不破 信和 ふわ のぶかず 先生

来歴等

略歴

1981年 三重大学医学部附属病院 研修医
1981年 浜松医科大学医学部附属放射線科 入局
1984年 愛知県がんセンター放射線治療部 勤務
1998年 愛知県がんセンター放射線治療部 部長
2006年 愛知県がんセンター放射線治療部 副院長兼務
2007年 一般財団法人脳神経疾患研究所附属 南東北がん陽子線治療 センター長
2012年 兵庫県立粒子線医療センター 院長
2015年 伊勢赤十字病院 放射線治療科 部長

論文

Unexpected radiation laryngeal necrosis after carbon ion therapy using conventional dose fractionation for laryngeal cancer.
Demizu Y, Fuwa N, et al. Jpn J Clin Oncol. 2015 Sep 9. pii: hyv121.
Recurrence of a mediastinal liposarcoma 20 years after surgery: A case of carbon ion radiotherapy resulting in fatal tracheoesophageal fistula.
Kawamura T, Fuwa N, et al. Respir Investig. 2015 Jul;53(4):170-2. doi: 10.1016/j.resinv.2015.
The long-term outcomes of alternating chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma: a multiinstitutional phase II study.
Fuwa N, et al. Cancer Med. 2015 Aug;4(8):1186-95. doi: 10.1002/cam4.469. Epub 2015 May 20.
Treatment outcomes of particle radiotherapy using protons or carbon ions as a single-modality therapy for adenoid cystic carcinoma of the head and neck.
Takagi M, Fuwa N. et al. Radiother Oncol. 2014 Dec;113(3):364-70.
Particle therapy for clinically diagnosed stage I lung cancer: comparison with pathologically proven non-small cell lung cancer.Fujii O, Fuwa N, et al Acta Oncol. 2015;54:315-21

