落合 淳志 おちあい あつし 先生

来歴等

略歴

1982年 広島大学医学部 卒業
1986年 広島大学大学院医学系研究科 病理学単位取得後終了
1985年 日本学術振興会 特別研究員
1987年 広島大学医学部第一病理学 助手・講師
1988年 西ドイツハノーバー医科大学実験病理学教室アレクサンダーフンボルト 招聘研究員
1991年 国立がんセンター研究所病理部 研究員・室長
1998年 国立がんセンター研究所支所臨床腫瘍病部 部長
2005年 国立がんセンター東病院臨床開発センター 臨床腫瘍病理分野長
2013年 国立がん研究センター東病院病理臨床検査科 科長
2014年 国立がん研究センター研究所 副所長
2017年 国立がん研究センター 先端医療開発センター長

論文

• Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma.Br J Cancer. 2019 Nov 25. doi: 10.1038/s41416-019-0622-3.

  Hatogai K, Fujii S, Kitano S, Kojima T, Daiko H, Yoshino T, Ohtsu A, Takiguchi Y, Doi T, Ochiai A.

• Meeting Report: The International Workshop on Harmonization and Standardization of Digital Pathology Image, Held on April 4, 2019 in Tokyo.Pathobiology. 2019;86(5-6):322-324. doi: 10.1159/000502718. Epub 2019 Nov 8. No

  Yoshida H, Yokota H, Singh R, Kiyuna T, Yamaguchi M, Kikuchi S, Yagi Y, Ochiai A.

• Assessment of Upper Limb Physiological Features in Patients with Lymphedema After Breast Surgery Using Multiple Instruments.Lymphat Res Biol. 2019 Oct 29. doi: 10.1089/lrb.2019.0039. [Epub ahead of print]

  Kojima M, Yamauchi C, Oyamada S, Hojo T, Iwase S, Naito A, Yamano K, Takahashi S, Ochiai A.

• Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung.Pathol Int. 2019 Sep;69(9):526-535. doi: 10.1111/pin.12853.

  Oki T, Aokage K, Ueda T, Sugano M, Tane K, Miyoshi T, Kojima M, Fujii S, Kuwata T, Ochiai A, Funai K, Tsuboi M, Ishii G.

• Interaction between cancer cells and cancer-associated fibroblasts after cisplatin treatment promotes cancer cell regrowth.Hum Cell. 2019 Oct;32(4):453-464. doi: 10.1007/s13577-019-00275-z. Similar articles

  Hisamitsu S, Miyashita T, Hashimoto H, Neri S, Sugano M, Nakamura H, Yamazaki S, Ochiai A, Goto K, Tsuboi M, Ishii G.

• Expression of Monocarboxylate Transporter 1 Is Associated With Better Prognosis and Reduced Nodal Metastasis in Pancreatic Ductal Adenocarcinoma.Ochiai A. Pancreas. 2019 Sep;48(8):1102-1110. doi: 10.1097/MPA.0000000000001369.

  Sukeda A, Nakamura Y, Nishida Y, Kojima M, Gotohda N, Akimoto T,

• Secretion of high amounts of hepatocyte growth factor is a characteristic feature of cancer-associated fibroblasts with EGFR-TKI resistance-promoting phenotype: A study of 18 cases of cancer-associated fibroblasts.Pathol Int. 2019 Aug;69(8):472-480. doi: 10.1111/pin.12838. Epub 2019 Jul 24.

  Suzuki E, Yamazaki S, Naito T, Hashimoto H, Okubo S, Udagawa H, Goto K, Tsuboi M, Ochiai A, Ishii G.

• Organoid culture containing cancer cells and stromal cells reveals that podoplanin-positive cancer-associated fibroblasts enhance proliferation of lung cancer cells.Lung Cancer. 2019 Aug;134:100-107. doi: 10.1016/j.lungcan.2019.04.007. Epub 2019 Apr 8.

