清水 渉 しみず わたる 先生

来歴等

略歴

1985年 広島大学医学部医学科卒業
1985年 広島大学医学部付属病院 内科 研修医
1987年 国立循環器病センター 心臓血管内科 レジデント
1990年 公立三次中央病院 内科 医員
1992年 国立循環器病センター 心臓血管内科 医員
1996年 米国、New York州、Masonic Medical Research 　
　　　　Laboratory (Charles Antzelevitch教授) 留学
1998年 国立循環器病センター 心臓血管内科 医員
2003年 国立循環器病センター 心臓血管内科 医長
2011年 国立循環器病研究センター 心臓血管内科 部長
2013年 日本医科大学大学院医学研究科 循環器内科学分野
　　　　大学院教授

著書

(英語著書、筆頭著者のみ)
1. Shimizu W, Ohe T, Nagata S, Shimomura K: Arrhythmogenic right ventricular dysplasia: Clinical features, diagnosis, treatment, and prognosis. in Sekiguchi M, Olsen E G L (eds): Cardiomyopathy Update 5. Prognosis and treatment of cardiomyopathies and myocarditis: p. 295-310, University of Tokyo Press, 1994
2. Shimizu W, Ohe T, Antzelevitch C: Early afterdepolarizations and polymorphic ventricular arrhythmias in acquired and congenital long QT syndrome: Observations from clinical and experimental studies. in Franz M R (ed): Monophasic Action Potentials. Bridging Cell and Bedside. p. 641-658, Futura Publishing Company, Inc., NY, 2000
3. Shimizu W: Acquired forms of Brugada syndrome. in Antzelevitch C (ed): The Brugada Syndrome: From bench to bedside, Chapter 14, p. 166-177, Blackwell Futura, UK, 2004
4. Shimizu W, Ackerman MJ: Chapter 28, Provocative testing in inherited arrhythmias. in Gussak I, Antzelevitch C, Wilde A, Friedman P, Ackerman MJ, Shen WK (eds): Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention, p. 424-433, Springer, UK, 2007
5. Shimizu W: Chapter 50, Acquired form of Brugada syndrome. in Gussak I, Antzelevitch C, Wilde A, Friedman P, Ackerman MJ, Shen WK (eds): Electrical Diseases of the Heart: Genetics, Mechanisms, Treatment, Prevention, p. 719-728, Springer, UK, 2007
6. Shimizu W, Antzelevitch C: Long QT syndrome. in Lang F (ed): Molecular mechanisms of disease: an Encyclopedic reference, p -, Springer, UK, 2011
7. Shimizu W: Diagnostic evaluation of long QT syndrome. in Priori SG (ed): Cardiac electrophysiology clinics. volume 4, p. 29-37, Elsevier, Philadelphia, 2012
8. Shimizu W, Ackerman MJ: Chapter 50, Provocative (drug) testing in inherited arrhythmias. in Gussak I, Antzelevitch C, Wilde A, Powell B, Ackerman MJ, Shen WK (eds): Electrical Diseases of the Heart (Second edition): Genetics, Mechanisms, Treatment, Prevention, Part IV. Clinical rhythmology: Diagnostic methods and tools, p. -, Springer, UK, Oxford, 2013 (in press)
9. Shimizu W: Chapter 40, Acquired form of Brugada syndrome. in Gussak I, Antzelevitch C, Wilde A, Powell B, Ackerman MJ, Shen WK (eds): Electrical Diseases of the Heart (Second edition): Genetics, Mechanisms, Treatment, Prevention, Part III. Secondary Hereditary and Acquired Cardiac Channelopathies, and Sudden Cardiac Death, p. -, Springer, UK, Oxford, 2013 (in press)

