桂 研一郎 かつら けんいちろう 先生

来歴等

略歴

1984年　　日本医科大学卒
1984年　　日本医科大学付属第一病院内科医員
1988年　　スウェーデン王国ルンド大学実験脳研究所留学
1989年　　日本医科大学大学院医学研究科修了・医学博士
1991年　　スウェーデン王国ルンド大学実験脳研究所助教授
1995年　　東京都立荏原病院神経内科勤務
1999年　　日本医科大学第二内科病棟医長
2005年　　日本医科大学第二内科医局長
2006年　　日本医科大学第二内科助教授
2007年　　日本医科大学内科神経・腎臓・膠原病リウマチ部門准教授
2011年　　日本医科大学大学院医学研究科　神経内科学分野　准教授
2014年　　日本医科大学多摩永山病院脳神経内科部長
2015年　　国際医療福祉大学三田病院予防医学センター長・神経内科教授
2017年　　国際医療福祉大学医学部　医学教育統括センター　教授
2018年　　国際医療福祉大学大学院医学研究科　神経内科学教授

論文

• 1. Extracellular pH in the brain during ischemia: relationship to the severity of lactic acidosis. J. Cereb. Blood Flow Metab. 11; 597-599.

  Katsura K, Ekholm A, Asplund B, Siesjö BK. (1991)

• 2. Tissue PCO2 in brain ischemia related to lactate content in normo- and hypercapnic rats. J. Cereb. Blood Flow Metab. 12; 270-280.

  Katsura K, Ekholm A, Siesjö BK. (1992)

• 3. Extra- and intracellular pH in the brain during ischemia, related to tissue lactate content in normo- and hypercapnic rats. Eur. J. Neurosci. 4; 166-176.

  Katsura K, Asplund B, Ekholm A, Siesjö BK. (1992)

• 4. Changes of labile metabolites during anoxia in moderately hypo- and hyperthermic rats: Correlation to membrane fluxes of K+. Brain Res. 590:6-12.

  Katsura K, Minamisawa H, Ekholm A, Forbergrová J, Siesjö BK. (1992)

• 5. Buffer capacity of rat cortical tissue, as well as of cultured neurons and astrocytes. Brain Res. 618;283-294.

  Katsura K, Mellergård P, Theander S, Ouyang Y, Siesjö BK. (1993)

• 6. The coupling amoung energy failure, loss of ion homeostasis, and phospholipase A2 and C activation during ischemia. J. Neurochem. 61; 1677-1684.

  Katsura K, Rodriguez de Turco EB, Folbergrová J, Bazan NG, Siesjö BK. (1993)

• 7. Acidosis induced by hypercapnia exaggerates ischemic brain damage. J. Cereb. Blood Flow Metab. 14; 243-250.

  Katsura K, Kristián T, Smith M-L, Siesjö BK. (1994)

• 8. Regulation of intra- and extracellular pH in the rat brain in acute hypercapnia: a re-appraisal. Brain Res. 651; 47-56.

  Katsura K, Kristian T, Nair R, Siesjö BK. (1994)

• 9. Functional, metabolic, and circulatory changes associated with seizure activity in the postischemic brain. J. Neurochem. 62; 1511-1515.

  Katsura K, Folbergrová J, Gidö G, Siesjö BK. (1994)

• 10. Changes in labile energy metabolites, redox state, and intracellular pH in postischemic brain of normo- and hyperglycemic rats. Brain Res. 726:57-63.

  Katsura K, Folbergrová J, Siesjö BK. (1996)

• 11. Acidosis enhances translocation of protein kinase C but not Ca2+/calmodulin-dependent protein kinase II to cell membranes during complete cerebral ischemia. Brain Res. 849:119-127.

  Katsura K, Kurihara J, Siesjö BK, Wieloch T. (1999)

• 12. Alterations in lipid and calcium metabolism associated with seizure activity in the postischemic brain.　 J. Neurochem. 75: 2521-2527.

  Katsura K, Rodriguez de Turco EB, Kristián T, Folbergrová J, Bazan NG, Siesjö BK. (2000)

• 13. Ischemic pre-conditioning affects the subcellular distribution of protein kinase C and calcium/calmodulin-dependent protein kinase II in the gerbil hippocampal CA1 neurons. Neurol. Res. 23, 751-754.

  Katsura K, Kurihara J, Kato H, Katayama Y. (2001)

• 14. Effects of FK506 on the translocation of protein kinase C and CaM kinase II in the gerbil hippocampal CA1 neurons. Neurol. Res. 25:522-527.

