小宮根 真弓 こみね まゆみ 先生

来歴等

略歴

1988年 東京大学医学部医学科 卒業
1988年 東京大学医学部附属病院 皮膚科 助手
1990年 関東逓信病院 皮膚科 勤務
1993年 ニューヨーク大学メディカルセンター 皮膚科 研究員（～1996年）
1996年 東京大学医学部附属病院 皮膚科 助手
1999年 東京大学医学部附属病院分院 皮膚科 講師・病棟医長
2000年 東京大学医学部附属病院分院 皮膚科 医局長
2001年 東京大学医学部附属病院 皮膚科 講師
2007年 自治医科大学医学部 皮膚科学講座 准教授
2008年 自治医科大学医学部 生化学教室病態生化学部門 准教授（兼任）
2014年 自治医科大学キャリア支援センター 副センター長（兼任）
2016年 自治医科大学キャリア支援センター センター長（兼任）
2018年 自治医科大学医学部 皮膚科学講座 教授
2019年 自治医科大学医学部 皮膚科学講座 科長、科目責任者

論文

• 1. Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging. Int J Mol Sci. 2021 Apr 12;22(8):3974. doi: 10.3390/ijms22083974. PMID: 33921444; PMCID: PMC8069861.

  Ansary TM, Hossain MR, Kamiya K, Komine M, Ohtsuki M.

• 2. Diversified Stimuli-Induced Inflammatory Pathways Cause Skin Pigmentation. Int J Mol Sci. 2021 Apr 12;22(8):3970. doi: 10.3390/ijms22083970. PMID: 33921371; PMCID: PMC8070342.

  Hossain MR, Ansary TM, Komine M, Ohtsuki M.

• 3. Generalized pustular psoriasis: current management status and unmet medical needs in Japan. Expert Rev Clin Immunol. 2021 Aug 17:1-13. doi: 10.1080/1744666X.2021.1961580. Epub ahead of print. PMID: 34402355.

  Komine M, Morita A.

• 4. Population pharmacokinetic and exposure-response analysis of apremilast in Japanese subjects with moderate to severe psoriasis. J Dermatol. 2021 Aug 15. doi: 10.1111/1346-8138.16068. Epub ahead of print. PMID: 34396569.

  Okubo Y, Ohtsuki M, Komine M, Imafuku S, Kassir N, Petric R, Nemoto O.

• 5. Japanese guidance for use of biologics for psoriasis (the 2019 version). J Dermatol. 2020 Mar;47(3):201-222. doi: 10.1111/1346-8138.15196. Epub 2020 Jan 8. PMID: 31916326.

  Saeki H, Terui T, Morita A, Sano S, Imafuku S, Asahina A, Komine M, Etoh T, Igarashi A, Torii H, Abe M, Nakagawa H, Watanabe A, Yotsuyanagi H, Ohtsuki M; Biologics Review Committee of the Japanese Dermatological Association for Psoriasis: Chair: Mamitaro Ohtsuki.

• 6. Recent Advances in Psoriasis Research; the Clue to Mysterious Relation to Gut Microbiome. Int J Mol Sci. 2020 Apr 8;21(7):2582. doi: 10.3390/ijms21072582. PMID: 32276410; PMCID: PMC7177330.

  Komine M.

• 7. Pharmacodynamic analysis of apremilast in Japanese patients with moderate to severe psoriasis: Results from a phase 2b randomized trial. J Dermatol. 2021 Jan;48(1):80-84. doi: 10.1111/1346-8138.15596. Epub 2020 Sep 10. PMID: 32909643; PMCID: PMC7821327.

  Imafuku S, Nemoto O, Okubo Y, Komine M, Schafer P, Petric R, Ohtsuki M.

• 8. Results of a retrospective study on the efficacy and safety of adalimumab 80 mg administrated every other week in patients with psoriasis at a single Japanese institution. J Dermatol. 2019 Mar;46(3):199-205. doi: 10.1111/1346-8138.14782. Epub 2019 Jan 23. PMID: 30672612.

  Kamiya K, Karakawa M, Komine M, Kishimoto M, Sugai J, Ohtsuki M.

• 9. Drug survival of apremilast in a real-world setting. J Dermatol. 2019 Jul;46(7):615-617. doi: 10.1111/1346-8138.14943. Epub 2019 Jun 10. PMID: 31180150.

  Kishimoto M, Komine M, Kamiya K, Sugai J, Ohtsuki M.

• 10. dsRNA induces IL-33 promoter activity through TLR3-EGFR-IRF3 pathway in normal human epidermal keratinocytes. J Dermatol Sci. 2019 Dec;96(3):178-180. doi: 10.1016/j.jdermsci.2019.11.002. Epub 2019 Nov 19. PMID: 31810599.

