古家 大祐 こや だいすけ 先生

来歴等

略歴

1984年 滋賀医科大学医学部医学科 卒業
1984年 滋賀医科大学医学部附属病院第三内科 研修医
1986年 千里保健医療センター新千里病院内科 医員
1989年 滋賀医科大学医学部附属病院第三内科 医員
1992年 滋賀医科大学医学部附属病院第三内科 助手
1994年 ジョスリン糖尿病センター 研究員
1997年 滋賀医科大学医学部附属病院第三内科 助手
2004年 滋賀医科大学医学部附属病院内科 講師
2005年 金沢医科大学内分泌代謝制御学 教授
2010年 金沢医科大学糖尿病・内分泌内科学 教授（講座名変更）
2010年 金沢医科大学栄養部 部長 併任
2014年 金沢医科大学病院 副院長 併任（-2017）
2017年 金沢医科大学 糖尿病・内分泌内科学 教授
2020年 金沢医科大学病院 副院長 （併任）
2021年 草津総合病院（現・淡海医療センター） 病院長

論文

• Diabetic kidney disease: its current trend and future therapeutic perspective.J Diabetes Investig. 2019 Jul 30. doi: 10.1111/jdi.13121.

  Koya D

• Prevalence of albuminuria and renal dysfunction and related clinical factors in Japanese patients with diabetes: The Japan Diabetes Complication and its Prevention prospective study (JDCP study 5).J Diabetes Investig. 2019 Jul 18. doi: 10.1111/jdi.13116.

  Shikata K, Kodera R, Utsunomiya K, Koya D, Nishimura R, Miyamoto S, Tajima N; JDCP study group.

• Proposal of classification of "chronic kidney disease (CKD) with diabetes" in clinical setting.Diabetol Int. 2019 Apr 29;10(3):180-182. doi: 10.1007/s13340-019-00396-8.

  Kitada M, Koya D

• Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice.Sci Rep. 2019 May 17;9(1):7519. doi: 10.1038/s41598-019-43730-5.

  Takagaki Y, Shi S, Katoh M, Kitada M, Kanasaki K, Koya D

• Relevance of Autophagy Induction by Gastrointestinal Hormones: Focus on the Incretin-Based Drug Target and Glucagon.Front Pharmacol. 2019 May 16;10:476. doi: 10.3389/fphar.2019.00476. eCollection 2019.

  Kanasaki K, Kawakita E, Koya D

• Identification of subgroups of patients with type 2 diabetes with differences in renal function preservation between sglt2 inhibitors and dpp4 inhibitors using a supervised machine learning algorithm (profile study): A Retrospective analysis of a japanese commercial medical database. Diabetes Obes Metab. 2019 May 3. doi: 10.1111/dom.13753.

  Zhou FL, Watada H, Tajima Y, Berthelot M, Kang D, Esnault C, Shuto Y, Maegawa H, Koya D

• The impact of dietary protein intake on longevity and metabolic health.EBioMedicine. 2019 Apr 8. pii: S2352-3964(19)30239-7. doi: 10.1016/j.ebiom.2019.04.005.

  Kitada M, Ogura Y, Monno I, Koya D

• βklotho is essential for the anti-endothelial mesenchymal transition effects of N-acetyl-seryl-aspartyl-lysyl-proline.FEBS Open Bio. 2019 May;9(5):1029-1038. doi: 10.1002/2211-5463.12638.

  Gao R, Kanasaki K, Li J, Kitada M, Okazaki T, Koya D

• Sirtuins and Type 2 Diabetes: Role in Inflammation, Oxidative Stress, and Mitochondrial Function.Front Endocrinol (Lausanne). 2019 Mar 27;10:187. doi: 10.3389/fendo.2019.00187.

  Kitada M, Ogura Y, Monno I, Koya D

• N-Acetyl-seryl-aspartyl-lysyl-proline is a potential biomarker of renal function in normoalbuminuric diabetic patients with eGFR ≥ 30 ml/min/1.73 m2.Clin Exp Nephrol. 2019 Apr 4. doi: 10.1007/s10157-019-01733-6.

  Nitta K, Nagai T, Mizunuma Y, Kitada M, Nakagawa A, Sakurai M, Toyoda M, Haneda M, Kanasaki K, Koya D

• Inhibition of dipeptidyl peptidase-4 accelerates epithelial-mesenchymal transition and breast cancer metastasis via the CXCL12/CXCR4/mTOR axis.Cancer Res. 2018 Dec 24. pii: canres.0620.2018. doi: 10.1158/0008-5472.CAN-18-0620.