Carbon ion therapy for early-stage non-small-cell lung cancer.
Demizu Y, Fuwa N, et al. Biomed Res Int. 2014;2014:727962. doi: 10.1155/2014/727962. Epub 2014 Sep 11. Review.
High-dose proton beam therapy for stage I non-small cell lung cancer: Clinical outcomes and prognostic factors.
Makita C, Fuwa N, et al. Acta Oncol. 2015;54:307-14.
Particle beam radiation therapy using carbon ions and protons for oligometastatic lung tumors.
Sulaiman NS, Fuwa N, et al. Radiat Oncol. 2014 Aug 16;9:183. doi: 10.1186/1748-717X-9-183.
Two-stage treatment with hepatectomy and carbon-ion radiotherapy for multiple hepatic epithelioid hemangioendotheliomas.
Komatsu S, Fuwa N, et al. World J Gastroenterol. 2014 14;20(26):8729-35.
Secure Surgical Method for Catheter Placement via the Occipital Artery to Achieve Retrograde Superselective Intra-Arterial Chemotherapy for Advanced Oral Cancer: Alternative to Approach via the Superficial Temporal Artery.
Iwai T, Fuwa N, et al. Indian J Otolaryngol Head Neck Surg. 2014 ;66(2):205-7.
Clinical efficacy of alternating chemoradiotherapy by conformal radiotherapy combined with intracavitary brachytherapy for high-risk cervical cancer.
Hirata K, Fuwa N, et al. Jpn J Clin Oncol. 2014 ;44(6):556-63.
Particle radiotherapy using protons or carbon ions for unresectable locally advanced head and neck cancers with skull base invasion.
Morimoto K, Fuwa N, et al.Jpn J Clin Oncol. 2014 ;44(5):428-34.
Clinical outcomes and toxicity of proton beam therapy for advanced cholangiocarcinoma.
Makita C, Fuwa N, et al. Radiat Oncol. 2014 Jan 14;9:26.
Particle therapy for mucosal melanoma of the head and neck. A single-institution retrospective comparison of proton and carbon ion therapy.
Demizu Y, Fuwa N, et al. Strahlenther Onkol. 2014;190(2):186-91.
Particle therapy using carbon ions or protons as a definitive therapy for patients with primary sacral chordoma.
Mima M, Fuwa N, et al.
Br J Radiol. 2014;87(1033):20130512.
A retrospective comparison of proton therapy and carbon ion therapy for stage I non-small cell lung cancer.
Fujii O, Fuwa N, et al. Radiother Oncol. 2013 Oct;109(1):32-7.
Upper gastrointestinal complications associated with gemcitabine-concurrent proton radiotherapy for inoperable pancreatic cancer.
Takatori K, Fuwa N, et al. J Gastroenterol. 2014 Jun;49(6):1074-80.
Proton beam therapy and continuous intra-arterial chemotherapy for polymorphous low-grade adenocarcinoma in the hard palate.
Makita C, Fuwa N, et al. Case Rep Oncol. 2013 Jan;6(1):66-71.
Long-term outcome of proton therapy and carbon-ion therapy for large (T2a-T2bN0M0) non-small-cell lung cancer.
Iwata H, Fuwa N. et al. J Thorac Oncol. 2013;8:726-35.
Occipital artery arising from the anterior aspect of the internal carotid artery identified by three-dimensional computed tomography angiography.
Iwai T, et al.Fuwa N, et al. Iran J Radiol. 2012;9:103-5.
Analysis of carotid artery deformation in different head and neck positions for maxillofacial catheter navigation in advanced oral cancer treatment.
Ohya T, Fuwa N, et al. Biomed Eng Online. 2012 4;11:65.
Alternating chemoradiotherapy in patients with nasopharyngeal cancer: prognostic factors and proposal for individualization of therapy.
Goto Y, Fuwa N, et al. J Radiat Res. 2013 ;54:98-107.
Thyrolinguofacial trunk arising from the carotid bifurcation determined by three-dimensional computed tomography angiography.
Iwai T, Fuwa N, et al. Surg Radiol Anat. 2013 ;35:75-8.
Phase I study of weekly docetaxel and cisplatin arterial infusion for recurrent head and neck cancer.
Nakamura T, Fuwa N, et al. Head Neck. 2012;34:1634-9.
Thyrolingual trunk arising from the common carotid artery identified by three-dimensional computed tomography angiography. Iwai T, Fuwa N, et al. Surg Radiol Anat. 2012;34:85-8.
A new method using MRI to delineate areas of head and neck cancer targeted by intra-arterial infusion via a superficial temporal artery.
Fuwa N, et al. Oral Oncol. 2011;47:387-90.
Factors associated with nodal metastasis in nasopharyngeal cancer: an approach to reduce the radiation field in selected patients.
Tomita N, Fuwa N, et al. Br J Radiol. 2011;84:265-70.