(英語原著、総説、筆頭著者のみ)
1. Shimizu W, Ohe T, Kurita T, Takaki H, Aihara N, Kamakura S, Matsuhisa M, Shimomura K: Early afterdepolarizations induced by isoproterenol in patients with congenital long QT syndrome. Circulation 84: 1915-1923, 1991
2. Shimizu W, Ohe T, Kurita T, Shimomura K: Differential response of QTU interval to exercise, isoproterenol, and atrial pacing in patients with congenital long QT syndrome. PACE 14: 1966-1970, 1991
3. Shimizu W, Ohe T, Shimomura K: Ventricular tachycardia originating from the right ventricular free wall in a patient with old myocardial infarction. CHEST 100: 276-277, 1991
4. Shimizu W, Tanaka K, Suenaga K, Wakamoto A: Bradycardia-dependent early afterdepolarizations in a patient with QTU prolongation and Torsade de Pointes in association with marked bradycardia and hypokalemia. PACE 14: 1105-1111, 1991
5. Shimizu W, Ohe T, Kurita T, Takaki H, Aihara N, Kamakura S, Matsuhisa M, Shimomura K: Effects of a combination of disopyramide and mexiletine on the anterograde accessory pathway conduction in patients with Wolff-Parkinson-White syndrome. Eur Heart J 13: 261-268, 1992
6. Shimizu W, Tsuchioka Y, Karakawa S, Nagata K, Mukai J, Yamagata T, Matsuura H, Kajiyama G, Matsuura Y: Differential effect of pharmacological autonomic blockade on some electrophysiological properties of the human ventricle and atrium. Br Heart J 71: 34-37, 1994
7. Shimizu W, Kamakura S, Ohe T, Kurita T, Takaki H, Aihara N, Shimomura K: Diagnostic value of recovery time measured by body surface mapping in patients with congenital long QT syndrome. Am J Cardiol 74: 780-785, 1994
8. Shimizu W, Ohe T, Kurita T, Tokuda T, Shimomura K: Epinephrine-induced ventricular premature complexes due to early afterdepolarizations and effects of verapamil and propranolol in a patient with congenital long QT syndrome. J Cardiovasc Electrophysiol 5: 438-444, 1994
9. Shimizu W, Ohe T, Kurita T, Kawade M, Arakaki Y, Aihara N, Kamakura S, Kamiya T, Shimomura K: Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. J Am Coll Cardiol 26: 1299-1309, 1995
10. Shimizu W, Kurita T, Suyama K, Aihara N, Kamakura S, Shimomura K: Reverse use dependence of human ventricular repolarization by chronic oral sotalol in monophasic action potential recordings. Am J Cardiol 77: 1004-1008, 1996
11. Shimizu W, Yamada K, Arakaki Y, Kamiya T, Shimomura K: Monophasic action potential recordings during T wave alternans in congenital long QT syndrome. Am Heart J 132: 699-701, 1996
12. Shimizu W, Kamakura S, Arakaki Y, Kamiya T, Shimomura K: T wave alternans in idiopathic long QT syndrome: Insight from body surface mapping. PACE 19: 1130-1133, 1996
13. Shimizu W, Antzelevitch C: Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long QT syndrome. Circulation 96: 2038-2047, 1997
14. Shimizu W, Kamakura S, Kurita T, Suyama K, Aihara N, Shimomura K: Influence of epinephrine, propranolol and atrial pacing on spatial distribution of recovery time measured by body surface mapping in congenital long QT syndrome. J Cardiovasc Electrophysiol 8: 1102-1114, 1997
15. Shimizu W, Kurita T, Inagaki M, Suyama K, Aihara N, Kamakura S, Kosakai Y, Isobe F, Shimomura K: Electrophysiological changes of arrhythmogenic substrate following Maze procedure in patients with lone and paroxysmal atrial fibrillation. Jpn Circ J 61: 988-996, 1997
16. Shimizu W, Kurita T, Matsuo K, Suyama K, Aihara N, Kamakura S, Towbin J A, Shimomura K: Improvement of repolarization abnormalities by a K+ channel opener in the LQT1 form of congenital long QT syndrome. Circulation 97: 1581-1588, 1998
17. Shimizu W, Antzelevitch C: Cellular basis for the electrocardiographic features of the LQT1 form of the long QT syndrome. Effects of β adrenergic agonists, antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation 98: 2314-2322, 1998
18. Shimizu W, Antzelevitch C: Cellular and ionic basis for T wave alternans under long QT conditions. Circulation 99: 1499-1507, 1999
19. Shimizu W, MacMahon B, Antzelevitch C: Sodium pentobarbital reduces transmural dispersion of repolarization and prevents torsade de pointes in models of acquired and congenital long QT syndrome. J Cardiovasc Electrophysiol 10: 154-164, 1999
