河野 宏明 かわの ひろあき 先生

来歴等

略歴

1990年 熊本大学医学部卒業 熊本大学医学部附属病院
1991年 八千総合病院、熊本地域医療センター
1992年 福岡徳洲会病院
1993年 熊本大学医学部循環器内科医員
1998年 熊本大学医学部附属病院助手（循環器内科）
2003年 熊本大学医学部附属病院講師（集中治療部副部長）
2013年 熊本大学大学院生命科学研究部臨床看護学教授

論文

英文総説

Kawano H. Medical care of premenopausal women with coronary artery disease. Ann Intern Med. 137(3):W1, 2002

Kawano H, Ogawa H. Endothelial dysfunction and coronary artery spasm. Current Drug Targets-Cardiovascular & Haematological Disorders 4:23-33, 2004.

Kawano H, Ogawa H. Endothelial function and coronary spastic angina. Int Med 44:91-99, 2005

Kawano H The relationship between testosterone and metabolic syndrome. Hypertension Res 33:537-538, 2010.

Kawano H, Node K. Medical agents Acting on the rennin-angiotensin-aldosterone axis for the treatment of heart failure. Hypertension Res 33:192-3, 2010.

JCS Joint Working Group Guidelines for Diagnosis and treatment of Patients with Vasospastic Angina (Coronary Spastic Angina) Circulation Journal 74:1745-1762, 2010

Kawano H, Node K. The Role of Vascular Failure in Coronary Artery Spasm.　 J Cardiol 57:2-7,2011

邦文総説

河野宏明, 泰江弘文. 硝酸薬耐性の予防. 日本医事新報. 3975:90-91, 2000.

河野宏明, 泰江弘文. 硝酸薬耐性. 日本医事新報. 3949:154-155, 2000.

河野宏明, 泰江弘文. 生活習慣病の予防. 産科と婦人科. April:459-467, 2000.

河野宏明, 泰江弘文. エストロゲンの生理作用. Hormone Frontier in Gynecology. 7:39-45, 2000.

河野宏明. 女性における虚血性心疾患の特徴. Heart View. 4:714-721, 2000

河野宏明. エストロゲンと動脈硬化. Medico. 32:104-109, 2001.

河野宏明, 小川久雄, 泰江弘文. 閉経前女性の異型狭心症例. Circulation Frontier. 5:43-47, 2001.

河野宏明. 閉経後女性の胸痛 –病態と診断、治療　 循環器専門医　日本循環器学会雑誌　9:31-36, 2002.

河野宏明. 狭心症に対するホルモン補充療法　内分泌・糖尿病科 14:319-327, 2002.

河野宏明. 生活習慣病の性差　Cardiovascular Med-Surg. 4:216-223, 2002.

河野宏明, 小川久雄. 降圧治療と臓器保護　心疾患－虚血性心疾患－　 成人病と生活習慣病 1499-1507，2003.

河野宏明. HRT（女性ホルモン補充療法）の臨床 循環器疾患・動脈硬化・高脂血症に対する効果　治療学　37:41-48, 2003

河野宏明, 小川久雄. 高血圧　Medicament News 1769:3-7, 2003

河野宏明. 虚血性心疾患とエストロゲン 分子心血管病　4:129-136, 2003.

河野宏明, 小川久雄. 心筋梗塞の一次、二次、三次予防　薬物療法　Ca拮抗薬 綜合臨床　52:1541-1548, 2003.

河野宏明. 女性と心臓病 カレントテラピー　21:67-72, 2003.

河野宏明, 小川久雄. 虚血性心疾患合併高血圧の治療 日本内科学会誌　92:250-257, 2003.

