赤木 究 あかぎ きわむ 先生

来歴等

略歴

1986年 宮崎医科大学医学部 卒業
1992年 熊本大学大学院 修了 医学博士取得
1992年 熊本大学分子遺伝学講座 助手
1993年 オランダ癌研究所分子遺伝学部門 リサーチフェロー
1997年 埼玉県立がんセンター研究所 研究員 遺伝子診断事業リーダー
2005年 埼玉県立がんセンター 腫瘍診断・予防科 科長兼副部長
2009年 埼玉県立がんセンター 腫瘍診断・予防科 科長兼部長
2019年 がんゲノム医療センター センター長

論文

• Comprehensive analysis of indels in whole-genome microsatellite regions and microsatellite instability across 21 cancer types. Genome Reserch published online March 24, 2020 doi: 10.1101/gr.255026.119

  Fujimoto A, Fujita M, Hasegawa T, Wong JH, Maejima K, Oku-Sasaki A, Nakano K, Shiraishi Y, Miyano S, Yamamoto G, Akagi K, Imoto S, and Nakagawa H.

• Japan Society of Clinical Oncology provisional clinical opinion for the diagnosis and use of immunotherapy in patients with deficient DNA mismatch repair tumors, cooperated by Japanese Society of Medical Oncology, First Edition. International Journal of Clinical Oncology, 2020 25(2), 217-239.

  Mishima S, Taniguchi H, Akagi K, Baba E, Fujiwara Y, Hirasawa A, Ikeda M, Maeda O, Muro K, Nishihara H, Nishiyama H, Takano T, Tsuchihara K, Yatabe Y, Kodera Y, Yoshino T.

• A multicentre, prospective study of plasma circulating tumour DNA test for detecting RAS mutation in patients with metastatic colorectal cancer. Br J Cancer. 2019 Apr 24. doi: 10.1038

  Bando H, Kagawa Y, Kato T, Akagi K, Denda T, Nishina T, Komatsu Y, Oki E, Kudo T, Kumamoto H, Yamanaka T, Yoshino T.

• Predictive model for high-frequency microsatellite instability in colorectal cancer patients over 50 years of age. Cancer Med. 2017 Jun;6(6):1255-1263

  Fujiyoshi K, Yamaguchi T, Kakuta M, Takahashi A, Arai Y, Yamada M, Yamamoto G, Ohde S, Takao M, Horiguchi SI, Natsume S, Kazama S, Nishizawa Y, Nishimura Y, Akagi Y, Sakamoto H, Akagi K.

• Utility of the quasi-monomorphic variation range in unresectable metastatic colorectal cancer patients. Cancer Sci. 2018 Nov;109(11):3411-3415.

  Bando H, Okamoto W, Fukui T, Yamanaka T, Akagi K, Yoshino T.

• The silent mutation MLH1 c.543C>T resulting in aberrant splicing can cause Lynch syndrome: a case report. Jpn J Clin Oncol. 2017 Jun 1;47(6):576-580.

  Yamaguchi T, Wakatsuki T, Kikuchi M, Horiguchi SI, Akagi K.

• DNA methylation epigenotype and clinical features of NRAS-mutation(+) colorectal cancer. Cancer Med. 2017 May;6(5):1023-1035.

  Takane K, Akagi K, Fukuyo M, Yagi K, Takayama T, Kaneda A.

• Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing. Int J Oncol. 2017 May;50(5):1579-1589.

  Yamamoto G, Kikuchi M, Kobayashi S, Arai Y, Fujiyoshi K, Wakatsuki T, Kakuta M, Yamane Y, Iijima Y, Mizutani H, Nakajima Y, Sudo J, Kinoshita H, Kurimoto F, Akiyama H, Uramoto H, Sakai H, Akagi Y, Akagi K.

• High concordance rate of KRAS/BRAF mutations and MSI-H between primary colorectal cancer and corresponding metastases. Oncol Rep. 2017 Feb;37(2):785-792.

  Fujiyoshi K, Yamamoto G, Takahashi A, Arai Y, Yamada M, Kakuta M, Yamaguchi K, Akagi Y, Nishimura Y, Sakamoto H, Akagi K.

• Two subtypes of colorectal tumor with distinct molecular features in familial adenomatous polyposis. Oncotarget. 2016; 7:84003-84016

  Takane K, Matsusaka K, Ota S, Fukuyo M, Yue Y, Nishimura M, Sakai E, Matsushita K, Miyauchi H, Aburatani H, Nakatani Y, Takayama T, Matsubara H, Akagi K, Kaneda A.

• 12-Gene Recurrence Score Assay Stratifies the Recurrence Risk in Stage II/III Colon Cancer With Surgery Alone: The SUNRISE Study. J Clin Oncol. 2016 Aug 20;34(24):2906-13.

  Yamanaka T, Oki E, Yamazaki K, Yamaguchi K, Muro K, Uetake H, Sato T, Nishina T, Ikeda M, Kato T, Kanazawa A, Kusumoto T, Chao C, Lopatin M, Krishnakumar J, Bailey H, Akagi K, Ochiai A, Ohtsu A, Ohashi Y, Yoshino T.

• Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway Int J Cancer. 2016;138(7):1634-44.

  Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K , Matsuhashi N, Fukushima J, Fukayama M, Akagi K , Aburatani H, Nakajima A, Kaneda A.