  Katsura K, Kurihara J, Hiraide T, Takahashi K, Kato H, Katayama Y. (2003)

• 15. Effects of hyperglycemia and hypercapnia on lipid metabolism during complete brain ischemia. Brain Res. 1030:133-140.

  Katsura K, Rodrigurez de Turco EB, Siesjö BK, Bazan NG. (2004)

• 16. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13:688-94.

  Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S. (2007)

• 17. Combination therapy with transductive anti-death FNK protein and FK506 ameliorate the brain damage with focal transient ischemia in rat. 　J. Neurochem. 106:258-270.

  Katsura K, Takahashi K, Watanabe M, Ohsawa I, Mori T, Igarashi H, Ohkubo S, Sakurazawa M, Asoh S, Katayama Y, Ohta S. (2008)

• 18. Involvement of mitoK(ATP) channel in protective mechanisms of cerebral ischemic tolerance. Brain Res. 1238C:199-207.

  Watanabe M, Katsura K, Ohsawa I, Mizukoshi G, Takahashi K, Asoh S, Ohta S, Katayama Y. (2008)

• 19.Systemic delivery of IL-10 by an AAV vector prevents vascular remodeling and end-organ damage in stroke-prone spontaneously hypertensive rat. Gene Ther. 16:383-391.

  Nomoto T, Okada T, Shimazaki K, Yoshioka T, Nonaka-Sarukawa M, Ito T, Takeuchi K, Katsura K, Mizukami H, Kume A, Ookawara S, Ikeda U, Katayama Y, Ozawa K. (2009)

• 20. Asymmetric dimethylarginine (ADMA) as a possible risk marker for ischemic stroke. J Neurol Sci. 290:12-15.

  Nishiyama Y, Ueda M, Katsura K, Otsuka,T, Abe A, Nagayama H, Katayama Y. (2010)

• 21. Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke. Neurol Res. 32:743-747.

  Katsumata T, Otori T, Nishiyama Y, Okubo S, Nishiyama Y, Nagayama H, Ueda M, Utsumi K, Yamazaki M, Komaba Y, Katsura K, Katayama Y. (2010)

• 22. Statin treatment decreased serum asymmetric dimethylarginine (ADMA) levels in ischemic stroke patients. J Atheroscler Thromb. 18:131-137.

  Nishiyama Y, Ueda M, Otsuka T, Katsura K, Abe A, Nagayama H, Katayama Y. (2011)

• 23. Combination therapy with bone marrow stromal cells and FK506 enhanced amelioration of ischemic brain damage in rats. Life Sci. 89:50-56.

  Suda S, Shimazaki K, Ueda M, Inaba T, Kamiya N, Katsura K, Katayama Y. (2011)

• 24. FK506 ameliorates oxidative damage and protects rat brain following transient focal cerebral ischemia. Neurol Res. 33:881-889.

  Nito C, Ueda M, Inaba T, Katsura K, Katayama, Y. (2011)

• 25. Mild hypothermia enhanced the protective effect of protein therapy with transductive anti-death FNK protein using a rat focal transient cerebral ischemia model. Brain Res. 1430:86-92.

  Sakurazawa M, Katsura K, Saito M, Asoh S, Ohta S, Katayama Y. (2012)

• 26. A preliminary study of fluvoxamine maleate on depressive state and serum melatonin levels in patients after cerebral infarction. Intern Med. 51:1187-1193.

  Sunami E, Usuda K, Nishiyama Y, Otori T, Katsura K, Katayama Y. (2012)

• 27. Valproic acid attenuates ischemia-reperfusion injury in the rat brain through inhibition of oxidative stress and inflammation. Eur J Pharmacol. 707:26-31

  Suda S, Katsura K, Kanamaru T, Saito M, Katayama Y. (2013)

• 28.Low serum n-3 polyunsaturated fatty acid/n-6 polyunsaturated fatty acid ratio predicts neurological deterioration in Japanese patients with acute ischemic stroke. Cerebrovasc. Dis. 36:388-393.

  Suda S, Katsumata T, Okubo S, Kanamaru T, Watanabe Y, Suzuki K, Katsura K, Katayama Y. (2013)

• 29. Continuous oral administration of atorvastatin ameliorates brain damage after transient focal ischemia in rats. Life Sci. 94:106-114.

  Saito T, Nito C, Ueda M, Inaba T, Kamiya F, Muraga K, Katsura K, Katayama Y. (2014)

• 30. Valproic acid enhances the effect of bone marrow-derived mononuclear cells in a rat ischemic stroke model. Brain Res, 1565:74-81.