河野宏明. 性差医療 治療学 38:881, 2004

河野宏明.　心筋梗塞危険因子の性差　性差と医療 vol1:29-36, 2004 　

河野宏明. 心血管系疾患の性差 成人病と生活習慣病 1:29-36, 2004

河野宏明. 心と性差医学 ホルモンと臨床 517-523, 2004

河野宏明 喫煙と女性 武田薬報　443:19-25, 2005

河野宏明, 小川久雄　　 虚血性心疾患 Cardiac Practice　16:335-341, 2005

河野宏明, 小川久雄 冠動脈疾患合併高血圧例における降圧薬選択と降圧目標 EBMジャーナル　6:175-179, 2005

河野宏明 女性と心疾患 Hormone Frontier in Gynecology　12:65-71, 2005

河野宏明 中高年女性の好発疾患とその対策　心血管疾患 実験治療　679:23-27, 2005

河野宏明 喫煙による循環器疾患の性差　性差と医療　2:287-290, 2005

河野宏明 閉経後女性 医学のあゆみ　212:807-811, 2005

河野宏明 予防における薬物の選択とは Medical Asahi　Feb:24-25, 2005

河野宏明 心疾患　治療学　3:266-272、2005

河野宏明 急性心筋梗塞危険因子の性差　　性差と医療　3:39-45, 2006

河野宏明 虚血性心疾患：危険因子における性差　心臓　「HEART’s Selection」　38:232-237, 2006　

河野宏明 女性の血管内皮機能　日本未病システム学会雑誌　12:33-35, 2006

河野宏明 エストロゲン治療（血管）に関する最新知見　 性差と医療　3:189-195, 2006

河野宏明 虚血性心疾患　 綜合臨床　55:275-280, 2006

河野宏明 女性における狭心症の臨床的特徴 熊本医学会ニューズレター　4:18-21, 2006

河野宏明 循環器疾患と性差 産科と婦人科 73:1158-1166, 2006

河野宏明 心疾患と性差 臨床婦人科産科 60:853-861, 2006

河野宏明, 小川久雄 虚血性心疾患と性差　　カレントテラピー 25:77-78, 2007

河野宏明 閉経は動脈硬化症の大きなリスクである 臨床婦人科産科　61:939-943, 2007

河野宏明 虚血性心疾患 Hormone Fronteir in Gyne. 14:19-26, 2007

河野宏明 性差のある臓器と疾患　心疾患　Aging & Health (長寿科学振興財団機関誌) 41:20-21, 2007

河野宏明 女性と心疾患 治療 89・2771-2778, 2007

河野宏明 女性における脂質管理 総合臨床 56:2329-2334, 2007

河野宏明 閉経後女性のリスク評価とサロゲートマーカー　　循環器科 61:116-121, 2007

河野宏明 コレステリルエステル転送蛋白（Cholesteryl Ester Transfer Protein: CETP） 日本臨床・増刊号 65:Suppl 7:195-198, 2007

河野宏明 女性の虚血性心疾患の特徴 血管医学 9:45-49, 2008

河野宏明 更年期女性の胸痛　日本医事新報 4382:61-65, 2008

河野宏明 循環器疾患における性差医療 成人病と生活習慣病 1107-1112, 2009

河野宏明 ACS（Acute Coronary Syndrome） Coagulation & Inflammation 112, 2009

河野宏明, 野出孝一, 永吉靖央, 小川久雄 高中性脂肪血症ならびに高コレステロール血症を合併した耐糖能障害例に対するロスバスタチンとべザフィブラートの併用　　Therapeutic Research　　　　31:818-821, 2010

河野宏明, 野出孝一 　　　　血液　　　　Anti-aging Science　　　　2:82-85, 2010

河野宏明, 野出孝一 エストロゲンと心肥大　　　　　循環器科　　　　　106-108, 2010

河野宏明, 野出孝一 高血糖と内皮依存性拡張反応　　月刊糖尿病　　　8:54‐57, 2010

河野宏明 循環器疾患の性差　　　　診断と治療　　　98:1105-1109, 2010

河野宏明, 野出孝一 診断メモ：心臓性急死 内科 199, 2010

河野宏明 女性のヘルスケアからみた動脈硬化予防, 産婦人科治療　永井書店　67－70、2011

河野宏明 食後高血糖と血管不全, 血管糖尿病　フジメディカル出版　2－7、2011

河野宏明, 野出孝一 私が推す2010年のこの１報, 血管糖尿病　フジメディカル出版　C2、2011

河野宏明 エストロゲンと冠攣縮, 循環器内科　科学評論社　309－312、2011

河野宏明 高血圧 臨床婦人科産科 2011

河野宏明 食後高血糖に対するARBの効果 月刊糖尿病 3:104-107, 2011

河野宏明 内科医から見たホルモン補充療法 更年期と加齢のヘルスケア 9: 24-27, 2011

河野宏明 高血圧, 日本女性医学会ニュースレター　協和企画　17:3, 2012

河野宏明 低容量の経口ホルモン補充療法, 産科と婦人科　診断と治療社　2012

河野宏明 更年期・老年期にどのような疾病をケアすべきか　臨床婦人科産科　2012

河野宏明 メタボリック症状群の性差, Heart View　メジカルビュー社　2012

河野宏明 心疾患とアンドロゲン, Geriatric Medicine　ライフサイエンス　2012

河野宏明 血栓症のリスクはどこまで許容されるのか？ 今日からできるホルモン補充療法　中外医学社　2012

河野宏明 高血圧の治療, 産科と婦人科　診断と治療社　2012

河野宏明 HRTに期待される作用、効果　血管機能、血圧に対する作用　臨床婦人科産科　2012

河野宏明 高血圧 産科と婦人科　診断と治療社　2012

英文原著論文
Uchino M, Uyama E, Kawano H, Hokamaki J, Kugiyama K, Murakami Y, Yasue H, Ando M. A histochemical and electron microscopic study of skeletal and cardiac muscle from a Fabry disease patient and carrier. Acta Neuropathol 90:334-338, 1995

Kugiyama K, Yasue H, Ohgushi M, Motoyama T, Kawano H, Inobe Y, Hirashima O, Sugiyama S. Deficiency in nitric oxide bioactivity in epicardial coronary arteries of cigarette smokers. J Am Coll Cardiol 28:1161-1167, 1996

Kawano H, Motoyama T, Kugiyama K, Hirashima O, Ohgushi M, Yoshimura M, Ogawa H, Okumura K, Yasue H. Menstrual cyclic variation of endothelium-dependent vasodilation of the brachial artery: possible role of estrogen and nitric oxide. Proc Assoc Am Physicians 108:473-480, 1996

