斯波 真理子 しば まりこ 先生

来歴等

略歴

1984年 滋賀医科大学医学部 卒業
1988年 滋賀医科大学医学部大学院 博士課程修了 医学博士号取得
1992年 国立循環器病研究センター研究所 循環動態機能部 室員
1996年 研究休職、米国ケースウェスタンリザーブ大学医学部生化学
1998年 帰国・復職
2002年 国立循環器病研究センター 研究所 バイオサイエンス部 室長
2013年 国立循環器病研究センター 研究所 病態代謝部 部長
2022年 大阪医科薬科大学 循環器センター 特務教授

論文

• 1. Prevalence and Clinical Characteristics of Familial Hypercholesterolemia in Patients with Acute Coronary Syndrome according to the Current Japanese Guidelines: Insight from the EXPLORE-J study. J Atheroscler Thromb. 2025;32:23-33.

  Takeji Y, Tada H, Takamura M, Tomura A and Harada-Shiba M.

• 2. Assessments of Atherosclerosis and Treatment Strategies for Heterozygous Familial Hypercholesterolemia. J Atheroscler Thromb. 2025;32:1211-1219.

  Tada H and Harada-Shiba M.

• 3. Subclassification of Phenotypic Homozygous Familial Hypercholesterolemia. JACC Asia. 2025;5:1217-1220.

  Tada H and Harada-Shiba M.

• 4. Characterization of lipidic plaque features in association with LDL-C<70 mg/dL and lipoprotein(a) <50 mg/dL. J Clin Lipidol. 2025;19:509-520.

  Shishikura D, Kataoka Y, Nicholls SJ, Ray KK, Puri R, Kusumoto H, Yamauchi Y, Sakane K, Fujisaka T, Morita H, Murai K, Iwai T, Sawada K, Matama H, Honda S, Fujino M, Yoneda S, Takagi K, Nakao K, Otsuka F, Nishihira K, Takamisawa I, Asaumi Y, Noguchi T, Harada-Shiba M and Hoshiga M.

• 5. Clinical Impact of Lipoprotein (a) and Cumulative Low-Density Lipoprotein Cholesterol Exposure on Coronary Artery Disease in Patients with Heterozygous Familial Hypercholesterolemia. J Atheroscler Thromb. 2025;32:100-110.

  Shishikura D, Harada-Shiba M, Michikura M, Fujioka S, Fujisaka T, Morita H, Kanzaki Y and Hoshiga M.

• 6. Recent advances in research and care of familial hypercholesterolaemia. Lancet Diabetes Endocrinol. 2025;13:1054-1071.

  Santos RD, Gidding SS, Bourbon M, Iatan I, Harada-Shiba M, Raal FJ, Vallejo-Vaz AJ, Wiegman A and Watts GF.

• 7. Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk. N Engl J Med. 2025;393:51-61.

  Nicholls SJ, Nelson AJ, Ditmarsch M, Kastelein JJP, Ballantyne CM, Ray KK, Navar AM, Nissen SE, Harada-Shiba M, Curcio DL, Neild A, Kling D, Hsieh A, Butters J, Ference BA, Laufs U, Banach M, Mehran R, Catapano AL, Huo Y, Szarek M, Balinskaite V, Davidson MH and Investigators B.

• 8. Lp(a) testing for the primary prevention of cardiovascular disease in high-income countries: a cost-effectiveness analysis. Atherosclerosis. 2025;409:120447.

  Morton JI, Kronenberg F, Daccord M, Bedlington N, Geanta M, Silberzahn T, Chen Z, Eisele JL, Eliasen B, Harada-Shiba M, Rijken M, Wiegman A, Thanassoulis G, Kamstrup PR, Gutierrez-Ibarluzea I, Coral P, Santos RD, Stroes E, Vrablik M, Watts GF, Ballantyne CM, Mora S, Nordestgaard BG, Ray KK, Nicholls SJ, Ademi Z and Lp International Taskforce i.

• 9. Association of Achilles tendon thickness with lipid profile and carotid IMT in patients with familial hypercholesterolemia. Atherosclerosis. 2025;403:119173.

  Michikura M, Ogura M, Hori M, Matsuki K, Makino H, Fujioka S, Shishikura D, Hoshiga M and Harada-Shiba M.

