吉川 衛 よしかわ まもる 先生

来歴等

略歴

1993年 東京慈恵会医科大学 卒業
1995年 東京慈恵会医科大学 耳鼻咽喉科学教室 助手
2000年 国立小児病院小児医療研究センター（現・国立成育医療研究センター） 免疫アレルギー研究部 研究員
2006年 東京慈恵会医科大学 耳鼻咽喉科学教室 講師
2012年 東邦大学医学部 耳鼻咽喉科学講座 准教授
2014年 東邦大学医学部 耳鼻咽喉科学講座 教授

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論文

• 1. Reduction of Rescue Treatment With Dupilumab for Chronic Rhinosinusitis With Nasal Polyps in Japan. Laryngoscope. 2025. Epub ahead of print.

  Yoshikawa M, Okano M, Takeuchi M, Sunaga Y, Orimo M, Ishida M.

• 2. Allergic Fungal Rhinosinusitis and Eosinophilic Chronic Rhinosinusitis Have Different Phenotypes in Japan. Int Forum Allergy Rhinol. 2025. Epub ahead of print.

  Nakayama T, Inoue N, Akutsu M, Tsunemi Y, Kashiwagi T, Matsuwaki Y, Yoshikawa M.

• 3. Elevated MS4A2 and IgE interaction in nasal polyps contributing to poor postoperative prognosis in patients with eosinophilic chronic rhinosinusitis. Allergol Int. 2025; 74(2): 283-291.

  Nakano M, Okada N, Inoue N, Hatano A, Yamaguchi S, Inoue H, Yoshikawa M.

• 4. Mepolizumab in CRSwNP/ECRS and NP: the phase III randomised MERIT trial in Japan, China, and Russia. Rhinology. 2024; 62(5): 576-589.

  Fujieda S, Wang C, Yoshikawa M, Asako M, Suzaki I, Bachert C, Han JK, Fuller A, Baylis L, Su L, Sasaki E, Sousa AR, Chan R, Zhang L.

• 5. Resident memory B cells are enriched in chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol Glob. 2024; 4(1): 100349.

  Sato Y, Inoue N, Osada E, Tsunemi Y, Nakashima D, Hirota T, Otori N, Yoshikawa M, Haruna SI, Nakayama T.

• 6. Clinical characteristics in Japanese patients with chronic rhinosinusitis who underwent endoscopic sinus surgery. Auris Nasus Larynx. 2024; 51(2): 286-294.

  Inoue N, Hirota T, Hatano A, Nakano M, Nakashima D, Nakayama T, Tamari M, Yoshikawa M.

• 7. Real-world burden and treatment of chronic rhinosinusitis in Japan: A retrospective claims database analysis. Laryngoscope Investig Otolaryngol. 2023; 8(2): 346-356.

  Yoshikawa M, Sunaga Y, Koshiba R, Inukai M, Takeuchi M.

• 8. A Phase II, Multicenter, Randomized, Placebo-Controlled Study of Benralizumab, a Humanized Anti-IL-5R Alpha Monoclonal Antibody, in Patients With Eosinophilic Chronic Rhinosinusitis. Am J Rhinol Allergy. 2021; 35(6): 861-870.

  Takabayashi T, Asaka D, Okamoto Y, Himi T, Haruna S, Yoshida N, Kondo K, Yoshikawa M, Sakuma Y, Shibata K, Suzuki M, Kobayashi M, Kawata R, Tsuzuki K, Okano M, Higaki T, Takeno S, Kodama S, Yonekura S, Saito H, Nozaki A, Otori N, Fujieda S.

• 9. A genetic variant near TSLP is associated with chronic rhinosinusitis with nasal polyps and aspirin-exacerbated respiratory disease in Japanese populations. Allergol Int. 2020; 69(1): 138-140.

  Nakayama T, Hirota T, Asaka D, Sakashita M, Ninomiya T, Morikawa T, Okano M, Haruna S, Yoshida N, Takeno S, Tanaka Y, Yoshikawa M, Ishitoya J, Hizawa N, Isogai S, Mitsui C, Taniguchi M, Kojima H, Fujieda S, Tamari M.

• 10. JESREC score and mucosal eosinophilia can predict endotypes of chronic rhinosinusitis with nasal polyps. Auris Nasus Larynx. 2019; 46(3): 374-383.

  Nakayama T, Sugimoto N, Okada N, Tsurumoto T, Mitsuyoshi R, Takaishi S, Asaka D, Kojima H, Yoshikawa M, Tanaka Y, Haruna SI.

• 11. Assessment of suitable reference genes for RT-qPCR studies in chronic rhinosinusitis. Sci Rep. 2018; 8(1): 1568.

  Nakayama T, Okada N, Yoshikawa M, Asaka D, Kuboki A, Kojima H, Tanaka Y, Haruna SI.

• 12. Distinct gene expression profiles and regulation networks of nasal polyps in eosinophilic and non-eosinophilic chronic rhinosinusitis. Int Forum Allergy Rhinol. 2018; 8(5): 592-604.

  Okada N, Nakayama T, Asaka D, Inoue N, Tsurumoto T, Takaishi S, Otori N, Kojima H, Matsuda A, Oboki K, Saito H, Matsumoto K, Yoshikawa M.

• 13. The usefulness of measuring tear periostin for the diagnosis and management of ocular allergic diseases. J Allergy Clin Immunol. 2016; 138(2): 459-467.e2.

  Fujishima H, Okada N, Matsumoto K, Fukagawa K, Igarashi A, Matsuda A, Ono J, Ohta S, Mukai H, Yoshikawa M, Izuhara K.