Inobe Y, Kugiyama K, Morita E, Kawano H, Okumura K, Tomiguchi S, Tsuji A, Kojima A, Takahashi M, Yasue H. Role of adenosine in pathogenesis of syndrome X: assessment with coronary hemodynamic measurements and thallium-201 myocardial single-photon emission computed tomography. J Am Coll Cardiol 28:890-896, 1996

Kugiyama K, Yasue H, Okumura K, Ogawa H, Fujimoto K, Nakao K, Yoshimura M, Motoyama T, Inobe Y, Kawano H. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation 94:266-272, 1996

Kugiyama K, Ohgushi M, Motoyama T, Sugiyama S, Ogawa H, Yoshimura M, Inobe Y, Hirashima O, Kawano H, Soejima H, Yasue H. Nitric oxide-mediated flow-dependent dilation is impaired in coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 30:920-926, 1997

Motoyama T, Kawano H, Kugiyama K, Hirashima O, Ohgushi M, Yoshimura M, Ogawa H, Yasue H. Endothelium-dependent vasodilation in the brachial artery is impaired in smokers: effect of vitamin C. Am J Physiol 273:H1644-H1650, 1997

◎Kawano H, Motoyama T, Kugiyama K, Hirashima O, Ohgushi M, Fujii H, Ogawa H, Yasue H. Gender difference in improvement of endothelium-dependent vasodilation after estrogen supplementation. J Am Coll Cardiol 30:914-919, 1997

Kugiyama K, Ohgushi M, Sugiyama S, Motoyama T, Kawano H, Hirashima O, Yasue H. Supersensitive dilator response to nitroglycerin but not to atrial natriuretic peptide in spastic coronary arteries in coronary spastic angina. Am J Cardiol 79:606-610, 1997

Motoyama T, Kawano H, Kugiyama K, Okumura K, Ohgushi M, Yoshimura M, Hirashima O, Yasue H. Flow-mediated, endothelium-dependent dilation of the brachial arteries is impaired in patients with coronary spastic angina. Am Heart J 133:263-267, 1997

Motoyama T, Kawano H, Kugiyama K, Hirashima O, Ohgushi M, Tsunoda R, Moriyama Y, Miyao Y, Yoshimura M, Ogawa H, Yasue H. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J Am Coll Cardiol 32:1672-1679, 1998

Kugiyama K, Motoyama T, Hirashima O, Ohgushi M, Soejima H, Misumi K, Kawano H, Miyao Y, Yoshimura M, Ogawa H, Matsumura T, Sugiyama S, Yasue H. Vitamin C attenuates abnormal.vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol 32:103-109, 1998

Kugiyama K, Doi H, Motoyama T, Soejima H, Misumi K, Kawano H, Nakagawa O, Yoshimura M, Ogawa H, Matsumura T, Sugiyama S, Nakano T, Nakajima K, Yasue H. Association of remnant lipoprotein levels with impairment of endothelium-dependent vasomotor function in human coronary arteries. Circulation 97:2519-2526, 1998

Kugiyama K, Motoyama T, Doi H, Kawano H, Hirai N, Soejima H, Miyao Y, Takazoe K, Moriyama Y, Mizuno Y, Tsunoda R, Ogawa H, Sakamoto T, Sugiyama S, Yasue H. Improvement of endothelial vasomotor dysfunction by treatment with alpha-tocopherol in patients with high remnant lipoproteins levels. J Am Coll Cardiol 33:1512-1518, 1999

Kugiyama K, Ohta Y, Takazoe K, Moriyama Y, Kawano H, Miyao Y, Sakamoto T, Soejima H, Ogawa H, Doi H, Sugiyama S, Yasue H. Circulating levels of secretory type II phospholipase A(2) predict coronary events in patients with coronary artery disease. Circulation 100:1280-1284, 1999

Kawano H, Motoyama T, Hirashima O, Hirai N, Miyao Y, Sakamoto T, Kugiyama K, Ogawa H, Yasue H. Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J Am Coll Cardiol 34:146-154, 1999

Kugiyama K, Doi H, Takazoe K, Kawano H, Soejima H, Mizuno Y, Tsunoda R, Sakamoto T, Nakano T, Nakajima K, Ogawa H, Sugiyama S, Yoshimura M, Yasue H. Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease. Circulation 99:2858-2860, 1999

Kugiyama K, Ota Y, Sugiyama S, Kawano H, Doi H, Soejima H, Miyamoto S, Ogawa H, Takazoe K, Yasue H. Prognostic value of plasma levels of secretory type II phospholipase A2 in patients with unstable angina pectoris. Am J Cardiol. 86:718-722, 2000

Miyao Y, Kugiyama K, Kawano H, Motoyama T, Ogawa H, Yoshimura M, Sakamoto T, Yasue H. Diffuse intimal thickening of coronary arteries in patients with coronary spastic angina. J Am Coll Cardiol. 36:432-437, 2000.

