植田 光晴 うえだ みつはる 先生

来歴等

略歴

1999年 熊本大学医学部 卒業
1999年 熊本大学医学部附属病院 神経内科 入局
2007年 熊本大学大学院博士課程 卒業、医学博士 取得
2007年 熊本大学大学院医学薬学研究部 病態情報解析学分野（臨床検査医学） 助教
2011年 米国インディアナ大学 臨床病理学 客員研究員
2012年 熊本大学医学部附属病院 中央検査部 講師
2013年 熊本大学医学部附属病院 神経内科 講師
2020年 熊本大学大学院生命科学研究部 脳神経内科学講座 教授

論文

• 1. Tissue biopsy for the diagnosis of amyloidosis: experience from some centres. Amyloid, 2022 (in press)

  Benson MD, Berk JL, Dispenzieri A, Damy T, Gillmore JD, Hazenberg BP, Lavatelli F, Picken MM, Röcken C, Schönland S, Ueda M, Westermark P.

• 2. Age-related amyloidosis outside the brain: A state-of-the-art review. Ageing Research Reviews, 70: 101388, 2021

  Tasaki M, Lavatelli F*, Obici L, Obayashi K, Miyamoto T, Merlini G, Palladini G, Ando Y, Ueda M*.

• 3. Apolipoprotein AI amyloid deposits in the ligamentum flavum in patients with lumbar spinal canal stenosis. Amyloid, 2021;28:107-112.

  Tasaki M, Okada M, Yanagisawa A, Nomura T, Ueda A, Inoue Y, Masuda T, Misumi Y, Yamashita T, Miyamoto T, Obayashi K, Ando Y, Ueda M.*

• 4. Long-term safety and efficacy of patisiran for hereditary transthyretin-mediated amyloidosis with polyneuropathy: 12-month results of an open-label extension study. Lancet Neurol, 2021;20:49-59.

  Adams D, Polydefkis M, Gonzalez-Duarte A, Wixner J, Kristen A, Schmidt H, Berk J, López I, Dispenzieri A, Conceiçao I, Slama M, Gillmore J, Kyriakides T, Ajroud-Driss S, Waddington-Cruz M, Mezei M, Plante-Bordeneuve V, Attarian S, Mauricio E, Brannagan T, Ueda M, Aldinc E, Wang J, White M, Vest J, Berber E, Sweetser M, Coelho T.

• 5. JCS 2020 Guideline on Diagnosis and Treatment of Cardiac Amyloidosis. Circ J, 2020;84:1610-1671.

  Kitaoka H, Izumi C, Izumiya Y, Inomata T, Ueda M, Kubo T, Koyama J, Sano M, Sekijima Y, Tahara N, Tsukada N, Tsujita K, Tsutsui H, Tomita T, Amano M, Endo J, Okada A, Oda S, Takashio S, Baba Y, Misumi Y, Yazaki M, Anzai T, Ando Y, Isobe M, Kimura T, Fukuda K; Japanese Circulation Society Joint Working Group.

• 6. Monitoring of asymptomatic family members at risk of hereditary transthyretin amyloidosis for early intervention with disease-modifying therapies. J Neurol Sci, 2020;414:116813.

  Ueda M,* Sekijima Y, Koike H, Yamashita T, Yoshinaga T, Ishii T, Ando Y.

• 7. Analysis of autonomic outcomes in APOLLO, a phase III trial of the RNAi therapeutic patisiran in patients with hereditary transthyretin-mediated amyloidosis. J Neurol, 2020;267:703-712.

  González-Duarte A, Berk J, Quan D, Mauermann M, Schmidt H, Polydefkis M, Waddington-Cruz M, Ueda M, Conceição I, Kristen A, Coelho T, Cauquil C, Tard C, Merkel M, Aldinc E, Chen J, Sweetser M, Wang J, Adams D.

• 8. Natural history and long-term effects of variant protein reduction in non-V30M ATTR amyloidosis. Neurology, 2019;93:714-716.

  Yamashita T, Ueda M, Nomura T, Okazaki T, Okada M, Tsuda Y, Inoue Y, Masada T, Misumi Y, Takamatsu K, Obayashi K, Inomata Y, Hibi T, Ando Y.

• 9. Nationwide survey on cerebral amyloid angiopathy in Japan. Eur J Neurol, 2019;26:1487-1493.

  Sakai K, Ueda M, Fukushima W, Tamaoka A, Shoji M, Ando Y, Yamada M.

• 10. A cell-based high-throughput screening method to directly examine transthyretin amyloid fibril formation at neutral pH. J Biol Chem, 2019;294:11259-11275.

  Ueda M, Okada M, Mizuguchi M, Kluve-Beckerman B, Kanenawa K, Isoguchi A, Misumi Y, Tasaki M, Ueda A, Kanai A, Sasaki R, Masuda T, Inoue Y, Nomura T, Shinriki S, Shuto T, Kai H, Yamashita T, Matsui H, Benson M, Ando Y.