  Yang F, Takagaki Y, Yoshitomi Y, Ikeda T, Li J, Kitada M, Kumagai A, Kawakita E, Shi S, Kanasaki K, Koya D

• Secular changes in clinical manifestations of kidney disease among Japanese adults with type 2 diabetes, 1996-2014.J Diabetes Investig. 2018 Nov 19. doi: 10.1111/jdi.12977

  Kume S, Araki SI, Ugi S, Morino K, Koya D, Nishio Y, Haneda M, Kashiwagi A, Maegawa H

• AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.nt J Mol Sci. 2018 Oct 9;19(10).

  Kumagai A, Itakura A, Koya D, Kanasaki K

• SIRT3 deficiency leads to induction of abnormal glycolysis in diabetic kidney with fibrosis.Cell Death Dis. 2018 Sep 24;9(10):997. doi: 10.1038/s41419-018-1057-0.

  Srivastava SP, Li J, Kitada M, Fujita H, Yamada Y, Goodwin JE, Kanasaki K, Koya D

• Effect of switching to teneligliptin from other dipeptidyl peptidase-4 inhibitors on glucose control and reno-protection in type 2 diabetic patients with diabetic kidney disease. J Diabetes Investig. 2018 Aug 23. doi: 10.1111/jdi.12917.

  Kitada M, Ogura Y, Nitta K, Fujii M, Kanasaki K, Konishi K, Iida Y, Nakagawa A, Koya D

• The Japanese Clinical Practice Guideline for acute kidney injury 2016.Japanese Clinical Practice Guideline for Acute Kidney Injury 2016 Committee. J Intensive Care. 2018 Aug 13;6:48. doi: 10.1186/s40560-018-0308-6.

  Doi K, Nishida O, Shigematsu T, Sadahiro T, Itami N, Iseki K, Yuzawa Y, Okada H, Koya D, Kiyomoto H, Shibagaki Y, Matsuda K, Kato A, Hayashi T, Ogawa T, Tsukamoto T, Noiri E, Negi S, Kamei K, Kitayama H, Kashihara N, Moriyama T, Terada Y

• The Japanese clinical practice guideline for acute kidney injury 2016. Japanese Clinical Practice Guideline for Acute Kidney Injury 2016 Committee. Clin Exp Nephrol. 2018 Jul 23. doi: 10.1007/s10157-018-1600-4.

  Doi K, Nishida O, Shigematsu T, Sadahiro T, Itami N, Iseki K, Yuzawa Y, Okada H, Koya D, Kiyomoto H, Shibagaki Y, Matsuda K, Kato A, Hayashi T, Ogawa T, Tsukamoto T, Noiri E, Negi S, Kamei K, Kitayama H, Kashihara N, Moriyama T, Terada Y

• Role of dietary amino acid balance in diet restriction-mediated lifespan extension, renoprotection, and muscle weakness in aged mice. Aging Cell. 2018 Jun 25:e12796. doi: 10.1111/acel.12796.

  Yoshida S, Yamahara K, Kume S, Koya D, Yasuda-Yamahara M, Takeda N, Osawa N, Chin-Kanasaki M, Adachi Y, Nagao K, Maegawa H, Araki SI

• Renal mitochondrial oxidative stress is enhanced by the reduction of Sirt3 activity, in Zucker diabetic fatty rats.Redox Rep. 2018 Dec;23(1):153-159. doi: 10.1080/13510002.2018.1487174.

  Ogura Y, Kitada M, Monno I, Kanasaki K, Watanabe A, Koya D

• Severe electrolytes disorders with the interstitial kidney alterations in the patient with the history of total thyroidectomy and parathyroidectomy: possible role of vitamin D deficiency.Clin Case Rep. 2018 Apr 6;6(6):983-989. doi: 10.1002/ccr3.1500.

  Kawakita E, Kanasaki K, Hirai T, Tsuda SI, Watanabe A, Nitta K, Kitada M, Ogura Y, Takagaki Y, Fujii M, Nagai T, Shimada K, Takagi S, Mizunuma Y, Monno I, Shino F, Minato H, Miyatake N, Nakagawa A, Koya D

• A Low-Protein Diet for Diabetic Kidney Disease: Its Effect and Molecular Mechanism, an Approach from Animal Studies. Nutrients. 2018 Apr 27;10(5). pii: E544. doi: 10.3390/nu10050544.