Kawano H, Fujii H, Motoyama T, Kugiyama K, Ogawa H, Yasue H. Myocardial ischemia due to coronary artery spasm during dobutamine stress echocardiography. Am J Cardiol 85:26-30, 2000

Kugiyama K, Ota Y, Kawano H, Soejima H, Ogawa H, Sugiyama S, Doi H, Yasue H. Increase in plasma levels of secretory type II phospholipase A(2) in patients with coronary spastic angina. Cardiovasc Res. 47:159-165, 2000

Moriyama Y, Yasue H, Yoshimura M, Mizuno Y, Nishiyama K, Tsunoda R, Kawano H, Kugiyama K, Ogawa H, Saito Y, Nakao K. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J Clin Endocrinol & Metab. 85:1834-1840, 2000

Sakamoto T, Ogawa H, Kawano H, Hirai N, Miyamoto S, Takazoe K, Soejima H, Kugiyama K, Yoshimura M, Yasue H. Rapid change of platelet aggregability in acute hyperglycemia detection by a novel laser-light scattering method. Thromb Haemost. 83:475-479, 2000

Hirashima O, Kawano H, Motoyama T, Hirai N, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. Improvement of endothelial function and insulin sensitivity with vitamin C in patients with coronary spastic angina: possible role of reactive oxygen species. J Am Coll Cardiol. 35:1860-1866, 2000

Hirai N, Kawano H, Hirashima O, Motoyama T, Moriyama Y, Sakamoto T, Kugiyama K, Ogawa H, Nakao K, Yasue H. Insulin resistance and endothelial dysfunction in smokers: effects of vitamin C. Am J Physiol. 279:H1172-1178, 2000.

Motoyama T, Kawano H, Hirai N, Tsunoda R, Moriyama Y, Miyao Y, Sakamoto T, Yoshimura M, Kugiyama K, Yasue H, Ogawa H. The relationship left ventricular mass with endothelium-dependent vasodilation of the brachial artery in patients with hypertension. Cardiology 96:7-15, 2001

Kawano H, Motoyama T, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina. Ann Intern Med 135:977-981, 2001

Kawano H, Motoyama T, Hirai N, Kugiyama K, Ogawa H, Yasue H. Estradiol supplementation suppresses hyperventilation-induced attacks in postmenopausal women with variant angina. J Am Coll Cardiol. 37:735-740, 2001

Kawano H, Motoyama T, Hirai N, Yoshimura T, Kugiyama K, Ogawa H, Okamura H, Yasue H. Effect of medroxyprogesterone acetate plus estradiol on endothelium-dependent vasodilation in postmenopausal women. Am J Cardiol. 87:238-240, 2001

Fukushima H, Kugiyama K, Sugiyama S, Honda O, Koide S, Nakamura S, Kawano H, Soejima H, Miyamoto S, Yoshimura M, Sakamoto T, Ogawa H. Comparison of remnant-like lipoprotein particles in postmenopausal women with and without coronary artery disease and with men with coronary artery disease. Am J Cardiol 88:1370-1373, 2001

Takazoe K, Ogawa H, Yasue H, Sakamoto T, Soejima H, Miyao Y, Kawano H, Moriyama Y, Misumi K, Suefuji H, Kugiyama K, Yoshimura M. Increased plasminogen activator inhibitor activity and diabetes predict subsequent coronary events in patients with angina pectoris. Ann Med. 33:206-212, 2001

Kugiyama K, Miyao Y, Sakamoto T, Kawano H, Soejima H, Miyamoto S, Yoshimura M, Ogawa H, Sugiyama S, Yasue H. Glutathione attenuates coronary constriction to acetylcholine in patients with coronary spastic angina. Am J Physiol Heart Circ Physiol. 280:H264-271, 2001

Kugiyama K, Sugiyama S, Soejima H, Kawano H, Sakamoto T, Takazoe K, Ogawa H, Doi H, Yasue H. Increase in plasma levels of oxidized low-density lipoproteins in patients with coronary spastic angina. Atherosclerosis. 154:463-467, 2001

Yoshimura M, Mizuno Y, Nakayama M, Sakamoto T, Sugiyama S, Kawano H, Soejima H, Hirai N, Saito Y, Nakao K, Yasue H, Ogawa H. B-type natriuretic peptide as a sensitive marker of time- and dose-dependent effects of ACE inhibitor in patients with heart failure. Am J Med 112:716-720, 2002

Kawano H, Motoyama T, Yasue H, Hirai N, Waly HM, Kugiyama K, Ogawa H. The endothelial function fluctuates with the diurnal variation in the frequency of ischemic episodes in patients with variant angina. J Am Coll Cardiol 40:266-270, 2002

Kawano H, Motoyama T, Hirai N, Kugiyama K, Yasue H, Ogawa H. Endothelial dysfunction in hypercholesterolemia is improved by L-arginine administration: possible role of oxidative stress. Atherosclerosis 161:375-380, 2002