Dose-volume comparison of proton radiotherapy and stereotactic body radiotherapy for non-small-cell lung cancer.
Kadoya N, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2011 15;79:1225-31.
Organ preservation with daily concurrent chemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery for T3 and T4 head and neck cancer.
Mitsudo K, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2011 1;79:1428-35.
Clinical usefulness of [18F] fluoro-2-deoxy-D-glucose uptake in 178 head-and-neck cancer patients with nodal metastasis treated with definitive chemoradiotherapy: consideration of its prognostic value and ability to provide guidance for optimal selection of patients for planned neck dissection.
Inokuchi H, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 201 1;79:747-55.
Retrospective analysis of definitive radiotherapy for patients with superficial esophageal carcinoma: Consideration of the optimal treatment method with a focus on late morbidity.
Kodaira T, Fuwa N, et al. Radiother Oncol. 2010;95:234-9.
Favorable consolidative effect of high-dose melphalan and total-body irradiation followed by autologous peripheral blood stem cell transplantation after rituximab-containing induction chemotherapy with in vivo purging in relapsed or refractory follicular lymphoma.
Kato H, Fuwa N, et al. Clin Lymphoma Myeloma. 2009;9:443-8.
Long-term follow-up and a detailed prognostic analysis of patients with oropharyngeal cancer treated with radiotherapy.
Tomita N, Fuwa N, et al. J Cancer Res Clin Oncol. 2010 ;136:617-23.
Clinical outcome of oropharyngeal carcinoma treated with platinum-based chemoradiotherapy.
Nakamura T, Fuwa N, et al. Oral Oncol. 2009;45:830-4.
A comparison of prone three-dimensional conformal radiotherapy with supine intensity-modulated radiotherapy for prostate cancer: which technique is more effective for rectal sparing?
Kato T, Fuwa N, et al. Br J Radiol. 2009;82:654-61.
False-positive positron emission tomography appearance with 18F-fluorodeoxyglucose after definitive radiotherapy for cancer of the mobile tongue.
Ariji Y, Fuwa N, et al. Br J Radiol. 2009;82:e3-7.
Determination of the irradiation field for clinical T1-T3N0M0 thoracic/abdominal esophageal cancer based on the postoperative pathological results.
Nakamura T, Fuwa N, et al. Jpn J Clin Oncol. 2009;39:86-91.
Dynamic conformal arc radiotherapy with rectum hollow-out technique for localized prostate cancer.
Tomita N, Fuwa N, et al. Radiother Oncol. 2009;90:346-52.
Aichi cancer center initial experience of intensity modulated radiation therapy for nasopharyngeal cancer using helical tomotherapy.
Kodaira T, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2009;73:1129-34.
Chemoradiotherapy for locally recurrent nasopharyngeal carcinoma: treatment outcome and prognostic factors.
Nakamura T, Fuwa N et al. pn J Clin Oncol. 2008;38:803-9.
Long-term observation of 64 patients with roentgenographically occult lung cancer treated with external irradiation and intraluminal irradiation using low-dose-rate iridium.
Fuwa N, et al. Jpn J Clin Oncol. 2008;38:581-8.
Identifying patients with peripheral-type early non-small cell lung cancer (T1N0M0) for whom irradiation of the primary focus alone could lead to successful treatment.
Fuwa N, et al. Br J Radiol. 2008 ;81:815-20.
Treatment results of boron neutron capture therapy using intra-arterial administration of boron compounds for recurrent head and neck cancer.
Fuwa N, et al. Br J Radiol. 2008;81:749-52.
Prospective study of alternating chemoradiotherapy consisting of extended-field dynamic conformational radiotherapy and systemic chemotherapy using 5-FU and nedaplatin for patients in high-risk group with cervical carcinoma.
Kodaira T, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2009 1;73:251-8.

Treatment results of continuous intra-arterial CBDCA infusion chemotherapy in combination with radiation therapy for locally advanced tongue cancer.
Fuwa N, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:714-9.
Arterial chemoradiotherapy for locally advanced tongue cancer: analysis of retrospective study of therapeutic results in 88 patients.
Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2008 15;72:1090-100.
Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: analysis of therapeutic results in 134 cases.
Fuwa N, et al.Br J Cancer. 2008 25;98:1039-45.
A new method of selective intra-arterial infusion therapy via the superficial temporal artery for head and neck cancer.
Fuwa N, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:783-9.
Clinical outcome of stage III non-small-cell lung cancer patients after definitive radiotherapy.
Nakamura T, Fuwa N, et al. Lung. 2008 ;186:91-6.
Phase I/II trial of sequential chemoradiotherapy using a novel hypoxic cell radiosensitizer, doranidazole (PR-350), in patients with locally advanced non-small-cell lung Cancer (WJTOG-0002).
Nishimura Y, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2007 1;69:786-92.
Factors involved in lymph node metastasis in clinical stage I non-small cell lung cancer--from studies of 604 surgical cases.
Fuwa N, et al. Lung Cancer. 2007;57:311-6.
Treatment and prognosis of squamous cell carcinoma of the external auditory canal and middle ear: a multi-institutional retrospective review of 87 patients.
Ogawa K, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2007 1;68:1326-34.
Dose escalation study of nedaplatin with 5-fluorouracil in combination with alternating radiotherapy in patients with head and neck cancer.
Fuwa N, et al. Jpn J Clin Oncol. 2007;37:161-7.
Chemoradiation therapy using radiotherapy, systemic chemotherapy with 5-fluorouracil and nedaplatin, and intra-arterial infusion using carboplatin for locally advanced head and neck cancer - Phase II study.
Fuwa N, et al.Oral Oncol. 2007;43:1014-20.