• 14. Novel scoring system and algorithm for classifying chronic rhinosinusitis: the JESREC Study. Allergy. 2015; 70(8): 995-1003.

  Tokunaga T, Sakashita M, Haruna T, Asaka D, Takeno S, Ikeda H, Nakayama T, Seki N, Ito S, Murata J, Sakuma Y, Yoshida N, Terada T, Morikura I, Sakaida H, Kondo K, Teraguchi K, Okano M, Otori N, Yoshikawa M, Hirakawa K, Haruna S, Himi T, Ikeda K, Ishitoya J, Iino Y, Kawata R, Kawauchi H, Kobayashi M, Yamasoba T, Miwa T, Urashima M, Tamari M, Noguchi E, Ninomiya T, Imoto Y, Morikawa T, Tomita K, Takabayashi T, Fujieda S.

• 15. Increased CXCL10 expression in nasal fibroblasts from patients with refractory chronic rhinosinusitis and asthma. Allergol Int. 2013 Dec;62(4):495-502.

  Yoshikawa M, Wada K, Yoshimura T, Asaka D, Okada N, Matsumoto K, Moriyama H.

• 16. Cholesteatoma fibroblasts promote epithelial cell proliferation through overexpression of epiregulin. PLoS One. 2013; 8(6): e66725.

  Yoshikawa M, Kojima H, Yaguchi Y, Okada N, Saito H, Moriyama H.

• 17. Sinus fungus ball in the Japanese population: clinical and imaging characteristics of 104 cases. Int J Otolaryngol. 2013; 2013: 731640.

  Nomura K, Asaka D, Nakayama T, Okushi T, Matsuwaki Y, Yoshimura T, Yoshikawa M, Otori N, Kobayashi T, Moriyama H.

• 18. A modified Lund-Mackay system for radiological evaluation of chronic rhinosinusitis. Auris Nasus Larynx. 2013; 40(6): 548-53.

  Okushi T, Nakayama T, Morimoto S, Arai C, Omura K, Asaka D, Matsuwaki Y, Yoshikawa M, Moriyama H, Otori N.

• 19. Endoscopic medial maxillectomy with preservation of inferior turbinate and nasolacrimal duct. Am J Rhinol Allergy. 2012; 26(5): 405-8.

  Nakayama T, Asaka D, Okushi T, Yoshikawa M, Moriyama H, Otori N.

• 20. Elevated levels of interleukin-33 in the nasal secretions of patients with allergic rhinitis. Int Arch Allergy Immunol. 2012; 158: s47-50.

  Asaka D, Yoshikawa M, Nakayama T, Yoshimura T, Moriyama H, Otori N.

• 21. Identification of chronic rhinosinusitis phenotypes using cluster analysis. Am J Rhinol Allergy. 2012; 26(3): 172-6.

  Nakayama T, Asaka D, Yoshikawa M, Okushi T, Matsuwaki Y, Moriyama H, Otori N.

• 22. Expression of nitric oxide synthases in leukocytes in nasal polyps. Ann Allergy Asthma Immunol. 2012; 108(3): 172-7.

  Yoshimura T, Moon TC, St Laurent CD, Puttagunta L, Chung K, Wright E, Yoshikawa M, Moriyama H, Befus AD.

• 23. Risk factors for complications of endoscopic sinus surgery for chronic rhinosinusitis. Am J Rhinol Allergy. 2012; 26(1): 61-4.

  Asaka D, Nakayama T, Hama T, Okushi T, Matsuwaki Y, Yoshikawa M, Yanagi K, Moriyama H, Otori N.

• 24. Nasal splinting using silicone plates without gauze packing following septoplasty combined with inferior turbinate surgery. Auris Nasus Larynx. 2012; 39(1): 53-8.

  Asaka D, Yoshikawa M, Okushi T, Nakayama T, Matsuwaki Y, Otori N, Moriyama H.

• 25. Evaluation of symptoms and QOL with calcium alginate versus chitin-coated gauze for middle meatus packing after endoscopic sinus surgery. Auris Nasus Larynx. 2012; 39(1): 31-7.

  Okushi T, Yoshikawa M, Otori N, Matsuwaki Y, Asaka D, Nakayama T, Morimoto T, Moriyama H.

• 26. Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. Allergol Int. 2008; 57(4): 429-36.

  Yoshimura T, Yoshikawa M, Otori N, Haruna S, Moriyama H.

• 27. Identification of specific gene expression profiles in fibroblasts derived from middle ear cholesteatoma. Arch Otolaryngol Head Neck Surg. 2006; 132(7): 734-42.

  Yoshikawa M, Kojima H, Wada K, Tsukidate T, Okada N, Saito H, Moriyama H.

• 28. TNF-alpha and IL-4 regulate expression of fractalkine (CX3CL1) as a membrane-anchored proadhesive protein and soluble chemotactic peptide on human fibroblasts. FEBS Lett. 2004; 561(1-3): 105-10.

  Yoshikawa M, Nakajima T, Matsumoto K, Okada N, Tsukidate T, Iida M, Otori N, Haruna S, Moriyama H, Imai T, Saito H.

• 29. TNF-alpha and IL-4 regulate expression of IL-13 receptor alpha2 on human fibroblasts. Biochem Biophys Res Commun. 2003; 312(4): 1248-55.

  Yoshikawa M, Nakajima T, Tsukidate T, Matsumoto K, Iida M, Otori N, Haruna S, Moriyama H, Saito H.

• 30. Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. Int Arch Allergy Immunol. 2002; 128: s3-11.

  Yoshikawa M, Matsumoto K, Iida M, Akasawa A, Moriyama H, Saito H.

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