Shimomura H, Ogawa H, Takazoe K, Soejima H, Miyamoto S, Sakamoto T, Kawano H, Suefuji H, Nishikawa H, Arai H, Hokamaki J, Kajiwara I, Kugiyama K, Yoshimura M. Comparison of urinary biopyrrins levels in acute myocardial infarction (after reperfusion therapy) –vs.- stable angina pectoris and their usefulness in predicting subsequent cardiac event. Am J Cardiol 90:108-111, 2002

Ito T, Yasue H, Yoshimura M, Nakamura S, Nakayama M, Simasaki Y, Harada E, Mizuno Y, Kawano H, Ogawa H. Paraoxonase gene gln192Arg (Q192R) polymorphism is associated with coronary artery spasm. Hum Genet 110:89-94, 2002

Miyao Y, Fujimoto K, Kugiyama K, Kawano H, Hirai N, Sugiyama S, Sakamoto T, Yoshimura M, Ogawa H. Plasminogen activator inhibitor contributes to the coronary wall thickening in patients with angiographically normal coronary. Thromb Res 112:123-129, 2003

Hirai N, Kawano H, Yasue H, Takazoe K, Shimomura H, Miyamoto S, Soejima H, Sakamoto T, Nakamura H, Kugiyama K, Yodoi J, Ogawa H. Attenuation of nitrate tolerance and oxidative stress by angiotensin II receptor blocker in patients with coronary spasm. Circulation 108:1446-1450, 2003

＊Kawano H, Yasue H, Hirai N, Yoshida T, Fukushima H, MD, Miyamoto S, Kojima S, Hokamaki J, Nakamura H, Yodoi J, Ogawa H. Effects of transdermal and oral estrogen supplementation on endothelial function, inflammation, and cellular redox state. International Journal of Clinical Pharmacology & Therapeutics. 41:346-353, 2003

Kawano H, Yasue H, Kitagawa A, Hirai N, Yoshida T, Soejima H, Miyamoto S, Nakano M, Ogawa H. Dehydroepiandrosterone supplementation improves endothelial function and insulin sensitivity in men. J Clin Endocri & Metab. 88:3190-3195, 2003

Miyamoto S, Kawano H, Sakamoto T, Soejima H, Kajiwara I, Shimomura H, Kojima S, Hokamaki J, Sugiyama S, Hirai N, Yoshimura M, Ozaki Y, Ogawa H. Formation of platelet microaggregates correlates with adverse clinical outcome in patients with coronary artery disease. Thromb Haemost 89:681-686, 2003

Maruyoshi H, Kojima S, Funahashi T, Miyamoto S, Hokamaki J, Soejima H, Sakamoto T, Kawano H, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H.　Adiponectin is inversely related to plasminogen activator inhibitor type 1 in patients with stable exertional angina. Thrombosis and Haemostasis 91:1026-30, 2004

Miyamoto S, Kawano H, Sakamoto T, Soejima H, Kajiwara I, Hokamaki J, Hirai N, Sugiyama S, Yoshimura M, Yasue H, Nakamura H, Yodoi J, Ogawa H. Increased plasma levels of thioredoxin in patients with coronary spastic angina Antioxidants & Redox Signaling 6:75-80, 2004

Hokamaki J, Kawano H, Yoshimura H, Soejima H, Miyamoto S, Kajiwara I, Kojima S, Sakamoto T,Sugiyama S, Hirai N, Shimomura H, Nagayoshi Y, Tsujita K, Shioji I, Sasaki S, Ogawa H. Urinary Biopyrrins Levels are Elevated in Relation to Severity of Heart Failure J Am Coll Cardiol 43:1880-1885, 2004.

Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, Hokamaki J, Yoshimura M, Nakamura H,Yodoi H, Ogawa H. Vitamin E improves fibrinolytic activity in patients with coronary spastic angina. Thromb Res 113:345-351, 2004.

Tsujita K, Shimomura H, Kawano H, Hokamaki J, Fukuda M, Yamashita T, Hida S, Nakamura Y, Nagayoshi Y, Sakamoto T, Yoshimura M, Arai H, Ogawa H. Effects of edaravone on reperfusion injury in patients with acute myocatdial infarction. Am J Cardiol 94:481-484, 2004

Soejima H, Miyamoto S, Kojima S, Hokamaki J, Tanaka T, Kawano H, Sugiyama S, Sakamoto T, Yoshimura M, Kishikawa H, Ogawa H. Coronary spastic angina in patients with connective tissue disease. Circ J 68:367-370, 2004

The Japanese Beta-blockers and Calcium Antagonists Myocardial Infarction Investigators (JBCMI). Comparison of the effects of beta blockers and calcium antagonists on cardiovascular events after acute myocardial infarction in Japanese subjects. Am J Cardiol 93:969-73, 2004

Honda O, Sugiyama S, Kugiyama K, Fukushima H, Nakamura S, Koide S, Kojima S, Hirai N, Kawano H, Soejima H, Sakamoto T, Yoshimura M, Ogawa H. Echolucent carotid plaques predict future coronary events in patients with coronary artery disease.　J Am Coll Cardiol　43:1177-1184, 2004