Treatment results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil--a phase II study.
Fuwa N, et al. Oral Oncol. 2007;43:948-55.
Impact of intra-arterial administration of boron compounds on dose-volume histograms in boron neutron capture therapy for recurrent head-and-neck tumors.
Suzuki M, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2006 1;66:1523-7.
Retrospective analysis: concurrent chemoradiotherapy using protracted continuous infusion of low-dose cisplatin and 5-fluorouracil for T2N0 glottic cancer. Itoh Y, Fuwa N.Radiat Med. 2006;24:277-81.
Relationship between the growth pattern of nasopharyngeal cancer and the cervical lymph nodes based on MRI findings: can the cervical radiation field be reduced in patients with nasopharyngeal cancer?
Fuwa N, et al.Br J Radiol. 2006;79:725-9.
Phase I study of S-1 and nedaplatin for patients with recurrence of head and neck cancer.
Kodaira T, Fuwa N, et al. Anticancer Res. 2006;26:2265-8.
Single-institute phase I/II trial of alternating chemoradiotherapy with 5-FU and nedaplatin for esophageal carcinoma. Kodaira T, Fuwa N, et al. Anticancer Res. 2006 ;26:471-8.
Analyses of dose-response in radiotherapy for patients with mature T/NK-cell lymphomas according to the WHO classification. Sakata K, Fuwa N, et al. Radiother Oncol. 2006;79:179-84.
Prospective trial of radiotherapy for patients 80 years of age or older with squamous cell carcinoma of the thoracic esophagus.
Kawashima M, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2006 15;64:1112-21.
Late complication in patients undergoing pancreatic resection with intraoperative radiation therapy: gastrointestinal bleeding with occlusion of the portal system.
Shimizu Y, Fuwa N, et al. J Gastroenterol Hepatol. 2005;20:1235-40.
Treatment results of stage I oral tongue cancer with definitive radiotherapy.
Ichimiya Y, Fuwa N, et al.Oral Oncol. 2005;41:520-5.
Phase I trial of weekly docetaxel and concurrent radiotherapy for head and neck cancer in elderly patients or patients with complications.
Kodaira T, Fuwa N, et al. Jpn J Clin Oncol. 2005;35:173-6.
A multi-institutional survey of the effectiveness of chemotherapy combined with radiotherapy for patients with nasopharyngeal carcinoma.
Kawashima M, Fuwa N, et al. Jpn J Clin Oncol. 2004;34:569-83.
MR features of masticatory muscles in adenoid cystic carcinoma involving the masticator space.
Ariji Y, Fuwa N, et al. Dentomaxillofac Radiol. 2004 ;33:345-50.
Long-term clinical outcomes of postoperative pelvic radiotherapy with or without prophylactic paraaortic irradiation for stage I-II cervical carcinoma with positive lymph nodes: retrospective analysis of predictive variables regarding survival and failure patterns.
Kodaira T, Fuwa N, et al. Am J Clin Oncol. 2004;27:140-8.
Stage I and II mobile tongue carcinomas treated by external radiation and gold seed implantation.
Kimura Y, Fuwa N, et al. Acta Oncol. 2003;42:763-70.
Clinical evaluation using magnetic resonance imaging for patients with stage III cervical carcinoma treated by radiation alone in multicenter analysis: its usefulness and limitations in clinical practice.
Kodaira T, Fuwa N, et al. Am J Clin Oncol. 2003;26:574-83.
Multivariate analysis of treatment outcome in patients with esophageal carcinoma treated with definitive radiotherapy. Kodaira T, Fuwa N, et al. Am J Clin Oncol. 2003 ;26:392-7.
