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1. Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor.Proc Natl Acad Sci USA 84: 7005-7008, 1987.
J. Takeda, Y. Seino, K. Tanaka, H. Fukumoto, T. Kayano, H. Takahashi, T. Mitani, M. Kurono, T. Suzuki, T. Tobe, and H. Imura.
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2. Nonsense mutation in the glucokinase gene causes early-onset non-insulin dependent diabetes mellitus.Nature 356: 721-722, 1992. #; These authors contributed equally to this work.
N. Vionnet #, M. Stoffel #, J. Takeda #, K. Yasuda, G. I. Bell, H. Zouali, S. Lesage, G. Velho, F. Iris, Ph. Passa, Ph.Froguel, and D.Cohen.
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3. Human glucokinase gene: Isolation, characterization, and identification of two missense mutations linked to early-onset non-insulin-dependent (Type 2) diabetes mellitus.Proc Natl Acad Sci USA 89: 7698-7702, 1992.
M. Stoffel, Ph. Froguel, J. Takeda, H. Zouali, N. Vionnet, S. Nishi, I. T .Weber, R. W. Harrison, S. J. Pilkis, S. Lesage, M. Vaxillare, G. Velho, F. Sun, F. Iris, Ph. Passa, D. Cohen, and G. I. Bell.
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4. Identification and analysis of the gene encoding human PC2, a prohormone convertase expressed in neuroendocrine tissues.Proc Natl Acad Sci USA 89: 4977-4981, 1992.
S. Ohagi, J. LaMendola, M. M. LeBeau, R. Espinosa III, J. Takeda, S. P. Smeekens, S. J. Chan, and D. F. Steiner.
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5. Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location and expression at low levels in adult tissues.Nucleic Acids Res 20: 4613-4620, 1992.
J. Takeda, S. Seino, and G. I. Bell.
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6. Cloning of the α1 subunit of a voltage-dependent calcium channel expressed in pancreatic β cells.Proc Natl Acad Sci USA 89: 584-588, 1992.
S. Seino, L. Chen, M. Seino, O. Blondel, J. Takeda, J. H. Johnson, and G. I. Bell.
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7. Structure/function studies of human β-cell glucokinase: Enzymatic properties of a sequence polymorphism, mutations associated with diabetes and other site-directed mutants.J Biol Chem 268: 15200-15204, 1993.
J. Takeda, M. Gidh-Jain, L. Z. Xu, Ph. Froguel, G. Velho, M. Vaxillaire, D. Cohen, F. Shimada, H. Makino, S. Nishi, M. Stoffel, N. Vionnet, R. St. Charles, R. W. Harrison, I. T. Weber, G. I. Bell, and S. J. Pilkis.
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8. Glucokinase mutations associated with non-insulin-dependent (Type2) diabetes mellitus have decreased enzymatic activity: Implications for structure/function relationships.Proc Natl Acad Sci USA 90: 1932-1936, 1993.
M. Gidh-Jain, J. Takeda, L. Z. Xu, A. J. Lange, N. Vionnet, M. Stoffel, G. Velho, F. Sun, D. Cohen, Ph. Froguel, P. Patel, Y-M. D. Lo, A. T. Hattersley, H. Luthman, A. Wedell, R. St. Charles, R. W. Harrison, I. T. Weber, G. I. Bell, and S. J. Pilkis.
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9. Familial hyperglycemia due to mutations in glucokinase: Definition of a new subtype of non-insulin-dependent (type 2) diabetes mellitus.N Engl J Med 328: 697-702, 1993.
Ph. Froguel, H. Zouali, N. Vionnet, G. Velho, M. Vaxillaire, F. Sun, S. Lesage, M-O. Butel, M. Stoffel, J. Takeda, J-J. Robert, Ph. Passa, A. Permutt, J. S. Beckmann, G. I. Bell, and D. Cohen.
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10. Organization of the human GLUT2 (pancreatic β-cell and hepatocyte) glucose transporter gene.Diabetes 42: 773-777, 1993.
J. Takeda, T. Kayano, H. Fukumoto, and G. I. Bell.
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11. A molecular inventry of human pancreatic islets: Sequence analysis of 1000 cDNA clones.Hum Mol Genet 2: 1793-1798, 1993.
J. Takeda, H. Yano, S. Eng, Y. Zeng, and G. I. Bell.
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12. Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci USA 90: 6736-6740, 1993.