Kojima S, Funahashi T, Maruyoshi H, Honda O, Sugiyama S, Kawano H, Soejima H, Miyamoto S, Hokamaki J, Sakamoto T, Yoshimura M, Kitagawa A, Matsuzawa Y, Ogawa H. Levels of the adipocyte-derived plasma protein, adiponectin, have a close relationship with atheroma. Thromb Res.　115:483-490, 2005

Maruyoshi H, Toyama K, Kojima S, Kawano H, Ogata N, Miyamoto S, Sakamoto T, Yoshimura M, Ogawa H. Sensorineural hearing loss combined with Takayasu's arteritis. Intern Med　44:124-128, 2005

Hokamaki J, Kawano H, Soejima H, Miyamoto S, Kajiwara I, Kojima S, Sakamoto T, Sugiyama S, Yoshimura M, Nakamura H, Yodoi J, Ogawa H. Plasma thioredoxin levels in patients with unstable angina. International Journal of Cardiology　99:225-231, 2005

Miyamoto S, Kawano H, Sugiyama S, Hokamaki J, Soejima H, Kojima S, Kudoh T, Sakamoto T, Yoshimura M, Nakamura H, Yodoi J, Ogawa H. Increased plasma levels of thioredoxin in patients with glucose intolerance. Intern Med.　44:1127-1132, 2005

Miyamoto S, Kawano H, Kudoh T, Soejima H, Kojima S, Hokamaki J, Maruyoshi H, Sakamoto T, Yoshimura M, Ozaki Y, Ogawa H. Usefulness of preprocedural platelet aggregation to predict restenosis after percutaneous coronary intervention. Am J Cardiol.　96:71-73, 2005

Hokamaki J, Kawano H, Soejima H, Miyamoto S, Kajiwara I, Kojima S, Sakamoto T, Sugiyama S, Yoshimura M, Nakamura H, Yodoi J, Ogawa H. Plasma thioredoxin levels in patients with unstable angina. Int. J Cardiol 99:225-231, 2005

Nagayoshi Y, Kawano H, Hokamaki J, Miyamoto S, Kojima S, Shimomura H, Tsujita K, Sakamoto T, Yoshimura M, Ogawa H. Urinary 8-hydroxy-2’-deoxyguanosine levels increase after reperfusion in myocardial infarction and may predict subsequent cardiac events. Am J Cardiol.　95:514-517, 2005

Yoshida T, Kawano H, Miyamoto S, Motoyama T, Fukushima H, Hirai N, Ogawa H. Prognostic value of flow-mediated dilation of the brachial artery in patients with cardiovascular disease. Intern Med　45:575-579, 2006

Tsujita K, Shimomura H, Kaikita K, Kawano H, Hokamaki J, Nagayoshi Y, Yamashita T, Fukuda M, Nakamura Y, Sakamoto T, Yoshimura M, Ogawa H. Long-Term efficacy of edaravone in patients with acute myocardial infarction. Circ J.　70:832-837, 2006

Kawano H, Soejima H, Kojima S, Kitagawa A, Ogawa H, Japanese Acute Coronary Syndrome Study (JACSS) Investigators. Sex differences of risk factors for acute myocardial infarction in Japanese patients. Circ J.　70:513-517, 2006

Yamabe H, Tanaka Y, Morihisa K, Uemura T, Kawano H, Nagayoshi Y, Kojima S, Ogawa H. Tachycardia Circuit in typical atrial flutter :The role of posterolateral line of block in the perpetuation of the tachycardia. Pacing Clin Electrophysiol　30:333-342, 2007

Soejima H, Irie A, Fukunaga T, Oe Y, Kojima S, Kaikita K, Kawano H, Sugiyama S, Yoshimura M, Kishikawa H, Nishimura Y, Ogawa H. Osteopontin expression of circulating T cells and plasma osteopontin levels are increased in relation to severity of heart failure. Circ J　71:1879-1884, 2007

Kawano H, Yoshida T, Miyao Y, Hokamaki J, Miyamoto S, Miyazaki Y, Nagayoshi Y, Yamabe H, Ogawa H. The relationship between endothelial function in the brachial artery and intima plus media thickening of the coronary arteries in patients with chest pain syndrome . Atherosclerosis　195:361-366, 2007

Miyazaki Y, Kawano H, Yoshida T, Miyamoto S, Hokamaki J, Nagayoshi Y, Yamabe H, Nakamura H, Yodoi J, Ogawa H Pancreatic beta-cells’ function is altered by oxidative stress induced by acute hyperglycemia. Diabetic Med　24:154-160, 2007

Yamabe H, Tanaka Y, Morihisa K, Uemura T, Kawano H, Nagayoshi Y, Kojima S, Ogawa H Electrophysiologic delineation of the tachycardia circuit in the slow-slow form of atrioventricular nodal reentrant tachycardia. Heart Rhythm.　4:713-721, 2007

Koyama J, Yamabe H, Tanaka Y, Morihisa K, Uemura T, Kawano H, Ogawa H, Odagawa Y, Honda T, Honda T. Spatial and topologic distribution of verapamil-sensitive atrial tachycardia originating from the vicinity of the atrioventricular node. Pacing Clin Electrophysiol. 30:1511-1521, 2007