• Woods, on behalf of InSiGHT, F.Macrae, M.Genuardi, Application of a five-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants lodged on the InSiGHT locus-specific database, Nature Genetics, 2014, 46,107-115.

  B.A.Thompson, A.B.Spurdle, JP.Plazzer, M.S.Greenblatt, K.Akagi, F.Al-Mulla, B.Bapat, I. Bernstein, G.Capellá, D.Sart, A.Fabre, M.P.Farrell, S.M. Farrington, I.M. Frayling, T. Frebourg, D.E. Goldgar, C.D. Heinen, E.Holinski-Feder, M.Kohonen-Corish, K.Lagerstedt-Robinson, S.Y.Leung, A.Martins, P.Moller, M.Morak, M.Nystrom, P.Peltomaki, M.Pineda, M.Qi, R.Ramesar, L.J.Rasmussen, B.Royer-Pokora, R.J. Scott, R.Sijmons, S.V.Tavtigian, C.M.Tops, T.Weber, J.Wijnen, M.O.

• Three DNA Methylation Epigenotypes in Human Colorectal Cancer. Clin Cancer Res; 16(1),21-33 (2010)

  Yagi K, Akagi K, Hayashi H, Nagae G, Tsuji S, Isagawa T, Midorikawa Y, Nishimura Y, Sakamoto H, Seto Y, Aburatani H, Kaneda A.

• Simple method to detect important epidermal growth factor receptor gene mutations with bronchoscopic specimens of lung cancer patients for gefitinib treatment　　Targeted Oncology (2007) 2(3), 145-151

  Akagi K, Sakai H, Sudo J, Hommura Y, Kurimoto F, Komagata H, Akiyama H, Yoneda S

• Characterization of a novel oncogenic K-ras mutation in colon cancer Biochem Biophys Res Commun. 352, 728-732 (2007)

  Akagi K, Uchibori R, Yamaguchi K, Kurosawa K, Tanaka Y, Kozu T

• MYND-less splice variants of AML1-MTG8 are expressed in leukemia with t(8;21).Genes Chrom. Cancer, 43, 45-53 (2005)

  Kozu,T., Fukuyama, T., Yamami,T., Akagi,K and Kaneko,Y.

• The clinical features of rectal cancers with high-frequency microsatellite instability (MSI-H) in Japanese males. Cancer Lett. 216, 55-62 (2004)

  Ishikubo,T., Nishimura, Y., Yamaguchi, K., Khansuwan, U., Arai, Y., Kobayashi, T., Ohkura, Y., Hashiguchi, Y., Tanaka Y. and Akagi, K.

• MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes Oncogene, 20, 6225-6232, (2001)

  Fukuyama,T.,Sueoka,E., Sugio,Y., Otsuka,T., Niho,Y., Akagi,K. and Kozu,T.

• Germline Mutation of Dihydropyrimidine Dehydrogenese Gene among a Japanese Population in Relation to Toxicity to 5-Fluorouracil Jpn. J. Cancer Res., 92: 337-342, (2001)

  Yamaguchi,K., Arai,Y., Kanda,Y. and Akagi,K.

• A novel tetracycline-dependent transactivator with E2F4 transcriptional activation domain Nucleic Acids Res., 29: e23 (2001)

  Akagi,K., Kanai,M., Saya,H., Kozu,T. and Berns,A.

• Cre-mediated somatic site-specific recombination in mice. 　 Nucleic Acids Res., 25: 1766-1773 (1997)

  Akagi,K.,Sandig,V., Vooijs,M., Valk,M.V.d., Giovannini,M., Strauss,M. and Berns,A.

• The 3' enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin V kappa-J kappa joining. 　　 Cell 83: 1113-1123 (1995)

  Hiramatsu,R., Akagi,K., Matsuoka,M., Sakumi,K., Nakamura,H., Kingsbury,L., David,C., Hardy,R.R., Yamamura,K., and Sakano,H.

• Differentiation of growth signal requirement of B lymphocyte precursor is directed by expression of immunoglobulin. EMBO J 10: 337-342 (1991)

  Era,T., Ogawa, M., Nishikawa, S., Okamoto, M., Honjo,T., Akagi, K., Miyazaki, J., Yamamura, K.

• Specific depletion of the B-cell population induced by aberrant expression of human interferon regulatory factor 1 gene in transgenic mice. Proc Natl Acad Sci U S A 88: 532-536 (1991)

  Yamada, G., Ogawa, M., Akagi, K., Miyamoto, H., Nakano, N., Itoh, S., Miyazaki, J.,Nishikawa, S., Yamamura, K., Taniguchi, T.

• Strain dependency of B and T lymphoma development in immunoglobulin heavy chain enhancer (Eμ)-myc transgenic mice. J.Exp.Med. 170:711-726, 1989.

  Yukawa, K., Kikutani, H., Inomoto, T., Uehira, M., Bin, S. H., Akagi, K., Yamamura, K., Kishimoto, T.

著書

• 【分担執筆】成人・小児進行固形がんにおける臓器横断的ゲノム診療のガイドライン　第2版　金原出版株式会社　2019年

• 【分担執筆】遺伝性大腸癌診療ガイドライン　第2版　金原出版株式会社　2016年

• 【分担執筆】大腸がん診療における遺伝子関連検査等のガイダンス 第3版　金原出版株式会社　2016年

その他

• 【受賞】2011年　大腸癌研究会　　優秀発表賞受賞