K. Yasuda, K. Raynor, H. Kong, C. D. Breder, J. Takeda, T. Reisine, and G. I. Bell.
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13. Insulin secretory abnormalities in subjects with hyperglycemia due to glucokinase mutations.J Clin Invest 93: 1120-1130, 1994.
M. M. Byrne, J. Sturis, K. Clement, N. Vionnet, M. Pueyo, M. Stoffel, J. Takeda, Ph. Passa, D. Cohen, G. I. Bell, G. Velho, Ph. Froguel, and K. S. Polonsky.
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14. Molecular analysis of the fructose transporter gene (GLUT5) in isolated fructose malabsorption.J Clin Invest 98: 2398-2402, 1996.
D. Wasserman, J. H. Hoekstra, V. Tolia, C. J. Taylor, B. S. Kirschner, J. Takeda, G. I. Bell, R. Taub, and E. B. Rand.
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15. Mutations in the hepatocyte nuclear factor 1α gene in maturity-onset diabetes of the young (MODY3).Nature 384: 455-458, 1996.
K. Yamagata, N. Oda, P. J. Kaisaki, S. Menzel, H. Furuta, M. Vaxillaire, R. D. Cox, G. M. Lathrop, V. V. Boriraj, X. Chen, N. J. Cox, Y. Oda, H. Yano, M. M. LeBeau, S. Yamada, H. Nishigori, J.Takeda, J-C. Chevre, S. S. Fajans, A. T. Hattersley, N. Iwasaki, O. Pedersen, K. S. Polonsky, R. C.Turner, P. Froguel, and G. I. Bell.
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16. Identification of mutations in the hepatocyte nuclear factor (HNF)-1α gene in Japanese subjects with IDDM.Diabetes 46: 1643-1647, 1997.
S. Yamada, H. Nishigori, H. Onda, T. Utsugi, T. Yanagawa, T. Maruyama, K. Onigata, K. Nagashima, R. Nagai, A. Morikawa, T. Takeuchi, and J. Takeda.
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17. Frameshift mutation, A263fsinsGG, in the hepatocyte nuclear factor-1β gene associated with diabetes and renal dysfunction.Diabetes 47: 1354-1355, 1998.
H. Nishigori, S. Yamada, T. Kohama, H. Tomura, K. Sho, Y. Horikawa, G. I. Bell, T. Takeuchi, and J. Takeda.
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18. Identification of mutations in the hepatocyte nuclear factor-1α gene in Japanese subjects with early-onset NIDDM and functional analysis of the mutant proteins.Diabetes 48: 645-648, 1999.
S. Yamada, H. Tomura, H. Nishigori, K. Sho, H. Mabe, N. Iwatani, T. Takumi, Y. Kito, N. Moriya, K. Muroya, T. Ogawa, K. Onigata, A. Morikawa, I. Inoue, and J. Takeda.
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19. Loss-of-function and dominant negative mechanisms associated with hepatocyte nuclear factor-1β mutations in familial Type 2 diabetes mellitus.J Biol Chem 274: 12975-12978, 1999.
H. Tomura, H. Nishigori, K. Sho, K. Yamagata, I. Inoue, and J. Takeda.
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20. Cloning of cDNA and the gene encoding human hepatocyte nuclear factor (HNF)-3β and mutation screening in Japanese subjects with MODY.Diabetologia 43: 121-124, 2000.
S. Yamada, Q. Zhu, Y. Aihara, H. Onda, Z. Zhang, L. Yu, L. Jin, Y. Si, H. Nishigori, H. Tomura, I. Inoue, A. Morikawa, K. Yamagata, T. Hanafusa, Y. Matsuzawa, and J. Takeda.
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21. Mutations in the small heterodimer partner gene are associated with mild obesity in Japanese subjects.Proc Natl Acad Sci USA 98: 575-580, 2001.
H. Nishigori, H. Tomura, N. Tonooka, M. Kanamori, S. Yamada, K. Sho, I. Inoue, N. Kikuchi, K. Onigata, I. Kojima, T. Kohama, K. Yamagata, Q. Yang, Y. Matsuzawa, T. Miki, S. Seino, M-Y. Kim, H-S. Choi, Y-K. Lee, D. D. Moore, and J. Takeda.
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22. Differential regulation of the orphan nuclear receptor SHP gene promoter by orphan nuclear receptor ERR isoforms.J Biol Chem 277: 1739-1748, 2002.
