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1. Sex Differences in Heart Failure With Preserved Ejection Fraction Reflected by B-type Natriuretic Peptide Level. Harada E, Mizuno Y, Kugimiya F, Shono M, Maeda H, Yano N, Yasue H. Am J Med Sci. 2018 Oct;356(4):335-343. doi: 10.1016/j.amjms.2018.06.009. Epub 2018 Jun 19. PMID: 30360801
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2. Harada E, Mizuno Y, Kugimiya F, Shono M, Maeda H, Yano N, Kuwahara K, Yasue H. B-Type Natriuretic Peptide in Heart Failure With Preserved Ejection Fraction - Relevance to Age-Related Left Ventricular Modeling in Japanese. Circ J. 2017 Jun 23;81(7):1006-1013. doi: 10.1253/circj.CJ-16-1282. Epub 2017 Apr 4. PubMed PMID: 28381705.
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3. Harada E, Mizuno Y, Katoh D, Kashiwagi Y, Morita S, Nakayama Y, Yoshimura M, Masuzaki H, Saito Y, Yasue H. Increased urinary aldosterone excretion is associated with subcutaneous not visceral, adipose tissue area in obese individuals: a possible manifestation of dysfunctional subcutaneous adipose tissue. Clin Endocrinol (Oxf). 2013 Oct;79(4):510-6. doi: 10.1111/cen.12083. Epub 2013 Apr 13. PubMed PMID: 23106315.
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4. Harada E, Yasue H, Mizuno Y, Morikawa Y, Nakagawa H, Semba F, Yoshimura M, Saito Y. Resistant hypertension in an aged woman presenting with clinical features simulating ectopic ACTH syndrome--response to spironolactone--. Intern Med. 2010;49(20):2235-9. Epub 2010 Oct 15. PubMed PMID: 20962442.
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5. Harada E, Yasue H, Mizuno Y, Ito T, Sakaino N, Yasue S, Masuzaki H. Metabolic derangements in an adult patient with tetralogy of Fallot: possible role of chronic systemic hypoxia. Am J Med Sci. 2007 Oct;334(4):301-4. Review. PubMed PMID: 18030188.
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6. Harada E, Yoshimura M, Yasue H, Nakagawa O, Nakagawa M, Harada M, Mizuno Y, Nakayama M, Shimasaki Y, Ito T, Nakamura S, Kuwahara K, Saito Y, Nakao K, Ogawa H. Aldosterone induces angiotensin-converting-enzyme gene expression in cultured neonatal rat cardiocytes. Circulation. 2001 Jul 10;104(2):137-9. PubMed PMID: 11447075.
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7. Harada E, Nakagawa O, Yoshimura M, Harada M, Nakagawa M, Mizuno Y, Shimasaki Y, Nakayama M, Yasue H, Kuwahara K, Saito Y, Nakao K. Effect of interleukin-1 beta on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture. J Mol Cell Cardiol. 1999 Nov;31(11):1997-2006. PubMed PMID: 10591026.
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8. Hokimoto S, Mizuno Y, Sueta D, Morita S, Akasaka T, Tabata N, Harada E, Arima Y, Yamamuro M, Tanaka T, Yamamoto E, Sakamoto K, Tsujita K, Kaikita K, Yasue H, Ogawa H. High incidence of coronary spasm after percutaneous coronary interventions: comparison between new generation drug-eluting stent and bare-metal stent. Int J Cardiol. 2015 Mar 1;182:171-3. doi: 10.1016/j.ijcard.2014.12.151. Epub 2014 Dec 30. PubMed PMID: 25577756.
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9. Ito T, Yoshimura M, Nakamura S, Nakayama M, Shimasaki Y, Harada E, Mizuno Y, Yamamuro M, Harada M, Saito Y, Nakao K, Kurihara H, Yasue H, Ogawa H. Inhibitory effect of natriuretic peptides on aldosterone synthase gene expression in cultured neonatal rat cardiocytes. Circulation. 2003 Feb 18;107(6):807-10. PubMed PMID: 12591748.
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10. Ito T, Yasue H, Yoshimura M, Nakamura S, Nakayama M, Shimasaki Y, Harada E, Mizuno Y, Kawano H, Ogawa H. Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm. Hum Genet. 2002 Jan;110(1):89-94. Epub 2001 Dec 6. PubMed PMID: 11810302.
