髙橋 剛 たかはし つよし 先生

来歴等

略歴

1998年 大阪大学医学部 卒業
2008年 大阪大学大学院 修了、医学博士 取得
2009年 大阪急性期総合医療センター 診療主任
2011年 大阪大学 消化器外科 助教
2020年 大阪大学医学科教育センター（併任消化器外科） 講師

論文

• 1. Feasibility study of real-time intestinal bloodstream evaluation by using probe-based confocal laser endomicroscopy in a porcine intestinal ischemia model Surg Endosc. 2018 32(2):1043-1050.

  Takahashi T, MD, Nakatsuka R, Hara H, Higashi S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Mori M, Doki Y, Nakajima K.

• 2. Genomic and transcriptomic analysis revealed mechanisms for acquired imatinib resistance beyond secondary KIT mutations in gastrointestinal stromal tumor Genes Chromosomes Cancer. 2017; 56(4):303-313

  Takahashi T, Elzawahry A, Mimaki S, Furukawa E, Nakatsuka R, Kurosaka I, Nishigaki T, Nakamura H, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, and Kato M

• 3. Surgical Strategy for the Gastric Gastrointestinal Stromal Tumors (GISTs) Larger Than 5 cm: Laparoscopic Surgery is Feasible, Safe, and Oncologically Acceptable. Surg Laparosc Endosc Percutan Tech. 2015 Apr;25(2):114-8.

  Takahashi T, Nakajima K, Miyazaki Y, Miyazaki Y, Kurokawa Y, Yamasaki M, Miyata H, Takiguchi S, Nishida T, Mori M, Doki Y.

• 4. New findings of kinase switching in gastrointestinal stromal tumor under imatinib using phosphoproteomic analysis. Int J Cancer. 2013 Dec 1;133(11):2737-43.

  Takahashi T, Serada S, Ako M, Fujimoto M, Miyazaki Y, Nakatsuka R, Ikezoe T, Yokoyama A, Taguchi T, Shimada K, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Mori M, Doki Y, Naka T, Nishida T.

• 5. Effect of Rikkunshito, a Chinese herbal medicine, on stasis of patients with pylorus-preserving gastrectomy. World J Surg 2009 33:296-302.

  Takahashi T, Endo S, Nakajima K, Souma Y, Nishida T.

• 6. Aberrant Expression of Glycosylation in Juvenile Gastrointestinal Stromal Tumors. Proteomics. Clin. Appl. 2008;2, 1246-1254.

  Takahashi T, Naka T, Fujimoto M, Serada S, Horino J, Terabe F, Hirota S, Miyoshi E, Hirai T, Nakajima K, Nishitani A, Souma Y, Sawa Y, Nishida T.

• 7. An enhanced risk-group stratification system for more practical prognostication of clinically malignant gastrointestinal stromal tumors. Int J Clin Oncol. 2007;12(5):369-374.

  Takahashi T, Nakajima K, Nishitani A, Souma Y, Hirota S, Sawa Y, Nishida T.

• 8. Combination of pimitespib (TAS-116) with sunitinib is an effective therapy for imatinib-resistant gastrointestinal stromal tumors　Int J Cancer. 2023 Feb 8. doi: 10.1002/ijc.34461. Online ahead of print.

  Teranishi R, Takahashi T, Obata Y, Nishida T, Ohkubo S, Kazuno H, Saito Y, Serada S, Fujimoto M, Kurokawa Y, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Hirota S, Naka T, Eguchi H, Doki Y.

• 9. Robotic Distal Gastrectomy Reduces Drain Amylase Values in Patients With a Small Pancreas-left Gastric Artery Angle Surg Laparosc Endosc Percutan Tech 2022 Jun 1;32(3):311-318.

  Teranishi R, Takahashi T, Kurokawa Y, Sugase T, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Motoori M, Kimura Y, Nakajima K, Eguchi H, Doki Y

• 10. Efficacy and safety of regorafenib in Japanese patients with advanced gastrointestinal stromal tumors　Int J Clin Oncol. 2022 Jul;27(7):1164-1172.

  Teranishi R, Takahashi T, Nishida T, Hirota S, Kurokawa Y, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Motoori M, Omori T, Nakajima K, Eguchi H, Doki Y.

• 11. New response evaluation criteria using early morphological change in imatinib treatment for patients with gastrointestinal stromal tumor Gastric Cancer. 2022 Jan;25(1):218-225.

  Ishida T, Takahashi T, Nishida T, Ohnishi H, Tsuboyama T, Sato S, Nakahara Y, Miyazaki Y, Takeno A, Kurokawa Y, Saito T, Yamashita K, Tanaka K, Yamamoto K, Makino T, Yamasaki M, Mtotoori M, Kimura Y, Nakajima K, Eguchi H and Doki Y

• 12. Real?world data on the efficacy and safety of adjuvant chemotherapy in Japanese patients with a high?risk of gastrointestinal stromal tumor recurrence Int J Clin Oncol 2022 May;27(5):921-929.