S. Sanyal, J-Y. Kim, H-J. Kim, J. Takeda, Y-K. Lee, D. D. Moore, and H-S. Choi.
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23. Small heterodimer partner, an orphan nuclear receptor, augments PPARγ transactivation.J Biol Chem 277: 1586-1592, 2002.
H. Nishizawa, K. Yamagata, M. Takahashi, H. Kuriyama, K. Kishida, K. Hotta, H. Nagaretani, N. Maeda, S. Kihara, T. Nakamura, H. Nishigori, H. Tomura, D. D. Moore, J. Takeda, T. Funahashi, and Y. Matsuzawa.
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24. Inhibitory effect of small heterodimer partner on hepatocyte nuclear factor-4 mediates bile acid-induced repression of human angiotensinogen gene.J Biol Chem 279: 7770-7776, 2004.
Y. Shimamoto, J. Ishida, K. Yamagata, T. Saito, H. Kato, T. Matsuoka, K. Hirota, H. Daitoku, M. Nangaku, K. Yamagata, H. Fuji, J. Takeda, and A. Fukamizu.
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25. Genetic variation in the HIF-1α gene is associated with type 2 diabetes in Japanese J Clin Endocrinol Metab 90: 5841-5847, 2005.
N. Yamada, Y. Horikawa, N. Oda, K. Iizuka, N. Shihara, S. Kishi, and J. Takeda.
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26. Mutations in the small heterodimer partner gene increase morbidity risk in Japanese type 2 diabetes patients.Hum Mutat 29: E271-E277, 2008.
M. Enya, Y. Horikawa, E. Kuroda, K. Yonemaru, N. Tonooka, H. Tomura, N. Oda, N. Yokoi, K. Yamagata, N. Shihara, K. Iizuka, T. Saibara, S. Seino, and J. Takeda.
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27. Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.Nat Genet 40: 1092-1097, 2008.
K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H. Mori, A. Jonsson, Y. Sato, K. Yamagata, Y. Hinokio, H-Y. Wang, T. Tanahashi, N. Nakamura, Y. Oka, N. Iwasaki, Y. Iwamoto, Y. Yamada, Y. Seino, H. Maegawa, A. Kashiwagi, J. Takeda, E. Maeda, H-D. Shin, Y-M. Cho, K-S. Park, H-K. Lee, M. Ng, R. Ma, W-Y. So, J. Chan, V. Lyssenko, T. Tuomi, P. Nilsson, L. Groop, N. Kamatani, A. Sekine, Y. Nakamura, K. Yamamoto, T. Yoshida, K. Tokunaga, M. Itakura, H. Makino, K. Nanjo, T. Kadowaki, and M. Kasuga.
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28. Screening of diabetes of youth for hepatocyte nuclear factor 1 mutations: clinical phenotype of HNF-1β related maturity-onset diabetes of the young and HNF-1α-related maturity-onset diabetes of the young in Japanese.Diabetic Med 31: 721-727, 2014.
Y. Horikawa, M. Enya, N. Fushimi, Y. Fushimi, and J. Takeda.
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29. NEUROD1-deficient diabetes (MODY6): Identifications of the first cases in Japanese and the clinical features.Pediatr Diabetes 19: 236-241. 2018.
Y. Horikawa, M. Enya, H. Mabe, M. Fukushima, N. Takubo, M. Ohashi, F. Ikeda, K. Hashimoto, H. Watada, and J. Takeda.
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30. L-arginine prevents cereblon-mediated ubiquitination of glucokinase and stimulates glucose-6-phosphate production in pancreatic β-cells.Commun Biol 3: 497; doi: 10.1038/s42003-020-01226-3, 2020.
J. Cho, Y. Horikawa, M. Enya, J. Takeda, Yo. Imai, Yu. Imai, H. Handa, and T. Imai.
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1. J. Takeda, Y. Seino, H. Fukumoto, G. Koh, M. Ikeda, S. Kuno, M. Yawata, K. Moridera, T. Morita, K. Tsuda, and H. Imura. Restriction fragment length polymorphism in the 5’-flanking region of the human insulin gene: Its lack of association with either IDDM or NIDDM in Japanese. In: Recent Trends in Management of Diabetes Mellitus. N. Sakamoto, K.G.M.M. Alberti, and N. Hotta (eds.), Elsevier, Amsterdam, pp150-153, 1987.