• 11. New simple and quick method to analyze serum variant transthyretins: direct MALDI method for the screening of hereditary transthyretin amyloidosis. Orphanet J Rare Dis, 2019;14:116.

  Nomura T, Ueda M, Tasaki M, Misumi Y, Masuda T, Inoue Y, Tsuda Y, Okada M, Okazaki T, Kanenawa K, Isoguchi A, Nakamura M, Obayashi K, Shinriki S, Matsui H, Yamashita T, Ando Y.

• 12. Characteristics of acquired transthyretin amyloidosis A case series and review of the literature. Neurology, 2019;93:e1587-e1596.

  Misumi Y, Ueda M, Masuda T, Tsuda Y, Nomura T, Okada M, Inoue Y, Tasaki M, Obayashi K, Yamashita T, Ando Y.

• 13. Early diagnosis of ATTR amyloidosis through targeted follow-up of identified carriers of TTR gene mutations. Amyloid, 2019;26:3-9.

  Conceição I, Damy T, Romero M, Galán L, Attarian S, Luigetti M, Sadeh M, Sarafov S, Tournev I, Ueda M.

• 14. Extreme adhesion activity of amyloid fibrils induces subcutaneous insulin resistance. Diabetes, 2019;68:609-616.

  Nakamura M, Misumi Y, Nomura T, Oka W, Isoguchi A, Kanenawa K, Masuda T, Yamashita T, Inoue Y, Ando Y, Ueda M.

• 15. A novel age-related venous amyloidosis derived from EGF-containing fibulin-like extracellular matrix protein 1. J Pathol, 2019;247:444-455 (*contributed equally).

  Tasaki M,* Ueda M,* Hoshii Y, Mizukami M, Matsumoto S, Nakamura M, Yamashita T, Ueda A, Misumi Y, Masuda T, Inoue Y, Torikai T, Nomura T, Tsuda Y, Kanenawa K, Isoguchi A, Okada M, Matsui H, Obayashi K, Ando Y.

• 16. Patisiran, a RNAi therapeutic, for hereditary transthyretin amyloidosis. N Engl J Med, 2018;379:11-21.

  Adams D, Gonzalez-Duarte A, O’Riordan W, Yang C, Ueda M, Kristen A, Tournev I, Schmidt H, Coelho T, Berk J, Lin K, Vita G, Attarian S, Plante-Bordeneuve V, Mezei M, Campistol J, Buades J, Brannagan T, Kim B, Oh J, Parman Y, Sekijima Y, Hawkins P, Solomon S, Polydefkis M, Dyck P, Gandhi P, Goyal S, Chen J, Strahs A, Nochur S, Sweetser M, Garg P, Vaishnaw A, Gollob J, Suhr O.

• 17. First Nationwide Survey on Wild-type ATTR Amyloidosis in Japan. Amyloid, 2018;25:8-10.

  Sekijima, Y, Yazaki M, Ueda M, Koike H, Yamada M, Ando Y.

• 18. Genetic and clinical characteristics of hereditary transthyretin amyloidosis in endemic and non-endemic areas: experience from a single-referral center in Japan. J Neurol, 2018;265:134-140.

  Yamashita T, Ueda M, Misumi Y, Masuda T, Nomura T, Tasaki M, Takamatsu K, Sasada K, Obayashi K, Matsui H, Ando Y.

• 19. Sushi repeat-containing protein 1: a novel disease-associated molecule in cerebral amyloid angiopathy. Acta Neuropathol, 2017;134:605-617.

  Inoue Y, Ueda M, Tasaki M, Takeshima A, Nagatoshi A, Masuda T, Misumi Y, Kosaka T, Nomura T, Mizukami M, Matsumoto S, Yamashita T, Takahashi H, Kakita A, Ando Y.

• 20. Early skin denervation in hereditary and iatrogenic transthyretin amyloid neuropathy. Neurology, 2017;88:2192–2197.

  Masuda T, Ueda M, Suenaga G, Misumi Y, Tasaki M, Izaki A, Yanagisawa Y, Inoue Y, Motokawa H, Matsumoto S, Mizukami M, Arimura A, Deguchi T, Nishio Y, Yamashita T, Inomata Y, Obayashi K, Ando Y.

• 21. Novel screening for transthyretin amyloidosis by using fat ultrasonography. Ann Neurol, 2017;81:604-608.

  Misumi Y, Ueda M, Yamashita T, Masuda T, Kinoshita Y, Tasaki M, Nagase T, Ando Y.

• 22. Knee osteoarthritis associated with different kinds of amyloid deposits and the impact of aging on type of amyloid. Amyloid, 2016;23:26-32.　

  Yanagisawa A, Ueda M, Sueyoshi T, Nakamura E, Tasaki M, Suenaga G, Motokawa H, Toyoshima R, Kinoshita Y, Misumi Y, Yamashita T, Sakaguchi M, Westermark P, Mizuta H, Ando Y.

• 23. Genotypic and phenotypic spectrum of CADASIL in Japan: the experience at a referral center in Kumamoto University from 1997 to 2014. J Neurol, 2015;262:1828-1836.