• 10. Current Diagnosis and Management of Familial Hypobetalipoproteinemia 1. J Atheroscler Thromb. 2024;31:1005-1023.

  Wakabayashi T, Takahashi M, Okazaki H, Okazaki S, Yokote K, Tada H, Ogura M, Ishigaki Y, Yamashita S, Harada-Shiba M, Committee on Primary Dyslipidemia under the Research Program on R, Intractable Disease of the Ministry of Health L and Welfare of J.

• 11. Risk Assessment for Cardiovascular Events using Achilles Tendon Thickness and Softness and Intima-Media Thickness in Familial Hypercholesterolemia. J Atheroscler Thromb. 2024;31:1607-1619.

  Michikura M, Ogura M, Matsuki K, Yamaoka M, Makino H and Harada-Shiba M.

• 12. Obicetrapib as an Adjunct to Stable Statin Therapy in Japanese Subjects: Results from a Randomized Phase 2 Trial. J Atheroscler Thromb. 2024;31:1386-1397.

  Harada-Shiba M, Davdison MH, Ditmarsch M, Hsieh A, Wuerdeman E, Kling D, Nield A, Dicklin MR, Nakata A, Sueyoshi A, Kuroyanagi S and Kastelein JJP.

• 13. Asymptomatic Intracranial Artery Stenosis/Occlusion in Heterozygous Familial Hypercholesterolemia: Its Frequency and Implications for Cerebrovascular and Cardiovascular Events. J Am Heart Assoc. 2024;13:e033972.

  Funabashi S, Kataoka Y, Hori M, Ogura M, Doi T, Morita Y, Kiyoshige E, Nishimura K, Noguchi T and Harada-Shiba M.

• 14. Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry. Nat Commun. 2023;14:7972.

  Terada C, Oh K, Tsubaki R, Chan B, Aibara N, Ohyama K, Shibata MA, Wada T, Harada-Shiba M, Yamayoshi A and Yamamoto T.

• 15. Clinical Characteristics of Homozygous Familial Hypercholesterolemia in Japan: A Survey Using a National Database. JACC Asia. 2023;3:881-891.

  Takeji Y, Tada H, Ogura M, Nohara A, Kawashiri MA, Yamashita S, Harada-Shiba M, Committee on Primary Dyslipidemia under the Research Program on R, Intractable Disease of the Ministry of Health L and Welfare of J.

• 16. A Low-Frequency APOB p.(Pro955Ser) Variant Contributes to the Severity of/Variability in Familial Hypercholesterolemia. J Clin Endocrinol Metab. 2023;108:422-432.

  Hori M, Takahashi A, Hosoda K, Ogura M and Harada-Shiba M.

• 17. Guidelines for the Diagnosis and Treatment of Pediatric Familial Hypercholesterolemia 2022. J Atheroscler Thromb. 2023;30:531-557.

  Harada-Shiba M, Ohtake A, Sugiyama D, Tada H, Dobashi K, Matsuki K, Minamino T, Yamashita S and Yamamoto Y.

• 18. Guidelines for the Diagnosis and Treatment of Adult Familial Hypercholesterolemia 2022. J Atheroscler Thromb. 2023;30:558-586.

  Harada-Shiba M, Arai H, Ohmura H, Okazaki H, Sugiyama D, Tada H, Dobashi K, Matsuki K, Minamino T, Yamashita S and Yokote K.

• 19. 2023 Update on European Atherosclerosis Society Consensus Statement on Homozygous Familial Hypercholesterolaemia: new treatments and clinical guidance. Eur Heart J. 2023;44:2277-2291.

  Cuchel M, Raal FJ, Hegele RA, Al-Rasadi K, Arca M, Averna M, Bruckert E, Freiberger T, Gaudet D, Harada-Shiba M, Hudgins LC, Kayikcioglu M, Masana L, Parhofer KG, Roeters van Lennep JE, Santos RD, Stroes ESG, Watts GF, Wiegman A, Stock JK, Tokgozoglu LS, Catapano AL and Ray KK.

• 20. Worldwide experience of homozygous familial hypercholesterolaemia: retrospective cohort study. Lancet. 2022;399:719-728.

