田中 浩 たなか ひろし 先生

来歴等

略歴

1982年 山口大学医学部 卒業
1987年 山口大学医学部（整形外科学講座） 助手
1992年 米国 N.I.H.（国立衛生研究所）N.I.A.（老年医学研究所） 留学（〜1994年）
1996年 山口大学医学部（整形外科学講座） 講師
2000年 英国ロンドン大学インペリアルカレッジ細胞工学センター 留学
2004年 山口大学医学部（整形外科学講座） 助教授
2007年 山口大学医学部（整形外科学講座） 准教授
2010年 山口県立総合医療センター 整形外科・リウマチ科 診療部長、人工関節センター長
2019年 山口県立総合医療センター 副院長、山口大学医学部 臨床教授
2023年 山口県立総合医療センター 顧問

論文

• 1. Isolation and characterization of the gene encoding bovine adenylate kinase isozyme 2.　Gene, 93(2): 221-7, 1990.

  Tanaka H., et al.

• 2. Characterization of a processed pseudogene derived from the gene encoding bovine adenylate kinase isozyme 2. Gene, 100(257): 257-60, 1991.

  Tanaka H., et al.

• 3. In vivo and in vitro effects of insulin-like growth factor-I (IGF-I) on femoral mRNA expression in old rats. Bone, 15(6): 647-53, 1994 .

  Tanaka H., et al.

• 4. Effect of platelet-derived growth factor on DNA synthesis and gene expression in bone marrow stromal cells derived from adult and old rats. J Cell Physiol, 164(2): 367-75, 1995.

  Tanaka H., et al.

• 5. Mitogenic activity but not phenotype expression of rat osteoprogenitor cells in response to IGF-I is impaired in aged rats. Mech Ageing Dev, 92(1): 1-10, 1996.

  Tanaka H., et al.

• 6. Effect of age on the expression of insulin-like growth factor-I, interleukin-6, and transforming growth factor-beta mRNAs in rat femurs following marrow ablation. Bone, 18(5): 473-8, 1996.

  Tanaka H., et al.

• 7. Effect of locally infused IGF-I on femoral gene expression and bone turnover activity in old rats.　J Bone Miner Res, 13(1): 13-9, 1998.

  Wakisaka A., Tanaka H., et al.

• 8. Vitamin K plus vitamin D treatment of bone problems in a child with skeletal unloading. J Bone Miner Res, 14(8): 1466-7, 1999.

  Sugiyama T., Tanaka H., et al.

• 9. Actions of bFGF on mitogenic activity and lineage expression in rat osteoprogenitor cells: effect of age. Mol Cell Endocrinol, 150(1-2): 1-10, 1999.

  Tanaka H., et al.

• 10. Local and Systemic Expression of Insulin-like Growth Factor-I (IGF-I) mRNAs in Rat after Bone Marrow Ablation. Biochem Biophys Res Commun, 287(5): 1157-62., 2001.

  Tanaka H., et al.

• 11. Involvement of bone morphogenic protein-2 (BMP-2) in the pathological ossification process of the spinal ligament. Rheumatology , 40(10): 1163-8., 2001.

  Tanaka H., et al.

• 12. Trochanteric bursitis in rheumatoid arthritis. J Rheumatol, 29(6): 1340-1., 2002.

  Tanaka H., et al.

• 13. Effect of IGF-I and PDGF administered in vivo on the expression of osteoblast-related genes in old rats. J Endocrinol, 174(1): 63-70., 2002.

  Tanaka H., et al.

• 14. Effects of basic fibroblast growth factor on osteoblast-related gene expression in the process of medullary bone formation induced in rat femur. J Bone Miner Metab, 21(2): 74-9, 2003.

  Tanaka H., et al.

• 15. Effects of basic fibroblast growth factor on the repair of large osteochondral defects of articular cartilage in rabbits: dose-response effects and long-term outcomes. Tissue Eng, 10(3-4): 633-41., 2004.

  Tanaka H., et al.

• 16. Chondrogenic differentiation of murine embryonic stem cells: Effects of culture conditions and dexamethasone.　J Cell Biochem, 93(3): 454-62., 2004.　

  Tanaka H., et al.

• 17. Dexamethasone induces human spinal ligament derived cells toward osteogenic differentiation. J Cell Biochem, 92(4): 715-22., 2004.

  Murata H., Tanaka H., et al.

• 18. A giant rheumatoid nodule. Clin Rheumatol, 23(5): 467-9.,2004.

  Mine T., Tanaka H., et al.

• 19. Effects of parathyroid hormone and alendronate alone or in combination in osteoporosis. N Engl J Med, 350(2): 189-92., 2004.

  Sugiyama T., Tanaka H., et al.

• 20. Carpal instability in rheumatoid wrists. Rheumatol Int, 24(1): 34-6, 2004.

  Muramatsu K., Tanaka H., et al.

• 21. Glucocorticoids and bone mineral content in the childhood nephrotic syndrome. N Engl J Med, 351(25): 2655-7., 2004.

  Sugiyama T., Tanaka H., et al.

• 22. Folate and vitamin B12 for hip fracture prevention after stroke. Glucocorticoids and bone mineral content in the childhood nephrotic syndrome. JAMA, 294(7): 792; 2005.

  Sugiyama T., Tanaka H., et al.

• 23. Juvenile rheumatoid arthritis manifesting in only limping due to flexion contraction of the knee. Clin Rheumatol.: 1-3., 2006.

  Mine T., Tanaka H., et al.

• 24. Peripheral neuropathies of the forearm and hand in rheumatoid arthritis: diagnosis and options for treatment. Rheumatol Int. 2008 Aug;28(10):951-7.

  Muramatsu K, Tanaka H, et al.

• 25. Expression of RANKL/OPG during bone remodeling in vivo. Biochem Biophys Res Commun. 2011 Aug 12;411(4):690-4.

  Tanaka H., et al.

• 26. Rotational acetabular osteotomy for habitual hip dislocation with posterior acetabular wall deficiency in patients with Down syndrome. Orthopedics. 2012 Mar 7;35(3):e426-9.

  Imagama T, Tanaka H, et al.

• 27. Knee joint destruction driven by residual local symptoms after anti-tumor necrosis factor therapy in rheumatoid arthritis. Clin Rheumatol. 2013 Jun;32(6):823-8

  Imagama T, Tanaka H, et al.