  Ushimaru Y, Takahashi T, Nakajima K, Teranishi R, Nishida T, Hirota S, Motoori M, Omori T, Kawabata R, Nishiawa K, Saito T, Yamashita K, Tanaka K, Yamamoto K, Makino T, Kurokawa Y, Eguchi H and Doki Y

• 13. Laparoscopic resection for imatinib-resistant recurrent tumors of gastric gastrointestinal stromal tumors: A case report Laparoscopic resection for imatinib-resistant recurrent tumors of gastric gastrointestinal stromal tumors: A case report Asian J Endosc Surg. 2022 Jul;15(3):638-641.

  Sekiguchi N, Takahashi T, Nakajima K, Kurokawa Y, Saito T, Yamashita K, Tanaka K, Yamamoto K, Makino T, Eguchi H and Doki

• 14. Laparoscopic resection for recurrent gastrointestinal stromal tumors and paraganglioma in a patient with Carney-Stratakis syndrome: A case report Asian J Endosc Surg. 2022 Jul 6.doi: 10.1111/ases.13104.

  Fukada A, Takahashi T, Kurokawa Y, Asaoka T, Teranishi R, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Umeda D, Morii E, Hirota S, Eguchi H and Doki

• 15. Targeted therapy for drug-tolerant persister cells after imatinib treatment for gastrointestinal stromal tumours Br J Cancer. 2021 Nov;125(11):1511-1522

  Ishida T, Takahashi T, Kurokawa Y, Nishida T, Hirota S, Serada S, Fujimoto M, Naka T, Teranishi R, Saito T, Yamashita K, Tanaka K, Yamamoto K, Makino T, Yamasaki M, Nakajima K, Eguchi H and Doki Y

• 16. Utility of monthly minodronate for osteoporosis after gastrectomy: Prospective multicenter randomized controlled trials Ann Gastroenterol Surg. 2021 Jul 9;5(6):754-766.

  Hirota M, Takahashi T, Saito Y, Kawabata R, Nakatsuka R, Imamura H, Motoori M, Makari Y, Takeno A, Kishi K, Adachi S, Miyagaki H, Kurokawa Y, Yamasaki M, Eguchi H, Doki U.

• 17. Pancreas-left gastric artery angle is associated with postoperative inflammation and drain amylase after laparoscopic gastrectomy Asian J Endosc Surg. 2021 Oct;14(4):756-766.

  Sugase T, Takahashi T, Takiguchi S, Kurokawa Y, Teranishi R, Saito T, Miyazaki Y, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Motoori M, Kimura Y, Yamasaki M, Eguchi H, Doki Y

• 18. Propranolol suppresses gastric cancer cell growth by regulating proliferation and apoptosis Gastric Cancer. 2021 2021 Sep;24(5):1037-1049..

  Koh M, Takahashi T, Kurokawa Y, Kobayashi T, Saito T, Ishida T, Serada S, Fujimoto M, Naka T, Wada N, Yamashita K, Tanaka K, Miyazaki Y, Makino T, Nakajima K, Yamasaki M, Eguchi H, Doki Y.

• 19. Clinical significance of surgical intervention for imatinib-resistant gastrointestinal stromal tumors in the era of multiple tyrosine kinase inhibitors Surg Today. 2021 Sep;51(9):1506-1512.

  Wada N, Takahashi T, Kurokawa Y, Nakajima K, Nishida T, Koh M, Akamaru Y, Motoori M, Kimura Y, Tanaka K, Miyazaki Y, Makino T, Yamasaki M, Eguchi H, Doki Y.

• 20. A case of diaphragmatic hernia incarceration after a heart transplant operation Asian J Endosc Surg. 2021 Jan;14(1):116-119. doi: 10.1111/ases.12811.

  Sasaki M, Takahashi T, Funaki S, Tanaka K, Miyazaki Y, Ose N, Makino T, Kurokawa Y, Yamazaki M, Nakajima K, Okumura M, Mori M, and Doki Y

• 21. Laparoscopic Gastrectomy for Heart failure Patients with Left Ventricular Assist Device. Asian J Endosc Surg. 2021 Jan;14(1):81-84.

  Ishida T, Takahashi T, Miyazaki Y, Kurokawa Y, Tanaka K, Makino T, Yamasaki M, Nakajima K, Mori M, and Doki Y

• 22. Laparoscopic surgery for familial multiple gastrointestinal stromal tumors with germ line c-kit gene mutation Asian J Endosc Surg. 2021 Apr;14(2):250-253

  Hashimoto M; Takahashi T, Nakajima K, Kurokawa Y, Miyazaki Y, Tanaka K, Makino T Yamasaki M, M Eguchi H, Mori M, Doki Y

• 23. Pancreas-left gastric artery angle is associated with postoperative inflammation and drain amylase after laparoscopic gastrectomy　Asian J Endosc Surg. 2021 Apr 26. doi: 10.1111/ases.12938. Online ahead of print.

