守田 吉孝 もりた よしたか 先生

来歴等

略歴

1991年　岡山大学 医学部 卒業
1991年　岡山大学 医学部 第3内科 入局
1998年　岡山大学 大学院 医学研究科 修了
1998年　米国Michigan大学 リウマチ科
2002年　岡山大学 医学部 腎・免疫・内分泌代謝内科 助手
2004年　川崎医科大学　腎臓・リウマチ内科 講師
2010年　川崎医科大学　リウマチ・膠原病学 講師 (改組による)　　
2012年　川崎医科大学　リウマチ・膠原病学 教授
　　　　 川崎医科大学附属病院　リウマチ・膠原病科 部長

論文

論文 (抜粋)
○ Mukai T, Gallant R, Ishida S, Kittaka M, Yoshitaka T, Fox DA, Morita Y, Nishida K, Rottapel R, Ueki Y. Loss of SH3 domain-binding protein 2 function suppresses bone destruction in tumor necrosis factor-driven and collagen-induced arthritis in mice. Arthritis Rheumatol 2015; 67:656-67.
○ Mukai T, Gallant R, Ishida S, Yoshitaka T, Kittaka M, Nishida K, Fox DA, Morita Y, Ueki Y. SH3BP2 gain-of-function mutation exacerbates inflammation and bone loss in a murine collagen-induced arthritis model. PLoS One 2014; 9:e105518.
○ Satoh M, Nagasu H, Morita Y, Yamaguchi TP, Kanwar SY, Kashihara N. Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling. Am J Physiol Renal Physiol 2012; 303:F1641-51.
○ Sakuta T, Morita Y, Satoh M, Fox DA, Kashihara N. Involvement of the renin-angiotensin system in the development of vascular damage in a rat arthritis model: effect of angiotensin receptor blockers. Arthritis Rheum 2010; 62: 1319-28.
○ Haruna Y, Morita Y, Yada T, Satoh M, Fox DA, Kashihara N. Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis. Arthritis Rheum 2007; 56: 1827-35.
○ Haruna Y, Morita Y, Komai N, Yada T, Sakuta T, Tomita N, Fox DA, Kashihara N. Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase. Arthritis Rheum 2006; 54: 1847-55.
○ Morita Y, Gupta R, Seidl KM, McDonagh KT, Fox DA. Cytokine production by dendritic cells genetically engineered to express IL-4: induction of Th2 responses and differential regulation of IL-12 and IL-23 synthesis. J Gene Med 2005; 7: 869-77.
○ Kawanaka N, Yamamura M, Aita T, Morita Y, Okamoto A, Kawashima M, Iwahashi M, Ueno A, Ohmoto Y, Makino H. CD14+CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum 2002; 46: 2578-86.
○ Morita Y, Yang J, Gupta R, Shimizu K, Shelden EA, Endres J, Mulé JJ, McDonagh KT, Fox DA. Dendritic cells genetically engineered to express IL-4 inhibit murine collagen-induced arthritis. J Clin Invest 2001; 107: 1275-84.
○ Morita Y, Yamamura, Kawashima M, Aita T, Harada S, Okamoto H, Inoue H, Makino H. Differential in vitro effects of IL-4, IL-10, and IL-13 on proinflammatory cytokine production and fibroblast proliferation in rheumatoid synovium. Rheum Int 2001; 20: 49-54.
○ Yamamura M, Kawashima M, Taniai M, Yamauchi H, Tanimoto T, Kurimoto M, Morita Y, Ohmoto Y, Makino H. Interferon-γ-inducing activity of interleukin-18 in the joint with rheumatoid arthritis. Arthritis Rheum 2001; 44: 275-85.
○ Yamamura Y, Gupta R, Morita Y, He X, Pai R, Endres J, Freiberg A, Chung K, Fox DA. Effector function of resting T cells: activation of synovial fibroblasts. J Immunol 2001; 166: 2270-5.