  Nakamura H, Sugano M, Miyashita T, Hashimoto H, Ochiai A, Suzuki K, Tsuboi M, Ishii G.

• Extra-perigastric Extranodal Metastasis is a Significant Prognostic Factor in Node-Positive Gastric Cancer.World J Surg. 2019 Oct;43(10):2499-2505. doi: 10.1007/s00268-019-05076-x.

  Tonouchi A, Sugano M, Tokunaga M, Sugita S, Watanabe M, Sato R, Kaito A, Akimoto T, Ochiai A, Kinoshita T, Kuwata T.

• The utility of longitudinal slicing method for rectal specimen: pathological analysis of circumferential resection margin of intersphincteric resection for low-lying rectal cancer.Pathol Int. 2019 May;69(5):272-281. doi: 10.1111/pin.12797. Epub 2019 Jun 23.

  Matsunaga R, Kojima M, Nishizawa Y, Yokota M, Hasegawa H, Saito N, Ito M, Ochiai A.

• Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles.Carcinogenesis. 2019 Jun 20. pii: bgz120. doi: 10.1093/carcin/bgz120. [Epub ahead of print]

  Mimaki S, Watanabe M, Kinoshita M, Yamashita R, Haeno H, Takemura S, Tanaka S, Marubashi S, Totsuka Y, Shibata T, Nakagama H, Ochiai A, Nakamori S, Kubo S, Tsuchihara K.

• Establishment of Novel Gastric Cancer Patient-Derived Xenografts and Cell Lines: Pathological Comparison between Primary Tumor, Patient-Derived, and Cell-Line Derived Xenografts.Cells. 2019 Jun 14;8(6). pii: E585. doi: 10.3390/cells8060585.

  Kuwata T, Yanagihara K, Iino Y, Komatsu T, Ochiai A, Sekine S, Taniguchi H, Katai H, Kinoshita T, Ohtsu A.

• Growth patterns of small peripheral squamous cell carcinoma of the lung and their impacts on pathological and biological characteristics of tumor cells.J Cancer Res Clin Oncol. 2019 Jul;145(7):1773-1783. doi: 10.1007/s00432-019-02937-9. Epub 2019 May 21.

  Omori T, Aokage K, Nakamura H, Katsumata S, Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Ikeda N, Tsuboi M, Ishii G.

• Cancer cell niche factors secreted from cancer-associated fibroblast by loss of H3K27me3.Gut. 2020 Feb;69(2):243-251. doi: 10.1136/gutjnl-2018-317645. Epub 2019 May 13.

  Maeda M, Takeshima H, Iida N, Hattori N, Yamashita S, Moro H, Yasukawa Y, Nishiyama K, Hashimoto T, Sekine S, Ishii G, Ochiai A, Fukagawa T, Katai H, Sakai Y, Ushijima T.

• Development and characterization of a cancer cachexia model employing a rare human duodenal neuroendocrine carcinoma-originating cell line.Oncotarget. 2019 Mar 29;10(25):2435-2450. doi: 10.18632/oncotarget.26764. eCollection 2019 Mar 29.

  Yanagihara K, Kubo T, Iino Y, Mihara K, Morimoto C, Seyama T, Kuwata T, Ochiai A, Yokozaki H.

• Systematic Review of Patient-Derived Xenograft Models for Preclinical Studies of Anti-Cancer Drugs in Solid Tumors.Cells. 2019 May 6;8(5). pii: E418. doi: 10.3390/cells8050418.

  Koga Y, Ochiai A.

• Endometrial cancer arising after complete remission of uterine malignant lymphoma: A case report and mutation analysis.Gynecol Oncol Rep. 2019 Feb 27;28:50-53. doi: 10.1016/j.gore.2019.02.007. eCollection 2019 May.

  Kuno I, Yoshida H, Kohno T, Ochiai A, Kato T.