  Sugase T, Takahashi T, Takiguchi S, Kurokawa Y, Teranishi R, Saito T, Miyazaki Y, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Motoori M, Kimura Y, Yamasaki M, Eguchi H, Doki Y.

• 24. Anti-glypican-1 antibody?drug conjugate is a potential therapy against pancreatic cancer Br J Cancer. 2020 32;122:1333-41.　

  Nishigaki T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hara H, SugaseT, Otsuru T, Saito Y, Tsujii S, Nomura T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Eguchi H, Yamasaki M, Mori6 M, Doki Y and Naka T.

• 25. TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-na?ve and imatinib-resistant gastrointestinal stromal tumours Br J Cancer. 2020 32;122(5):658-667.

  Saito Y, Takahashi T, Obata Y, Nishida T, Ohkubo S, Nakagawa F, Serada S, Fujimoto M, Ohkawara T, Nishigaki T, Sugase T, Koh M, Ishida T, Tanaka K,Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Hirota S, Naka T, Mori M and Doki Y

• 26. Innovation in surgery/operating room driven by Internet of Things on medical devices. Surg Endosc. 2019 Jan 22. doi: 10.1007/s00464-018-06651-4. [Epub ahead of print]

  Ushimaru Y, Takahashi T, Souma Y, Yanagimoto Y, Nagase H, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Mori M, Doki Y, Nakajima K.

• 27. Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in gastric cancer Oncotarget 9(68): 32917?32928. in press

  Takahito Sugase, Tsuyoshi Takahashi, Satoshi Serada, Minoru Fujimoto, Tomoharu Ohkawara, Kosuke Hiramatsu, Masahiro Koh, Yurina Saito1, Koji, Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto, Yamasaki, Kiyokazu Nakajima, Kazuhiro Hanazaki, Masaki Mori, Yuichiro Doki and Tetsuji Naka

• 28. SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling. Gastric Cancer. 2018 21．968-976. doi: 10.1007/s10120-018-0822-1. [Epub ahead of print]

  Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T.

• 29. Correction to: Laparoscopic repair of an incarcerated diaphragmatic hernia after right hepatectomy for hepatic injury: a case report. Surg Case Rep. 2018 Dec 21;4(1):147　

  Takaichi S, Takahashi T, Funaki S, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Okumura M, Mori M, Doki Y. Takaichi S, Takahashi T, Funaki S, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Okumura M, Mori M, Doki Y.

• 30. SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma. Cancer Res. 2017 Dec 15;77(24):6975-6986. doi: 10.1158/0008-5472.CAN-17-1525. Epub 2017 Oct 17.

  Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.

• 31. suppressor of cytokine signaling-1 gene therapy in patient-derived esophageal squamous cell carcinoma xenografts in mice Int J Cancer. 2017 140(11):2608-2621

  Takahito Sugase, Tsuyoshi Takahashi, Satoshi Serada, Rie Natatsuka, Minoru Fujimoto, Tomohiro Ookawara, Hisashi Hara,　Takahiko Nishigaki, Kouji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Yukinori Kurokawa, Makoto Yamasaki, Kiyokazu Nakajima, Shuji Takiguchi, Tadamitsu Kishimoto, Masaki Mori, Yuichiro Doki, Tetsuji Naka Antitumor effect of

• 32. Appropriate follow-up strategies for gastrointestinal stromal tumor patients based on the analysis of recurrent interval and patterns Digestion. 2017;95(2):115-121

  Noriko Wada, Tsuyoshi Takahashi, Yukinori Kurokawa, Kiyokazu Nakajima,Toru Masuzawa, Rie Nakatsuka, Junji Kawada, Toshirou Nishida, Yutaka Kimura, Kouji Tanaka, Yasuhiro Miyazaki, Tomoki Makino, Makoto Yamasaki, Shuji Takiguchi, Masaki Mori, and Yuichiro Doki

• 33. Clinicopathological Characteristics, Surgery and Survival Outcomes of Patients with Duodenal Gastrointestinal Stromal Tumors. Digestion. 2016 13;94(1):30-36.

  Sugase T, Takahashi T, Nakajima K, Hirota S, Masuzawa T, Nishida T, Kimura Y, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Takiguchi S, Mori M, Doki Y.

• 34. Familial Gastrointestinal Stromal Tumor with Germline KIT Mutations Accompanying Hereditary Breast and Ovarian Cancer Syndrome. Anticancer Res. 2017 Mar;37(3):1425-1431.

  Sekido Y, Ohigashi S, Takahashi T, Hayashi N, Suzuki K, Hirota S.