Tanaka Y, Yamabe H, Morihisa K, Uemura T, Kawano H, Nagayoshi Y, Kojima S, Ogawa H. Incidence and mechanism of dislocated fast pathway in various forms of atrioventricular nodal reentrant tachycardia. Circ J 71:1099-1106, 2007

Japan Arteriosclerosis Longitudinal Study (JALS) Group. Japan Arteriosclerosis Longitudinal Study-Existing Cohorts Combine (JALS-ECC): rationale, design, and population characteristics. Circ J　72:1563-1568, 2008

Kawano H, Nagayoshi Y, Soejima H, Tanaka Y, Hokamaki J, Miyamoto S, Miyazaki Y, Yamabe H, Ogawa H. B-type natriuretic peptide after hormone replacement therapy in postmenopausal women with chest pain and normal coronary angiogram. Menopause　15:352-356, 2008

Kawano H, Nagayoshi Y, Soejima H, Tanaka Y, Yamabe H, Kinoshita Y, Ogawa H Dehydroepiandrosterone levels vary according as heart failure condition in patients with idiopathic dilated cardiomyopathy. International Journal of Cardiology 125:277-279, 2008

Uemura T, Yamabe H, Tanaka Y, Morihisa K, Kawano H, Kaikita K, Sumida H, Sugiyama S, Ogawa H Catheter ablation of a polymorphic ventricular tachycardia inducing monofocal premature ventricular complex. Intern Med.47:1799-1802, 2008

Fukunaga T, Soejima H, Irie A, Fukushima R, Oe Y, Kawano H, Sumida H, Kaikita K, Sugiyama S, Nishimura Y, Ogawa H. High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome. Circ J. 73:1914-1919, 2009.

Soejima H, Oe Y, Nakayama H, Matsuo K, Fukunaga T, Sugamura K, Kawano H, Sugiyama S, Shinohara M, Izumi Y, Ogawa H. Periodontal status and prevotella intermedia antibody in acute coronary syndrome. Int J Cardiol. 137:304-306., 2009

Kawano H, Soejima H, Fujii H, Nakayama S, Katayama I, Irisa K, Marubayashi T, Goshi S, Nagayoshi Y, Tanaka Y, Yamabe H, Ogawa H Prevalence of undiagnosed glucose intolerance changes according to age and gender in Japanese middle aged working people. Circ J 73:1062-1066, 2009

Oe Y. Soejima H. Nakayama H. Fukunaga T. Sugamura K. Kawano H. Sugiyama S. Matsuo K. Shinohara M. Izumi Y. Ogawa H. Significant association between score of periodontal disease and coronary artery disease. Heart & Vessels. 24:103-107, 2009

Morihisa K. Yamabe H. Uemura T. Tanaka Y. Enomoto K. Kawano H. Nagayoshi Y. Kaikita K. Sumida H. Sugiyama S. Ogawa H. Analysis of atrioventricular nodal reentrant tachycardia with variable ventriculoatrial block: characteristics of the upper common pathway. Pacing & Clinical Electrophysiology. 32:484-493, 2009.

Tanaka Y, Yamabe H, Yamasaki H, Tsuda H, Nagayoshi Y, Kawano H, Kimura Y, Hokamura Y, Ogawa H A case of reversible ventricular tachycardia and complete atrioventricular block associated with primary cardiac B-cell lymphoma. Pacing Clin Electrophysiol. 32:816-819, 2009

Yamabe H, Morihisa K, Tanaka Y, Uemura T, Enomoto K, Kawano H, Ogawa H. Mechanisms of the maintenance of atrial fibrillation: Role of the complex fractionated atrial electrogram assessed by noncontact mapping. Heart Rhythm. 6:1120-1128, 2009

Fukunaga T, Soejima H, Irie A, Fukushima R, Oe Y, Kawano H, Sumida H, Kaikita K, Sugiyama S, Nishimura Y, Ogawa H. High ratio of myeloid dendritic cells to plasmacytoid dendritic cells in blood of patients with acute coronary syndrome. Circ J. 73;1914-1919, 2009.

Nagayoshi Y, Kawano H, Hokamaki J, Uemura T, Soejima H, Kaikita K, Sugiyama S, Yamabe H, Shioji I, Sasaki S, Kuroda Y, Ogawa H Differences in oxidative stress markers based on the aetiology of heart failure: comparison of oxidative stress in patients with and without coronary artery disease. Free Radic Res. 43:1159-1166, 2009.

