(8):799-802, 2005.
20. Shimizu Y, Hakuba N, Hyodo J, Taniguchi M, Gyo K. / Kanamycin ototoxicity in glutamate transporter knockout mice. Neurosci Lett. 380(3):243-246, 2005.
21. Hato N, Kohno H, Okada M, Hakuba N, Gyo K, / Iwakura T, Tateno M. A new tool for testing ossicular mobility during middle ear surgery: preliminary report of four cases. Otol. Neurotol. 27(5):592-595, 2006.
22. Yoshida T, Hakuba N, Morizane I, Fujita K, Cao F, Zhu P, Uchida N, Kameda K, Sakanaka M, Gyo K, Hata R. / Hematopoietic stem cells prevent hair cell death after transient cochlear ischemia through paracrine effects. Neuroscience. 145(3):923-930, 2007.
23. Fujita K, Hakuba N, Hata R, Morizane I, Yoshida T, Shudou M, Sakanaka M, Gyo K. / Ginsenoside Rb1 protects against damage to the spiral ganglion cells after cochlear ischemia. Neurosci Lett. 415(2):113-117, 2007.
24. Hato N, Okada M, Hakuba N, Hyodo M, Gyo K. / Repair of a malleus-handle fracture using calcium phosphate bone cement. Laryngoscope. 117(2):361-363, 2007.
25. Gyo K, Hato N, Shinomori Y, Hakuba N. / Storage of the incus in the mastoid bowl for use as a columella in staged tympanoplasty. Auris Nasus Larynx. 34(1):5-8, 2007.
26. Fujiwara T, Hato N, Nakagawa T, Tabata Y, Yoshida T, Komobuchi H, Takeda S, Hyodo J, Hakuba N, Gyo K. / Insulin-like growth factor 1 treatment via hydrogels rescues cochlear hair cells from ischemic injury. Neuroreport. 19(16):1585-1588, 2008.
27. Takeda S, Hakuba N, Yoshida T, Fujita K, Hato N, Hata R, Hyodo J, Gyo K. / Postischemic mild hypothermia alleviates hearing loss because of transient ischemia. Neuroreport. 19(13):1325-1328, 2008.
28. Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T.　/ Ear-pick injury as a traumatic ossicular damage in Japan. Eur Arch Otorhinolaryngol. 267(7):1035-1039, 2009.
29. Watanabe F, Hakuba N, Gyo K. / Measurement of DPOAE after ischemia/reperfusion injury of the cochlea in gerbils. Neurosci Lett. 467(2):135-138, 2009.
30. Maetani T, Hyodo J, Takeda S, Hakuba N, Gyo K. / Prednisolone prevents transient ischemia-induced cochlear damage in gerbils. Acta Otolaryngol Suppl. 562:24-27, 2009.

