宮塚 健 みやつか たけし 先生

来歴等

略歴

1993年 東京大学薬学部 卒業
1997年 大阪大学医学部 卒業
2004年 大阪大学大学院医学系研究科 医学博士取得
2006年 カリフォルニア大学サンフランシスコ校 博士研究員
2012年 大阪大学医学部内分泌代謝内科学 特任助教
2013年 順天堂大学代謝内分泌内科学 准教授
2021年 北里大学医学部内分泌代謝内科学 主任教授

論文

• 1. STAT3 suppression and β-cell ablation enhance α-to-β reprogramming mediated by Pdx1. Sci Rep. 12:21419, 2022

  Wakabayashi Y, Miyatsuka T*, Miura M, Himuro M, Taguchi T, Iida H, Nishida Y, Fujitani Y, Watada H.

• 2. Spatial and transcriptional heterogeneity of pancreatic beta-cell neogenesis revealed by a time-resolved reporter system. Diabetologia 65:811-828, 2022

  Sasaki S*, Lee M, Wakabayashi Y, Suzuki L, Winata H, Himuro M, Matsuoka T, Shimomura I, Watada H, Lynn F*, Miyatsuka T*.

• 3. Suppression of STAT3 signaling promotes cellular reprogramming into insulin-producing cells induced by defined transcription factors. EBioMedicine 36: 358-366, 2018

  Miura M, Miyatsuka T*, Katahira T, Sasaki S, Suzuki L, Himuro M, Nishida Y, Fujitani Y, Matsuoka TA, Watada H.

• 4. Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon+ α-cells. Nat Cell Biol 20: 1267-1277, 2018

  Cigliola V, Ghila L, Thorel F, van Gurp L, Baronnier D, Oropeza D, Gupta S, Miyatsuka T, Kaneto H, Magnuson MA, Osipovich AB, Sander M, Wright CEV, Thomas MK, Furuyama K, Chera S, Herrera PL.

• 5. Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice. Diabetologia 58: 2582-2591, 2015

  Sasaki S, Miyatsuka T*, Matsuoka TA, Takahara M, Yamamoto Y, Yasuda T, Kaneto H, Fujitani Y, German MS, Akiyama H, Watada H, Shimomura I

• 6. Chronological analysis with Fluorescent Timer reveals unique features of newly generated β cells. Diabetes 63: 3388-3393, 2014

  Miyatsuka T*, Matsuoka TA, Sasaki S, Kubo F, Shimomura I, Watada H, German MS, Hara M

• 7. Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a. Proc Natl Acad Sci USA 108: 185-190, 2011

  Miyatsuka T, Kosaka Y, Kim H, German MS*

• 8. Serotonin regulates pancreatic beta cell mass during pregnancy. Nat Med 16: 804-808, 2010

  Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS*:

• 9. Rfx6 directs islet formation and insulin production in mice and humans. Nature 463: 775-780, 2010

  Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Desir J, Eijnden SV, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C*, German MS*:

• 10. Chronology of islet differentiation revealed by temporal cell labeling. Diabetes 58: 1863-1868, 2009

  Miyatsuka T, Li Z, German MS*:

• 11. Persistent expression of PDX-1 in the pancreas causes acinar-to-ductal metaplasia through Stat3 activation. Genes Dev 20: 1435-1440, 2006

  Miyatsuka T*, Kaneto H, Shiraiwa T, Matsuoka TA, Yamamoto K, Kato K, Nakamura Y, Akira S, Takeda K, Kajimoto Y, Yamasaki Y, Sandgren EP, Kawaguchi Y, Wright CV, Fujitani Y*: