高野 賢一 たかの けんいち 先生

来歴等

略歴

2001年 札幌医科大学医学部 卒業
2001年 札幌医科大学医学部附属病院 臨床研修医
2006年 札幌医科大学医学研究科大学院 修了（医学博士）
2006年 帯広厚生病院 耳鼻咽喉科
2007年 帯広協会病院 耳鼻咽喉科
2008年 札幌医科大学医学部耳鼻咽喉科・頭頸部外科学講座 助教
2011年 米国Yale大学医学部免疫生物学部門 訪問研究員
2013年 札幌医科大学医学部耳鼻咽喉科・頭頸部外科学講座 助教 講師
2016年 札幌医科大学医学部耳鼻咽喉科・頭頸部外科学講座 准教授
2018年 札幌医科大学医学部耳鼻咽喉科・頭頸部外科学講座 教授

論文

• 1. Tubarial gland involvement in IgG4-related diseases. Acta Otolaryngol. 2022 Jul-Aug;142(7-8):616-619. doi: 10.1080/00016489.2022.2104368.

  Takano K, Kurose M, Kamekura R, Kanda M, Yamamoto M, Takahashi H.

• 2. CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma. Cancer Med. 2022 Oct 27. doi: 10.1002/cam4.5392. .(in press)

  Yorozu A, Sekiguchi S, Takasawa A, Okazaki F, Niinuma T, Kitajima H, Yamamoto E, Kai M, Toyota M, Hatanaka Y, Nishiyama K, Ogi K, Dehari H, Obata K, Kurose M, Kondo A, Osanai M, Miyazaki A, Takano K, Suzuki H.

• 3. Head and neck small-cell carcinoma: A multicenter study of 39 cases from 10 institutions. Front Surg. 2022 Nov 14;9:1049116. doi: 10.3389/fsurg.2022.1049116.

  Matsuyama H, Ueki Y, Okamoto I, Nagao T, Honda K, Yamazaki K, Okabe R, Togashi T, Shodo R, Ota H, Takahashi T, Omata J, Yokoyama Y, Saijo K, Tanaka R, Tsukahara K, Kitahara T, Uemura H, Yoshimoto S, Matsumoto F, Okami K, Sakai A, Takano K, Kondo A, Inohara H, Eguchi H, Oridate N, Tanabe T, Nakamizo M, Yokoshima K, Miura K, Kitani Y, Horii A.

• 4. Inhibition of HDAC and Signal Transduction Pathways Induces Tight Junctions and Promotes Differentiation in p63-Positive Salivary Duct Adenocarcinoma. Cancers (Basel). 2022 May 24;14(11):2584. doi: 10.3390/cancers14112584.

  Nakano M, Ohwada K, Shindo Y, Konno T, Kohno T, Kikuchi S, Tsujiwaki M, Ishii D, Nishida S, Kakuki T, Obata K, Miyata R, Kurose M, Kondoh A, Takano K, Kojima T.

• 5. A hydroxypropyl methylcellulose plaque assay for human respiratory syncytial virus. J Virol Methods. 2022 Jun;304:114528. doi: 10.1016/j.jviromet.2022.114528.

  Takumi-Tanimukai Y, Yamamoto S, Ogasawara N, Nakabayashi S, Mizuta K, Yamamoto K, Miyata R, Kakuki T, Jitsukawa S, Sato T, Tsutsumi H, Kojima T, Takano K, Yokota SI.

• 6. Narrow band imaging accentuates differences in contrast between cartilage and perichondrium in the elevation of the muco-perichondrium flap during septoplasty and open septorhinoplasty. Auris Nasus Larynx. 2022 Dec;49(6):973-979. doi: 10.1016/j.anl.2022.03.007.

  Yamamoto K, Okuni T, Kurose M, Kakuki T, Nakano M, Sakamoto H, Takano K.

• 7. The differential diagnosis of IgG4-related disease based on machine learning. Arthritis Res Ther. 2022 Mar 19;24(1):71. doi: 10.1186/s13075-022-02752-7.

  Yamamoto M, Nojima M, Kamekura R, Kuribara-Souta A, Uehara M, Yamazaki H, Yoshikawa N, Aochi S, Mizushima I, Watanabe T, Nishiwaki A, Komai T, Shoda H, Kitagori K, Yoshifuji H, Hamano H, Kawano M, Takano K, Fujio K, Tanaka H.

• 8. Self-reported Smell and Taste Disorders in Patients With COVID-19: A Japanese Single-center Study. In Vivo. 2022 Mar-Apr;36(2):918-924. doi: 10.21873/invivo.12781.

  Yamamoto K, Fujiya Y, Kuronuma K, Ogasawara N, Ohkuni T, Yokota SI, Takahashi S, Takano K.

• 9. FOXO3/TGF-β signal-dependent ciliogenesis and cell functions during differentiation of temperature-sensitive mouse cochlear precursor hair cells. Histochem Cell Biol 2022 Apr;157(4):415-426. doi: 10.1007/s00418-021-02068-8.

  Kakuki T, Kohno T, Nishida S, Konno T, Kikuchi S, Ohwada K, Nakano M, Tezuka M, Takano K, Kojima T.

• 10. Abnormal [18F] fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease. 2022 Feb;36(2):200-207. doi: 10.1007/s12149-021-01691-8.

  Nagahata K, Kanda M, Kamekura R, Sugawara M, Yama N, Suzuki C, Takano K, Hatakenaka M, Takahashi H.

• 11. Dysfunction of epithelial permeability barrier induced by HMGB1 in 2.5D cultures of human epithelial cells. Tissue Barriers. 2021 Sep 18:1972760.

  Kojima T, Shindo Y, Konno T, Kodera Y, Arai W, Miyakawa M, Ohwada K, Tanaka H, Tsujiwaki M, Sakuma Y, Kikuchi S, Ohkuni T, Takano K, Watanabe A, Kohno T.

• 12. Effects of HMGB1 on Tricellular Tight Junctions via TGF-β Signaling in Human Nasal Epithelial Cells. Int J Mol Sci. 2021 Aug 4;22(16):8390

  Ohwada K, Konno T, Kohno T, Nakano M, Ohkuni T, Miyata R, Kakuki T, Kondoh M, Takano K, Kojima T.

• 13. HDAC inhibitors suppress the proliferation, migration and invasiveness of human head and neck squamous cell carcinoma cells via p63_mediated tight junction molecules and p21_mediated growth arrest. Oncol Rep. 2021 Apr;45(4):46.

  Kakiuchi A, Kakuki T, Ohwada K, Kurose M, Kondoh A, Obata K, Nomura K, Miyata R, Kaneko Y, Konno T, Kohno T, Himi T, Takano K, Kojima T.

• 14. Telefitting of Nucleus Cochlear Implants: A Feasibility Study. Am J Audiol. 2021 Mar 10;30(1):16-21

  Takano K, Kaizaki A, Kimura A, Nomura K, Yamazaki N, Shintani T, Himi T.

• 15. Cigarette Smoke Underlies the Pathogenesis of Palmoplantar Pustulosis via an IL-17A-Induced Production of IL-36γ in Tonsillar Epithelial Cell. J Invest Dermatol. 2021 Jun;141(6):1533-1541.e4.

  Kobayashi K, Kamekura R, Kato J, Kamiya S, Kamiya T, Takano K, Ichimiya S, Uhara H.

• 16. Tracheostomy in Patients With COVID-19: A Single-center Experience. In Vivo. 2020 Nov-Dec;34(6):3747-3751.

  Obata K, Miyata R, Yamamoto K, Byn-Ya N, Kasai T, Inoue H, Narimatsu E, Takano K.

• 17. Upregulation of adipocyte enhancer-binding protein 1 in endothelial cells promotes tumor angiogenesis in colorectal cancer. Cancer Sci. 2020 May;111(5):1631-1644.

  Yorozu A, Yamamoto E, Niinuma T, Tsuyada A, Maruyama R, Kitajima H, Numata Y, Kai M, Sudo G, Kubo T, Nishidate T, Okita K, Takemasa I, Nakase H, Sugai T, Takano K, Suzuki H.

• 18. Cytotoxic Tph-like cells are involved in persistent tissue damage in IgG4-related disease. Mod Rheumatol. 2021 Jan;31(1):249-260.

  Yabe H, Kamekura R, Yamamoto M, Murayama K, Kamiya S, Ikegami I, Shigehara K, Takaki H, Chiba H, Takahashi H, Takano K, Takahashi H, Ichimiya S.