31. Hyodo J, Hakuba N, Hato N, Takeda S, Okada M, Omotehara Y, Gyo K. / Glutamate agonist causes irreversible degeneration of inner hair cells. Neuroreport. 20(14):1255-1259, 2009.
32. Takeda S, Hata R, Cao F, Yoshida T, Hakuba N, Hato N, Gyo K. / Ischemic tolerance in the cochlea. Neurosci Lett. 462(3); 263-266, 2009.
33 . Hakuba N, Iwanaga M, Tanaka S, Hiratsuka Y, Kumabe Y, Konishi M, Okanoue Y, Hiwatashi N, Wada T. / Basic fibroblast growth factor combined with atelocollagen for closing chronic tympanic membrane perforations in 87 patients. Otol Neurotol. 31(1):118-121, 2010.
34. Cao F, Hata R, Zhu P, Takeda S, Yoshida T, Hakuba N, Sakanaka M, Gyo K. / Delayed neuronal cell death in brainstem after transient brainstem ischemia in gerbils. BMC Neurosci. 14;11:115, 2010.
35. Hato N, Hyodo J, Takeda S, Takagi D, Okada M, Hakuba N, Gyo K. / Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss. Auris Nasus Larynx. 37(5):626-630, 2010.
36. Okada M, Kawaguchi AT, Hakuba N, Takeda S, Hyodo J, Imai K, Hato N, Gyo K. / Liposome-Encapsulated Hemoglobin Alleviates Hearing Loss After Transient Cochlear Ischemia and Reperfusion in the Gerbil. Artif Organs. 71(6):1789-93. 2011.
37. Omotehara Y, Hakuba N, Hato N, Okada M, Gyo K. / Protection against ischemic cochlear damage by intratympanic administration of AM-111. Otol Neurotol. 32(9):1422-7. 2011.
38. Hato N, Nota J, Hakuba N, Gyo K, Yanagihara N. / Facial nerve decompression surgery in patients with temporal bone trauma: analysis of 66 cases. J Trauma. 71(6):1789-93. 2011.
39.Teraoka M, Hato N, Wakisaka H, Takahashi H, Komobuchi H, Sawai N, Okada M, Hakuba H, Gyo K. / Myogenin gene expression in the facial muscle following compression or resection of the facial nerve. Acta Otolaryngol. 132(9):1013-7. 2012.
40.Takagi D, Hato N, Okada M, Hakuba N, Gyo K, Shigemoto K, Toda T, Ogasawara M, Kameda K. / Galectin-7 as a marker of cholesteatoma residue and its detection during surgery by immunofluorescent method - A preliminary study. Otol Neurotol. 33(3):396-9. 2012.
41.Sawai N, Hato N, Hakuba N, Takahashi H, Okada M, Gyo K. / Facial motion analysis for objective assessment of facial palsy utilizing face sensing technology "OkaoⓇ vision". Acta Otolaryngol. 132(9):1013-7. 2012.
42. Nota J, Takahashi H, Hakuba N, Hato N, Gyo K. / Treatment of neural anosmia by topical application of basic fibroblast growth factor-gelatin hydrogel in the nasal cavity: an experimental study in mice. JAMA Otolaryngol Head Neck Surg. 139(4):396-400. 2013.
43. Hakuba N, Hato N, Omotehara Y, Okada M, Gyo K. / Epithelial pearl formation following tympanic membrane regeneration therapy using an atelocollagen/silicone membrane and basic fibroblast growth factor. Clini Otolaryng. 2013 Aug 8. doi: 10.1111/coa.12164.
44. Okada M, Kawaguchi AT, Hakuba N, Hyodo J, Hato N, Gyo K. / Liposome-encapsulated hemoglobin alleviates hearing loss after transient cochlear ischemia: An experimental study in the gerbil. Neurosci Lett. 2013 doi:pii: S0304-3940(13)00776-3. 2013.
45. Hakuba N, Tabata Y, Hato N, Fujiwara T, Gyo K. / Gelatin hydrogel with basic fibroblast growth factor for tympanic membrane regeneration. Otol Neurotol. 35(3):540-4. 2014.
46. Takagi T, Gyo K, Hakuba N, Hyodo J, Hato N. / Clinical features, presenting symptoms, and surgical results of congenital cholesteatoma based on Potsic's staging system. Acta Oto-Laryngol. 134(5):462-7. 2014.
47. Takagi T, Yoshida T, Okada M, Hata R, Hato N, Gyo K, Hakuba N. Intravenous administration of bone marrow mononuclear cells alleviates hearing loss after transient cochlear ischemia through paracrine effects.Neuroreport. 2014 May 16. [Epub ahead of print]
48. Hakuba N, Hato N, Okada M, Mise K, Gyo K. Preoperative factors affecting tympanic membrane regeneration therapy using an atelocollagen and basic fibroblast growth factor. JAMA Otolaryngol Head Neck Surg. 141(1):60-6. 2015.
49. Hakuba N, Ikemune K, Okada M, Hato N. Use of ambulatory anesthesia with manually assisted ventilation for tympanic membrane regeneration therapy in children. Am J Otolaryngol. 36(2):153-7. 2015

著書

1. 耳鳴りに対する低出力レーザー治療, 中山書店, 2001年
2. 鼓膜・中耳の外傷，今日の耳鼻咽喉科頭頚部外科治療指針，医学書院，110, 2008年
3.虚血性内耳障害の病態と治療, 耳鼻咽喉科・頭頸部外科学の最新医療，先端医療技術研究所， 2005年
4. 難聴とコルチ器の病変．虚血性内耳障害の発症機序と臨床, 佐川印刷, 2007年
5. グルタミン酸による障害機序．虚血性内耳障害の発症機序と臨床, 佐川印刷, 2007年
6. グルタミン酸トランスポ－タと内耳障害．虚血性内耳障害の発症機序と臨床, 佐川印刷, 2007年
7. アテロコラーゲン/シリコン膜とヒト線維芽細胞増殖因子(bFGF)製剤を用いた鼓膜穿孔閉鎖術，遺伝子医学MOOK 再生遺伝子治療　患者までとどいている再生誘導治療, 2009年
8. bFGF徐放化ハイドロゲルを用いた鼓膜再生治療．ものづくり技術からみる再生医療―細胞研究・創薬・治療―，株式会社シーエムシー出版, 2011年
9. 有毛細胞の再生. 再生医療業書4, 朝倉書店, 2013年
10. 【こんなときの対応法がわかる 耳鼻咽喉科手術ガイド】　耳の手術 中耳根本手術(解説/特集)耳鼻咽喉科・頭頸部外科 中外医学社, 2015年

その他

• 【受賞】1999年　日本耳鼻咽喉科臨床学会　学会賞受賞

• 【受賞】2003年　日本耳鼻咽喉科臨床学会　ポスター賞受賞

• 【受賞】2003年　日本耳科学会　奨励賞受賞

• 【受賞】2003年　愛媛県えひめ産業振興財団　優秀賞受賞

• 【受賞】2005年　長寿科学振興財団奨励賞受賞

• 【症例報告】Gyo K, Kawakita S, Kobayashi J, Hakuba N, Matsumoto S. / Chondroma of the bony external auditory canal attached to the short process of the malleus. Int J Pediatr Otorhinolaryngol. 68(11):1441-1444,2004.

• 【症例報告】Hakuba N, Hyodo M, Yokoi T, Sato H. / Irinotecan (CPT-11) combined with cisplatin for small cell carcinoma of the nasal cavity. Auris Nasus Larynx. 33(1):67-70, 2006.

• 【症例報告】Okada M, Hato N, Okada Y, Sato E, Yamada H, Hakuba N, Gyo K. A case of hypertrophic cranial pachymeningitis associated with invasive Aspergillus mastoiditis. Auris Nasus Larynx. 2015 Dec;42(6):488-91.