秋山 治彦 あきやま はるひこ 先生

来歴等

略歴

1980年 京都大学医学部 卒業
1980年 京都大学医学部附属病院神経内科
1981年 関西電力病院内科
1983年 京都大学大学院医学研究科内科系神経内科学
1987年 京都大学大学院医学研究科内科系神経内科学 修了（医学博士）
1987年 カナダ，ブリティッシュ・コロンビア大学精神科キンズメン神経学研究所
1990年 京都大学医学部附属病院神経内科
1991年 東京都精神医学総合研究所
2011年 東京都医学総合研究所
2016年 横浜市立脳卒中・神経脊椎センター臨床研究部 部長

論文

• (2014) Tau accumulation in the nucleus accumbens in tangle-predominant dementia. Acta Neuropathol Commun. 2(1):40. doi: 10.1186/2051-5960-2-40.

  Kawakami I, Hasegawa M, Arai T, Ikeda K, Oshima K, Niizato K, Aoki N, Omi K, Higashi S, Hosokawa M, Hirayasu Y, Akiyama H

• (2013) Pathological features of FTLD-FUS in a Japanese population: Analyses of nine cases. J Neurol Sci 335:89-95. doi: 10.1016/j.jns.2013.08.035

  Kobayashi Z, Kawakami I, Arai T, Yokota O, Tsuchiya K, Kondo H, Shimomura Y, Haga C, Aoki N, Hasegawa M, Hosokawa M, Oshima K, Niizato K, Ishizu H, Terada S, Onaya M, Ikeda M, Oyanagi K, Nakano I, Murayama S, Akiyama H, Mizusawa H.

• (2012) Localization of fused in sarcoma (FUS) protein to the post-synaptic density in the brain. Acta Neuropathol 124:383-394

  Aoki N, Higashi S, Kawakami I, Kobayashi Z, Hosokawa M, Katsuse O, Togo T, Hirayasu Y, Akiyama H

• (2008) Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies. Exp Neurol 210:409-420

  Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H

• Relative paucity of tau accumulation in the small areas with abundant Abeta42-positive capillary amyloid angiopathy within a given cortical region in the brain of patients with Alzheimer pathology, Acta Neuropathol 111:510-518, 2006

  Oshima K, Akiyama H, Tsuchiya K, Kondo H, Haga C, Shimomura Y, Iseki E, Uchikado H, Kato M, Niizato K, Arai H

• Immunohistochemical study of tau accumulation in early stages of Alzheimer-type neurofibrillary lesions，Acta Neuropathol 107:504-508，2004

  Togo T, Akiyama H, Iseki E, Uchikado H, Kondo H, Ikeda K, Tsuchiya K, de Silva R, Leesd A Kosaka K

• Specificity of mechanisms for plaque removal after Abeta immunotherapy for Alzheimer's disease，Nat Med 10: 117-118，2004

  Akiyama H, McGeer PL

• Expression of BRI, the normal precursor forof the amyloid protein of familial British dementia, in human brain，Acta Neuropathol 107:53-84，2004

  Akiyama H, Kondo H, Arai T, Ikeda K, Kato M, Iseki E, Scwab C, McGeer PL

• Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases，J Neuroimmunol 124:83-92，2002

  Togo T, Akiyama H, Iseki E, Kondo H, Ikeda K, Kato M, Oda T, Tsuchiya K, Kosaka K

• Immunohistochemical localization of neprilysin in the human cerebral cortex: inverse association with vulnerability to amyloid beta-protein(Abeta) deposition，Brain Res 902:277-281，2001

  Akiyama H, Kondo H, Ikeda K, Kato M, McGeer PL

• Occurrence of the diffuse amyloid β-protein(Aβ) deposits with numerous Aβ-containing glial cells in the cerebral cortex of patients with Alzheimer's disease, Glia 25: 324-331, 1999

  Akiyama H, Mori M, Saido T, Kondo H, Iked K, and McGeer PL

• Variable deposition of amyloid β-protein(Aβ) with the carboxy-terminus that ends at a residue valine40(Aβ40) in the cerebral cortex of patients with Alzheimer's disease - A double-labeling immunohistochemical study with antibodies specific for Aβ40 and Aβ that ends at residues alanine42/threonine43(Aβ42), Neurochem Res 22:1499-1506, 1997