• 19. Localization of Tricellular Tight Junction Molecule LSR at Midbody and Centrosome During Cytokinesis in Human Epithelial Cells. J Histochem Cytochem. 2020 Jan;68(1):59-72.

  Konno T, Kohno T, Kikuchi S, Shimada H, Satohisa S, Takano K, Saito T, Kojima T.

• 20. Role of RANK-L as a potential inducer of ILC2-mediated type 2 inflammation in chronic rhinosinusitis with nasal polyps. Mucosal Immunol. 2020 Jan;13(1):86-95.

  Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, Conley DB, Raviv JR, Soroosh P, Takano K, Himi T, Kern RC, Schleimer RP, Kato A.

• 21. TNF induces production of type 2 cytokines in human group 2 innate lymphoid cells. J Allergy Clin Immunol. 2020 Jan;145(1):437-440.

  Ogasawara N, Poposki JA, Klingler AI, Tan BK, Hulse KE, Stevens WW, Peters AT, Grammer LC, Welch KC, Smith SS, Conley DB, Takano K, Himi T, Kern RC, Schleimer RP, Kato A.

• 22. Circulating PD-1+CXCR5-CD4+ T cells underlying the immunological mechanisms of IgG4-related disease. Rheumatol Adv Pract. 2018 Oct 17;2(2):rky043.

  Kamekura R, Yamamoto M, Takano K, Yabe H, Ito F, Ikegami I, Takaki H, Shigehara K, Suzuki C, Himi T, Takahashi H, Ichimiya S.

• 23. Predicting therapeutic response in IgG4-related disease based on cluster analysis. Immunol Med. 2018 Mar;41(1):30-33.

  Yamamoto M, Takano K, Kamekura R, Suzuki C, Tabeya T, Murakami R, Honda S, Mukai M, Nojima M, Ichimiya S, Himi T, Nakase H, Takahashi H.

• 24. Rho-kinase and PKCα Inhibition Induces Primary Cilia Elongation and Alters the Behavior of Undifferentiated and Differentiated Temperature-sensitive Mouse Cochlear Cells. J Histochem Cytochem. 2019 Jul;67(7):523-535

  Kakiuchi A, Kohno T, Kakuki T, Kaneko Y, Konno T, Hosaka Y, Hata T, Kikuchi S, Ninomiya T, Himi T, Takano K, Kojima T.

• 25. Induction of airway progenitor cells via p63 and KLF11 by Rho-kinase inhibitor Y27632 in hTERT-human nasal epithelial cells. Am J Transl Res. 2019 Feb 15;11(2):599-611.

  Kaneko Y, Konno T, Kohno T, Kakuki T, Miyata R, Ohkuni T, Kakiuchi A, Yajima R, Ohwada K, Kurose M, Himi T, Takano K, Kojima T.

• 26. Analysis of allergic reaction in IgG4-related disease. Mod Rheumatol. 2019 Nov;29(6):1063-1065.

  Yamamoto M, Takano K, Kamekura R, Aochi S, Suzuki C, Ichimiya S, Takahashi H.

• 27. IL-10+ T follicular regulatory cells are associated with the pathogenesis of IgG4-related disease. Immunol Lett. 2019 Mar;207:56-63.

  Ito F, Kamekura R, Yamamoto M, Takano K, Takaki H, Yabe H, Ikegami I, Shigehara K, Himi T, Takahashi H, Ichimiya S.

• 28. Interleukin 5-producing ST2+ memory Th2 cells in IgG4-related dacryoadenitis and sialadenitis. Mod Rheumatol. 2019 Sep;29(5):856-860.

  Yamamoto M, Takano K, Kamekura R, Aochi S, Suzuki C, Ichimiya S, Nakase H, Himi T, Takahashi H.

• 29. Mechanism of fibrogenesis in submandibular glands in patients with IgG4-RD. J Mol Histol. 2018 Dec;49(6):577-587.

  Yajima R, Takano K, Konno T, Kohno T, Kaneko Y, Kakuki T, Nomura K, Kakiuchi A, Himi T, Kojima T.

• 30. Early Therapeutic Intervention for IgG4-related Dacryoadenitis and Sialadenitis: The Balance Between Risk of Observation Only and Therapeutic Adverse Effects. J Rheumatol. 2018 Aug;45(9):1339-1340.

  Yamamoto M, Takano K, Takahashi H.