Comparison of prognostic value of MRI and FIGO stage among patients with cervical carcinoma treated with radiotherapy. Kodaira T, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2003 1;56:769-77.
A case of subglottic carcinoma effectively treated with intraluminal irradiation using low dose rate iridium-192 thin wires combined with external beam irradiation.
Wakisaka M, Fuwa N, et al. Jpn J Clin Oncol. 2003;33:89-92.
Single institute experience of chemotherapy and adjuvant radiotherapy for localized aggressive non-Hodgkin's lymphoma: retrospective analysis of the clinical efficacy of radiation therapy.
Kodaira T, Fuwa N, et al. Am J Clin Oncol. 2002;25:612-8.
Phase I study of combination chemotherapy with 5-fluorouracil (5-FU) and nedaplatin (NDP): adverse effects and eecommended dose of NDP administered after 5-FU.
Fuwa N, et al. Am J Clin Oncol. 2002;25:565-9.
Retrospective analysis of postoperative radiotherapy for node-negative cervical carcinoma with stage IB-IIB disease. Kodaira T, Fuwa N, et al. Jpn J Clin Oncol. 2002 ;32:255-61.
Treatment and prognosis of thymic carcinoma: a retrospective analysis of 40 cases.
Ogawa K, Fuwa N, et al. Cancer. 2002 15;94:3115-9.
Denervation atrophy of the masticatory muscles in a patient with nasopharyngeal cancer: MR examinations before and after radiotherapy. Ariji Y, Fuwa N, et al. Dentomaxillofac Radiol. 2002;31:204-8.
Continuous infusion low-dose CDDP/5-FU plus radiation in inoperable or recurrent non-small-cell lung cancer: preliminary experience. Itoh Y, Fuwa N, et al. Am J Clin Oncol. 2002;25:230-4.
Therapeutic results of alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil: its usefulness and controversial points. Fuwa N, et al. Jpn J Clin Oncol. 2001;31:589-95.
Severe obstruction of the superior vena cava caused by tumor invasion. Recanalization using a PTFE-covered Z stent. Dendo S, Fuwa N, et al. J Cardiovasc Surg (Torino). 2002;43:287-90.
DNA ploidy analysis performed prospectively using fresh tumor samples in early glottic carcinoma treated with radiotherapy. Ii N, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2002 1;52:415-9.
Brain metastases from esophageal carcinoma: natural history, prognostic factors, and outcome.
Ogawa K, Fuwa N, et al. Cancer. 2002 1;94:759-64.
Continuous selective intraarterial chemotherapy in combination with irradiation for locally advanced cancer of the tongue and tongue base. Furutani K, Fuwa N, et al. Oral Oncol. 2002;38:145-52.
Clinical assessment by MRI for patients with stage II cervical carcinoma treated by radiation alone in multicenter analysis: are all patients with stage II disease suitable candidates for chemoradiotherapy?
Kodaira T, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2002 1;52:627-36.
Patterns of failure in carcinoma of the uterine cervix treated with definitive radiotherapy alone.
Sasaoka M, Fuwa N, et al. Am J Clin Oncol. 2001;24:586-90.
Alternating chemoradiotherapy for nasopharyngeal cancer using cisplatin and 5-fluorouracil: a preliminary report of phase II study. Fuwa N, et al. Radiother Oncol. 2001;61:257-60.
Outcomes of radiotherapy for inoperable locally advanced (T4) esophageal cancer-retrospective analysis-.
Itoh Y, Fuwa N, et al. Radiat Med. 2001;19:231-5.