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11. Itoh T, Mizuno Y, Harada E, Yoshimura M, Ogawa H, Yasue H. Coronary spasm is associated with chronic low-grade inflammation. Circ J. 2007 Jul;71(7):1074-8. PubMed PMID: 17587713.
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12. Kashiwagi Y, Harada E, Mizuno Y, Morita S, Shono M, Murohara T, Yoshimura M, Yasue H. Coronary spastic angina is associated with insulin resistance ? possible involvement of endothelial dysfunction. Coron Artery Dis. 2013 Nov;24(7):559-65. doi: 10.1097/MCA.0000000000000024. PubMed PMID: 23965946.
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13. Kashiwagi Y, Mizuno Y, Harada E, Shono M, Morita S, Yoshimura M, Yano M, Yasue H. Suppression of primary aldosteronism and resistant hypertension by the peroxisome proliferator-activated receptor gamma agonist pioglitazone. Am J Med Sci. 2013 Jun;345(6):497-500. doi: 10.1097/MAJ.0b013e31827ad893. PubMed PMID: 23313950.
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14. Katoh D, Mizuno Y, Harada E, Ito T, Morikawa Y, Nakagawa H, Saito Y, Yoshimura M, Yasue H. High incidence of provoked coronary spasm in the presence of a stent after myocardial infarction: therapeutic and prognostic implications. Coron Artery Dis. 2012 May;23(3):141-5. doi: 10.1097/MCA.0b013e32835115ee. PubMed PMID: 22327063.
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15. Mizuno Y, Harada E, Nakagawa H, Morikawa Y, Shono M, Kugimiya F, Yoshimura M, Yasue H. The diabetic heart utilizes ketone bodies as an energy source. Metabolism. 2017 Dec;77:65-72. doi: 10.1016/j.metabol.2017.08.005. Epub 2017 Aug 31. PubMed PMID: 29132539.
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16. Mizuno Y, Hokimoto S, Harada E, Kinoshita K, Nakagawa K, Yoshimura M, Ogawa H, Yasue H. Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction. J Am Heart Assoc. 2016 May 6;5(5). pii: e003247. doi: 10.1161/JAHA.116.003247. PubMed PMID: 27153870; PubMed Central PMCID: PMC4889196.
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17. Mizuno Y, Hokimoto S, Harada E, Kinoshita K, Yoshimura M, Yasue H. Variant Aldehyde Dehydrogenase 2 (ALDH2*2) in East Asians Interactively Exacerbates Tobacco Smoking Risk for Coronary Spasm - Possible Role of Reactive Aldehydes. Circ J. 2016 Dec 22;81(1):96-102. doi: 10.1253/circj.CJ-16-0969. Epub 2016 Nov 29. PubMed PMID: 27904031.
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18. Mizuno Y, Harada E, Morita S, Kinoshita K, Hayashida M, Shono M, Morikawa Y, Murohara T, Nakayama M, Yoshimura M, Yasue H. East asian variant of aldehyde dehydrogenase 2 is associated with coronary spastic angina: possible roles of reactive aldehydes and implications of alcohol flushing syndrome. Circulation. 2015 May 12;131(19):1665-73. doi: 10.1161/CIRCULATIONAHA.114.013120. Epub 2015 Mar 10. PubMed PMID: 25759460.
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19. Mizuno Y, Harada E, Morita S, Kinoshita K, Hayashida M, Shono M, Morikawa Y, Murohara T, Nakayama M, Yoshimura M, Yasue H. Response to Letter Regarding Article, "East Asian Variant of Aldehyde Dehydrogenase 2 Is Associated With Coronary Spastic Angina: Possible Roles of Reactive Aldehydes and Implications of Alcohol Flushing Syndrome". Circulation. 2015 Dec 15;132(24):e383-4. doi: 10.1161/CIRCULATIONAHA.115.018755. PubMed PMID: 26667105.
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20. Mizuno Y, Morita S, Harada E, Shono M, Morikawa Y, Murohara T, Yasue H. Alcohol flushing and positive ethanol patch test in patients with coronary spastic angina: possible role of aldehyde dehydrogenase 2 polymorphisms. Intern Med. 2013;52(23):2593-8. PubMed PMID: 24292747.