  Jin M, Komine M, Tsuda H, Oshio T, Ohtsuki M.

• 11. Drug survival of biologic agents for psoriatic patients in a real-world setting in Japan. J Dermatol. 2020 Jan;47(1):33-40. doi: 10.1111/1346-8138.15146. Epub 2019 Nov 6. PMID: 31696543.

  Kishimoto M, Komine M, Kamiya K, Sugai J, Mieno M, Ohtsuki M.

• 12. Acute generalized exanthematous pustulosis induced by amoxicillin/clavulanic acid, manifesting as severe laryngeal edema. J Dermatol. 2019 Nov;46(11):e443-e444. doi: 10.1111/1346-8138.15016. Epub 2019 Jul 19. PMID: 31321789.

  Hioki T, Kamiya K, Tsuda H, Maekawa T, Komine M, Murata S, Ohtsuki M.

• 13. Differential expression of alarmins: IL-33 as a candidate marker for early diagnosis of toxic epidermal necrolysis. J Allergy Clin Immunol Pract. 2019 Jan;7(1):325-327. doi: 10.1016/j.jaip.2018.05.037. Epub 2018 Jun 21. PMID: 29936189.

  Adachi A, Komine M, Tsuda H, Nakajima S, Kabashima K, Ohtsuki M.

• 14. Interleukin-33 is expressed in the lesional epidermis in herpes virus infection but not in verruca vulgaris. J Dermatol. 2018 Jul;45(7):855-857. doi: 10.1111/1346-8138.14334. Epub 2018 Apr 25. PMID: 29696682.

  Jin M, Komine M, Tsuda H, Oshio T, Ohtsuki M.

• 15. Long-term survival of a patient with neurofibromatosis type 1 diagnosed with multiple malignant peripheral nerve sheath tumors. J Dermatol. 2019 Jan;46(1):e48-e49. doi: 10.1111/1346-8138.14527. Epub 2018 Jul 2. PMID: 29963712.

  Adachi A, Maekawa T, Komine M, Murata S, Ohtsuki M.

• 16. Real-world use of apremilast for patients with psoriasis in Japan. J Dermatol. 2018 Nov;45(11):1345-1348. doi: 10.1111/1346-8138.14617. Epub 2018 Aug 31. PMID: 30168880.

  Kishimoto M, Komine M, Hioki T, Kamiya K, Sugai J, Ohtsuki M.

• 17. Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP. J Dermatol. 2018 Nov;45(11):1235-1270. doi: 10.1111/1346-8138.14523. Epub 2018 Sep 19. PMID: 30230572.

  Fujita H, Terui T, Hayama K, Akiyama M, Ikeda S, Mabuchi T, Ozawa A, Kanekura T, Kurosawa M, Komine M, Nakajima K, Sano S, Nemoto O, Muto M, Imai Y, Yamanishi K, Aoyama Y, Iwatsuki K; Japanese Dermatological Association Guidelines Development Committee for the Guidelines for the Management and Treatment of Generalized Pustular Psoriasis.

• 18. Diagnosis of pseudoxanthoma elasticum in a 4-year-old boy. J Dermatol. 2018 Feb;45(2):244-246. doi: 10.1111/1346-8138.13805. Epub 2017 Mar 22. PMID: 28328114.

  Maki N, Komine M, Tsuda H, Fujita Y, Fujita E, Murata S, Demitsu T, Utani A, Ohtsuki M.

• 19. Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: Efficacy, safety and tolerability results from a phase 2b randomized controlled trial. J Dermatol. 2017 Aug;44(8):873-884. doi: 10.1111/1346-8138.13829. Epub 2017 Apr 9. PMID: 28391657; PMCID: PMC5573969.

  Ohtsuki M, Okubo Y, Komine M, Imafuku S, Day RM, Chen P, Petric R, Maroli A, Nemoto O.

• 20. Involvement of M2 macrophages in the pathomechanisms of multicentric reticulohistiocytosis. Int J Dermatol. 2017 Aug;56(8):e173-e175. doi: 10.1111/ijd.13661. Epub 2017 May 29. PMID: 28556889.

  Kamiya K, Komine M, Murata S, Ohtsuki M.

• 21. Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma. Acta Derm Venereol. 2017 Jun 9;97(6):756-758. doi: 10.2340/00015555-2640. PMID: 28224164.

  Adachi A, Komine M, Maekawa T, Murata S, Shiohama A, Kubo A, Ohtsuki M.

• 22. Methotrexate, but not narrowband ultraviolet B radiation, suppresses interleukin-33 mRNA levels in psoriatic plaques and protein levels in serum of patients with psoriasis. J Dermatol. 2018 Mar;45(3):322-325. doi: 10.1111/1346-8138.14009. Epub 2017 Aug 24. PMID: 28836690.