  Suda S, Katsura K, Saito M, Kamiya N, Katayama Y. (2014).

著書

• 1. Chapter 3 The neuroendocrine system and its regulation. In Neuroanesthesia and Cerebro-Spinal Protection. Eds Uchino H, Ushijima K, Ikeda Y. Springer, Tokyo, 2015

• 2. FK506 facilitates the normalization of post-ischemic perturbation of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors. In " Molecular Mechanisms and Epochal Therapeutics of Ischemic Stroke and Dementia" Ed. Abe K. Elsevier, Amsterdam, International Congress Series 1252: 135-140.

• 3. FK506 attenuates the post-ischemic perturbation of protein kinases and tyrosine phosphorylation in the gerbil hippocampal CA1 sectors. In "Brain Edema XII". Eds. Kuroiwa T, Baethmann A, et al. Springer-Verlag, Wien, New York, Acta Neurochir (suppl) 86:113-116.

• 4. Acid-base metabolism in ischemia. In "pH and Brain Function", Eds. Kaila K., Ransom BR. New York, Wiley-liss, pp549-568.

• 5. Acidosis as a complicating factor, in "Primer on Cerebrovascular Diseases", Eds. Welch KML, Caplan LR, Reis DJ, Siesjö BK, Weir B, San Diego, London, Acadmic Press, pp 159-162.

• 6.The role of calcium in delayed postischemic brain damage. In Cerebrovascular Diseases, Ninetheenth Prinston Stroke Coference. Eds. Moskovitz, M. and Caplan, L. Butterworth Heinemann, Boston, pp. 353-370.

• 7.Ischemic brain damage: Focus on lipids and lipid mediators. in Neurobiology of Essential Fatty Acids, Advances in Experimental Medicine & Biology. Eds. Bazan NG, Toffano G, Murphy M. New York, Plenum Press, vol 318, pp41-56.

• 8. The multiple causes of ischemic brain damage: a speculative synthesis. in ""Phamacology of Cerebral Ischemia"" Eds. Krieglstein J, Oberpichler H. Wissenschaftliche Verlagsgesellshaft, Stuttgart, pp511-525.

• 9. Ion fluxes in ischemia: relationship to excitatory amino acids. Alfred Benzon Symposium 32: Drug Research Related to Neuroactive Amino Acids, Munksgaard Copenhagen pp351-362.

• 10. The type of ischemia determines the pathophysiology of brain lesions and the therapeutic response to calcium channel blockade. Eds. Krieglstein J, Oberpichler H. in ""Phamacology of Cerebral Ischemia"" Wissenschafliche Verlagsgesellschaft, Stuttgart pp79-88.

• 1. 興奮毒性アミノ酸 脳血管２０００-文献レビュー　金芳堂、京都、pp142-147

• 2. 興奮毒性アミノ酸 脳血管２００１-文献レビュー金芳堂、京都、pp124-128

• 3.エダラボンの臨床報告６　「脳梗塞急性期治療の進歩-エダラボンの臨床-」　医薬ジャーナル社、東京　pp92-96.

• 4.脳出血　「今日の治療と看護・改訂版」南江堂、東京732-737

• 5.脳保護薬、「脳血管障害の最新医療」　先端医療技術研究所、東京、pp327-331

• 6.「総合診療マニュアル」　金芳堂、京都、pp 5-10.

• 7.国際共同治験Q&Aと英文モニタリング報告書の書き方例　メディファーマ　パブリッシング, 東京

• 8.「脳卒中専門医試験　問題・解説集」　中山書店、東京

• 9.脳血管障害の合併症（誤嚥性肺炎を中心に）「今日の治療指針2012年版」 医学書院、東京、pp762.

• 10.JRC蘇生ガイドライン2015　一過性脳虚血発作（TIA）　医学書院、東京

• 11.神経麻酔　「神経麻酔に求められる脳内内分泌調整機構」pp15-19. 克誠堂　東京

• 12.脳血管障害の合併症（誤嚥性肺炎を中心に）「今日の治療指針2012年版」 医学書院、東京、pp762.

• 13.図説神経機能解剖テキスト　代表的疾患の神経機能解剖アプローチ　脳梗塞　pp211-213

• 14.脳ドックのガイドライン2019　問診、診察および一般検査　響文社　札幌

その他

• 【受賞】2003年日本医科大学医学会奨学賞

• 【受賞】1999年日本医科大学同窓会奨励賞