Randomized phase I study of standard-fractionated or accelerated-hyperfractionated radiotherapy with concurrent cisplatin and vindesine for unresectable non-small cell lung cancer: a report of Japan Clinical Oncology Group Study (JCOG 9601). Tsuchiya S, Fuwa N, et al. Jpn J Clin Oncol. 2001;31:488-94.
Therapeutic effects of simultaneous intraluminal irradiation and intraluminal hyperthermia on oesophageal carcinoma. Fuwa N, et al. Br J Radiol. 2001;74:709-14.
Pancreatic ductal adenocarcinoma associated with Potter type III cystic disease.
Sakurai Y, Fuwa N, et al.J Gastroenterol. 2001;36:422-8.
Doppler sonography of the deep lingual artery. Kimura Y, Fuwa N, et al. Acta Radiol. 2001;42:306-11.
Aichi Cancer Center 10-year experience with conservative breast treatment of early breast cancer: retrospective analysis regarding failure patterns and factors influencing local control.
Kodaira T, Fuwa N, et al. Int J Radiat Oncol Biol Phys. 2001 1;49:1311-6.
External irradiation and intraluminal irradiation using middle-dose-rate iridium in patients with roentgenographically occult lung cancer. Fuwa N, et al. Int J Radiat Oncol Biol Phys. 200115;49:965-71.
A combination therapy of continuous superselective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma. Phase I study. Fuwa N, et al. Cancer. 2000 15;89:2099-105.
The treatment results of 40 patients with localized endobronchial cancer with external beam irradiation and intraluminal irradiation using low dose rate (192)Ir thin wires with a new catheter.
Fuwa N, et al. Radiother Oncol. 2000;56:189-95.
Treatment results of chemoradiation for T1 esophageal cancer with lymph node metastases.
Itoh Y, Fuwa N, et al. Radiat Med. 2000;18:81-5.
MR analysis of nasopharyngeal carcinoma: correlation of the pattern of tumor extent at the primary site with the distribution of metastasized cervical lymph nodes. Preliminary results. Wakisaka M, Fuwa N, et al. Eur Radiol. 2000;10:970-7.
A case of esophageal carcinoma surgically treated after discontinuance of the simultaneous application of radiotherapy and chemotherapy with low doses of CDDP and 5-FU.
Itoh Y, Fuwa N, et al. Radiat Med. 2000;18:55-8.
Analysis of 57 nonagenarian cancer patients treated by radical radiotherapy: a survey of eight institutions.
Ikeda H, Fuwa N, et al. pn J Clin Oncol. 1999;29:378-81.
New superselective intra-arterial infusion via superficial temporal artery for cancer of the tongue and tumour tissue platinum concentration after carboplatin (CBDCA) infusion.
Tohnai I, Fuwa N, et al. Oral Oncol. 1998 ;34:387-90.

Clinical features of esophageal cancer in the octogenarian treated by definitive radiotherapy: a multi-institutional retrospective survey.
Kawashima M, Fuwa N, et al. Jpn J Clin Oncol. 1998;28:301-7.
Radical radiotherapy for medically inoperable non-small cell lung cancer in clinical stage I: a retrospective analysis of 149 patients. Morita K, Fuwa N, et al. Radiother Oncol. 1997 ;42:31-6.
Clinical research into hyperthermia treatment of cancer using a 430 MHz microwave heating system with a lens applicator.
Matsuda T, Fuwa N, et al. Int J Hyperthermia. 1991;7:425-40.

• Carbon ion therapy for early-stage non-small-cell lung cancer.

  Demizu Y, Fuwa N, et al. Biomed Res Int. 2014;2014:727962. doi: 10.1155/2014/727962. Epub 2014 Sep 11. Review.

その他

• 1993年　優秀論文賞受賞（日本ハイパーサーミア学会）