○ Harada S, Yamamura M, Okamoto H, Morita Y, Kawashima M, Makino H. Fibroblast-like synoviocytes from patients with rheumatoid arthritis can produce interleukin-7 and interleukin-15. Arthritis Rheum 1999; 42: 1508-16.
○ Morita Y, Yamamura M, Nishida K, Harada S, Okamoto H, Inoue H, Ohmoto Y, Modlin RL, Makino H. Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis. Arthritis Rheum 1998; 41: 306-14.
○ Morita Y, Kashihara N, Yamamura M, Okamoto H, Harada S, Kawashima M, Makino H. Antisense oligonucleotides targeting c-fos mRNA inhibit rheumatoid synovial fibroblast proliferation. Ann Rheum Dis 1998; 57: 122-4.
○ Morita Y, Yamamura M, Kawashima M, Harada S, Tsuji K, Shibuya K, Maruyama K, Makino H. Flow cytometric single-cell analysis of cytokine production by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthritis Rheum 1998; 41: 1669-76.
○ Okamoto H, Yamamura M, Morita Y, Harada S, Makino H, Ota Z. The synovial expression and serum levels of interleukin-6, interleukin-11, leukemia inhibitory factor, and oncostatin M in rheumatoid arthritis. Arthritis Rheum 1997; 40: 1096-105.
○ Morita Y, Kashihara N, Yamamura M, Okamoto H, Harada S, Maeshima Y, Okamoto K, Makino H. Inhibition of rheumatoid synovial fibroblast proliferation by antisense oligonucleotides targeting proliferating cell nuclear antigen messenger RNA. Arthritis Rheum 1997; 40: 1292-7.
○ Akagi T, Mukai T, Mito T, Kawahara K, Tsuji S, Fujita S, Uchida HA, Morita Y.　Effect of angiotensin II on bone erosion and systemic bone loss in mice with tumor necrosis factor-mediated arthritis. Int J Mol Sci 2020 ;21(11):4145.
○ Hada Y, Uchida HA, Mukai T, Kojima F, Yoshida M, Takeuchi H, Kakio Y, Otaka N, Morita Y, Wada J. Inhibition of interleukin-6 signaling attenuates aortitis, left ventricular hypertrophy and arthritis in interleukin-1 receptor antagonist deficient mice. Clin Sci (Lond) 2020 ;134(20):2771-87.
○ Tsuji S, Mukai T, Hirano H, Morita Y. In vivo analysis of thrombus formation in arthritic mice. Mod Rheumatol 2020 :1-6.
○ Tsuji S, Matsuzaki H, Iseki M, Nagasu A, Hirano H, Ishihara K, Ueda N, Honda Y, Horiuchi T, Nishikomori R, Morita Y, Mukai T. Functional analysis of a novel G87V TNFRSF1A mutation in patients with TNF receptor-associated periodic syndrome. Clin Exp Immunol 2019; 198(3):416-429.
○ Nagasu A, Mukai T, Iseki M, Kawahara K, Tsuji S, Nagasu H, Ueki Y, Ishihara K, Kashihara N, Morita Y. Sh3bp2 gain-of-function mutation ameliorates lupus phenotypes in B6.MRL-Fas lpr Mice. Cells 2019; 8(5):402.
○ Yahagi A, Saika T, Hirano H, Takai-Imamura M, Tsuji F, Aono H, Iseki M, Morita Y, Igarashi H, Saeki Y, Ishihara K. IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis. RMD Open 2019; 5(2):e000853
○ Fujita S, Mukai T, Mito T, Kodama S, Nagasu A, Kittaka M, Sone T, Ueki Y, Morita Y. Pharmacological inhibition of tankyrase induces bone loss in mice by increasing osteoclastogenesis. Bone 2018; 106:156-66.

その他

• 【受賞】1998-2001　　米国リウマチ財団　　Postdoctoral Fellowship Award

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