清水 伸幸 しみず のぶゆき 先生

来歴等

略歴

1989年　東京大学医学部医学科卒業
1989年　東京大学医学部附属病院分院外科研修医
1990年　埼玉医科大学総合医療センター放射線科研修医
1991年　東京大学医学部附属病院分院麻酔科研修医
1996年　愛知県がんセンター研究所　病理学第一部
2001年　東京大学医学部附属病院外科助手
2004年　ハーバード大学Massachusetts General Hospital Research Fellow
2007年　東京大学医学部附属病院外科講師
2009年　東京大学医学部附属病院 准教授
2013年　国際医療福祉大学 保健医療学部教授　兼　山王病院　外科部長
2015年　山王病院　副院長

論文

1．Shimizu N, Inada K, Nakanishi H, Tsukamoto T, Ikehara Y, Kaminishi M, Kuramoto S, Sugiyama A, Katsuyama T and Tatematsu M: Helicobacter pylori infection enhances glandular stomach carcinogenesis in Mongolian gerbils treated with chemical carcinogens. Carcinogenesis. 20, 669-676, 1999
2．Shimizu N, Inada KI, Tsukamoto T, Nakanishi H, Ikehara Y, Yoshikawa A, Kaminishi M, Kuramoto S and Tatematsu M: New animal model of glandular stomach carcinogenesis in Mongolian gerbils infected with Helicobacter pylori and treated with a chemical carcinogen. J Gastroenterol. 34, 61-66, 1999
3．Hiki N, Kurosaka H, Tatsutomi Y, Shimoyama S, Tsuji E, Kojima J, Shimizu N, Ono H, Hirooka T, Noguchi C, Mafune K and Kaminishi M: Peppermint oil reduces gastric spasm during upper endoscopy: a randomized, double-blind, double-dummy controlled trial. Gastrointest Endosc. 57, 475-482, 2003
4．Hiki N, Shimizu N, Yamaguchi H, Imamura K, Kami K, Kubota K and Kaminishi M: Manipulation of the small intestine as a cause of the increased inflammatory response after open compared with laparoscopic surgery. Br J Surg. 93, 195-204, 2006
5．Raher MJ, Thibault HB, Buys ES, Kuruppu D, Shimizu N, Brownell AL, Blake SL, Rieusset J, Kaneki M, Derumeaux G, Picard MH, Bloch KD and Scherrer-Crosbie M: A short duration of high-fat diet induces insulin resistance and predisposes to adverse left ventricular remodeling after pressure overload. Am J Physiol Heart Circ Physiol. 295, H2495-2502, 2008
6．Goto O, Mitsui T, Fujishiro M, Wada I, Shimizu N, Seto Y and Koike K: New method of endoscopic full-thickness resection: a pilot study of non-exposed endoscopic wall-inversion surgery in an ex vivo porcine model. Gastric Cancer. 14, 183-187, 2011
7．Tanioka T, Tamura Y, Fukaya M, Shinozaki S, Mao J, Kim M, Shimizu N, Kitamura T and Kaneki M: iNOS and NO donor decrease IRS-2 protein expression by promoting proteasome-dependent degradation in pancreatic β-cells: Involvement of GSK-3β. J Biol Chem. 286, 29388-29396, 2011
8．Ikehara Y., Sakakita H, Shimizu N, Ikehara S, Nakanishi H. Formation of Membrane-like Structures in Clotted Blood by Mild Plasma Treatment during Hemostasis. J Photopol Sci Tech 26(4), 555-557, 2013
9．Mitsui T, Goto O, Shimizu N, Hatao F, Wada I, Niimi K, Asada-Hirayama I, Fujishiro M, Koike K, Seto Y. Novel technique for full-thickness resection of gastric malignancy: feasibility of nonexposed endoscopic wall-inversion surgery (news) in porcine models. Surg Laparosc Endosc Percutan Tech. 23(6):e217-21, 2013
10．Kakiuchi M, Nishizawa T, Ueda H, Gotoh K, Tanaka A, Hayashi A, Yamamoto S, Tatsuno K, Katoh H, Watanabe Y, Ichimura T, Ushiku T, Funahashi S, Tateishi K, Wada I, Shimizu N, Nomura S, Koike K, Seto Y, Fukayama M, Aburatani H, Ishikawa S. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma. Nature Genetics 46(6):583-587, 2014
11．Mori K, Yamada K, Fukuda T, Mitsui T, Kitamura T, Yamaguchi D, Ando J, Wada I, Nomura S, Shimizu N, Seto Y: Landiolol hydrochloride for early postoperative tachycardia after transthoracic esophagectomy. Surg Today. 44:848-854, 2014
12．Mitsui T, Niimi K, Yamashita H, Goto O, Aikou S, Hatao F, Wada I, Shimizu N, Fujishiro M, Koike K, Seto Y. Non-exposed endoscopic wall-inversion surgery as a novel partial gastrectomy technique. Gastric Cancer. 17(3):594-599, 2014
13．Wada I, Matsushita H, Noji S, Mori K, Yamashita H, Nomura S, Shimizu N, Seto Y, Kakimi K. Intraperitoneal injection of in vitro expanded Vγ9Vδ2 T cells together with zoledronate for the treatment of malignant ascites due to gastric cancer. Cancer Med. 3(2): 362-375, 2014