  Kitada M, Ogura Y, Monno I, Koya D

• A ketogenic amino acid rich diet benefits mitochondrial homeostasis by altering the AKT/4EBP1 and autophagy signaling pathways in the gastrocnemius and soleus.Biochim Biophys Acta. 2018 Jul;1862(7):1547-1555. doi: 10.1016/j.bbagen.2018.03.013.

  Li J, Kanasaki M, Xu L, Kitada M, Nagao K, Adachi Y, Jinzu H, Noguchi Y, Kohno M, Kanasaki K, Koya D

• A low-protein diet exerts a beneficial effect on diabetic status and prevents diabetic nephropathy in Wistar fatty rats, an animal model of type 2 diabetes and obesity.Nutr Metab (Lond). 2018 Mar 2;15:20. doi: 10.1186/s12986-018-0255-1.

  Kitada M, Ogura Y, Suzuki T, Monno I, Kanasaki K, Watanabe A, Koya D

• Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high-fat diet.J Diabetes Investig. 2018 Sep;9(5):1025-1032. doi: 10.1111/jdi.12802

  Takagi S, Li J, Takagaki Y, Kitada M, Nitta K, Takasu T, Kanasaki K, Koya D.

• FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p.Biochem Biophys Res Commun. 2018 Jan 15;495(3):2214-2220.

  Hu Q, Li J, Nitta K, Kitada M, Nagai T, Kanasaki K, Koya D

• The Effect of Piceatannol from Passion Fruit (Passiflora edulis) Seeds on Metabolic Health in Humans. Nutrients. 2017 Oct 18;9(10). pii: E1142. doi: 10.3390/nu9101142

  Kitada M, Ogura Y, Maruki-Uchida H, Sai M, Suzuki T, Kanasaki K, Hara Y, Seto H, Kuroshima Y, Monno I, Koya D

• Decline in estimated glomerular filtration rate is associated with risk of end-stage renal disease in type 2 diabetes with macroalbuminuria: an observational study from JDNCS.Clin Exp Nephrol. 2017 Sep 9. doi: 10.1007/s10157-017-1467-9.

  Shimizu M, Furuichi K, Toyama T, Funamoto T, Kitajima S, Hara A, Ogawa D, Koya D, Ikeda K, Koshino Y, Kurokawa Y, Abe H, Mori K, Nakayama M, Konishi Y, Samejima KI, Matsui M, Yamauchi H, Gohda T, Fukami K, Nagata D, Yamazaki H, Yuzawa Y, Suzuki Y, Fujimoto S, Maruyama S, Kato S, Naito T, Yoshimura K, Yokoyama H, Wada T; Research Group of Diabetic Nephropathy, the Ministry of Health, Labour, and Welfare of Japan and Japan Agency for Medical Research and Development.

• Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance.J Endocrinol. 2017 Aug 30. pii: JOE-17-0351. doi: 10.1530/JOE-17-0351.

  Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T

• A cyclic and intermittent very low-protein diet can have beneficial effects against advanced diabetic nephropathy in Wistar fatty (fa/fa) rats, an animal model of type 2 diabetes and obesity.Nephrology (Carlton). 2017 Aug 12. doi: 10.1111/nep.13152.

  Kitada M, Ogura Y, Suzuki T, Monnno I, Kanasaki K, Watanabe A, Koya D

• Deficiency in catechol-o-methyltransferase is linked to a disruption of glucose homeostasis in mice.Sci Rep. 2017 Aug 11;7(1):7927.

  Kanasaki M, Srivastava SP, Yang F, Xu L, Kudoh S, Kitada M, Ueki N, Kim H, Li J, Takeda S, Kanasaki K, Koya D

著書

• 【共著】古家大祐ほか/金沢医科大学出版局/2017：なるほど！そうだったのか！糖尿病教室

• 古家大祐/マガジンハウス/2011　老けない人は腹七分目

その他

• 【受賞】平成12年 日本糖尿病合併症学会 Young Investigator Award

• 【受賞】平成15年 日本医師会研究助成

• 【受賞】平成24年 日本抗加齢研究奨励賞

• 【受賞】平成26年 杉田玄白賞

• 【受賞】令和元年 日本糖尿病合併症学会 Expert Investigator Award