  Meephansan J, Subpayasarn U, Ponnikorn S, Chakkavittumrong P, Juntongjin P, Komine M, Ohtsuki M, Poovorawan Y.

• 23. Generalized pustular psoriasis in a 92-year-old man with a homozygous nonsense mutation in IL36RN. J Dermatol. 2018 Mar;45(3):326-328. doi: 10.1111/1346-8138.14132. Epub 2017 Dec 7. PMID: 29215143.

  Ueda Y, Komine M, Kamiya K, Tsuda H, Maekawa T, Murata S, Ohtsuki M.

• 24. Efficacy and safety of secukinumab in patients with generalized pustular psoriasis: A 52-week analysis from phase III open-label multicenter Japanese study. J Dermatol. 2016 Sep;43(9):1011-7. doi: 10.1111/1346-8138.13306. Epub 2016 Feb 26. PMID: 26919410.

  Imafuku S, Honma M, Okubo Y, Komine M, Ohtsuki M, Morita A, Seko N, Kawashima N, Ito S, Shima T, Nakagawa H.

• 25. Case of generalized pustular psoriasis exacerbated during pregnancy, successfully treated with infliximab. J Dermatol. 2016 Dec;43(12):1439-1440. doi: 10.1111/1346-8138.13429. Epub 2016 Apr 30. PMID: 27130289.

  Adachi A, Komine M, Hirano T, Tsuda H, Karakawa M, Murata S, Ohtsuki M.

• 26. Pediatric case of microscopic polyangiitis with skin manifestations resembling vesiculobullous type erythema elevatum diutinum with immunoglobulin A antineutrophil cytoplasmic antibody. J Dermatol. 2016 Nov;43(11):1377-1378. doi: 10.1111/1346-8138.13394. Epub 2016 Apr 21. PMID: 27097593.

  Adachi A, Komine M, Murata S, Tsuda H, Kawahara Y, Morimoto A, Ohtsuki M.

• 27. Case of mixed form primary cutaneous mucinous carcinoma with the initial lesion exhibiting similar histopathological features to those of syringomatous carcinoma. J Dermatol. 2016 Nov;43(11):1364-1365. doi: 10.1111/1346-8138.13410. Epub 2016 Apr 30. PMID: 27129609.

  Adachi A, Komine M, Murata S, Maekawa T, Ansai SI, Ohtsuki M.

• 28. Oral colchicine monotherapy for epidermolysis bullosa acquisita: Mechanism of action and efficacy. J Dermatol. 2016 Nov;43(11):1389-1391. doi: 10.1111/1346-8138.13395. Epub 2016 May 6. PMID: 27153772.

  Adachi A, Komine M, Suzuki M, Murata S, Hirano T, Ishii N, Hashimoto T, Ohtsuki M.

• 29. Effects of maxacalcitol ointment on skin lesions in patients with psoriasis receiving treatment with adalimumab. J Dermatol. 2016 Nov;43(11):1354-1357. doi: 10.1111/1346-8138.13515. Epub 2016 Jul 23. PMID: 27450634.

  Karakawa M, Komine M, Kishimoto M, Maki N, Matsumoto A, Sugai J, Ohtsuki M.

• 30. Nuclear expression of IL-33 in epidermal keratinocytes promotes wound healing in mice. J Dermatol Sci. 2017 Feb;85(2):106-114. doi: 10.1016/j.jdermsci.2016.10.008. Epub 2016 Oct 17. PMID: 27839630.

  Oshio T, Komine M, Tsuda H, Tominaga SI, Saito H, Nakae S, Ohtsuki M.

• 31. Adalimumab administration after infliximab therapy is a successful treatment strategy for generalized pustular psoriasis. J Dermatol. 2017 Feb;44(2):202-204. doi: 10.1111/1346-8138.13632. Epub 2016 Oct 15. PMID: 27743397.

  Matsumoto A, Komine M, Karakawa M, Kishimoto M, Ohtsuki M.

• 32. Identification of the promoter region of human IL-33 responsive to induction by IFNγ. J Dermatol Sci. 2017 Feb;85(2):137-140. doi: 10.1016/j.jdermsci.2016.11.002. Epub 2016 Nov 9. PMID: 27955843.

  Tsuda H, Komine M, Tominaga SI, Ohtsuki M.

受賞

• 1. 2013 年　自治医科大学　平成24年度優秀論文賞（Corresponding author）

• 2. 2006 年　JSID Shiseido Award, JSID

• 3. 2001 年　Galderma賞, Galderma pharmaceutical company

• 4. 1996 年　Husic Prize, Ronald O. Perelman Department of Dermatology, New York University School of Medicine