著書

1．Tatematsu M, Shimizu N and Sugiyama A: Helicobacter pylori infection and glandular stomach carcinogenesis--Small animal models and chemoprevention--. In: New Frontiers in Mechanistic Cancer Research in Animal Models. S Cohen, O Hino, T Ishikawa, H Nakagame, T Shirai, T Sugimura (ed.) Princess Takamatsu Cancer Research Fund, Tokyo, Japan, pp117-119, 2000
2．Shimizu N, IkeharaY, Nozaki K, Kaminishi M, Tsuda H, Sugiyama A, Katsuyama T and Tatematsu M: Effects of lactoferrin administration in Helicobacter pylori infection animal model. In: Lactoferrin: Structure, Function and Applications. K Shimazaki, H Tsuda, M Tomita, T Kuwata, J Perraudin (ed.) Elsevier, Amsterdam, Netherlands, pp209-215, 2000
3．Shimizu N, Tatematsu M and Kaminishi M: Helicobacter pylori and Gastric Carcinoma. In: The Diversity of Gastric Carcinoma. M Kaminishi, K Takubo, K Mafune (ed.) Springer-Verlag Tokyo, Tokyo, Japan, pp75-86, 2005
4．Kaminishi M, Shimoyama S, Yamaguchi H, Aoki F, Shimizu N, Nomura S, Miura T, Hiki N, Kawahara M, Seto Y and Mafune K: Surgical treatment and survival rate of early cancer. In: Early Cancer of the Gastrointestinal Tract. R Fujita, JR Jass, M Kaminishi, RJ Schlemper (ed.) Springer-Verlag Tokyo, Tokyo, Japan, pp259-272, 2006
5. Shimizu N., Hatao F., Kiyokawa T., Goto O., Fujishiro M. and Seto Y: Single port surgery for gastric tumors. In: IGCC 2011 9th International Gastric Cancer Congress. SH Noh, YJ Mok, HK Yang (ed.) Monduzzi Editore, Bologna, Italy, pp247-252, 2011

その他

• 1998年 Young Researcher’s Award, Japanese Gastric Cancer Association, presented at 70th Japan Gastric Cancer Congress

• 1997-1999年 Research Resident Fellowship, The Foundation for Promotion of Cancer Research

• 文部科学省新学術領域研究「プラズマ医療科学の創成」

• 分子生物学的解析に基づくプラズマ誘起細胞増殖・腫瘍細胞死誘起メカニズムの体系化

• Agency: NIH

• R01 DK58127-06 - M Kaneki (PI)

• Role: Co Investigator

• Title: Inducible nitric oxide synthase and insulin resistance

• Period: 07/01/02-08/31/10

• The goals of the project are to clarify molecular mechanisms by which iNOS causes insulin resistance, and elucidate roles for S-nitrosoglutathione reductase (GSNOR) and protein S-nitrosylation in obesity-associated insulin resistance.