Yamabe H, Tanaka Y, Morihisa K, Uemura T, Enomoto K, Kawano H, Ogawa H. Analysis of the anatomical tachycardia circuit in verapamil-sensitive atrial tachycardia originating from the vicinity of the atrioventricular node. Circ Arrhythm Electrophysiol. 3:2-6, 2010

Nagayoshi Y, Nakaura T, Awai K, Oishi S, Arima Y, Sugiyama S, Kawano H, Kuroda Y, Yamashita Y Ogawa H. Coronary artery tree and myocardial perfusion in patients with tako-tsubo cardiomyopathy: evaluation with coronary digital subtraction angiography J Cardiol Cases. 4:e71-75, 2011

Guo W, Kawano H, Piao L, Itoh N, Node K, Sato T. Effects of aerobic exercise on lipid profiles and high molecular weight adiponectin in Japanese workers. Intern Med 5:389-395, 2011

Kawano H, Nagayoshi Y, Kojima S, Kakihara N, Sakuma S, Uchino M, Komatsu A, Asaka M, Shimomura M, Yamabe H, Ogawa H, Node K. Clinical feature of Japanese patients with fulminant myocarditis International Journal of Clinical Medicine 2:260-263, 2011

Nagayoshi Y, Kawano H, Kojima S, Soejima H, Kaikita K, Nakayama M, Sumida H, Sugiyama S, Ogawa H. Significance of coronary vasospasm in the perioperative management of non-cardiac surgery. Circ J 2012 in press

邦文原著論文

野崎雅裕、河野宏明、永田英明、若槻明彦 女性の心血管疾患の予防・治療におけるホルモン補充療法の効果に関する研究, 厚生労働省科学研究費報告 2003

木下順弘、白石健治、具嶋泰弘、鷺島克之、入江弘基、河野宏明、武田多一. 九州各県におけるメディカルコントロール体制構築に関する調査 日救九地誌 4:35-40, 2004

米満弘一郎、白石健治、鷺嶋克之、具嶋泰弘、入江弘基、河野宏明、武田多一、木下順弘. 集中治療下経皮的気管切開術における気管支鏡モニターの必要性の検討. 日本集中治療医学会誌 12:137-140, 2005

米満弘一郎、貞光大海、島原由美子、若井聡智、前野良人、大西光雄、白鴻成、西野正人、河野宏明、木下順弘. 当救急センターにおける入院時3点MRSAスクリーニング検査の調査結果. 日本救急医学会雑誌 10:592-597, 2007

廣佐古進、門岡康弘、鷺島克之、蒲原英伸、杉田裕樹、河野宏明、興梠博次、木下順弘 ペグインターフェロン、リパビリン併用療法中に発症した重症呼吸不全の１例について ICUとCCU 33:415-420, 2009

大橋靖雄、島本和明、佐藤眞一、磯博康、喜多義邦、北村明彦、斉藤功、清原裕、河野宏明、中川秀昭、豊嶋英明、上島弘嗣、JALSグループ　肥満を含む循環器リスクファクターの重積と脳卒中発症リスクの検討－日本動脈硬化縦断研究（JALS）0次統合研究－　日本公衆衛生雑誌, 2012

著書

邦文著書監修

河野宏明, 野出孝一　　心不全Q&A, 南山堂, 2011
河野宏明　　　佐賀県糖尿病連携手帳作成、発刊、2012

邦文著書

河野宏明, 泰江弘文. 女性における生活習慣改善の虚血性心疾患予防効果 女性における虚血性心疾患.　医学書院. pp118-124, 2000
河野宏明, 泰江弘文. 女性における冠攣縮性狭心症の臨床的特徴.　 女性における虚血性心疾患.　医学書院. pp56-66, 2000
河野宏明. 心電図、超音波心臓検査. 基本的臨床能力学習ガイド.　金原出版. pp252-259, 2002
河野宏明. 動脈硬化の評価. 臨床医のための婦人科検査マニュアル.　医学書院. pp201-206, 2002
河野宏明, 小川久雄. 硝酸エステル薬（外用薬） 治療薬ガイド2003～2004 pp173-177, 2003
河野宏明. 血管不全と疾患　閉経 血管不全フロンティア　メディカルレビュー社　pp159-167, 2004
河野宏明. 心臓超音波　臨床研修指導医の手引き　診断と治療社　pp431-441，2004
河野宏明. 心不全の超音波診断 慢性心不全のマネジメント医薬ジャーナル社pp17-27，2004
河野宏明 内皮依存性血管拡張能　糖尿病カレントライブラリー3, 文光堂. 167-172, 2005
河野宏明　病態と疾患からみたエストロゲン２）心筋梗塞　臨床分子内分泌学、pp590-596, 2005
河野宏明 虚血性心疾患　女性の循環器疾患診療　メディカルレビュー社　58-63, 2005
河野宏明 心臓超音波検査　クリクラナビ　金原出版　300-304, 2006
河野宏明 女性における慢性冠動脈疾患の治療慢性 冠動脈疾患の臨床　中山書店　240-244, 2006
河野宏明 虚血性心疾患の性差 新目でみる循環器病シリーズ　メディカルレビュー社　132-140, 2006
河野宏明 循環器検査　 女性総合外来　文光堂, 144-153, 2007　
河野宏明 動悸　 女性総合外来　文光堂, 112-116, 2007

その他

• 【受賞】1999年　肥後医育振興会研究奨励賞

• 【受賞】2000年　臨床血管機能研究 優秀賞

• 【受賞】2000年　ホルモン補充療法研究会 メノポーズ・アワード

• 【受賞】2000年　日本心血管内分泌代謝学会 Young Investigator Award

• 【受賞】2001年　American Heart Association Young Investigator Award