20. Shimizu W, Antzelevitch C: Cellular basis for long QT, transmural dispersion of repolarization and Torsade de Pointes in the long QT syndrome. J Electrocardiol　32: 177-184, 1999
21. Shimizu W, Antzelevitch C: Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 35: 778-786, 2000
22. Shimizu W, Antzelevitch C: Effects of a K+ channel opener to reduce transmural dispersion of repolarization and prevent Torsade de Pointes in LQT1, LQT2 and LQT3 models of the long-QT syndrome. Circulation 102: 706-712, 2000
23. Shimizu W, Matsuo K, Takagi M, Tanabe Y, Aiba T, Taguchi A, Suyama K, Kurita T, Aihara N, Kamakura S: Body surface distribution and response to drugs of ST segment elevation in the Brugada syndrome: Clinical implication of 87-leads body surface potential mapping and its application to 12-leads electrocardiograms. J Cardiovasc Electrophysiol 11: 396-404, 2000
24. Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S: Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol 11: 1320-1329,2000
25. Shimizu W: Editorial comment, T wave alternans: From cell to clinical. J Cardiovasc Electrophysiol 12: 428-430, 2001
26. Shimizu W, Aiba T, Kurita T, Kamakura S: Paradoxical abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation. J Cardiovasc Electrophysiol 12: 1418-1421, 2001
27. Shimizu W, Kamakura S: Catecholamines in children with congenital long QT syndrome and Brugada syndrome. J Electrocardiol 34: 173-175, 2001
28. Shimizu W, Tanabe Y, Aiba T, Inagaki M, Kurita T, Suyama K, Nagaya N, Taguchi A, Aihara N, Sunagawa K, Nakamura K, Ohe T, Towbin J A, Priori S G, Kamakura S: Differential effects of -blockade on dispersion of repolarization in absence and presence of sympathetic stimulation between LQT1 and LQT2 forms of congenital long QT syndrome. J Am Coll Cardiol 39; 1984-1991, 2002
29. Shimizu W, Satomi K, Kamakura S: Visualization of activation and repolarization in congenital long QT syndrome. Heart 88; 190, 2002
30. Shimizu W: Effects of sympathetic stimulation on various repolarization indices in the congenital long QT syndrome. Ann Noninvasive Electrocardiol 4: 332-342, 2002
31. Shimizu W, Noda T, Takaki H, Kurita T, Nagaya N, Satomi K, Suyama K, Aihara N, Kamakura S, Echigo S, Nakamura K, Sunagawa K, Ohe T, Towbin J A, Napolitano C, Priori S G: Epinephrine unmasks latent mutation carriers with LQT1 form of congenital long QT syndrome. J Am Coll Cardiol 41: 633-642, 2003
32. Shimizu W: Genotype-specific clinical manifestation in long QT syndrome. Expert Review of Cardiovascular Therapy 1: 401-409, 2003
33. Shimizu W: Editorial comment, Gender difference and drug challenge in Brugada syndrome. J Cardiovasc Electrophysiol 15: 70-71, 2004
34. Shimizu W, Noda T, Takaki H, Nagaya N, Satomi K, Kurita T, Suyama K, Aihara N, Sunagawa K, Echigo S, Miyamoto Y, Yoshimasa Y, Nakamura K, Ohe T, Towbin J A, Priori S G, Kamakura S: Diagnostic value of epinephrine test for genotyping LQT1, LQT2 and LQT3 forms of congenital long QT syndrome. Heart Rhythm 1: 276-283, 2004
35. Shimizu W, Horie M, Ohno S, Takenaka K, Yamaguchi M, Shimizu M, Washizuka T, Aizawa Y, Nakamura K, Ohe T, Aiba T, Miyamoto Y, Yoshimasa Y, Towbin J A, Priori S G, Kamakura S: Mutation site-specific differences in arrhythmic risk and sensitivity to sympathetic stimulation in LQT1 form of congenital long QT syndrome - Multi-center study in Japan -. J Am Coll Cardiol 44: 117-125, 2004
36. Shimizu W, Aiba T, Antzelevitch C: Specific therapy based on the genotype and cellular mechanism in inherited cardiac arrhythmias. - Long QT syndrome and Brugada syndrome -. Curr Pharm Design 11: 1561-1572, 2005
37. Shimizu W: The long QT syndrome: Therapeutic implications of a genetic diagnosis. Cardiovasc Res 67: 347-356, 2005
38. Shimizu W, Aiba T, Kamakura S: Mechanisms of disease: current understanding and future challenges in Brugada syndrome. Nat Clin Pract Cardiovasc Med 2, 408-414, 2005
39. Shimizu W: Acquired forms of the Brugada syndrome. J Electrocardiol 38 Suppl:22-25, 2005