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21. Mizuno Y, Harada E, Katoh D, Kashiwagi Y, Morikawa Y, Nakagawa H, Yoshimura M, Saito Y, Yasue H. Cardiac production of B-type natriuretic peptide is inversely related to the plasma level of free fatty acids in obese individuals - possible involvement of the insulin resistance -. Endocr J. 2013;60(1):87-95. Epub 2012 Oct 22. PubMed PMID: 23006812.
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22. Mizuno Y, Yasue H, Yoshimura M, Harada E, Fujii H, Nakamura S, Yamamoto N, Ogawa H, Nakao K. Adrenocorticotropic hormone is produced in the ventricle of patients with essential hypertension. J Hypertens. 2005 Feb;23(2):411-6. PubMed PMID: 15662230.
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23. Mizuno Y, Yasue H, Yoshimura M, Fujii H, Yamamoto N, Nakayama M, Harada E, Sakamoto T, Nakamura S, Ito T, Shimasaki Y, Ogawa H, Saito Y, Nakao K. Effects of perindopril on aldosterone production in the failing human heart. Am J Cardiol. 2002 May 15;89(10):1197-200. PubMed PMID: 12008175.
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24. Mizuno Y, Yoshimura M, Yasue H, Sakamoto T, Ogawa H, Kugiyama K, Harada E, Nakayama M, Nakamura S, Ito T, Shimasaki Y, Saito Y, Nakao K. Aldosterone production is activated in failing ventricle in humans. Circulation. 2001 Jan 2;103(1):72-7. PubMed PMID: 11136688.
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25. Mizuno Y, Yoshimura M, Harada E, Nakayama M, Sakamoto T, Shimasaki Y, Ogawa H, Kugiyama K, Saito Y, Nakao K, Yasue H. Plasma levels of A- and B-type natriuretic peptides in patients with hypertrophic cardiomyopathy or idiopathic dilated cardiomyopathy. Am J Cardiol. 2000 Nov 1;86(9):1036-40, A11. PubMed PMID: 11053725.
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26. Morikawa Y, Mizuno Y, Harada E, Katoh D, Kashiwagi Y, Morita S, Yoshimura M, Uemura S, Saito Y, Yasue H. Aerobic interval exercise training in the afternoon reduces attacks of coronary spastic angina in conjunction with improvement in endothelial function, oxidative stress, and inflammation. Coron Artery Dis. 2013 May;24(3):177-82. doi: 10.1097/MCA.0b013e32835cbef5. PubMed PMID: 23249633.
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27. Morikawa Y, Mizuno Y, Harada E, Kuboyama O, Yoshimura M, Yasue H. Nitrate tolerance as a possible cause of multidrug-resistant coronary artery spasm. Int Heart J. 2010 May;51(3):211-3. PubMed PMID: 20558913.
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28. Morita S, Mizuno Y, Harada E, Kashiwagi Y, Yoshimura M, Murohara T, Yasue H. Pioglitazone, a peroxisome proliferator-activated receptor γ activator, suppresses coronary spasm. Coron Artery Dis. 2014 Dec;25(8):671-7. doi: 10.1097/MCA.0000000000000144. PubMed PMID: 25025992.
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29. Morita S, Mizuno Y, Harada E, Nakagawa H, Morikawa Y, Saito Y, Katoh D, Kashiwagi Y, Yoshimura M, Murohara T, Yasue H. Differences and interactions between risk factors for coronary spasm and atherosclerosis--smoking, aging, inflammation, and blood pressure. Intern Med. 2014;53(23):2663-70. Epub 2014 Dec 1. PubMed PMID: 25447646.
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30. Nakagawa H, Mizuno Y, Harada E, Morikawa Y, Kuwahara K, Saito Y, Yasue H. Brain Natriuretic Peptide Counteracting the Renin-angiotensin-aldosterone System in Accelerated Malignant Hypertension. Am J Med Sci. 2016 Nov;352(5):534-539. doi: 10.1016/j.amjms.2016.08.001. Epub 2016 Aug 3. Review. PubMed PMID: 27865304.
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31. Nakagawa H, Morikawa Y, Mizuno Y, Harada E, Ito T, Matsui K, Saito Y, Yasue H. Coronary spasm preferentially occurs at branch points: an angiographic comparison with atherosclerotic plaque. Circ Cardiovasc Interv. 2009 Apr;2(2):97-104. doi: 10.1161/CIRCINTERVENTIONS.108.803767. Epub 2009 Feb 20. PubMed PMID: 20031702.