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2. H. Fukumoto, Y. Seino, J. Takeda, T. Kayano, G. Koh, Y. Yamaoka, K. Ozawa, and H. Imura.A comparison of glucose transporter gene and insulin receptor gene expression in human tissue. In: Best Approach to the Ideal Therapy of Diabetes Mellitus. Y. Shigeta, H. E. Levovitz, J. E. Grich, and W. J. Malaaise (eds.), Elsevier, Amsterdam, pp221, 1987.
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6. G. I. Bell, M. M. Byrne, M. Stoffel, J. Sturis, J. Takeda, and K. S. Polonsky.Glucokinase-deficient diabetes mellitus: a subtype of non-insulin-dependent (Type 2) diabetes mellitus characterized by a defect in glucose-stimulated insulin secretion.In: Pathogenesis and treatment of NIDDM and its related problems. N. Sakamoto, and K. G. M. M. Alberti (eds.), Excerpta Medica, Amsterdam, pp91-98, 1994.
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10. 武田 純、清野 裕、武村次郎、西 重生、石田 均、瀬野倫代、大野雅史、井村裕夫 Gastric inhibitory polypeptide (GIP)の分泌動態に対するインスリンの意義について消化管ホルモン(V)、消化管ホルモン研究会、医学図書出版、pp270-276、1985.
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12. 武田 純 グルコキナーゼ遺伝子の異常とearly-onset NIDDM：糖尿病の新しい一亜型 「分子糖尿病学の進歩 基礎から臨床へ1994」、金原出版、pp110-117、1994.
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13. 武田 純 若年発症のインスリン非依存型糖尿病 (MODY) の発症遺伝子 Annual Review 内分泌代謝 1999、中外医学社、pp.23-27、1999.
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14. 武田 純 転写因子遺伝子異常 糖尿病遺伝子診断ガイド、日本糖尿病学会（編）、文光堂、pp52-55、2001.
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15. 堀川幸男、武田 純 2 型糖尿病の発症関連遺伝子 Annual Review 内分泌代謝、中外医学社、pp32-38、2002.
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16. 西郡秀和、武田 純 新しい小太り遺伝子の発見 分子糖尿病学の進歩 - 基礎から臨床へ- 2001、金原出版、2002.
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17. 武田 純 糖尿病遺伝子と妊娠 妊娠と糖尿病：診断スタンダード、金芳社、pp241-244、2003.
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21. 門脇 孝、岡本 宏、吉川隆一、清野 進、武田 純、仁木 厚、牧野英一、牧野 進、松澤祐次 糖尿病研究の50年 糖尿病学の変遷を見つめて、日本糖尿病学会、2008.
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22. 諏訪哲也, 堀川幸男, 武田 純 2型糖尿病 糖尿病研修ノート、診断と治療社、pp125-128、2010.
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23. 武田 純 療養指導委員会 糖尿病治療の質的向上と制度化を図る 50年の歩み 希望の未来へ、日本糖尿病協会、pp60、2011.
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24. 塩谷真由美, 堀川幸男, 武田 純 遺伝子異常による糖尿病／耐糖能異常 スマートな糖尿病診断と治療の進め方、中山書店、pp69-76、2011.
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25. 武田 純 妊娠時の薬剤選択の注意点 「妊娠と糖尿病」母児管理のエッセンス、金芳堂、pp195-199、2013.
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26. 堀川幸男、塩谷真由美、廣田卓男、飯塚勝美、諏訪哲也、橋本健一、丹羽啓之、武田 純 DPP-IV阻害薬の使い方 インクレチンインパクト、日経メディカル開発、pp59-114、2014.
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27. 塩谷真由美、堀川幸男、武田 純 遺伝子による糖尿病 糖尿病学、西村書店、pp250-256、2015.
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28. 武田 純 糖尿病診療におけるチーム医療の重要性 新時代の臨床糖尿病学、日本臨床（増刊）、pp666-672、2016.
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29. 堀川幸男、武田 純 遺伝子異常による糖尿病 内分泌代謝専門医ガイドブック、診断と治療社、pp623-627、2018.
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30. 堀川幸男 塩谷真由美 武田 純. 最新遺伝研究と遺伝カウンセリング、最新多因子遺伝性疾患研究と遺伝カウンセリング 遺伝子医学MOOK 別冊（脂質異常症シリーズ）、pp131-137、2018.