  Ueda A, Ueda M, Nagatoshi A, Hirano T, Ito T, Arai N, Uyama E, Mori K, Nakamura M, Shinriki S, Ikeda K, Ando Y.

• 24. Amyloid deposits derived from transthyretin in the ligamentum flavum as related to lumbar spinal canal stenosis. Mod Pathol, 2015;28:201-207.

  Yanagisawa A, Ueda M, Sueyoshi T, Okada T, Fujimoto T, Ogi Y, Kitagawa K, Tasaki M, Misumi Y, Oshima T, Jono H, Obayashi K, Hirakawa K, Uchida H, Westermark P, Ando Y, Mizuta H.

• 25. Changes in pathological and biochemical findings of systemic tissue sites in familial amyloid polyneuropathy more than 10 years after liver transplantation. J Neurol Neurosurg Psychiatry, 2014;85:740-746. (*contributed equally)

  Oshima T,* Kawahara S,* Ueda M,* Kawakami Y, Tanaka R, Okazaki T, Misumi Y, Obayashi K, Yamashita T, Ohya Y, Ihse E, Shinriki S, Tasaki M, Jono H, Asonuma K, Inomata Y, Westermark P, Ando Y.

• 26. Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy. Neurology, 2012;78:637-643.

  Yamashita T, Ando Y, Okamoto S, Misumi Y, Hirahara T, Ueda M, Obayashi K, Nakamura M, Jono H, Shono M, Asonuma K, Inomata Y, Uchino M.

• 27. Aged vervet monkeys developing transthyretin amyloidosis with the human disease-causing Ile122 allele: A valid pathological model of the human disease. Lab Invest, 2012;92:474-484.

  Ueda M, Ageyama N, Nakamura S, Nakamura M, Chambers J, Misumi Y, Mizuguchi M, Shinriki S, Kawahara S, Tasaki M, Jono H, Obayashi K, Sasaki E, Une Y, Ando Y.

• 28. Clinicopathological features of senile systemic amyloidosis: an ante- and postmortem study. Mod Pathol, 2011;24:1533-1544. (*contributed equally).

  Ueda M*, Horibata Y*, Shono M, Misumi Y, Oshima T, Su Y, Tasaki M, Shinriki S, Kawahara S, Jono H, Obayashi K, Ogawa H, Ando Y.

• 29. Wild-type transthyretin-derived amyloidosis in various ligaments and tendons. Hum Pathol, 2011;42:1259-1264.

  Sueyoshi T, Ueda M, Jono H, Irie H, Sei A, Ide J, Ando Y, Mizuta H.

• 30. SELDI-TOF MS evaluation of variant transthyretins for diagnosis and pathogenesis of familial amyloidotic polyneuropathy. Clin Chem 2009;55:1223-7

  Ueda M, Misumi Y, Mizuguchi M, Nakamura M, Yamashita T, Sekijima Y, Ota K, Shinriki S, Jono H, Ikeda SI, Suhr OB, Ando Y.

著書

• 1. 最新 アミロイドーシスのすべて 診療ガイドライン2017とQ&A、医歯薬出版、2017年

• 2. 21世紀の疾患：神経関連アミロイドーシス、医学と看護社、2020年

特許

• 1. アミロイド線維形成抑制剤 （発明者）安東由喜雄、有馬英俊、城野博史、植田光晴、本山敬一、（権利者）熊本大学、 （出願番号）特願2008-260965（出願年月日）2008年10月7日、国内

• 2. アミロイド線維形成抑制剤およびその利用 （発明者）安東由喜雄、城野博史、植田光晴、三隅洋平、（権利者）熊本大学、 （出願番号）特願2009-042102、（出願年月日）2009年2月25日、国内

• 3. アミロイド線維形成抑制剤およびその利用 （発明者）城野博史、安東由喜雄、有馬英俊、植田光晴、本山敬一、（権利者）熊本大学、 （出願番号）特願2009-155158（出願年月日）2009年6月30日、国内

• 4. 整理番号：１６０２９ＡＡ１４（日本） 出願番号：特願2019-094992 出願日：令和1年5月21日(2019/05/21) 発明の名称： アミロイドーシス治療薬の新規スクリーニング方法及びアミロイドーシスのための医薬組成物 出願人：国立大学法人　熊本大学　 （富山大学は非承継） 発明者：植田光晴; 安東由喜雄; 水口峰之（富山大学）

• 5. 整理番号：20032PC09，20033PC09（ＰＣＴ） 出願番号：PCT/JP2021/037039，PCT/JP2021/037040 国際出願日：2021/10/06 発明の名称： トランスサイレチン四量体安定化剤、及び、トランスサイレチンアミロイドーシス予防剤又は進行抑制剤 出願人：国立大学法人　熊本大学；株式会社カネカ；学校法人九州文化学園 長崎国際大学 発明者：植田光晴；増田曜章；三隅洋平；澤下仁子；安東由喜雄；松下博昭