• 31. Guanylate binding protein-1-mediated epithelial barrier in human salivary gland duct epithelium. Exp Cell Res. 2018 Oct 1;371(1):31-41.

  Konno T, Takano K, Kaneko Y, Kakuki T, Nomura K, Yajima R, Kakiuchi A, Kohno T, Himi T, Kojima T.

• 32. Immunoreactivity patterns of tight junction proteins are useful for differential diagnosis of human salivary gland tumors. Med Mol Morphol. 2019 Mar;52(1):23-35.

  Aoyama T, Takasawa A, Murata M, Osanai M, Takano K, Hasagawa T, Sawada N.

• 33. Potential utility of core needle biopsy in the diagnosis of IgG4-related dacryoadenitis and sialadenitis. Mod Rheumatol. 2019 Mar;29(2):393-396.

  Takano K, Okuni T, Yamamoto K, Kamekura R, Yajima R, Yamamoto M, Takahashi H, Himi T.

• 34. Stage classification of IgG4-related dacryoadenitis and sialadenitis by the serum cytokine environment. Mod Rheumatol. 2018 Nov;28(6):1004-1008.

  Yamamoto M, Takano K, Kamekura R, Suzuki C, Ichimiya S, Himi T, Nakase H, Takahashi H.

• 35. Clinical and Prognostic Analysis of Hypopharyngeal Squamous Cell Carcinoma with Synchronous and Metachronous Multiple Malignancies. In Vivo. 2018 Jan-Feb;32(1):165-170.

  Yamamoto K, Takano K, Kondo A, Kurose M, Obata K, Himi T.

• 36. Downregulation of lipolysis-stimulated lipoprotein receptor promotes cell invasion via claudin-1-mediated matrix metalloproteinases in human endometrial cancer. Oncol Lett. 2017 Dec;14(6):6776-6782.

  Shimada H, Satohisa S, Kohno T, Konno T, Takano K, Takahashi S, Hatakeyama T, Arimoto C, Saito T, Kojima T.

• 37. Clinical utility of 18 F-fluorodeoxyglucose/positron emission tomography in diagnosis of immunoglobulin G4-related sclerosing sialadenitis. Laryngoscope. 2018 May;128(5):1120-1125.

  Takano K, Yajima R, Kamekura R, Yamamoto M, Takahashi H, Yama N, Hatakenaka M, Himi T.

• 38. Cutting Edge: A Critical Role of Lesional T Follicular Helper Cells in the Pathogenesis of IgG4-Related Disease. J Immunol. 2017 Oct 15;199(8):2624-2629.

  Kamekura R, Takano K, Yamamoto M, Kawata K, Shigehara K, Jitsukawa S, Nagaya T, Ito F, Sato A, Ogasawara N, Tsubomatsu C, Takahashi H, Nakase H, Himi T, Ichimiya S.

• 39. The role of transcriptional factor p63 in regulation of epithelial barrier and ciliogenesis of human nasal epithelial cells. Sci Rep. 2017 Sep 7;7(1):10935.

  Kaneko Y, Kohno T, Kakuki T, Takano K, Ogasawara N, Miyata R, Kikuchi S, Konno T, Ohkuni T, Yajima R, Kakiuchi A, Yokota SI, Himi T, Kojima T.

• 40. Regulation of claudin-4 via p63 in human epithelial cells. Ann N Y Acad Sci. 2017 Oct;1405(1):25-31

  Kojima T, Kohno T, Kubo T, Kaneko Y, Kakuki T, Kakiuchi A, Kurose M, Takano K, Ogasawara N, Obata K, Nomura K, Miyata R, Konno T, Ichimiya S, Himi T.

• 41. Loss of sorting nexin 5 stabilizes internalized growth factor receptors to promote thyroid cancer progression. J Pathol. 2017 Nov;243(3):342-353.

  Jitsukawa S, Kamekura R, Kawata K, Ito F, Sato A, Matsumiya H, Nagaya T, Yamashita K, Kubo T, Kikuchi T, Sato N, Hasegawa T, Kiyonari H, Mukumoto Y, Takano K, Himi T, Ichimiya S.

• 42. Histone deacetylase inhibition prevents cell death induced by loss of tricellular tight junction proteins in temperature-sensitive mouse cochlear cells. PLoS One. 2017 Aug 2;12(8):e0182291.