  Akiyama H, Mori H, Sahara N, Kondo H, Ikeda K, Nishimura T, Oda T, McGeer PL

• Reduction of telencephalin immunoreactivity in the brain of patients with Alzheimer's disease, Brain Res 753:353-357, 1997

  Hino H, Mori K, Yoshihara Y, Iseki E, Akiyama H, Nishimura T, Ikeda K, Kosaka K

• The amino-terminally truncated forms of amyloid β-protein in brain macrophages in the ischemic lesions of Alzheimer's disease patients. Neurosci Lett 219:115-118, 1996

  Akiyama H, Kondo H, Mori H, Kametani F, Nishimura T, Ikeda K, Kato M, McGeer PL

• Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein, Neurosci Lett 206:169-172, 1996

  Akiyama H, Schwab C, Kondo H, Mori H, Kametani F, Ikeda K, McGeer PL

• Immunohistochemical detection of coagulation factor XIIIa in postmortem human brain tissue, Neurosci Lett 202:29-32, 1995

  Akiyama H, Kondo H, Ikeda K, Arai T, Kato M, McGeer PL

• Fas antigen expression in brains of patients with Alzheimer-type dementia, Brain Res 695:137-145, 1995

  Nishimura T, Akiyama H, Yonehara S, Kondo H, Ikeda K, Kato M, Iseki E, Kosaka K

• Expression of MRP14, 27E10, alpha-interferon and leucocyte common antigen by reactive microglia in postmortem human brain tissue, J Neuroimmunol 50:195-202, 1994

  Akiyama H, Ikeda K, Katoh M, McGeer EG, McGeer PL

• Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis, Brain Res 639:171-174, 1994

  Akiyama H, Nishimura T, Kondo H, Ikeda K, Hayashi Y, McGeer PL

• Columnar arrangement of beta-amyloid protein deposits in the cerebral cortex of patients with Alzheimer's disease, Acta Neuropathol 85:400-403, 1993

  Akiyama H, Yamada T, McGeer PL, Kawamata T, Tooyama I, Ishii T

• Expression of Intercellular Adhesion Molecule(ICAM)-1 by a Subset of Astrocytes in Alzheimer and Some Other Degenerative Neurological Disorders, Acta Neuropathol 85:628-634, 1993

  Akiyama, H., Kawamata, T., Yamada, T., Tooyama, I., Ishii,T., McGeer, P.L

• Morphological diversities of CD44 positive astrocytes in the cerebral cortex of normal subjects and patients with Alzheimer's disease, Brain Res 632:249-259, 1993

  Akiyama H, Tooyama I, Kawamata T, Ikeda T, McGeer PL

• Thrombin Accumulation in Brains of Patients with Alzheimer's Disease, Neurosci Lett 146:152-154, 1992

  Akiyama, H., Ikeda, K., Kondo, H., McGeer, P.L.

• Association of Amyloid P Component with Complement Proteins in Neurologically Diseased Brain Tissue, Brain Res 548:349-352, 1991

  Akiyama H, Yamada T, Kawamata T, McGeer PL

• Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue, J Neuroimmunol 32:19-28, 1991

  Akiyama H, Kawamata T, Dedhar S, McGeer PL

• Occurrence of Diffuse Amyloid Deposits in the Presubicular Parvopyramidal Layer in Alzheimer's Disease, Acta Neuropathol 79:537-544, 1990

  Akiyama H, Tago H, Itagaki S, McGeer PL

• Brain Microglia Constitutively Express β-2 Integrins, J Neuroimmunol 30:81-93, 1990

  Akiyama H, McGeer PL

• Distribution of Phosphate-Activated Glutaminase in the Human Cerebral Cortex, J Comp Neurol 297:239-252, 1990

  Akiyama H, Takeshi K, Mizuno N, McGeer PL

• Loss of Glutaminase-positive Cortical Neurons in Alzheimer's Disease, Neurochem Res 14:453-458, 1989

  Akiyama H, McGeer PL, McGeer EG, Kaneko T

• Crossed cerebellar and uncrossed basal ganglia and thalamus diaschisis in Alzheimer' disease, Neurol 39:541-548, 1989

  Akiyama H, Harrop R, McGeer PL, Peppard R, McGeer EG

その他

• 【受賞】2004年　東京都職員表彰

• 【受賞】2005年　日本痴呆学会特別功労賞