40. Shimizu W: The Brugada syndrome. - An update -. Internal Med 44: 1224-1231, 2005
41. Shimizu W: Editorial comment. Does an overlap syndrome really exist between Brugada syndrome and progressive cardiac conduction defect (Lenegre syndrome)? J Cardiovasc Electrophysiol 17: 276-278, 2006
42. Shimizu W, Matsuo K, Kokubo Y, Satomi K, Kurita T, Noda T, Nagaya N, Suyama K, Aihara N, Kamakura S, Inamoto N, Akahoshi M, Tomoike H: Sex hormone and gender difference. - Role of testosterone on male predominance in Brugada syndrome. J Cardiovasc Electrophysiol 18: 415-421, 2007
43. Shimizu W, Aiba T, Kamakura S: Mechanism and new findings in the Brugada syndrome. Circ J 71: (Suppl A) A32-A39, 2007
44. Shimizu W: Editorial Commentary. Proarrhythmic effect of altered ventricular activation sequence in patients with permanent pacemaker. Heart Rhythm 4: 1487-1488, 2007
45. Moss AJ*, Shimizu W*, Wilde AAM*, Towbin JA*, Zareba Z, Robinson JL, Qi M, Vincent GM, Ackerman MJ, Kaufman ES, Hofman N, Seth R, Kamakura S, Miyamato Y, Goldenberg I, Andrews ML, McNitt S: Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene. Circulation 115:2481-2489, 2007 * These 4 authors equally contributed
46. Shimizu W: Genetics of congenital long QT syndrome and Brugada syndrome. Future Cardiology 4: 379-389, 2008
47. Shimizu W: Clinical impact of genetic studies in lethal inherited cardiac arrhythmias. Circ J 72: 1926-1936, 2008
48. Shimizu W, Moss AJ, Wilde AAM, Towbin JA, Ackerman MJ, January C, Tester DJ, Zareba W, Robinson JL, Qi M, Vincent GM, Kaufman ES, Hofman N, Noda T, Kamakura S, Miyamoto Y, MD, Shah S, Amin V, Goldenberg I, Andrews ML, McNitt S: Genotype-phenotype aspects of type-2 long-QT syndrome. J Am Coll Cardiol 54: 2052-2062; 2009
49. Shimizu W: Arrhythmias originating from the RVOT: How to distinguish “malignant” from “benign”? Heart Rhythm 6: 1507-1511, 2009
50. Shimizu W: Editorial Commentary. Diagnostic values of bipolar precordial leads in Brugada syndrome: More accurate, more simple, or more theoretical? Heart Rhythm 7: 216-217, 2010
51. Shimizu W: How the knowledge of genetic "makeup" and cellular data can affect the analysis of repolarization in surface ECG. J Electrocardiol 43: 583-587, 2010
52. Shimizu W, Horie M: Phenotypical manifestations of mutations in genes encoding subunits of cardiac potassium channels. Circ Res 109: 97-109, 2011
53. Shimizu W: Clinical features of Brugada syndrome. J Arrhythmia 29: 65-70, 2013
54. Shimizu W: Update of diagnosis and management in inherited cardiac arrhythmias. Circ J 77(12): 2867-2872, 2013
55. Shimizu W: Editorial comment. Importance of clinical analysis in this era of new technology of molecular genetic screening. J Am Coll Cardiol: 64(1): 80-82, 2014
56. Shimizu W: Clinical and genetic diagnosis for inherited cardiac arrhythmias. J Nippon Med Sch. 81(4):203-210, 2014
57. Shimizu W: Where does heterogeneity exist in ventricular tachyarrhythmias? Heart Rhythm. 12(6):1304-1305, 2015
58. Hayashi M*, Shimizu W*, Albert CM: The spectrum of epidemiology underlying sudden cardiac death. Circ Res. 116(12):1887-1906, 2015 *Equally contributed
59. Wilde AA*, Moss AJ*, Kaufman ES*, Shimizu W*, Peterson DR, Benhorin J, Lopes C, Towbin JA, Spazzolini C, Crotti L, Zareba W, Goldenberg I, Kanters JK, Robinson JL, Qi M, Hofman N, Tester DJ, Bezzina C, Alders M, Aiba T, Kamakura S, Miyamoto Y, Andrews ML, McNitt S, Polonsky B, Schwartz PJ, Ackerman MJ: Clinical aspects of type 3 long QT syndrome: An international multicenter study. Circulation. 134(12): 872-882, 2016 * These 4 authors equally contributed
60. Yamagata K*, Horie M, Aiba T, Ogawa S, Aizawa Y, Ohe T, Yamagishi M, Makita N, Sakurada H, Tanaka T, Shimizu A, Hagiwara N, Kishi R, Nakano Y, Takagi M, Makiyama T, Ohno S, Fukuda K, Watanabe H, Morita H, Hayashi K, Fukushima-Kusano K, Kamakura S, Yasuda S, Ogawa H, Miyamoto Y, Kapplinger J, Ackerman M, Shimizu W*: Genotype-phenotype correlation of SCN5A mutation for clinical and electrocardiographic characteristics of probands with Brugada Syndrome: A Japanese multicenter registry. Circulation. 135(23):2255-2270, 2017 *Equally contributed