  Takano K, Kakuki T, Kaneko Y, Kohno T, Kikuchi S, Himi T, Kojima T.

• 43. High frequency of Bob1lo T follicular helper cells in florid reactive follicular hyperplasia. Immunol Lett. 2017 Nov;191:23-30.

  Matsumiya H, Kawata K, Kamekura R, Tsubomatsu C, Jitsukawa S, Asai T, Akasaka S, Kamei M, Yamashita K, Ito F, Kubo T, Sato N, Takano K, Himi T, Ichimiya S.

• 44. Factors associated with successful decannulation in pediatric tracheostomy patients. Acta Otolaryngol. 2017 Oct;137(10):1104-1109

  Takahashi N, Takano K, Mitsuzawa H, Kurose M, Himi T.

• 45. Chorda tympani nerve dysfunction associated with congenital microtia. Acta Otolaryngol. 2017 Jul;137(7):686-689.

  Takano K, Takahashi N, Ogasawara N, Yotsuyanagi T, Himi T.

• 46. Loss of tricellular tight junction protein LSR promotes cell invasion and migration via upregulation of TEAD1/AREG in human endometrial cancer. Sci Rep. 2017 Jan 10;7:37049.

  Shimada H, Abe S, Kohno T, Satohisa S, Konno T, Takahashi S, Hatakeyama T, Arimoto C, Kakuki T, Kaneko Y, Takano K, Saito T, Kojima T.

• 47. Recent advances in knowledge regarding the head and neck manifestations of IgG4-related disease. Auris Nasus Larynx. 2017 Feb;44(1):7-17.

  Takano K, Yamamoto M, Takahashi H, Himi T.

• 48. Lipid mediators foster the differentiation of T follicular helper cells. Immunol Lett. 2017 Jan;181:51-57.

  Nagaya T, Kawata K, Kamekura R, Jitsukawa S, Kubo T, Kamei M, Ogasawara N, Takano K, Himi T, Ichimiya S.

• 49. Assessing the usefulness of salivary gland biopsy for diagnosis of type-1 autoimmune pancreatitis. Mod Rheumatol. 2017 May;27(3):548-550.

  Takano K, Yamamoto M, Ichimiya S, Takahashi H, Himi T.

著書

• 1. Takano K. Hearing Loss in Congenital Microtia. In Stavros Hatzopoulos editor. An Excursus into Hearing Loss. London: In InTech Open Limited; 2018, pp47-54.高野賢一：聴覚障害のリハビリテーション診療. 聴覚障害のリハビ

• 2. リテーション診療の実際耳鼻咽喉科頭頸部外科領域のリハビリテーション医学・医療テキスト，日本リハビリテーション医学教育推進機構，2022，p80−89.

• 3. 高野賢一：唾液腺炎. 標準耳鼻咽喉科・頭頸部外科学第4版，医学書院，2022, p255-256

• 4. 高野賢一：オンライン診療・先天性難聴．今日の治療指針 2021，医学書院，東京，2021, 電子版

• 5. 高野賢一、氷見徹夫：口唇嚢胞・ガマ腫、耳鼻咽喉・頭頸部手術アトラス第2版、医学書院; 2020, pp13-14.

• 6. 高野賢一：オンライン診療・先天性難聴、今日の治療指針2020、医学書院; 2020, 電子版

• 7. 高野賢一．IgG4関連疾患．山岨達也 編．医学のあゆみBOOKS．耳鼻咽喉科診療の進歩 40のエッセンス．東京：医歯薬出版; 2018, pp142-146.

• 8. 高野賢一，氷見徹夫．口腔・咽喉頭．前田直之ら 編．日本医師会雑誌特別号．東京：日本医師会；2018, pp68-69.

• 9. 高野賢一．口腔アレルギー症候群．大森孝一，藤枝重治，小島博己，_原秀典 編．今日の耳鼻咽喉科・頭頸部外科治療指針 第4版．東京：医学書院；2018, pp382-383.

• 10. 高野賢一．IgG4関連疾患．大森孝一，藤枝重治，小島博己，_原秀典 編．今日の耳鼻咽喉科・頭頸部外科治療指針 第4版．東京：医学書院；2018, pp585-587

受賞

• 1. 平成18年度札幌医科大学医師会賞受賞

• 2. 第21回日本シェーグレン症候群学会奨励賞受賞

SNS・ブログ等

• その他メディア
  • 教室HP