• Combination Treatment of Preoperative Embryo Cryopreservation and Endoscopic Surgery (Surgery-ART Hybrid Therapy) in Infertile Women with Diminished Ovarian Reserve and Uterine Myomas or Ovarian Endometriomas. J Minim Invasive Gynecol. 2019 Nov - Dec;26(7):1369-1375. doi: 10.1016/j.jmig.2019.02.008. Epub 2019 Feb 19.

  Kuroda K, Ikemoto Y, Ochiai A, Ozaki R, Matsumura Y, Nojiri S, Nakagawa K, Sugiyama R.

• Recommendation of long-term and systemic management according to the risk factors in rectal NETs patients.Sci Rep. 2019 Feb 20;9(1):2404. doi: 10.1038/s41598-018-37707-z.

  Kojima M, Chen Y, Ikeda K, Tsukada Y, Takahashi D, Kawano S, Amemiya K, Ito M, Ohki R, Ochiai A.

• Clinicopathological characteristics associated with necrosis in pulmonary metastases from colorectal cancer.Virchows Arch. 2019 May;474(5):569-575. doi: 10.1007/s00428-019-02535-7. Epub 2019 Feb 14.

  Suzuki J, Kojima M, Aokage K, Sakai T, Nakamura H, Ohara Y, Tane K, Miyoshi T, Sugano M, Fujii S, Kuwata T, Ochiai A, Ito M, Suzuki K, Tsuboi M, Ishii G.

• Development and Biological Analysis of a Novel Orthotopic Peritoneal Dissemination Mouse Model Generated Using a Pancreatic Ductal Adenocarcinoma Cell Line.Pancreas. 2019 Mar;48(3):315-322. doi: 10.1097/MPA.0000000000001253.

  Yanagihara K, Kubo T, Mihara K, Kuwata T, Ochiai A, Seyama T, Yokozaki H.

• Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study.Cancer Sci. 2019 Apr;110(4):1480-1490. doi: 10.1111/cas.13969. Epub 2019 Apr 2.

  Sunami K, Ichikawa H, Kubo T, Kato M, Fujiwara Y, Shimomura A, Koyama T, Kakishima H, Kitami M, Matsushita H, Furukawa E, Narushima D, Nagai M, Taniguchi H, Motoi N, Sekine S, Maeshima A, Mori T, Watanabe R, Yoshida M, Yoshida A, Yoshida H, Satomi K, Sukeda A, Hashimoto T, Shimizu T, Iwasa S, Yonemori K, Kato K, Morizane C, Ogawa C, Tanabe N, Sugano K, Hiraoka N, Tamura K, Yoshida T, Fujiwara Y, Ochiai A, Yamamoto N, Kohno T.

• Imaging of Metastatic Cancer Cells in Sentinel Lymph Nodes using Affibody Probes and Possibility of a Theranostic Approach.Int J Mol Sci. 2019 Jan 19;20(2). pii: E427. doi: 10.3390/ijms20020427.

  Tsuchimochi M, Yamaguchi H, Hayama K, Okada Y, Kawase T, Suzuki T, Tsubokawa N, Wada N, Ochiai A, Fujii S, Fujii H.

• Spatiotemporal characteristics of fibroblasts-dependent cancer cell invasion.J Cancer Res Clin Oncol. 2019 Feb;145(2):373-381. doi: 10.1007/s00432-018-2798-y. Epub 2018 Nov 23.

  Miyashita T, Omori T, Nakamura H, Sugano M, Neri S, Fujii S, Hashimoto H, Tsuboi M, Ochiai A, Ishii G.

その他

• 【受賞】1996年　日本癌学会奨励賞

• 【受賞】1996年 日本病理学会学術研究賞（A演説）

• 【受賞】1997年　国立がんセンター田宮賞

• 【受賞】1999年　ベルツ賞　授賞

• 【受賞】1999年　がん研究会振興財団がん研究振興財団助成金

• 【受賞】2004年　高松宮妃癌研究基金高松宮妃癌研究助成金

• 【受賞】2006年　日本病理学会日本病理学賞