その他

• 【受賞】1992年10月 第8回木村栄一賞最優秀賞 (第9回日本心電学会)

• 【受賞】1997年5月 第18回北米ペーシング電気生理学会(NASPE)

• 【受賞】若手研究奨励賞最優秀賞(基礎部門)

• 【受賞】1998年3月 第47回米国心臓病学会(ACC)

• 【受賞】若手研究奨励賞(基礎部門)

• 【受賞】1999年4月 第24回国際コンピューター心電学会(ISCE)

• 【受賞】Jos Willems若手研究奨励賞最優秀賞

• 【受賞】2003年9月 第3回日本心電学会医科学応用研究財団論文賞

• 【受賞】最優秀賞

• 【受賞】2008年3月 第33回日本心臓財団 佐藤賞

• 【受賞】(第72回日本循環器学会学術集会)

• 【学会開催】2011年4月 第36回国際コンピューター心電学会(ISCE’11) 大会長
(4月13~17日, Dolce Hayes Mansion, San Jose, California, US)


• 【社会における活動】準編集員 (Associate Editor)

• 【社会における活動】2007年- Cardiology Journal (Folia Cardiologica)

• 【社会における活動】2012年- Journal of Cardiology Cases

• 【社会における活動】2012年- Journal of Arrhythmia (不整脈心電学会・APHRS 公式雑誌)

• 【社会における活動】2016年- Circulation Journal (日本循環器学会 公式雑誌)

• 【社会における活動】2016年- Internal Medicine (日本内科学会 公式雑誌)

• 【編集委員 (Editorial Board)】2003年- Journal of Cardiovascular Electrophysiology

• 【編集委員 (Editorial Board)】2004年- Heart Rhythm (米国Heart Rhythm Society 公式雑誌)

• 【編集委員 (Editorial Board)】2007年- Europace (Europiean Heart Rhythm Association 公式雑誌)

• 【ガイドライン作成】2002年- 日本循環器学会「心臓突然死の予知と予防法の合同ガイドライン作成班」協力員

• 【ガイドライン作成】2005年- 日本循環器学会「QT延長症候群(先天性・二次性)とBrugada

• 【ガイドライン作成】症候群の診療に関するガイドライン作成班」協力員

• 【ガイドライン作成】2009年- 日本循環器学会「慢性心不全治療ガイドライン

• 【ガイドライン作成】2010年度改 訂版作成班」協力員

• 【ガイドライン作成】2009年- 日本循環器学会「心臓突然死の予知と予防法の合同ガイドライン2010年度改訂版作成班」協力員

• 【ガイドライン作成】2011年- 日本循環器学会「QT延長症候群(先天性・二次性)とBrugada症候群の診療に関するガイドライン2011年度改訂版作成班」協力員

• 【ガイドライン作成】2013年- 日本循環器学会「循環器病薬の血中濃度モニタリング(TDM)に関するガイドライン」班員

• 【ガイドライン作成】2016年- 日本循環器学会「QT延長症候群(先天性・二次性)とBrugada症候群の診療に関するガイドライン2016年度改訂版作成班」班員

• 【ガイドライン作成】2016年- 日本循環器学会「急性・慢性心不全診療ガイドライン(2018年改訂版)」班員【ガイドライン作成】2016年- 日本循環器学会「急性・慢性心不全診療ガイドライン(2018年改訂版)」班員

• 【ガイドライン作成】2016年- 日本循環器学会「不整脈非薬物療法ガイドライン(2018年改訂版)」班員