  Tromp TR, Hartgers ML, Hovingh GK, Vallejo-Vaz AJ, Ray KK, Soran H, Freiberger T, Bertolini S, Harada-Shiba M, Blom DJ, Raal FJ, Cuchel M and Homozygous Familial Hypercholesterolaemia International Clinical C.

• 21. Achilles Tendon Thickness Assessed by X-ray Predicting a Pathogenic Mutation in Familial Hypercholesterolemia Gene. J Atheroscler Thromb. 2022;29:816-824.

  Shoji T, Akiyama Y, Fujii H, Harada-Shiba M, Ishibashi Y, Ishida T, Ishigaki Y, Kabata D, Kihara Y, Kotani K, Kurisu S, Masuda D, Matoba T, Matsuki K, Matsumura T, Mori K, Nakagami T, Nakazato M, Taniuchi S, Ueno H, Yamashita S, Yoshida H and Yoshida H.

• 22. The impact of gene variants on the thickness and softness of the Achilles tendon in familial hypercholesterolemia. Atherosclerosis. 2022;358:41-46.

  Michikura M, Hori M, Ogura M, Hosoda K and Harada-Shiba M.

• 23. Identification of a novel large duplication (exon2_6dup): copy number variation in the LDLR gene in a large family with familial hypercholesterolemia by whole-genome sequencing. J Clin Lipidol. 2022;16:167-172.

  Hori M, Takahashi A, Hosoda K and Harada-Shiba M.

• 24. Familial Hypercholesterolemia in Patients with Acute Coronary Syndrome: Genetic Insights from EXPLORE-J. J Atheroscler Thromb. 2022;29:1201-1212.

  Harada-Shiba M, Ako J, Hirayama A, Nakamura M, Nohara A, Sato K, Murakami Y, Koshida R, Ozaki A and Arai H.

• 25. Drug discovery and development scheme for liver-targeting bridged nucleic acid antisense oligonucleotides. Mol Ther Nucleic Acids. 2021;26:957-969.

  Wada F, Yamamoto T, Kobayashi T, Tachibana K, Ito KR, Hamasaki M, Kayaba Y, Terada C, Yamayoshi A, Obika S and Harada-Shiba M.

• 26. Current Diagnosis and Management of Abetalipoproteinemia. J Atheroscler Thromb. 2021;28:1009-1019.

  Takahashi M, Okazaki H, Ohashi K, Ogura M, Ishibashi S, Okazaki S, Hirayama S, Hori M, Matsuki K, Yokoyama S and Harada-Shiba M.

• 27. Diagnosis and Management of Sitosterolemia 2021. J Atheroscler Thromb. 2021;28:791-801.

  Tada H, Nomura A, Ogura M, Ikewaki K, Ishigaki Y, Inagaki K, Tsukamoto K, Dobashi K, Nakamura K, Hori M, Matsuki K, Yamashita S, Yokoyama S, Kawashiri MA and Harada-Shiba M.

• 28. Current Diagnosis and Management of Primary Chylomicronemia. J Atheroscler Thromb. 2021;28:883-904.

  Okazaki H, Gotoda T, Ogura M, Ishibashi S, Inagaki K, Daida H, Hayashi T, Hori M, Masuda D, Matsuki K, Yokoyama S and Harada-Shiba M.

• 29. Homozygous Familial Hypercholesterolemia. J Atheroscler Thromb. 2021;28:665-678.

  Nohara A, Tada H, Ogura M, Okazaki S, Ono K, Shimano H, Daida H, Dobashi K, Hayashi T, Hori M, Matsuki K, Minamino T, Yokoyama S and Harada-Shiba M.

• 30. Lipid Management and 2-Year Clinical Outcomes in Japanese Patients with Acute Coronary Syndrome: EXPLORE-J. J Atheroscler Thromb. 2021;28:1307-1322.

  Nakamura M, Ako J, Arai H, Hirayama A, Nohara A, Murakami Y, Ozaki A and Harada-Shiba M.

受賞

• 1.2024年7月 日本動脈硬化学会 学会賞

その他

• 1. 【テレビ出演】NHK あさイチ

• 2. 【テレビ出演】NHK ためしてガッテン

• 3. 【テレビ出演】NHK Eテレ きょうの健康

• 4. 【テレビ出演】NHK Eテレ チョイス＠病気になったとき

• 5. 【ラジオ出演】NHK 病院ラジオ